c-Rel Antibody (YA4798)

c-Rel Antibody (YA4798) is a mouse-derived and non-conjugated monoclonal antibody, targeting to c-Rel. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse.

c-Rel is a proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and involved in biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis, and apoptosis. NF-kappa-B forms homo- or heterodimeric complexes with Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL, and NFKB2/p52. These dimers bind to kappa-B sites in the DNA of target genes, with distinct affinities and specificities for different kappa-B sites. Different dimer combinations act as transcriptional activators or repressors. NF-kappa-B activity is regulated by post-translational modifications, subcellular localization, and interactions with cofactors or corepressors. Inactive NF-kappa-B complexes are sequestered in the cytoplasm by NF-kappa-B inhibitor (I-kappa-B) family members. In the canonical activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) and degraded, releasing the active NF-kappa-B complex for nuclear translocation. The NF-kappa-B heterodimer RELA/p65-c-Rel functions as a transcriptional activator.

Q04864

Predicted band size: 69 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse

WB: 1:500-1:2000; ICC/IF: 1:200-1:1000; ELISA: 1:10000

WB, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human c-Rel expressed in E. Coli.