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Results for "

amination

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

2

Fluorescent Dye

4

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y0006
    XPhos

    2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl

    		 Biochemical Assay Reagents Others
    XPhos is a dual aryl monophosphine ligand. XPhos is an efficient and stable palladium catalytic ligand. XPhos can be used for amination of aryl sulfonate esters .
    XPhos
  • HY-W040209
    2-(Naphthalen-1-yl)-5-phenyloxazole

    α-NPO

    		 Fluorescent Dye Others
    2-(Naphthalen-1-yl)-5-phenyloxazole (α-NPO) is an organic fluorescent dye. 2-(Naphthalen-1-yl)-5-phenyloxazole has a nitrogen atom in its structure that can interfere with the nitrogen content from the amination step .
    2-(Naphthalen-1-yl)-5-phenyloxazole
  • HY-W000438
    N-Boc-O-tosyl hydroxylamine

    		Amino Acid Derivatives Cancer
    N-Boc-O-tosyl hydroxylamine is used as a safe and efficient nitrogen source for the N-amination of aryl and alkyl amines .
    N-Boc-O-tosyl hydroxylamine
  • HY-W021597
    N-Boc-5-bromoindole

    		Drug Intermediate Others
    N-Boc-5-bromoindole is formed as an intermediate for the synthesis of di-Boc-protected 5-aminoindole via a Buchwald-Hartwig amination with tBu-carbamate followed by regioselective bromination .
    N-Boc-5-bromoindole
  • HY-W099634
    9-Heptadecanone

    Heptadecan-9-one

    		 Biochemical Assay Reagents Others
    9-Heptadecanone (Heptadecan-9-one) is an aliphatic molecule with a central ketone on a C17 chain. The ketone may react with amines in reductive aminations to link this molecule to larger lipid structures.
    9-Heptadecanone
  • HY-117293
    Phenyl sulfamate

    		Drug Intermediate Others
    Phenyl sulfamate is a nitrogen source that can be used in the amination of intermolecular .
    Phenyl sulfamate
  • HY-W586329
    Thalidomide-4-carbaldehyde

    		Ligands for E3 Ligase Others
    Thalidomide-4-carbaldehyde is a Thalidomide analogue with an aldehyde. Thalidomide recruiits E3 ligase for the ubiquitinylation and subsequent proteolysis of target proteins. The aldehyde is highly reactive towards amine nucleophiles through reductive amination among other reactions.
    Thalidomide-4-carbaldehyde
  • HY-W451211
    Thalidomide-5-carbaldehyde

    		Ligands for E3 Ligase Cancer
    Thalidomide-5-carbaldehyde is a Thalidomide analogue with an aldehyde. Thalidomide recruiits E3 ligase for the ubiquitinylation and subsequent proteolysis of target proteins. The aldehyde is highly reactive towards amine nucleophiles through reductive amination among other reactions.
    Thalidomide-5-carbaldehyde
  • HY-154927
    DSPE-PEG-Cy5

    		Liposome Cancer
    DSPE-PEG-Cy5 is an ammoniated reagent that can be used for the preparation of tumor-targeting vectors .
    DSPE-PEG-Cy5
  • HY-W010685
    [1,4-BIs(diphenylphosphino)butane](1,5-cyclooctadiene)rhodium(I) tetrafluoroborate

    [Rh(dppb)(COD)]BF4

    		 Biochemical Assay Reagents Endogenous Metabolite Others
    [1,4-Bis(diphenylphosphino)butane](1,5-cyclooctadiene)rhodium(I) tetrafluoroborate ([Rh(dppb)(COD)]BF4) serves as a rhodium-based catalyst that facilitates regioselective hydrogenation and enantioselective reductive amination reactions.
    [1,4-BIs(diphenylphosphino)butane](1,5-cyclooctadiene)rhodium(I) tetrafluoroborate
  • HY-P2768
    Leucine dehydrogenase, Microorganism

    LDH, EC 1.4.1.9

    		 Endogenous Metabolite Metabolic Disease
    Leucine dehydrogenase, Microorganism (EC 1.4.1.9) can be purified from Bacillus spheroides. Leucine dehydrogenase catalyzed the oxidative deamination of L-leucine, L-valine, L-isoleucine, L-norvaline, L-alpha-aminobutyrate, and L-norleucine, and the reductive amination of their keto analogues .
    Leucine dehydrogenase, Microorganism
  • HY-W003601
    2-Bromo-4-fluoropyridine

    		Biochemical Assay Reagents Others
    2-Bromo-4-fluoropyridine is a synthetic halogenated heterocyclic organic compound and a key intermediate in the pharmaceutical and agrochemical industries. 2-Bromo-4-fluoropyridine can be used to synthesize bioactive molecules through cross-coupling reactions, such as Suzuki coupling or Buchwald-Hartwig amination.
    2-Bromo-4-fluoropyridine
  • HY-D1336
    FAM amine, 6-isomer

    		Fluorescent Dye
    FAM amine, 6-isomer is a fluorescein derivative with an amine group and contains an isomer of the fluorophore. Can be used to modify biomolecules through enzymatic transamination. Its fatty amine groups can also react with electrophiles such as activated esters. The amine can also be conjugated to carbonyl compounds (aldehydes and ketones) by reductive amination.
    FAM amine, 6-isomer
  • HY-I0259
    8-Amino-2-naphthol

    		Fluorescent Dye Others
    8-Amino-2-naphthol is a photoactive charge transfer compounds, which can be used as fluorescent probe. 8-Amino-2-naphthol undergoes excited-state proton transfer (ESPT) to form a zwitterion under acidic conditions, where the photoacidity of its hydroxyl group is regulated by the protonation state of the amino group, enabling pH to act as an on/off switch for photoacidity. 8-Amino-2-naphthol is also utilized as chiral organocatalyst .
    8-Amino-2-naphthol
  • HY-167931
    Cinnamohydrazide

    		Drug Derivative Metabolic Disease
    Cinnamohydrazide, an unsaturated carboxylic acid derivative, serves as a precursor to aspartame through enzyme-mediated amination to phenylalanine. This compound may offer potential benefits in the prevention and treatment of diabetes by facilitating insulin secretion, enhancing pancreatic β-cell function, inhibiting hepatic gluconeogenesis, promoting glucose uptake, amplifying insulin signaling pathways, delaying carbohydrate digestion and glucose absorption, and reducing protein glycation and insulin fibrillation.
    Cinnamohydrazide
  • HY-W712314
    4-Arm PEG-amine (MW 5000)

    		Biochemical Assay Reagents Others
    4-Arm PEG-amine (MW 5000) is a PEG Linker. The reactive primary amine or NH2 rapidly react with aldehyde, ketone to form imine. Imine upon further reduction forms secondary amine via reductive amination. Amine reacts with activated carboxyl acid, NHS ester to form stable amide bonds. 4-Arm PEG reagents are useful crosslinking reagent and used for drug delivery .
    4-Arm PEG-amine (MW 5000)
  • HY-W800833
    Benzyl N-[2-(prop-2-enamido)ethyl]carbamate

    		Biochemical Assay Reagents Others
    Benzyl N-[2-(prop-2-enamido)ethyl]carbamate is a short aliphatic linker featuring a Cbz-protected amine and an acrylamide. Acrylamide is a Michael acceptor which is a good Michael acceptor which can be used in thiol-based bioconjugation or polymerization. Meanwhile, the Cbz protecting group can be removed using Pd-C hydrogenation to reveal a free amine that can participate in a wide variety of reactions such as couplings or reductive amination.
    Benzyl N-[2-(prop-2-enamido)ethyl]carbamate
  • HY-W800837
    t-Boc-N-amido-PEG4-Val-Cit

    		ADC Linker Cancer
    t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is cleavable by cell proteases and features a carboxylic acid which is free for coupling reactions with amines to form amides. The Boc can be removed under acidic conditions to reveal a free primary amine, which may be used in a variety of reactions such as coupling or reductive amination.
    t-Boc-N-amido-PEG4-Val-Cit
  • HY-100707
    IC 86621

    		DNA-PK Apoptosis Inflammation/Immunology Cancer
    IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis .
    IC 86621
  • HY-W145053
    ChloraMine-T hydrate

    Sodium chloro(4-methylbenzenesulfonyl)azanide hydrate

    		 Factor Xa Bacterial Infection
    ChloraMine-T hydrate (Sodium chloro(4-methylbenzenesulfonyl)azanide (hydrate)) is a common reagent in various synthetic processes. It has been used as a reagent in aminohydroxylation and allylic amination reactions, a nitrogen source in aziridination reactions of alkenes and alkenes, and deprotection of sulfur groups in sulfur-containing compounds. It has been used as a reagent in the synthesis of factor Xa inhibitors. ChloraMine-T hydrate (Sodium chloro(4-methylbenzenesulfonyl)azanide (hydrate)) (0.2% w/v) is also an antimicrobial agent that kills Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and Enterococcus cloacae.
    ChloraMine-T hydrate
  • HY-40190
    5-Bromo-2,3-dihydro-1H-inden-1-one

    		Biochemical Assay Reagents Drug Intermediate Metabolic Disease
    5-Bromo-2,3-dihydro-1H-inden-1-one is a bromoindanone compound. 5-Bromo-2,3-dihydro-1H-inden-1-one acts as a key intermediate in organic synthesis, participating in reactions such as Suzuki coupling and Buchwald amination. 5-Bromo-2,3-dihydro-1H-inden-1-one can be used in the research of obesity-related metabolic diseases .
    5-Bromo-2,3-dihydro-1H-inden-1-one
  • HY-W800618
    NH2-PEG3-Val-Cit-PAB-OH

    		ADC Linker Others
    NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
    NH2-PEG3-Val-Cit-PAB-OH
  • HY-W800617
    NH2-PEG1-Val-Cit-PAB-OH

    		ADC Linker Cancer
    NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
    NH2-PEG1-Val-Cit-PAB-OH
  • HY-W800619
    NH2-PEG4-Val-Cit-PAB-OH

    		ADC Linker Others
    NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
    NH2-PEG4-Val-Cit-PAB-OH
  • HY-W800620
    NH2-PEG6-Val-Cit-PAB-OH

    		ADC Linker Others
    NH2-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
    NH2-PEG6-Val-Cit-PAB-OH

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