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Results for "

bmal1

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148765
    CLK8

    		Cryptochrome Metabolic Disease Cancer
    CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms [1].
    CLK8
  • HY-148711
    STL1267
    2 Publications Verification

    		 REV-ERB Metabolic Disease Inflammation/Immunology Cancer
    STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1 [1].
    STL1267
  • HY-115672
    KS15
    2 Publications Verification

    		 Cryptochrome Cancer
    KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity [1] .
    KS15
  • HY-N10319
    Artepillin C

    		Epigenetic Reader Domain Necroptosis TRP Channel Metabolic Disease Inflammation/Immunology Cancer
    Artepillin C is an orally active CREB/CRTC2 inhibitor and TRPA1 covalent agonist (EC50=1.8 μM). Artepillin C inhibits CREB/CRTC2-mediated gene transcription and downregulates BMAL1 expression to regulate glucose and lipid metabolism. Artepillin C can also activate TRPA1 channels to induce spicy taste signals. Artepillin C can inhibit tumor cell proliferation, induce necroptosis, improve insulin resistance and inhibit liver lipid synthesis. Artepillin C can be used in the study of metabolic syndrome, tumor prevention and treatment, and inflammation [1] .
    Artepillin C
  • HY-14414
    GSK4112
    Maximum Cited Publications
    10 Publications Verification

    SR6452

    		 REV-ERB Apoptosis Metabolic Disease
    GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways [1].
    GSK4112
  • HY-RS23574
    Bmal1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Bmal1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bmal1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Bmal1 Rat Pre-designed siRNA Set A
    Bmal1 Rat Pre-designed siRNA Set A
  • HY-RS17129
    Bmal1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Bmal1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmal1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Bmal1 Mouse Pre-designed siRNA Set A
    Bmal1 Mouse Pre-designed siRNA Set A
  • HY-RS01529
    BMAL1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    BMAL1 Human Pre-designed siRNA Set A contains three designed siRNAs for BMAL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BMAL1 Human Pre-designed siRNA Set A
    BMAL1 Human Pre-designed siRNA Set A
  • HY-176851
    GSK1362

    		REV-ERB Inflammation/Immunology
    GSK1362 is a selective inverse agonist of REV-ERB. GSK1362disrupts the interaction of REV-ERBα with repressive co-modulators (NCoR1, SMRT2, RIP140). GSK1362 exerts an inverse agonist effect by increasing the transcription of BMAL1 to relieve BMAL1 repression by endogenous REV-ERB ligands. GSK1362 suppresses LPS (HY-D1056)-induced inflammatory cytokine expression, inhibits IL-1β-induced Cxcl5 transcription in cells. GSK1362 can be used for the study of inflammatory diseases [1].
    GSK1362
  • HY-N10319R
    Artepillin C (Standard)

    		Reference Standards TRP Channel Necroptosis Epigenetic Reader Domain Metabolic Disease Inflammation/Immunology Cancer
    Artepillin C (Standard) is the analytical standard of Artepillin C (HY-N10319). This product is intended for research and analytical applications. Artepillin C is an orally active CREB/CRTC2 inhibitor and TRPA1 covalent agonist (EC50=1.8 μM). Artepillin C inhibits CREB/CRTC2-mediated gene transcription and downregulates BMAL1 expression to regulate glucose and lipid metabolism. Artepillin C can also activate TRPA1 channels to induce spicy taste signals. Artepillin C can inhibit tumor cell proliferation, induce apoptosis, improve insulin resistance and inhibit liver lipid synthesis. Artepillin C can be used in the study of metabolic syndrome, tumor prevention and treatment, and inflammation [1] .
    Artepillin C (Standard)

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