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Isoforms Recommended:	c-Rel

Results for "

c-Rel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) Caspase (2) IKK (1) Interleukin Related (1) MALT1 (1) MHC (1) MyD88 (2) NF-κB (5) PIKfyve (2) Reactive Oxygen Species (ROS) (2) Small Interfering RNA (siRNA) (2) SOD (2)
By Research Areas:	Cancer (4) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124179

IT-901	NF-κB	Cancer
IT-901 is an orally active and potent NF-κB subunit *c-Rel* inhibitor with an IC₅₀ of 0.1 μM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively. IT-901, a bioactive naphthalenethiobarbiturate derivative, has the potential for human lymphoid tumors and ameliorate graft-versus-host disease (GVHD) .

HY-121508

(E/Z)-IT-603	NF-κB	Inflammation/Immunology Cancer
(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an IĸBα/c-Rel inhibitor. IT-603 is a *c-Rel* inhibitor with an IC₅₀ of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases .

HY-12276

MALT1 inhibitor MI-2 5+ Cited Publications	MALT1	Cancer
MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC₅₀=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals .

HY-Y1881B

Copper sulfate pentahydrate, for cell culture, 98%	Biochemical Assay Reagents Reactive Oxygen Species (ROS) MyD88 SOD Caspase	Others
Copper sulfate pentahydrate, for cell culture, 98% is a biochemical reagent. Copper sulfate pentahydrate, for cell culture, 98% reduces the production of ROS and the expression levels of MyD88 as well as *c-Rel* genes. Copper sulfate pentahydrate, for cell culture, 98% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, for cell culture, 98% is cytotoxic to various cells .

HY-160477

DC-SX029	PIKfyve NF-κB IKK	Inflammation/Immunology
DC-SX029 is a potent SNX10 protein-protein interaction (PPI) inhibitor with oral activity with an estimated K_D constant of ~0.935 μM by surface plasmon resonance (SPR). DC-SX029 blocks the SNX10-PIKfyve interaction, thereby decreased the TBK1/c-Rel signaling activation. DC-SX029 does not affect the protein level of SNX10. DC-SX029 has the potential for inflammatory bowel disease (IBD) research .

HY-Y1881A

Copper sulfate pentahydrate, 99.9%	Biochemical Assay Reagents Reactive Oxygen Species (ROS) MyD88 SOD Caspase	Neurological Disease Metabolic Disease Cancer
Copper sulfate pentahydrate, 99% is a biochemical reagent. Copper sulfate pentahydrate, 99% reduces the production of ROS and the expression levels of MyD88 as well as *c-Rel* genes. Copper sulfate pentahydrate, 99% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, 99% is cytotoxic to various cells. Copper sulfate pentahydrate, 99% has antioxidant activity. Copper sulfate pentahydrate, 99% can be used in the research of diabetes, Parkinson's disease and DMBA (HY-W011845)-induced tumors .

HY-123876

AS2677131	PIKfyve Interleukin Related MHC	Inflammation/Immunology
AS2677131 is a potent and orally active PIKfyve inhibitor. AS2677131 inhibits f IL-12p40, IL-6 and IL-1β through a PIKfyve-c-Rel pathway. AS2677131 selectively inhibits DNA-binding activity of c-Rel to IL-12p40 and IL-1β promoter. AS2677131 inhibits MHC class II expression on B cells. AS2677131 can be used for the researches of inflammation and immunology, such as arthritis .

HY-RS11824

Rel Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NF-κB	Others
Rel Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rel gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rel Mouse Pre-designed siRNA Set A Rel Mouse Pre-designed siRNA Set A

HY-RS11823

REL Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NF-κB	Others
REL Human Pre-designed siRNA Set A contains three designed siRNAs for REL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

REL Human Pre-designed siRNA Set A REL Human Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library	1,337 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 1,337 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

NF-κB Signaling Compound Library

1,337 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 1,337 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-Y1881B

Copper sulfate pentahydrate, for cell culture, 98%	Buffer Reagents
Copper sulfate pentahydrate, for cell culture, 98% is a biochemical reagent. Copper sulfate pentahydrate, for cell culture, 98% reduces the production of ROS and the expression levels of MyD88 as well as *c-Rel* genes. Copper sulfate pentahydrate, for cell culture, 98% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, for cell culture, 98% is cytotoxic to various cells .

Copper sulfate pentahydrate, for cell culture, 98%

Buffer Reagents

Copper sulfate pentahydrate, for cell culture, 98% is a biochemical reagent. Copper sulfate pentahydrate, for cell culture, 98% reduces the production of ROS and the expression levels of MyD88 as well as c-Rel genes. Copper sulfate pentahydrate, for cell culture, 98% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, for cell culture, 98% is cytotoxic to various cells .

HY-Y1881A

Copper sulfate pentahydrate, 99.9%	Buffer Reagents
Copper sulfate pentahydrate, 99% is a biochemical reagent. Copper sulfate pentahydrate, 99% reduces the production of ROS and the expression levels of MyD88 as well as *c-Rel* genes. Copper sulfate pentahydrate, 99% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, 99% is cytotoxic to various cells. Copper sulfate pentahydrate, 99% has antioxidant activity. Copper sulfate pentahydrate, 99% can be used in the research of diabetes, Parkinson's disease and DMBA (HY-W011845)-induced tumors .

Copper sulfate pentahydrate, 99.9%

Buffer Reagents

Copper sulfate pentahydrate, 99% is a biochemical reagent. Copper sulfate pentahydrate, 99% reduces the production of ROS and the expression levels of MyD88 as well as c-Rel genes. Copper sulfate pentahydrate, 99% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, 99% is cytotoxic to various cells. Copper sulfate pentahydrate, 99% has antioxidant activity. Copper sulfate pentahydrate, 99% can be used in the research of diabetes, Parkinson's disease and DMBA (HY-W011845)-induced tumors .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80093

	c-Rel Antibody (YA490)	WB, IHC-P, IP	Human
	c-Rel Antibody (YA490) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Rel.

HY-P84485

	c-Rel Antibody (YA4182) Rel; c-Rel	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
	c-Rel Antibody (YA4182) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to c-Rel.

HY-P85106

	c-Rel Antibody (YA4798) Rel; Proto-oncogene c-Rel	WB, ICC/IF, ELISA	Human, Mouse
	c-Rel Antibody (YA4798) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to c-Rel.

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Cat. No.	Product Name		Classification

HY-RS11824

Rel Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Rel Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rel gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11823

REL Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
REL Human Pre-designed siRNA Set A contains three designed siRNAs for REL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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