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chlorinated

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32

Inhibitors & Agonists

1

Biochemical Assay Reagents

9

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W006267
    4-Chloroindole-3-acetic acid

    4-Cl-IAA

    		 Endogenous Metabolite Others
    4-Chloroindole-3-acetic acid (4-Cl-IAA) is a chlorinated analogue of indole-3-acetic acid (IAA) (HY-18569) auxin that functions as a plant hormone, which is found in the seeds of Medicago truncatula、Melilotus indicus and Trifolium .
    4-Chloroindole-3-acetic acid
  • HY-N7535
    Chlorovaltrate K

    		Others Cancer
    Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC50 values of 2.32-8.26 μM .
    Chlorovaltrate K
  • HY-133621
    9,10-Dichlorostearic acid

    		Biochemical Assay Reagents Cancer
    9,10-Dichlorostearic acid is a chlorinated stearic acid with antimutagenic properties. 9,10-Dichlorostearic acid can cause membrane damage by inducing leakage of adenosine triphosphate (ATP) from mammalian tumour cells in vitro .
    9,10-Dichlorostearic acid
  • HY-133596
    12,14-Dichlorodehydroabietic acid

    		Potassium Channel GABA Receptor Neurological Disease
    12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca 2+-activated K + (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca 2+ and stimulates transmitter release .
    12,14-Dichlorodehydroabietic acid
  • HY-106136
    TIK-301

    PD-6735; LY-156735

    		 Melatonin Receptor 5-HT Receptor Neurological Disease
    TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment .
    TIK-301
  • HY-133599
    4,5-Dichloroguaiacol

    		Biochemical Assay Reagents Others
    4,5-Dichloroguaiacol is the major component of chlorinated phenol .
    4,5-Dichloroguaiacol
  • HY-133602
    Tetrachloroguaiacol

    		Biochemical Assay Reagents Others
    Tetrachloroguaiacol is the major chlorinated phenol produced during chlorine bleaching of wood pulp .
    Tetrachloroguaiacol
  • HY-133606
    3,4,5-Trichlorosyringol

    		Biochemical Assay Reagents Others
    3,4,5-Trichlorosyringol is a chlorophenolic compound synthetised by chlorination of syringol in carbon disulphide (CS2) .
    3,4,5-Trichlorosyringol
  • HY-132183
    Chloride peroxidase

    		Endogenous Metabolite Metabolic Disease
    Chloride peroxidase is a monomeric, heme-containing enzyme. Chloride peroxidase is capable of electrophilic chlorinations through the umpolung of chloride by oxidation with hydrogen peroxide .
    Chloride peroxidase
  • HY-133603
    4,5-Dichloroveratrole

    		Drug Derivative Others
    4,5-Dichloroveratrole is a chlorinated product formed by reaction of Veratryl alcohol (VE; HY-107858) with chlorine dioxide solution .
    4,5-Dichloroveratrole
  • HY-N11494
    Dauricumine

    		NF-κB Others
    Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts .
    Dauricumine
  • HY-108712
    TDCPP
    5+ Cited Publications

    Tris(1,3-dichloroisopropyl)phosphate

    		 Biochemical Assay Reagents Cancer
    TDCPP is a chlorinated analog of tris(2,3-dibromopropyl)phosphate (Tris) which is one of the most detected organophosphorus flame retardants (OPFRs) in the environment.
    TDCPP
  • HY-W460141
    Thalidomide 4-chloro

    		Ligands for E3 Ligase Cancer
    Thalidomide 4-chloro is a chlorinated E3 ligase activator. Thalidomide 4-chloro may be used for further derivitization by substitution of chlorine.
    Thalidomide 4-chloro
  • HY-133607
    5,6-Dichlorovanillin

    		Drug Derivative Others
    5,6-Dichlorovanillin is a product upon chlorination to afford 4,5,6-trichloroguaiacol, together with tetrachloroguaiacol and the unreacted starting materials .
    5,6-Dichlorovanillin
  • HY-W006000
    Tetrachlorocatechol

    		Drug Metabolite Others
    Tetrachlorocatechol is a metabolite of pentachlorophenol. Tetrachlorocatechol is one of the most toxic chlorinated catechol produced by the chlorobleaching of pulp and frequently found in the kraft pulp mill effluents .
    Tetrachlorocatechol
  • HY-133653
    3,3-Dibromopropenoic acid

    3,3-Dibromoacrylic acid

    		 Drug Derivative Others
    3,3-Dibromopropenoic acid is a 3,3-dibromo product based on propenoic acid. 3,3-Dibromopropenoic acid is a polar aromatic brominated disinfection byproduct during chlorination in water .
    3,3-Dibromopropenoic acid
  • HY-108712R
    TDCPP (Standard)

    Tris(1,3-dichloroisopropyl)phosphate (Standard)

    		 Biochemical Assay Reagents Reference Standards Cancer
    TDCPP (Standard) is the analytical standard of TDCPP. This product is intended for research and analytical applications. TDCPP is a chlorinated analog of tris(2,3-dibromopropyl)phosphate (Tris) which is one of the most detected organophosphorus flame retardants (OPFRs) in the environment.
    TDCPP (Standard)
  • HY-W006000R
    Tetrachlorocatechol (Standard)

    		Drug Metabolite Reference Standards Others
    Tetrachlorocatechol (Standard) is the analytical standard of Tetrachlorocatechol. This product is intended for research and analytical applications. Tetrachlorocatechol is a metabolite of pentachlorophenol. Tetrachlorocatechol is one of the most toxic chlorinated catechol produced by the chlorobleaching of pulp and frequently found in the kraft pulp mill effluents[1][2].
    Tetrachlorocatechol (Standard)
  • HY-133654
    2,3,3-Tribromopropenoic acid

    		Drug Derivative Others
    2,3,3-Tribromopropenoic acid is a 2,3,3-Tribromo product based on propenoic acid. 2,3,3-Tribromopropenoic acid is a polar aromatic brominated disinfection byproduct during chlorination in water and shows cytotoxic potency in mammalian cell chronic cytotoxicity experiments .
    2,3,3-Tribromopropenoic acid
  • HY-Y0532
    N-Chlorosuccinimide

    Succinchlorimide

    		 Bacterial Infection
    N-Chlorosuccinimide is a five-membered N-containing heterocyclic molecule. N-Chlorosuccinimide is a versatile reagent and can be used for different types of reactions, such as aliphatic and aromatic chlorination. N-Chlorosuccinimide can enhance the antimicrobial effect of Benzalkonium chloride (HY-B2232) on biofilm Pseudomonas aeruginosa .
    N-Chlorosuccinimide
  • HY-162827
    RAR/RXR agonist-1

    		RAR/RXR Apoptosis Cancer
    RAR/RXR agonist-1 (compound 7) is a chlorinated retinoic acid isomer, a selective RARα agonist and a partial RXRα agonist. RAR/RXR agonist-1 can activate RXRα and induce G2/M arrest and apoptosis in cancer cells .
    RAR/RXR agonist-1
  • HY-66053
    5-Bromo-3-pyridinol

    		Fungal Others
    5-Bromo-3-pyridinol is a potential fungicide. 5-Bromo-3-pyridinol provides at least 70% control of Plasmopara viticola at 200 ppm. Chlorinated derivatives of 5-Bromo-3-pyridinol have been used to control fungal infections of plants .
    5-Bromo-3-pyridinol
  • HY-B0497S1
    Niclosamide-13C6

    BAY2353-13C6

    		 Isotope-Labeled Compounds STAT Parasite Antibiotic Infection Cancer
    Niclosamide- 13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
    Niclosamide-13C6
  • HY-N6786
    Ochratoxin B

    		Endogenous Metabolite Metabolic Disease
    Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .
    Ochratoxin B
  • HY-W041171
    3-Chloro-L-tyrosine
    1 Publications Verification

    3-Chlorotyrosine

    		 Glutathione Peroxidase Others
    3-Chloro-L-tyrosine is a specific biomarker in myeloperoxidase-catalyzed oxidation. 3-Chloro-L-tyrosine can be used as a molecular marker for oxidative stress and inflammation to determine whether myeloperoxidase-mediated tyrosine chlorination occurs. 3-Chloro-L-tyrosine is therefore used in the diagnosis of chlorine poisoning in forensic toxicology and in the auxiliary diagnosis of inflammation such as colorectal cancer .
    3-Chloro-L-tyrosine
  • HY-N6937
    (R,R)-Secoisolariciresinol diglucoside

    (R,R)-SDG; (R,R)-LGM2605

    		 Others Inflammation/Immunology
    (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
    (R,R)-Secoisolariciresinol diglucoside
  • HY-N6786R
    Ochratoxin B (Standard)

    		Endogenous Metabolite Reference Standards Metabolic Disease
    Ochratoxin B (Standard) is the analytical standard of Ochratoxin B (HY-N6786). This product is intended for research and analytical applications. Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .
    Ochratoxin B (Standard)
  • HY-N6786S
    Ochratoxin B-13C20

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Ochratoxin B- 13C20 is 13C-labeled Ochratoxin B (HY-N6786). Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .
    Ochratoxin B-13C20
  • HY-B1970
    o,p'-DDT

    2,4'-DDT

    		 Insecticide Endocrinology
    o,p'-DDT (2,4'-DDT) is a chlorinated organic pesticide with estrogenic activity. o,p'-DDT is persistent in the environment, can accumulate in organisms and disrupt the endocrine system. o,p'-DDT is used in agriculture as a pesticide, especially for controlling insect pests. The use of o,p'-DDT has led to toxic effects in organisms, raising widespread concern about its environmental and health effects. o,p'-DDT has also led to research into its long-term effects in ecosystems .
    o,p'-DDT
  • HY-N6937S1
    (R,R)-Secoisolariciresinol diglucoside-d6

    (R,R)-SDG-d6; (R,R)-LGM2605-d6

    		 Isotope-Labeled Compounds Inflammation/Immunology
    (R,R)-Secoisolariciresinol diglucoside-d6 is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
    (R,R)-Secoisolariciresinol diglucoside-d6
  • HY-W773487
    FtsZ-IN-10

    		Bacterial Infection
    FtsZ-IN-10 is a bacterial division inhibitor that interferes with the normal assembly of FtsZ. FtsZ-IN-10 specifically binds to Bacillus subtilis FtsZ monomers, thereby affecting their polymerization behavior. FtsZ-IN-10 may also activate nucleotide-free archaeal FtsZ to form ordered polymers. FtsZ-IN-10 can hinder the localization of FtsZ in the Z ring and inhibit bacterial cell division. Chlorinated analogs of FtsZ-IN-10 show the ability to inhibit the growth of antibiotic-resistant clinical isolates such as Staphylococcus aureus and Enterococci .
    FtsZ-IN-10
  • HY-N6937R
    (R,R)-Secoisolariciresinol diglucoside (Standard)

    (R,R)-SDG (Standard); (R,R)-LGM2605 (Standard)

    		 Reference Standards Others Inflammation/Immunology
    (R,R)-Secoisolariciresinol diglucoside (Standard) is the analytical standard of (R,R)-Secoisolariciresinol diglucoside. This product is intended for research and analytical applications. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
    (R,R)-Secoisolariciresinol diglucoside (Standard)

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