Search Result

Results for "

cellular proliferation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Akt (6) Androgen Receptor (1) Apoptosis (14) Bacterial (4) Bcl-2 Family (1) Bcr-Abl (1) Biochemical Assay Reagents (3) Calcium Channel (2) Caspase (1) CDK (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) EGFR (5) Endogenous Metabolite (21) Epigenetic Reader Domain (2) ERK (2) Estrogen Receptor/ERR (1) FAK (1) Fluorescent Dye (1) Fungal (1) G Protein-coupled Receptor Kinase (GRK) (1) Histone Methyltransferase (1) HPV (1) Interleukin Related (1) Isotope-Labeled Compounds (7) Liposome (2) LPL Receptor (1) MHC (1) Mitochondrial Metabolism (1) mRNA (2) NAMPT (1) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (1) Orexin Receptor (OX Receptor) (1) p38 MAPK (1) PAK (3) PARP (1) PDGFR (1) PDHK (2) Phosphatase (1) Phosphodiesterase (PDE) (1) PI3K (1) PKC (1) Potassium Channel (1) PROTAC Linkers (1) PROTACs (3) Pyruvate Kinase (1) Ras (2) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Ser/Thr Kinase (1) Ser/Thr Protease (1) Src (3) TNF Receptor (2) VD/VDR (1) VEGFR (3)
By Research Areas:	Cancer (62) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (2)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (1)
Oligonucleotides:	Emulsifiers (1) mRNA (2) Solubilizing Agents (1) Phospholipids (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-165035

Glucosylceramide (gaucher's spleen) Glucocerebrosides; Gaucher cerebroside; GluCers (gaucher's spleen)	Endogenous Metabolite	Neurological Disease Metabolic Disease
Glucosylceramides are sphingolipid molecules found in both neuronal and non-neuronal mammalian tissues, as well as in low quantities across various plant species. Elevated levels of glucosylceramides provide cellular protection and prepare certain cells for proliferation; however, they have also been linked to obesity-induced insulin resistance in mice and to neuronal deficits observed in neuronopathic Gaucher disease .

HY-32343

Secalciferol 5+ Cited Publications (24R)-24,25-Dihydroxyvitamin D3	Endogenous Metabolite VD/VDR	Metabolic Disease Inflammation/Immunology
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .

HY-N0650

L-Serine 10+ Cited Publications Serine	Endogenous Metabolite Bacterial	Cancer
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-124404A

12(S)-HETE	ERK DNA/RNA Synthesis p38 MAPK	Cancer
12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells .

HY-P2982

Ceramide 1-phosphate	Liposome	Metabolic Disease
Ceramide 1-phosphate is a bioactive lipid and one of the key components of sphingolipids. Ceramide 1-phosphate playing diverse roles in cellular behaviors such as cell differentiation, migration, proliferation and death .

HY-N0650S8

L-Serine-d3 2 Publications Verification (-)-Serine-d₃; (S)-Serine-d₃	Endogenous Metabolite	Cancer
L-Serine-d₃ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-148771

MTX-23 PROTAC AR-V7 degrader-2	PROTACs Androgen Receptor Apoptosis	Cancer
MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis .

HY-113041F

Prostaglandin A2-biotin PGA2-biotin; Medullin-biotin	Biochemical Assay Reagents	Others
Prostaglandin A2-biotin (PGA2-biotin) is a biotin-labeled Prostaglandin A2 (HY-113041). Prostaglandin A2-biotin retains the activity of inhibiting cellular proliferation. Prostaglandin A2-biotin is an effective tool for studying the interaction between Prostaglandin A2 and cellular proteins and exploring the mechanism of its inhibition of cellular proliferation .

HY-145925C

(S,R)-CFT8634	PROTACs Epigenetic Reader Domain	Cancer
(S,R)-CFT8634 (compound 176) is a selective and orally active PROTAC-class BRD9 protein degrader. (S,R)-CFT8634 has the potential to study BRD9-mediated diseases, including but not limited to abnormal cell proliferation. (S,R)-CFT8634 consists of a target protein ligand (red part) BRD9 ligand-5 (HY-169988), an E3 ligase ligand (blue part) CRBN ligand-11 (HY-169989), and a PROTAC linker (black part) 1-(3,3-Difluoro-4-piperidinyl)piperazine (HY-169991). E3 ligase ligand and linker can form E3 Ligase Ligand-linker Conjugate 142 (HY-169990) .

HY-N0650S12

L-Serine-d3,15n	Bacterial Endogenous Metabolite	Cancer
L-Serine- ¹⁵N,d₃ is the deuterium and ¹⁵N labeled L-Serine[1]. L-Serine ((-)-Serine;(S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation[2].

HY-N0650S7

L-Serine-d2 (-)-Serine-d₂; (S)-Serine-d₂	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine-d₂ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S11

L-Serine-d7 (-)-Serine-d₇; (S)-Serine-d₇	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine-d₇ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S10

L-Serine-15N (-)-Serine-¹⁵N; (S)-Serine-¹⁵N	Endogenous Metabolite	Cancer
L-Serine- ¹⁵N is the ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S1

L-Serine-13C (-)-Serine-¹³C; (S)-Serine-¹³C	Endogenous Metabolite	Cancer
L-Serine- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S

L-Serine-13C3 1 Publications Verification (-)-Serine-¹³C₃; (S)-Serine-¹³C₃	Endogenous Metabolite	Cancer
L-Serine- ¹³C₃ is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650R

L-Serine (Standard) Serine (Standard)	Reference Standards Endogenous Metabolite Bacterial	Cancer
L-Serine (Standard) is the analytical standard of L-Serine. This product is intended for research and analytical applications. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S2

L-Serine-1-13C (-)-Serine-1-¹³C; (S)-Serine-1-¹³C	Endogenous Metabolite	Cancer
L-Serine-1- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-145499

XTT sodium hydrate	Fluorescent Dye	Others
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.

HY-N0650S4

L-Serine-2-13C (-)-Serine-2-¹³C; (S)-Serine-2-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine-2- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-135954A

PDK4-IN-1 hydrochloride 2 Publications Verification	PDHK Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has antidiabetic, anticancer and anti-allergic activity .

HY-135954

PDK4-IN-1 2 Publications Verification	PDHK Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity .

HY-123450

S116836	Bcr-Abl Apoptosis PDGFR	Cancer
S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies . S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0650S9

L-Serine-15N,d3 (-)-Serine-¹⁵N,d₃; (S)-Serine-¹⁵N,d₃	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine- ¹⁵N,d₃ is the deuterium and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S5

L-Serine-13C3,15N (-)-Serine-¹³C₃,¹⁵N; (S)-Serine-¹³C₃,¹⁵N	Endogenous Metabolite	Cancer
L-Serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-P3766

Protein kinase C (alpha) peptide TFA	PKC	Others
Protein kinase C α peptide (TFA) is a peptide of PKC-α. PKC-α acts as a lipid-dependent ser/thr protein kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on .

HY-N0650S6

L-Serine1-13C,15N (-)-Serine-¹³C,¹⁵N; (S)-Serine-¹³C,¹⁵N	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-126775

Xenoclauxin	Mitochondrial Metabolism Endogenous Metabolite	Cancer
Xenoclauxin is a secondary metabolite isolated from certain species of the Penicillium genus, which exhibits an inhibitory effect on the proliferation of tumor cells. Xenoclauxin affects cellular energy metabolism, particularly by inhibiting ATP synthesis in the mitochondria. Xenoclauxin can be used for anti-tumor research .

HY-W106456

3-Methoxy-9H-Carbazole	Caspase Reactive Oxygen Species (ROS) Apoptosis	Cancer
3-Methoxy-9H-Carbazole induces caspase-3 activities and the cellular generation of eactive oxygen species. 3-Methoxy-9H-Carbazole inhibits cancer cell proliferation and induces apoptosis .

HY-160972

MM0299	Cytochrome P450	Cancer
MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC₅₀ of 2.2 μM. MM0299 inhibits cell proliferation of Mut6 with an IC₅₀ of 0.0182 μM, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol .

HY-174627

Human IL1B mRNA	mRNA	Inflammation/Immunology
Human IL1B mRNA encodes the human interleukin 1 beta (IL1B) protein, a member of the interleukin 1 cytokine family. IL1B is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.

HY-N0650S3

L-Serine-13C3,15N,d3 (-)-Serine-¹³C₃,¹⁵N,d₃; (S)-Serine-¹³C₃,¹⁵N,d₃	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine- ¹³C₃, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-174542

Human PRKCB mRNA	mRNA	Cancer
Human PRKCB mRNA encodes the human protein kinase C beta (PRKCB) protein, a member of Protein kinase C (PKC) family. PRKCB has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption.

HY-157395

malonyl-NAC 1 Publications Verification	Pyruvate Kinase	Cancer
malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity. In addition, malonyl-NAC limits the metabolism and proliferation of a highly glycolytic kidney cancer cell line harboring a tricarboxylic acid cycle mutation .

HY-164513

NHTD	Ras Phosphodiesterase (PDE)	Cancer
NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC) .

HY-135312

AZ'6421	Estrogen Receptor/ERR PROTACs	Cancer
AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 has a potent anti-tumour effect to inhibit the uncontrolled cellular proliferation which arises from malignant disease. AZ'6421 can be used for the research of cancer such as breast cancer .

HY-Y0537E

Potassium chloride, for cell culture	Biochemical Assay Reagents Potassium Channel Calcium Channel	Neurological Disease
Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .

HY-156334

FAK-IN-12	FAK	Cancer
FAK-IN-12 (Compound 12S) is a FAK inhibitor (IC₅₀ = 47 nM). FAK-IN-12 inhibits MGC-803, HCT-116 and KYSE30 cell proliferation (IC₅₀: 0.24, 0.45, 0.44 μM). FAK-IN-12 induces apoptosis and cellular senescence .

HY-142032

RBM10-8	LPL Receptor	Inflammation/Immunology
RBM10-8 is irreversible inhibitor of recombinant human sphingosine-1-phosphate lyase (hS1PL) . Sphingosine-1-phosphate (S1P) is a sphingolipid (SL) that acts as a signaling molecule regulating diverse cellular processes such as cell proliferation and differentiation, angiogenesis, immune function, inflammation, and development .

HY-E70791

Biotin-AKT2 Recombinant Human Active Protein Kinase	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. Biotin-AKT2 Recombinant Human Active Protein Kinase is obtained by expressing AKT2 proteins and is biotinylated .

HY-P2818C

Alkaline phosphatase, microorganism 1 Publications Verification Apase, microorganism	Endogenous Metabolite	Metabolic Disease
Alkaline phosphatase, microorganism is a membrane-bound glycoprotein. It can hydrolyze monophosphate esters at alkaline pH, releasing inorganic phosphate. Alkaline phosphatase, microorganism is also capable of dephosphorylating proteins, and the balance between protein phosphorylation and dephosphorylation plays a key role in regulating various cellular functions. Alkaline phosphatase, microorganism can regulate cell proliferation and differentiation .

HY-E70792

Biotin-AKT3 Recombinant Human Active Protein Kinase	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. Biotin-AKT3 Recombinant Human Active Protein Kinase is obtained by expressing AKT3 proteins and is biotinylated .

HY-E70790

Biotin-AKT1 Recombinant Human Active Protein Kinase	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. Biotin-AKT1 Recombinant Human Active Protein Kinase is obtained by expressing AKT1 proteins and is biotinylated .

HY-13007A

PF-3758309 hydrochloride PF-03758309 hydrochloride	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 hydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-13007

PF-3758309 5+ Cited Publications PF-03758309	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-13007B

PF-3758309 dihydrochloride PF-03758309 dihydrochloride	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) dihydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 dihydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-112055

DIM-C-pPhOH 5+ Cited Publications	Nuclear Hormone Receptor 4A/NR4A Apoptosis	Cancer
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively .

HY-101960A

Tyrphostin A51 1 Publications Verification AG-183	EGFR	Cancer
Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

HY-176237

Nampt-IN-16	NAMPT Apoptosis	Cancer
Nampt-IN-16 (Compound 9a) is an orally active NAMPT inhibitor with an IC₅₀ of 0.15 μM. Nampt-IN-16 can reduce intracellular NAD ⁺ and ATP levels. Nampt-IN-16 can inhibit the proliferation, migration, and invasion, induce cell cycle arrest and apoptosis, and alter cellular metabolism of gastric cancer cells. Nampt-IN-16 can be used in the research of tumors such as gastric cancer .

HY-101960

(Z)-Tyrphostin A51 (Z)-AG-183	EGFR	Others
(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

HY-153421

PRMT5-IN-28	Histone Methyltransferase	Cancer
PRMT5-IN-28 (compound 36) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) enzyme. Protein arginine methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis, enhance invasion and metastasis, and affect immune escape .

Cat. No.	Product Name

HY-L081

Phosphatase Inhibitor Library

160 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 160 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

HY-L010

MAPK Compound Library

832 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 832 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

HY-L045

Oxygen Sensing Compound Library

3,391 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 3,391 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Type

HY-145499

XTT sodium hydrate	Fluorescent Dyes/Probes
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.

Cat. No.	Product Name	Type

HY-Y0537E

Potassium chloride, for cell culture

Buffer Reagents

Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .

Cat. No.	Product Name	Target	Research Area

HY-156002

LUNA18 Paluratide	Ras ERK	Cancer
LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor. LUNA18 phosphorylates ERK and AKT and decreases cell proliferation in RAS-mutated cancer cells. LUNA18 exhibits RAS signal inhibition and potent anti-cancer activities through inhibiting interaction between RAS and guanine nucleotide exchange factors (GEFs) in a mouse xenograft model. LUNA18 shows significant cellular efficacy against cell lines with KRAS genetic alterations, such as colon cancer, stomach cancer, non-small cell lung cancer and pancreaticcancer .

HY-P3766

Protein kinase C (alpha) peptide TFA	PKC	Others
Protein kinase C α peptide (TFA) is a peptide of PKC-α. PKC-α acts as a lipid-dependent ser/thr protein kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on .

HY-P3720

YEQLRNSRA	Peptides	Cancer
YEQLRNSRA is a MycC Peptide. MycC Peptide is encoded by c-myc proto-oncogene, the c-myc oncogene has been implicated in malignant progression in a variety of human tumors. MycC Peptide regulates fundamental cellular processes like growth control, metabolism, proliferation, differentiation, and apoptosis .

HY-P10105

TCL1(10-24)	Akt Apoptosis	Cancer
TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo .

Cat. No.	Product Name	Target	Research Area

HY-P990189

Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243)	MHC Apoptosis Reactive Oxygen Species (ROS)	Infection Cancer
Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to monkey/human MHC class II. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can inhibits tumor cells proliferation and induce apoptosis. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) increases cellular reactive oxygen species (ROS) and loss of mitochondrial membrane potential in human endothelial cells. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can be used for the researches of cancer and infection, such as lymphoma .

HY-P991555

XmAb5485	TNF Receptor Apoptosis	Cancer
XmAb5485 is an Fc-engineered humanized anti-CD40 monoclonal antibody with high affinity to Fc-γ receptors. XmAb5485 induces potent antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) against tumor cells. XmAb5485 inhibits proliferation and induces apoptosis of tumor cells. XmAb5485 shows highly cytotoxic against lymphoma, leukemia and multiple myeloma cell lines as well as primary cancer cells .

HY-P991613

BGB-A445	Orexin Receptor (OX Receptor) NF-κB	Cancer
BGB-A445 is a humanized non-ligand-blocking agonistic OX40 monoclonal antibody with high affinity to OX40. BGB-A445 activates downstream NF-κB pathway to induce immune cell activation, proliferation, and survival. BGB-A445 dose-dependently and significantly depletes regulatory T cells via antibody-dependent cellular cytotoxicity (ADCC). BGB-A445 demonstrates robust and dose-dependent antitumor efficacy in the MC38 mice models. BGB-A445 can be used for the researches of cancer, such as colon adenocarcinoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-32343

Secalciferol 5+ Cited Publications (24R)-24,25-Dihydroxyvitamin D3	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite VD/VDR
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .

HY-N0650

L-Serine 10+ Cited Publications Serine	Structural Classification Classification of Application Fields Anti-aging Source classification Endocrine diseases Amino acids Endogenous metabolite Microorganisms Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder Cancer	Endogenous Metabolite Bacterial
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-124404A

12(S)-HETE	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	ERK DNA/RNA Synthesis p38 MAPK
12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells .

HY-N0650R

L-Serine (Standard) Serine (Standard)	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Reference Standards Endogenous Metabolite Bacterial
L-Serine (Standard) is the analytical standard of L-Serine. This product is intended for research and analytical applications. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-W106456

3-Methoxy-9H-Carbazole	Structural Classification Alkaloids Pyrrole Alkaloids Clausena heptaphylla (Roxb.) Wight & Arn. Source classification Rutaceae Plants	Caspase Reactive Oxygen Species (ROS) Apoptosis
3-Methoxy-9H-Carbazole induces caspase-3 activities and the cellular generation of eactive oxygen species. 3-Methoxy-9H-Carbazole inhibits cancer cell proliferation and induces apoptosis .

HY-N6739

Beauvericin	Cardiovascular Disease Structural Classification Human Gut Microbiota Metabolites Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields	Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related
Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages .

HY-126775

Xenoclauxin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Mitochondrial Metabolism Endogenous Metabolite
Xenoclauxin is a secondary metabolite isolated from certain species of the Penicillium genus, which exhibits an inhibitory effect on the proliferation of tumor cells. Xenoclauxin affects cellular energy metabolism, particularly by inhibiting ATP synthesis in the mitochondria. Xenoclauxin can be used for anti-tumor research .

HY-W107409

Meridianin C	Structural Classification Alkaloids Other Alkaloids Marine natural products Source classification	Others
Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation .

Cat. No.	Product Name	Chemical Structure

HY-N0650S8

L-Serine-d3 2 Publications Verification
L-Serine-d₃ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S11

L-Serine-d7
L-Serine-d₇ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S10

L-Serine-15N
L-Serine- ¹⁵N is the ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S1

L-Serine-13C
L-Serine- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S

L-Serine-13C3 1 Publications Verification
L-Serine- ¹³C₃ is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S2

L-Serine-1-13C
L-Serine-1- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S12

L-Serine-d3,15n
L-Serine- ¹⁵N,d₃ is the deuterium and ¹⁵N labeled L-Serine[1]. L-Serine ((-)-Serine;(S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation[2].

HY-N0650S7

L-Serine-d2
L-Serine-d₂ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S4

L-Serine-2-13C
L-Serine-2- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S9

L-Serine-15N,d3
L-Serine- ¹⁵N,d₃ is the deuterium and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S5

L-Serine-13C3,15N
L-Serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S6

L-Serine1-13C,15N
L-Serine1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S3

L-Serine-13C3,15N,d3
L-Serine- ¹³C₃, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N6739S

Beauvericin-13C45

Beauvericin- ¹³C₄₅ is ¹³C labeled Beauvericin (HY-N6739). Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages .

Cat. No.	Product Name		Classification

HY-118411

5-Ethynyl-2'-deoxyuridine 20+ Cited Publications EdU		Alkynes PROTAC Synthesis
5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation . 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-154644

Soya Lecithin		Emulsifiers Solubilizing Agents
Soya Lecithin is a phospholipid mixture that can be used as a drug delivery vehicle and is a pharmaceutical excipient. Soya Lecithin can form a lipid bilayer structure through self-assembly, and its binding properties are amphiphilic (hydrophilic head and hydrophobic tail), encapsulating hydrophobic drugs. Soya Lecithin forms stable nanoliposomes or microemulsions, improves the solubility and cellular uptake efficiency of poorly soluble drugs (such as Curcumin (HY-N0005)), and exerts activities such as enhancing drug delivery and regulating cell proliferation .

HY-174627

Human IL1B mRNA		mRNA
Human IL1B mRNA encodes the human interleukin 1 beta (IL1B) protein, a member of the interleukin 1 cytokine family. IL1B is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.

HY-174542

Human PRKCB mRNA		mRNA
Human PRKCB mRNA encodes the human protein kinase C beta (PRKCB) protein, a member of Protein kinase C (PKC) family. PRKCB has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption.

HY-W783254

C18 LPA PA(18:0e/0:0)		Phospholipids
C18 LPA (PA(18:0e/0:0)) is a water-soluble phospholipid that functions as a signaling molecule, influencing various cellular responses through G protein-coupled receptors (GPCRs). It is known to promote smooth muscle contraction, cytoskeletal rearrangement, and chemotaxis, while also playing a role in neurotransmitter release, cell proliferation, platelet aggregation, and Ca2+ mobilization. Elevated levels of C18 LPA in human plasma are associated with ovarian cancer and atherosclerosis, suggesting its potential as a biomarker for ovarian cancer.

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