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Results for "

cardiac glycoside

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (1) Apoptosis (2) Atg8/LC3 (1) Autophagy (5) Bacterial (2) Beclin1 (1) Biochemical Assay Reagents (1) Dengue Virus (2) Drug Metabolite (2) Endogenous Metabolite (2) Enterovirus (2) Flavivirus (2) Interleukin Related (2) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (2) Na+/K+ ATPase (8) Necroptosis (2) NF-κB (3) Nuclear Hormone Receptor 4A/NR4A (1) P-glycoprotein (2) Parasite (1) Potassium Channel (1) PPAR (2) PTEN (2) Pyroptosis (2) Reactive Oxygen Species (ROS) (2) Reference Standards (6)
By Research Areas:	Cancer (16) Cardiovascular Disease (16) Infection (2) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (3)

By Targets:

Adrenergic Receptor (1)

Akt (1)

Apoptosis (2)

Atg8/LC3 (1)

Autophagy (5)

Bacterial (2)

Beclin1 (1)

Biochemical Assay Reagents (1)

Dengue Virus (2)

Drug Metabolite (2)

Endogenous Metabolite (2)

Enterovirus (2)

Flavivirus (2)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

Mitochondrial Metabolism (2)

Na+/K+ ATPase (8)

Necroptosis (2)

NF-κB (3)

Nuclear Hormone Receptor 4A/NR4A (1)

P-glycoprotein (2)

Parasite (1)

Potassium Channel (1)

PPAR (2)

PTEN (2)

Pyroptosis (2)

Reactive Oxygen Species (ROS) (2)

Reference Standards (6)

By Research Areas:

Cancer (16)

Cardiovascular Disease (16)

Infection (2)

Inflammation/Immunology (9)

Metabolic Disease (1)

Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4252

Periplocymarin	Others	Cancer
Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound .

HY-114252

Strophanthidin	Na+/K+ ATPase	Cardiovascular Disease
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-A0154

Deslanoside Deacetyllanatoside C; Desacetyllanatoside C	Na+/K+ ATPase Drug Metabolite	Cardiovascular Disease
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-131486

Digoxigenin bisdigitoxoside	Nuclear Hormone Receptor 4A/NR4A	Cancer
Digoxigenin bisdigitoxoside is an anticancer agent and an active derivative of cardiac glycosides. Cardiac glycosides exert their apoptotic effects through the Nur77-dependent apoptotic pathway. Digoxigenin bisdigitoxoside is cytotoxic .

HY-N2414

Periplogenin 1 Publications Verification	Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related	Inflammation/Immunology Cancer
Periplogenin is a cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-N8735

k-Strophanthoside	Others	Cardiovascular Disease
k-Strophanthoside is a cardiac glycoside compound that can be isolated from the seeds of Strophanthus kombe .

HY-N9149

Cryptanoside A	Na+/K+ ATPase Akt NF-κB	Cardiovascular Disease Inflammation/Immunology Cancer
Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits Na+/K+-ATPase activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB .

HY-N12147

Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside	Others	Cancer
Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside (Compound 12) is a cardiac glycoside that can be isolated from seeds of Thevetia peruvian. Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside shows cytotoxicity against SW1990 and MGC-803 cells (IC₅₀: 9.52 and 7.70 μM) .

HY-114252R

Strophanthidin (Standard)	Reference Standards Na+/K+ ATPase	Cardiovascular Disease
Strophanthidin (Standard) is the analytical standard of Strophanthidin. This product is intended for research and analytical applications. Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration .

HY-A0154R

Deslanoside (Standard) Deacetyllanatoside C (Standard); Desacetyllanatoside C (Standard)	Reference Standards Na+/K+ ATPase Drug Metabolite	Cardiovascular Disease
Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-145154

Digoxigenin monodigitoxoside	Na+/K+ ATPase	Metabolic Disease
Digoxigenin monodigitoxoside is a Na+/K+ ATPase inhibitor and cardiac glycoside metabolite of digoxin.

HY-N12799

Digitalin Digitalinum verum	Others	Others
Digitalin (Digitalinum verum) is a cardiac glycoside and can be isolated from Digitalis .

HY-N2414R

Periplogenin (Standard)	Reference Standards Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related	Inflammation/Immunology Cancer
Periplogenin (Standard) is the analytical standard of Periplogenin (HY-N2414). Periplogenin is a cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-N12745

3-Epigitoxigenin	Others	Cardiovascular Disease
3-Epigitoxigenin is a cardiac glycoside that can be isolated from the seeds of Strophanthus diuaricatus .

HY-106530

Gitoformate AC 2770; Formiloxin; Formiloxine	Others	Others
Gitoformate (AC 2770) is a semisynthetic cardiac glycoside. Gitoformate can be used for renal function research .

HY-16022

Acetyldigitoxin Digitoxin 3'''-Acetate	Others	Others
Acetyldigitoxin (Digitoxin 3'''-Acetate) is a cardiac glycoside. Acetyldigitoxin can come from the leaves of Digitalis species. Acetyldigitoxin reduces the heart rate and can be used for cardiac failure rasearch .

HY-121592

Yokonoside	Endogenous Metabolite	Others
Yokonoside is a cardiac glycoside, which can be isolated from Aconitum japonicum. Yokonoside exhibits antioxidant efficacy .

HY-W671746

Thevetin A	Endogenous Metabolite	Others
Thevetin A is a thevetia cardiac glycoside. Thevetin A can be isolated from the methanol extract of the seeds of Cascabela thevetioides .

HY-N12749

16-Anhydro Digitalin	Others	Cardiovascular Disease
16-Anhydro Digitalin (compound 11) is a cardiac glycoside with a 16-dehydroisosyringyl aglycone structure .

HY-W779529

Cerberin 2'-Acetylneriifolin	Na+/K+ ATPase	Cancer
Cerberin is a cardiac glycoside that has been found in C. odollam and has cytotoxic and cardiac modulatory activities. It is cytotoxic to KB and NCI H187 cancer cells (IC₅₀s=1.92 and 1.24 μg/mL).1 Cerberin inhibits Na+/K+-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells.

HY-N0824

Syringin 1 Publications Verification Eleutheroside B	Autophagy	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Syringin is a main bioactive phenolic glycoside in Acanthopanax senticosus, with anti-osteoporosis activity. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy .

HY-B1030

Lanatoside C 5 Publications Verification	Flavivirus Dengue Virus Autophagy Enterovirus	Cardiovascular Disease Cancer
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-N1156A

α-Thevetin B	Others	Cardiovascular Disease Cancer
α-Thevetin B（Compound 24） is a cardiac glycoside that can be isolated from Thevetia peruviana. α-Thevetin B（Compound 24） can be used in lung cancer, gastric cancer and pancreatic cancer research .

HY-B1030R

Lanatoside C (Standard)	Dengue Virus Flavivirus Reference Standards Autophagy Enterovirus	Cardiovascular Disease Cancer
Lanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-111934

Cymarin	Parasite Potassium Channel	Others Cancer
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

HY-W755679

Digitoxigenin-21,23,23-d3 Cerberigenin-d₃; Echujetin-d₃	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
Digitoxigenin-21,23,23-d₃ (Cerberigenin-d₃; Echujetin-d₃) is the deuterium labeled Digitoxigenin (HY-B2151). Digitoxigenin is a steroid derivative commonly found in various plants, especially the foxglove plant (Digitalis purpurea). Digitoxigenin has unique chemical properties that make it an important precursor for the synthesis of cardiac glycosides, a group of drugs used to improve heart failure and certain types of arrhythmias. It works by inhibiting the sodium potassium ATPase pump, thereby increasing the force and efficiency of cardiac contractions.

HY-N12140

2'-epi-2'-O-Acetylthevetin B GHSC-74	Apoptosis	Cancer
2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be isolated from the seeds of Cerbera manghas L. 2'-epi-2'-O-Acetylthevetin B inhibits cell viability, induces apoptosis and loss of mitochondrial membrane potential in HepG2 cells .

HY-N8441

Neriifolin 17β-Neriifolin	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1	Cardiovascular Disease Inflammation/Immunology Cancer
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-N2453

Convallatoxin	PPAR NF-κB P-glycoprotein	Inflammation/Immunology Cancer
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-121312

Flutonidine ST-600	Adrenergic Receptor	Cardiovascular Disease
Flutonidine (ST-600) is a Clonidine (HY-12721) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1, α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors. Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides .

HY-N12143

Acetylthevetin A	Others	Others
Acetylthevetin A is a natural product isolated from oleander (Cascabela thevetioides) .

HY-N2453R

Convallatoxin (Standard)	Reference Standards PPAR NF-κB P-glycoprotein	Inflammation/Immunology Cancer
Convallatoxin (Standard) is the analytical standard of Convallatoxin. This product is intended for research and analytical applications. Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-N1441

Afzelin Maximum Cited Publications 6 Publications Verification Kaempferol-3-O-rhamnoside	Mitochondrial Metabolism PTEN Autophagy Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

HY-N1441R

Afzelin (Standard) Kaempferol-3-O-rhamnoside (Standard)	Mitochondrial Metabolism PTEN Autophagy Bacterial Reference Standards	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Afzelin (Standard) is the analytical standard of Afzelin. This product is intended for research and analytical applications. Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

HY-N1156

Thevetin B	Others	Others
Thevetin B (compound 1) is a betalain isolated from Thevetia peruviana .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4252

Periplocymarin	other families Classification of Application Fields Cardiacglycosides Source classification Plants Disease Research Fields Steroids Cancer	Others
Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound .

HY-114252

Strophanthidin	Cardiovascular Disease Classification of Application Fields Source classification Plants Brassicaceae Disease Research Fields Steroids Erysimum cheiranthoides Linn.	Na+/K+ ATPase
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-A0154

Deslanoside Deacetyllanatoside C; Desacetyllanatoside C	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Cardiacglycosides Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Na+/K+ ATPase Drug Metabolite
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-N2414

Periplogenin 1 Publications Verification	other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related
Periplogenin is a cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-N8735

k-Strophanthoside	Apocynaceae Triterpenes Terpenoids Source classification Plants Strophanthus kombe Oliv.	Others
k-Strophanthoside is a cardiac glycoside compound that can be isolated from the seeds of Strophanthus kombe .

HY-N9149

Cryptanoside A	Apocynaceae Triterpenes Terpenoids Source classification Plants Cryptolepis buchananii Roem. et Schult.	Na+/K+ ATPase Akt NF-κB
Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits Na+/K+-ATPase activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB .

HY-N12147

Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside	Apocynaceae Polysaccharides Source classification Thevetia peruviana (Pers.) K. Schum. Plants Saccharides Monosaccharides	Others
Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside (Compound 12) is a cardiac glycoside that can be isolated from seeds of Thevetia peruvian. Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside shows cytotoxicity against SW1990 and MGC-803 cells (IC₅₀: 9.52 and 7.70 μM) .

HY-114252R

Strophanthidin (Standard)	Source classification Plants Brassicaceae Steroids Erysimum cheiranthoides Linn.	Reference Standards Na+/K+ ATPase
Strophanthidin (Standard) is the analytical standard of Strophanthidin. This product is intended for research and analytical applications. Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration .

HY-A0154R

Deslanoside (Standard) Deacetyllanatoside C (Standard); Desacetyllanatoside C (Standard)	Digitalis purpurea Linn. Cardiacglycosides Source classification Scrophulariaceae Plants Steroids	Reference Standards Na+/K+ ATPase Drug Metabolite
Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-N12799

Digitalin Digitalinum verum	Plantaginaceae Polysaccharides Digitalis ciliata Trautv. Source classification Plants Saccharides	Others
Digitalin (Digitalinum verum) is a cardiac glycoside and can be isolated from Digitalis .

HY-N2414R

Periplogenin (Standard)	other families Source classification Plants Steroids	Reference Standards Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related
Periplogenin (Standard) is the analytical standard of Periplogenin (HY-N2414). Periplogenin is a cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-N12745

3-Epigitoxigenin	Apocynaceae Natural Products Source classification Strophanthus divaricatus (Lour.) Hook. & Arn. Plants	Others
3-Epigitoxigenin is a cardiac glycoside that can be isolated from the seeds of Strophanthus diuaricatus .

HY-16022

Acetyldigitoxin Digitoxin 3'''-Acetate	Plantaginaceae Cardiacglycosides Source classification Stauranthus perforatus Plants Steroids	Others
Acetyldigitoxin (Digitoxin 3'''-Acetate) is a cardiac glycoside. Acetyldigitoxin can come from the leaves of Digitalis species. Acetyldigitoxin reduces the heart rate and can be used for cardiac failure rasearch .

HY-121592

Yokonoside	Cardiacglycosides Ranunculaceae Source classification Plants Aconitum japonicum Thunberg Steroids	Endogenous Metabolite
Yokonoside is a cardiac glycoside, which can be isolated from Aconitum japonicum. Yokonoside exhibits antioxidant efficacy .

HY-W671746

Thevetin A	Apocynaceae Natural Products Source classification Plants Cascabela thevetioides (Kunth) Lippold	Endogenous Metabolite
Thevetin A is a thevetia cardiac glycoside. Thevetin A can be isolated from the methanol extract of the seeds of Cascabela thevetioides .

HY-N12749

16-Anhydro Digitalin	Adenium obesum (Forssk.) Roem. & Schult. Apocynaceae Natural Products Source classification Plants	Others
16-Anhydro Digitalin (compound 11) is a cardiac glycoside with a 16-dehydroisosyringyl aglycone structure .

HY-N0824

Syringin 1 Publications Verification Eleutheroside B	Cardiovascular Disease Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Disease Research Fields Araliaceae	Autophagy
Syringin is a main bioactive phenolic glycoside in Acanthopanax senticosus, with anti-osteoporosis activity. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy .

HY-B1030

Lanatoside C 5 Publications Verification	other families Classification of Application Fields Cardiacglycosides Source classification Plants Disease Research Fields Steroids Cancer	Flavivirus Dengue Virus Autophagy Enterovirus
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-N1156A

α-Thevetin B	Apocynaceae Polysaccharides Source classification Thevetia peruviana (Pers.) K. Schum. Plants Saccharides	Others
α-Thevetin B（Compound 24） is a cardiac glycoside that can be isolated from Thevetia peruviana. α-Thevetin B（Compound 24） can be used in lung cancer, gastric cancer and pancreatic cancer research .

HY-B1030R

Lanatoside C (Standard)	other families Cardiacglycosides Source classification Plants Steroids	Dengue Virus Flavivirus Reference Standards Autophagy Enterovirus
Lanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-111934

Cymarin	Apocynaceae Classification of Application Fields Cardiacglycosides Source classification Other Diseases Plants Disease Research Fields Apocynum Steroids	Parasite Potassium Channel
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

HY-N12140

2'-epi-2'-O-Acetylthevetin B GHSC-74	Apocynaceae Polysaccharides Source classification Cerbera manghas Linn. Plants Saccharides	Apoptosis
2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be isolated from the seeds of Cerbera manghas L. 2'-epi-2'-O-Acetylthevetin B inhibits cell viability, induces apoptosis and loss of mitochondrial membrane potential in HepG2 cells .

HY-N8441

Neriifolin 17β-Neriifolin	Apocynaceae Classification of Application Fields Cardiacglycosides Cerbera manghas Linn. Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-N2453

Convallatoxin	Triterpenes Classification of Application Fields Terpenoids Ranunculaceae Adonis amurensis Regel et Radde Plants Inflammation/Immunology Disease Research Fields	PPAR NF-κB P-glycoprotein
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-N12143

Acetylthevetin A	Apocynaceae Polysaccharides Source classification Thevetia peruviana (Pers.) K. Schum. Plants Saccharides	Others
Acetylthevetin A is a natural product isolated from oleander (Cascabela thevetioides) .

HY-N2453R

Convallatoxin (Standard)	Triterpenes Terpenoids Ranunculaceae Adonis amurensis Regel et Radde Plants	Reference Standards PPAR NF-κB P-glycoprotein
Convallatoxin (Standard) is the analytical standard of Convallatoxin. This product is intended for research and analytical applications. Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-N1441

Afzelin Maximum Cited Publications 6 Publications Verification Kaempferol-3-O-rhamnoside	Flavonols Flavonoids Saururaceae Houttuynia cordata Thunb. Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Mitochondrial Metabolism PTEN Autophagy Bacterial
Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

HY-N1441R

Afzelin (Standard) Kaempferol-3-O-rhamnoside (Standard)	Flavonols Flavonoids Saururaceae Houttuynia cordata Thunb. Source classification Phenols Polyphenols Plants	Mitochondrial Metabolism PTEN Autophagy Bacterial Reference Standards
Afzelin (Standard) is the analytical standard of Afzelin. This product is intended for research and analytical applications. Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

HY-N1156

Thevetin B	Apocynaceae Polysaccharides Source classification Thevetia peruviana (Pers.) K. Schum. Plants Saccharides	Others
Thevetin B (compound 1) is a betalain isolated from Thevetia peruviana .

Cat. No.	Product Name	Chemical Structure

HY-W755679

Digitoxigenin-21,23,23-d3

Digitoxigenin-21,23,23-d₃ (Cerberigenin-d₃; Echujetin-d₃) is the deuterium labeled Digitoxigenin (HY-B2151). Digitoxigenin is a steroid derivative commonly found in various plants, especially the foxglove plant (Digitalis purpurea). Digitoxigenin has unique chemical properties that make it an important precursor for the synthesis of cardiac glycosides, a group of drugs used to improve heart failure and certain types of arrhythmias. It works by inhibiting the sodium potassium ATPase pump, thereby increasing the force and efficiency of cardiac contractions.

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cardiac glycoside

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