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Results for "

cytotoxic effect

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CTLA-4 (1) ADC Cytotoxin (1) Adrenergic Receptor (3) Akt (1) AMPK (1) Amyloid-β (4) Androgen Receptor (1) Antibiotic (8) Antibody-Drug Conjugates (ADCs) (1) Antifolate (1) Apoptosis (19) Autophagy (7) Bacterial (23) Bcl-2 Family (2) Biochemical Assay Reagents (3) Calcium Channel (1) Caspase (1) CD19 (1) CD3 (1) Cholinesterase (ChE) (1) COX (2) DNA/RNA Synthesis (10) Drug Derivative (1) Drug Metabolite (3) DYRK (1) E1/E2/E3 Enzyme (3) EGFR (1) Endogenous Metabolite (10) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (2) FAK (1) Ferroptosis (7) Fungal (10) GABA Receptor (4) GLUT (2) Glutathione Peroxidase (2) GnRH Receptor (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (2) HIV (1) HIV Integrase (1) HSP (1) Imidazoline Receptor (3) Influenza Virus (3) Insecticide (1) Insulin Receptor (2) Interleukin Related (1) Isotope-Labeled Compounds (6) JNK (1) Lipoxygenase (1) MDM-2/p53 (1) Microtubule/Tubulin (3) MMP (1) Monoamine Oxidase (3) Monocarboxylate Transporter (1) nAChR (5) NAMPT (3) NF-κB (5) NO Synthase (3) NOD-like Receptor (NLR) (1) Opioid Receptor (3) P-glycoprotein (2) p38 MAPK (2) Parasite (3) PARP (2) PD-1/PD-L1 (1) Pim (1) PKA (1) PKC (1) Potassium Channel (1) PPAR (1) PROTACs (2) Reactive Oxygen Species (2) ROS Kinase (2) SARS-CoV (3) SOD (1) STAT (1) Thymidylate Synthase (2) Tim3 (1) TNF Receptor (5) Topoisomerase (2) Trk Receptor (1) Tyrosinase (1) ULK (1) Urea Transporter (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (90) Cardiovascular Disease (9) Endocrinology (3) Infection (41) Inflammation/Immunology (22) Metabolic Disease (5) Neurological Disease (16)

By Targets:

CTLA-4 (1)

ADC Cytotoxin (1)

Adrenergic Receptor (3)

Akt (1)

AMPK (1)

Amyloid-β (4)

Androgen Receptor (1)

Antibiotic (8)

Antibody-Drug Conjugates (ADCs) (1)

Antifolate (1)

Apoptosis (19)

Autophagy (7)

Bacterial (23)

Bcl-2 Family (2)

Biochemical Assay Reagents (3)

Calcium Channel (1)

Caspase (1)

CD19 (1)

CD3 (1)

Cholinesterase (ChE) (1)

COX (2)

DNA/RNA Synthesis (10)

Drug Derivative (1)

Drug Metabolite (3)

DYRK (1)

E1/E2/E3 Enzyme (3)

EGFR (1)

Endogenous Metabolite (10)

Epigenetic Reader Domain (1)

Estrogen Receptor/ERR (2)

FAK (1)

Ferroptosis (7)

Fungal (10)

GABA Receptor (4)

GLUT (2)

Glutathione Peroxidase (2)

GnRH Receptor (1)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (2)

HIV (1)

HIV Integrase (1)

HSP (1)

Imidazoline Receptor (3)

Influenza Virus (3)

Insecticide (1)

Insulin Receptor (2)

Interleukin Related (1)

Isotope-Labeled Compounds (6)

JNK (1)

Lipoxygenase (1)

MDM-2/p53 (1)

Microtubule/Tubulin (3)

MMP (1)

Monoamine Oxidase (3)

Monocarboxylate Transporter (1)

nAChR (5)

NAMPT (3)

NF-κB (5)

NO Synthase (3)

NOD-like Receptor (NLR) (1)

Opioid Receptor (3)

P-glycoprotein (2)

p38 MAPK (2)

Parasite (3)

PARP (2)

PD-1/PD-L1 (1)

Pim (1)

PKA (1)

PKC (1)

Potassium Channel (1)

PPAR (1)

PROTACs (2)

Reactive Oxygen Species (2)

ROS Kinase (2)

SARS-CoV (3)

SOD (1)

STAT (1)

Thymidylate Synthase (2)

Tim3 (1)

TNF Receptor (5)

Topoisomerase (2)

Trk Receptor (1)

Tyrosinase (1)

ULK (1)

Urea Transporter (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (90)

Cardiovascular Disease (9)

Endocrinology (3)

Infection (41)

Inflammation/Immunology (22)

Metabolic Disease (5)

Neurological Disease (16)

157

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: CTLA-4

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124473

Naphthofluorescein Naphthafluorescein	HIF/HIF Prolyl-Hydroxylase	Cancer
Naphthofluorescein inhibits the interaction between HIF-1 and Mint3. Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo . Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging .

HY-N8718

Izalpinin	Others	Others
Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura .

HY-137200

N-Desmethyl Bendamustine	Drug Metabolite	Cancer
N-Desmethyl Bendamustine is a metabolite of Bendamustine (HY-13567). N-Desmethyl Bendamustine has cytotoxic effect in several lymphoma cell lines and peripheral blood lymphocytes .

HY-146197

Apoptotic agent-1	Apoptosis	Cancer
Apoptotic agent-1 (Compound 8a) is an apoptotic agent with high antiproliferative activity against cancer cells and low cytotoxic effect. Apoptotic agent-1 induces over-expression of Fas receptor and Cyto C genes .

HY-P5608

Maximin 4	Bacterial	Infection
Maximin 4 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 4 has cytotoxicity on tumor cells and spermicidal effect .

HY-P5609

Maximin 5	Bacterial	Infection
Maximin 5 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 5 has cytotoxicity on tumor cells and spermicidal effect .

HY-P5604

Maximin 1	Bacterial	Infection
Maximin 1 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 1 has cytotoxicity on tumor cells and spermicidal effect .

HY-P5605

Maximin 2	Bacterial	Infection
Maximin 2 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 2 has cytotoxicity on tumor cells and spermicidal effect .

HY-P5606

Maximin 3	Bacterial	Infection
Maximin 3 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 3 has cytotoxicity on tumor cells and spermicidal effect. Maximin 3 has significant anti-HIV activity .

HY-N11766

Calythropsin	Microtubule/Tubulin	Cancer
Calythropsin is a cytotoxic chalcone, with weak effect on mitosis, and presumably also on tubulin polymerization .

HY-W020044

DL-alpha-Tocopherol 5 Publications Verification DL-α-Tocopherol	Ferroptosis DNA/RNA Synthesis Apoptosis	Cancer
DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-N2483

Hydroprotopine	Others	Cancer
Hydroprotopine is a alkaloid from Hypecoum leptocarpumand. Leptopidine can suppress growth and induce cytotoxicity in breast cancer cells and that the cytotoxicity of leptopidine may be related to its inhibitory effect on fatty acid synthase expression .

HY-B1878

Faltan	Fungal	Infection
Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells .

HY-116885

Thunalbene	NO Synthase	Inflammation/Immunology
Thunalbene is a stilbene derivative isolated from Thunia alba. Thunalbene has a weak inhibitory effect on nitric oxide production and is not cytotoxic .

HY-N10350

2,3-Dihydro-3-methoxywithaferin A	Others	Cancer
2,3-Dihydro-3-methoxywithaferin A is an analogue of 2,3-dihydrowithaferin-A. 2,3-Dihydro-3-methoxywithaferin A inhibits proiiferation of P388 cells[1].

HY-165043

1,3-Diarachidonoyl glycerol DG(20:4/0:0/20:4); 1,3-Diarachidonin	Biochemical Assay Reagents	Others
1,3-Diarachidonoyl glycerol (DG(20:4/0:0/20:4)) is a compound that is being studied for its selective cell killing mechanism, and it has a selective killing effect on cells transformed by the E1A gene of adenovirus type 12. Its killing effect is attributed to lipid peroxidation, and its structural characteristics are crucial to the specificity of this cytotoxicity, which ultimately exerts cytotoxic effects by destroying the cell membrane.

HY-P1388

β-Amyloid (1-42), (rat/mouse) 4 Publications Verification Amyloid β-peptide (1-42) (rat/mouse)	Amyloid-β	Neurological Disease
β-Amyloid (1-42), (rat/mouse) is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

HY-W020044S

DL-alpha-Tocopherol-13C3	Ferroptosis	Others
DL-alpha-Tocopherol- ¹³C₃ is the ¹³C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB[1].

HY-W020044S1

DL-alpha-Tocopherol-d9	Ferroptosis	Others
DL-alpha-Tocopherol-d₉ is the deuterium labeled DL-alpha-Tocopherol[1]. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB[2].

HY-W020044R

DL-alpha-Tocopherol (Standard) 5 Publications Verification	Ferroptosis DNA/RNA Synthesis Apoptosis	Cancer
DL-alpha-Tocopherol (Standard) is the analytical standard of DL-alpha-Tocopherol. This product is intended for research and analytical applications. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-148058

Topoisomerase I inhibitor 8	Topoisomerase	Cancer
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells .

HY-N1318S

Salvigenin-d9 Psathyrotin-d₉	Autophagy	Neurological Disease Inflammation/Immunology Cancer
Salvigenin-d₉ is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties[1][2].

HY-168183

MG28	Apoptosis	Cancer
MG28 exhibits a remarkable cytotoxic effect, which is the likely consequence of its direct and intense DNA damaging activity. MG28 can be used for the research of cancer .

HY-N3563

Celaphanol A	Others	Neurological Disease
Celaphanol A is a diterpene that can be isolated from the root bark of Celastrus orbiculatus. Celaphanol A shows neuroprotective effect against a hydrogen peroxide-induced cytotoxicity in PC12 cells .

HY-P1388A

β-Amyloid (1-42), (rat/mouse) TFA 4 Publications Verification Amyloid β-peptide (1-42) (rat/mouse) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42), (rat/mouse) TFA is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

HY-N12469

Gypsogenin 3-O-glucuronide	Others	Others
Gypsogenin 3-O-glucuronide is a glucuronide that can be isolated from Gypsophila. Gypsogenin 3-O-glucuronide has cytotoxic effect on THP-1 cells .

HY-N10071

Poricoic acid G	Others	Cancer
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-33351

Eugenin	Biochemical Assay Reagents	Cardiovascular Disease Cancer
Eugenin is a chromone that can be isolated from Formosan Peucedanum japonicum and has an effective antiplatelet aggregation effect. In addition, Eugenin has certain cytotoxicity against tumor cells .

HY-N1272

Secaubryenol	Endogenous Metabolite	Others
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 μg/mL .

HY-115969

F-17	Bacterial	Infection
F-17 is a potential inhibitor of virulence factor. F-17 shows very significant inhibitory effect on biofilm, elastase, pyocyanin, and swarming motility. F-17 also shows a good binding effect on LasR and PqsR. F-17 has no obvious cytotoxicity .

HY-N4265

Vinaginsenoside R4	Others	Inflammation/Immunology
Vinaginsenoside R4, isolated from the leaves of hydroponic Panax ginseng. It has an inhibitory effect on melanin biosynthesis without any cytotoxic effects on the melan-a cells, and enhances the depigmentation on the zebrafish .

HY-N2081

Skimmianine 2 Publications Verification	Others	Inflammation/Immunology Cancer
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-N14775

Lavanduquinocin	Others	Infection
Lavanduquinocin is a protective agent of nerve cells and has the effect of reducing L-glutamate on cytotoxicity of neuronal hybridoma N18-RE-105 with an ED₅₀ of 15.5 nM .

HY-N14911

Actinoplanone A	Antibiotic Bacterial Fungal DNA/RNA Synthesis	Infection Cancer
Actinoplanone A is a polycyclic xanthone antibiotic. Actinoplanone A has strong antimicrobial activities against bacteria and the rice blast fungus. Actinoplanone A is cytotoxic to various tumor cells and has an inhibitory effect on DNA synthesis .

HY-N10417

Apoptosis inducer 5	Apoptosis Autophagy	Cancer
Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells .

HY-170488

CM-728	ROS Kinase Bacterial	Infection Cancer
CM-728 is a oxazepine-naphthoquinone that has cytotoxic and bactericidal effect. CM-728 is a human peroxiredoxin-1 inhibitor. CM-728 is an oxidative stressor that affects mitochondrial function .

HY-B1878S

Faltan-d4	Fungal	Infection
Faltan-d₄ is the deuterium labeled Faltan[1]. Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells[2].

HY-B1878R

Faltan (Standard)	Fungal	Infection
Faltan (Standard) is the analytical standard of Faltan. This product is intended for research and analytical applications. Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells .

HY-N14370

Menoxymycin A	Antibiotic Bacterial	Infection Cancer
Menoxymycin A is an antibiotic. Menoxymycin A has a cytotoxic effect. Menoxymycin A inhibits KB and N18-RE-105 cells with IC₅₀s of 0.86 μM and 0.14 μM .

HY-N10890

Alpinoid D	Others	Cancer
Alpinoid D, a diarylheptanoid, can be isolated from the MeOH extract from the rhizomes of Alpinia officinarum Hance. Alpinoid D shows cytotoxic effect against IMR-32 human neuroblastoma cell line .

HY-N1318

Salvigenin 4 Publications Verification Psathyrotin	Autophagy Apoptosis ROS Kinase	Neurological Disease Inflammation/Immunology Cancer
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-124414

4'-Hydroxytamoxifen	Estrogen Receptor/ERR Drug Metabolite	Cancer
4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells .

HY-149996

Pim-1 kinase inhibitor 6	Pim	Cancer
Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC₅₀ value of 0.46 μM, and has significant cytotoxic effect on cancer cells .

HY-122288

SC 28538	Bacterial	Infection
SC 28538 is a compound with antimicrobial activity. SC 28538 exerts its antimicrobial effect by reducing its nitro moiety in an anaerobic environment to form cytotoxic free radicals that can damage DNA and other key biomolecules of microorganisms .

HY-123081

Eburicol	Bacterial	Infection Cancer
Eburicol is a natural sterol with antiproliferative and antimicrobial activities. Eburicol has a weak antimicrobial activity against S. aureus. Eburicol shows cytotoxic effect against MCF-7 and MDA-MB-231 cell lines .

HY-N14344

Manumycin G	Bacterial	Infection
Manumycin G has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin G inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC₅₀ is 15.6 μg/mL) .

HY-N14342

Manumycin E	Bacterial	Infection
Manumycin E has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin E inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC₅₀ is 15.6 μg/mL) .

HY-N14343

Manumycin F	Bacterial	Infection
Manumycin F has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin F inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC₅₀ is 15.6 μg/mL) .

HY-P5762

Phoenixin-14 PNX-14	GnRH Receptor	Neurological Disease
Phoenixin-14 (PNX-14) is one of the endogenous active isoform, and generates anxiolytic effect via the activation of the AHA GnRH system in mice. Phoenixin-14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia .

HY-Y0790S

Cuminaldehyde-d8 p-Isopropylbenzaldehyde-d₈	Endogenous Metabolite Isotope-Labeled Compounds	Cancer
Cuminaldehyde-d8 is deuterated labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

Cat. No.	Product Name

HY-L133

Cuproptosis Compound Library

282 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 282 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P1388

β-Amyloid (1-42), (rat/mouse) 4 Publications Verification Amyloid β-peptide (1-42) (rat/mouse)	Amyloid-β	Neurological Disease
β-Amyloid (1-42), (rat/mouse) is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

HY-P1388A

β-Amyloid (1-42), (rat/mouse) TFA 4 Publications Verification Amyloid β-peptide (1-42) (rat/mouse) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42), (rat/mouse) TFA is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

HY-P5762

Phoenixin-14 PNX-14	GnRH Receptor	Neurological Disease
Phoenixin-14 (PNX-14) is one of the endogenous active isoform, and generates anxiolytic effect via the activation of the AHA GnRH system in mice. Phoenixin-14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia .

HY-N6693

Valinomycin 5 Publications Verification NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-P5608

Maximin 4	Bacterial	Infection
Maximin 4 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 4 has cytotoxicity on tumor cells and spermicidal effect .

HY-P5609

Maximin 5	Bacterial	Infection
Maximin 5 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 5 has cytotoxicity on tumor cells and spermicidal effect .

HY-P5604

Maximin 1	Bacterial	Infection
Maximin 1 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 1 has cytotoxicity on tumor cells and spermicidal effect .

HY-P5605

Maximin 2	Bacterial	Infection
Maximin 2 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 2 has cytotoxicity on tumor cells and spermicidal effect .

HY-P5606

Maximin 3	Bacterial	Infection
Maximin 3 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 3 has cytotoxicity on tumor cells and spermicidal effect. Maximin 3 has significant anti-HIV activity .

HY-144334

CHIKV-IN-3	DNA/RNA Synthesis	Infection
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC₅₀ values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability(CC₅₀ > 100 µM). Prophylactic effect .

HY-P1474

β-Amyloid (22-35) Amyloid β-Protein (22-35)	Amyloid-β	Neurological Disease
β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution) .

HY-P1474A

β-Amyloid (22-35) (TFA) Amyloid β-Protein (22-35) (TFA)	Amyloid-β	Neurological Disease
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution) .

Cat. No.	Product Name	Target	Research Area

HY-P99623

Flotetuzumab MGD006; S80880	CD3	Cancer
Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML) .

HY-P99015

Dacetuzumab	TNF Receptor	Cancer
Dacetuzumab (SGN-40) is a humanized IgG1, anti-CD40 monoclonal antibody with anti-lymphoma activity. Dacetuzumab kills tumor cells via immune effector functions (antibody-dependent cellular cytotoxicity and phagocytosis [ADCC/ADCP]). Dacetuzumab ((SGN-40) can be used for multiple myeloma research .

HY-P99653

Ianalumab VAY-736	TNF Receptor	Cancer
Ianalumab (VAY-736) is a human, decarboxylated antibody against BAFF-R. Ianalumab can block the interaction between BAFF and BAFF-R and antagonize the apoptosis protection mediated by BAFF. Ianalumab exerts antibody-dependent cytotoxic (ADCC), depending on effector cell activation mediated by immune receptor tyrosine activation motif (ITAM) .

HY-P99117

Cadonilimab AK104	PD-1/PD-L1 CTLA-4	Inflammation/Immunology Cancer
Cadonilimab (AK104) is a humanized tetravalent IgG1 bispecific antibody targeting PD1/CTLA4. Cadonilimab blocks both PD-1 and CTLA-4 pathways, thereby relieving their corresponding immunosuppressive effects and reversing tumor specific T cell exhaustion. Cadonilimab significantly downregulates Fc-mediated effector functions, including antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement dependent cytotoxicity (CDC). Cadonilimab can be used for research of metastatic cervical cancer, as well as other malignancies such as gastric cancer, GEJ adenocarcinoma and non-small cell lung cancer (NSCLC) .

HY-P99113A

Inebilizumab (FUT8-KO)	CD19	Inflammation/Immunology
Inebilizumab (FUT8-KO) is an anti-CD19 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Inebilizumab (HY-P99113) is a monoclonal antibody (mAb) targeting CD19, exhibiting enhanced antibody-dependent cellular cytotoxicity (ADCC) against B cells. Inebilizumab can be used for research on multiple sclerosis and neuromyelitis optica .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P990076

Lorukafusp alfa APN-301; hu14.18-IL2; EMD 273063	Inhibitory Antibodies	Cancer
Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity .

HY-P9977A

Amivantamab (FUT8-KO)	EGFR	Cancer
Amivantamab (FUT8-KO) is an anti-EGFR-MET monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W020044

DL-alpha-Tocopherol 5 Publications Verification DL-α-Tocopherol	Structural Classification Duchesnea indica (Andr.) Focke Monophenols Classification of Application Fields Source classification Rosaceae Other Diseases Phenols Plants Disease Research Fields	Ferroptosis DNA/RNA Synthesis Apoptosis
DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-W020044R

DL-alpha-Tocopherol (Standard) 5 Publications Verification	Structural Classification Duchesnea indica (Andr.) Focke Classification of Application Fields Source classification Rosaceae Other Diseases Phenols Plants Disease Research Fields	Ferroptosis DNA/RNA Synthesis Apoptosis
DL-alpha-Tocopherol (Standard) is the analytical standard of DL-alpha-Tocopherol. This product is intended for research and analytical applications. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-N8718

Izalpinin	Source classification Muntingia calabura L. Plants Muntingiaceae	Others
Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura .

HY-N11766

Calythropsin	Structural Classification Faramea salicifolia Presi Source classification Rubiaceae Phenols Polyphenols Plants	Microtubule/Tubulin
Calythropsin is a cytotoxic chalcone, with weak effect on mitosis, and presumably also on tubulin polymerization .

HY-N2483

Hydroprotopine	Alkaloids Classification of Application Fields Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Others
Hydroprotopine is a alkaloid from Hypecoum leptocarpumand. Leptopidine can suppress growth and induce cytotoxicity in breast cancer cells and that the cytotoxicity of leptopidine may be related to its inhibitory effect on fatty acid synthase expression .

HY-116885

Thunalbene	Structural Classification Thunia alba (Lindl.) Rchb. F. Orchidaceae Source classification Phenols Plants	NO Synthase
Thunalbene is a stilbene derivative isolated from Thunia alba. Thunalbene has a weak inhibitory effect on nitric oxide production and is not cytotoxic .

HY-N10350

2,3-Dihydro-3-methoxywithaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Others
2,3-Dihydro-3-methoxywithaferin A is an analogue of 2,3-dihydrowithaferin-A. 2,3-Dihydro-3-methoxywithaferin A inhibits proiiferation of P388 cells[1].

HY-N3563

Celaphanol A	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Celastrus Plants Celastrus orbiculatus Thunb.	Others
Celaphanol A is a diterpene that can be isolated from the root bark of Celastrus orbiculatus. Celaphanol A shows neuroprotective effect against a hydrogen peroxide-induced cytotoxicity in PC12 cells .

HY-N12469

Gypsogenin 3-O-glucuronide	Structural Classification Ketones, Aldehydes, Acids Source classification Gypsophila paniculata Linn . Plants Caryophyllaceae	Others
Gypsogenin 3-O-glucuronide is a glucuronide that can be isolated from Gypsophila. Gypsogenin 3-O-glucuronide has cytotoxic effect on THP-1 cells .

HY-N10071

Poricoic acid G	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-33351

Eugenin	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Source classification Phenols Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Disease Research Fields	Biochemical Assay Reagents
Eugenin is a chromone that can be isolated from Formosan Peucedanum japonicum and has an effective antiplatelet aggregation effect. In addition, Eugenin has certain cytotoxicity against tumor cells .

HY-N1272

Secaubryenol	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 μg/mL .

HY-N4265

Vinaginsenoside R4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology Araliaceae	Others
Vinaginsenoside R4, isolated from the leaves of hydroponic Panax ginseng. It has an inhibitory effect on melanin biosynthesis without any cytotoxic effects on the melan-a cells, and enhances the depigmentation on the zebrafish .

HY-N2081

Skimmianine 2 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Inflammation/Immunology Disease Research Fields	Others
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-N14775

Lavanduquinocin	Structural Classification Natural Products Microorganisms Source classification	Others
Lavanduquinocin is a protective agent of nerve cells and has the effect of reducing L-glutamate on cytotoxicity of neuronal hybridoma N18-RE-105 with an ED₅₀ of 15.5 nM .

HY-N14911

Actinoplanone A	Structural Classification Natural Products Microorganisms Xanthones Source classification Phenols	Antibiotic Bacterial Fungal DNA/RNA Synthesis
Actinoplanone A is a polycyclic xanthone antibiotic. Actinoplanone A has strong antimicrobial activities against bacteria and the rice blast fungus. Actinoplanone A is cytotoxic to various tumor cells and has an inhibitory effect on DNA synthesis .

HY-N10417

Apoptosis inducer 5	Monophenols Classification of Application Fields Source classification Lignans Rosaceae Phenols Phenylpropanoids Crataegus pinnatifida Bge. Plants Disease Research Fields Cancer	Apoptosis Autophagy
Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells .

HY-N14370

Menoxymycin A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Menoxymycin A is an antibiotic. Menoxymycin A has a cytotoxic effect. Menoxymycin A inhibits KB and N18-RE-105 cells with IC₅₀s of 0.86 μM and 0.14 μM .

HY-N10890

Alpinoid D	Structural Classification Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Others
Alpinoid D, a diarylheptanoid, can be isolated from the MeOH extract from the rhizomes of Alpinia officinarum Hance. Alpinoid D shows cytotoxic effect against IMR-32 human neuroblastoma cell line .

HY-N1318

Salvigenin 4 Publications Verification Psathyrotin	Structural Classification Monophenols Flavonoids other families Neurological Disease Classification of Application Fields Flavones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-123081

Eburicol	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
Eburicol is a natural sterol with antiproliferative and antimicrobial activities. Eburicol has a weak antimicrobial activity against S. aureus. Eburicol shows cytotoxic effect against MCF-7 and MDA-MB-231 cell lines .

HY-N14344

Manumycin G	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Manumycin G has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin G inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC₅₀ is 15.6 μg/mL) .

HY-N14342

Manumycin E	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Manumycin E has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin E inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC₅₀ is 15.6 μg/mL) .

HY-N14343

Manumycin F	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Manumycin F has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin F inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC₅₀ is 15.6 μg/mL) .

HY-N14496

Nisamycin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Nisamycin has stronger anti-Gram-positive bacteria and weaker anti-fungal and individual Gram-negative bacteria activities. Nisamycin has weak cytotoxic effect. The IC₅₀ of mouse leukemia P388 cells is 4.8 μg/mL .

HY-N10789

(2S)-4'-Hydroxy-7-methoxyflavan	Other Terpenoids Phyllodium pulchellum (L.) Desv. Structural Classification Terpenoids Source classification Plants Compositae	Others
(2S)-4'-Hydroxy-7-methoxyflavan is a Flavan. Flavan (4′-hydroxy-7-methoxyflavan) showed an important cytotoxic effect on human leukemic Molt 4 cells .

HY-N14371

Menoxymycin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Menoxymycin B is an antibiotic. Menoxymycin B has a cytotoxic effect. Menoxymycin B inhibits KB and N18-RE-105 cells with IC₅₀s of 0.22 μM and 0.023 μM .

HY-N0206

Ardisiacrispin A Deglucocyclamin; LTS-4; Saxifragifolin B	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Ardisia Myrsinaceae Disease Research Fields Cancer	Antibiotic
Ardisiacrispin A (Deglucocyclamin) is a common triterpenoid saponin from Ardisia species. Ardisiacrispin A has similar biological properties with some triterpenoid saponins in A. crenata which is one of the species of genus Ardisia and exhibits cytotoxic effect on tumor cells, immunomodulatory and antiviral activities .

HY-N6842

ArnicolideC	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Source classification Plants Compositae Disease Research Fields Cancer	Others
ArnicolideC is a sesquiterpene lactone isolated Centipeda minima . ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation .

HY-N7980

Rubipodanone A	Quinones Structural Classification Classification of Application Fields Rubia podantha Source classification Rubiaceae Plants Naphthalene Quinones Disease Research Fields Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-N2906

Limonianin Atalantoflavone	Structural Classification Flavonoids Flavones Source classification Rutaceae Atalantia buxifolia (Poir.) Oliv. Plants	Parasite
Limonianin (Atalantoflavone) is a flavone, that can be isolated from Erythrina sigmoidea and the root bark of Citrus limonia. Limonianin presents inhibitory effect against P. gingivalis. Limonianin shows cytotoxic activity against multidrug-resistant (MDR) cancer cell lines .

HY-N2081R

Skimmianine (Standard)	Alkaloids Structural Classification Source classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort.	Others
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-N6642

Ankaflavin	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	PPAR Apoptosis
Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects .

HY-123325

Kapurimycin A1	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Kapurimycin A1 is an anbitiotic that can be isolated from Streptomyces. Kapurimycin A1 has a significant inhibitory effect on Gram-positive bacteria, exhibits cytotoxicity to cultured mammalian cells, and shows strong antitumor activity against the mouse leukemia P388 cell line .

HY-N8015

Octanal	Infection Structural Classification Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields	Endogenous Metabolite Bacterial Fungal
Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL .

HY-N2892

Aristolactam A IIIa Aristololactam A IIIa; Sch 546909	Structural Classification Antibiotics Fissistigma balansae (A. DC.) Merr. Source classification Disease Research Plants Annonaceae Anticancer Other Antibiotics	DYRK
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells .

HY-N3017

Artemitin	Flavonols Structural Classification Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Antibiotic
Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED₅₀ of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED₅₀ of 1.6 μg/kg, and has analgesic activity .

HY-N6031

Dendrophenol 1 Publications Verification Moscatilin	Structural Classification Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Dendrobium chrysanthum Wall. ex Lindl. Cancer	NF-κB Apoptosis COX HIF/HIF Prolyl-Hydroxylase Wnt β-catenin JNK
Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification by inhibiting the activation of WNT3/β-catenin .

HY-N2741

Vitexin B-1	Structural Classification Monophenols Verbenaceae Source classification Phenols Plants Vitex negundo Linn.	Bcl-2 Family
Vitexin B-1 is an inhibitor of Bcl-2 and the agonist of Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC₅₀s of 3.2, 2.1, 1.8 and 0.39 μM, respectively .

HY-N12586

Pheophytin a	Suaeda vermiculata Forssk. ex J.F.Gmel. Structural Classification Alkaloids Other Alkaloids Source classification Amaranthaceae Plants	Reactive Oxygen Species
Pheophytin a is a chlorophyll that can be isolated from S. vermiculata extracts. Pheophytin a has antioxidant activity with IC₅₀ values of? 200.5 and 137.7 μg/mL for SOD, and NO respectively. Pheophytin a has reducing power with an IC₅₀ value of 4.2 μg/mL . Pheophytin a has a cytotoxic effect on the MCF-7 cell line(IC₅₀= 35.9 μg/mL)^[1].

HY-N8015R

Octanal (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Source classification Plants	Endogenous Metabolite Bacterial Fungal
Octanal (Standard) is the analytical standard of Octanal. This product is intended for research and analytical applications. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL .

HY-108262

UCN-02 7-epi-Hydroxystaurosporine	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics Cancer	PKC PKA
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC₅₀s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells .

HY-N6693

Valinomycin 5 Publications Verification NSC 122023	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Apoptosis Antibiotic Autophagy Fungal
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-N15297

Isotenulin	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Helenium arizonicum S.F.Blake	P-glycoprotein
Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142) .

HY-N4192

Toringin	Cardiovascular Disease Monophenols Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Plants Disease Research Fields Docyniopsis tschonoski Cancer	Others
Toringin, a bioflavonoid, is isolated from the bark of Docyniopsis tschonoski. Toringin progressively decreases not only the cis-effect of the expanded CTG repeats but cytotoxicity as well. Exposure to isosakuranetin, Toringin rescues PC12 neuronal cells. Flavonoids are efficacious for ameliorating the RNA gain of function caused by expanded CTG repeats, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies .

HY-155851

Lepadin E	Structural Classification Alkaloids Animals Marine natural products Source classification Other marine organisms Quinoline Alkaloids	Ferroptosis MDM-2/p53 Glutathione Peroxidase
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-N0755

Rhoifolin	Structural Classification Rhus succedanea Flavonoids Classification of Application Fields Flavones Plants Disease Research Fields Endocrinology Anacardiaceae Cancer	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-W437569

Melicopine	Structural Classification Alkaloids Cornaceae Cornus officinalis Sieb. et Zucc. Source classification Acridone Alkaloids Plants	Parasite Insecticide
Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC₅₀ values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC₅₀ values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC₅₀ greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields .

HY-B1178R

Cotinine (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Nicotiana tabacum L. Source classification Pyridine Alkaloids Solanaceae Plants Endogenous metabolite	Endogenous Metabolite nAChR
Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke

HY-B1178

Cotinine 1 Publications Verification (-)-Cotinine; (S)-Cotinine; NIH-10498	Alkaloids Structural Classification Pyrrole Alkaloids Nicotiana tabacum L. Classification of Application Fields Source classification Other Diseases Pyridine Alkaloids Solanaceae Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite nAChR
Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .

Cat. No.	Product Name	Chemical Structure

HY-N8015S

Octanal-d16
Octanal-d₁₆ is the deuterium labeled Octanal. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL .

HY-W020044S

DL-alpha-Tocopherol-13C3
DL-alpha-Tocopherol- ¹³C₃ is the ¹³C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB[1].

HY-W020044S1

DL-alpha-Tocopherol-d9
DL-alpha-Tocopherol-d₉ is the deuterium labeled DL-alpha-Tocopherol[1]. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB[2].

HY-N1318S

Salvigenin-d9
Salvigenin-d₉ is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties[1][2].

HY-B1878S

Faltan-d4
Faltan-d₄ is the deuterium labeled Faltan[1]. Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells[2].

HY-Y0790S

Cuminaldehyde-d8
Cuminaldehyde-d8 is deuterated labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

HY-W015307S

4-Ethyloctanoic acid-13C2
4-Ethyloctanoic acid- ¹³C₂ is ¹³C labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

HY-N8015S2

Octanal-d4

Octanal-d₄ is deuterated labeled Methyl vanillate (HY-75342). Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL .

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

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