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dASK 1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174862
    dASK1

    		PROTACs ASK1 Inflammation/Immunology
    dASK1 is a selective and cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1). dASK1 forms a stable ternary complex with ASK1, facilitating ASK1 rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 demonstrates potent ASK1 degradation. dASK1 can be used for the research of steatohepatitis . (Structure Note: Pink: ASK1 ligand (HY-174860); Blue: E3 ligase ligand (HY-10984); Black: linker; E3-linker (HY-174863))
    dASK1
  • HY-174858
    dASK1-VHL

    		PROTACs ASK1 p38 MAPK Metabolic Disease
    dASK1-VHL is an orally active PROTAC degrader targeting ASK1. dASK1-VHL can effectively bind VHL and promote the selective degradation of ASK1. dASK1-VHL effectively reduces ASK1 protein levels, inhibits the activation of p38 MAPK, and reduces liver lipid content. dASK1-VHL provides new ideas for the study of Metabolic dysfunction-associated steatohepatitis (MASH) (Pink: ASK1 ligand 1 (HY-174860); Blue: E3 ligand (S,R,S)-AHPC (HY-125845); Black: Linker, (S,R,S)-AHPC-CO-C2-PEG-NHCO-C2-COOH (HY-174861) .
    dASK1-VHL
  • HY-174860
    ASK1 ligand 1

    		Ligands for Target Protein for PROTAC ASK1 Cancer
    ASK1 ligand 1 is a binding ligand for ASK1 and can be used to synthesize PROTACs such as dASK1-VHL (HY-174858 )[1].
    ASK1 ligand 1
  • HY-174861
    (S,R,S)-AHPC-CO-C2-PEG-NHCO-C2-COOH

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-CO-C2-PEG-NHCO-C2-COOH is a synthetic E3 ubiquitin ligase ligand-linker conjugate that can be used to synthesize PROTACs such as dASK1-VHL (HY-174858) .
    (S,R,S)-AHPC-CO-C2-PEG-NHCO-C2-COOH
  • HY-174863
    Pomalidomide-C2-PEG-NHCO-C2-COOH

    		E3 Ligase Ligand-Linker Conjugates Inflammation/Immunology
    Pomalidomide-C2-PEG-NHCO-C2-COOH is a conjugate of the E3 ligase ligand (HY-10984) and the linker (E3 Ligase Ligand-Linker Conjugate). Pomalidomide-C2-PEG-NHCO-C2-COOH can be used for synthesizing PROTAC ASK1 degrader dASK1 (HY-174862) .
    Pomalidomide-C2-PEG-NHCO-C2-COOH

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