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Results for "

alpha 2 adrenergic receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (113) 5-HT Receptor (34) AAK1 (2) Adenosine Receptor (1) Adenylate Cyclase (1) Androgen Receptor (1) Autophagy (8) Cytochrome P450 (4) Dopamine Receptor (23) Drug Metabolite (3) Endogenous Metabolite (14) Fluorescent Dye (1) GABA Receptor (3) GnRH Receptor (2) Histamine Receptor (7) Imidazoline Receptor (4) Isotope-Labeled Compounds (11) mAChR (2) Monoamine Oxidase (3) nAChR (3) Opioid Receptor (3) Potassium Channel (1) Reference Standards (13) Sigma Receptor (2)
By Research Areas:	Cancer (19) Cardiovascular Disease (35) Endocrinology (52) Inflammation/Immunology (4) Metabolic Disease (7) Neurological Disease (73)

By Targets:

Adrenergic Receptor (113)

5-HT Receptor (34)

AAK1 (2)

Adenosine Receptor (1)

Adenylate Cyclase (1)

Androgen Receptor (1)

Autophagy (8)

Cytochrome P450 (4)

Dopamine Receptor (23)

Drug Metabolite (3)

Endogenous Metabolite (14)

Fluorescent Dye (1)

GABA Receptor (3)

GnRH Receptor (2)

Histamine Receptor (7)

Imidazoline Receptor (4)

Isotope-Labeled Compounds (11)

mAChR (2)

Monoamine Oxidase (3)

nAChR (3)

Opioid Receptor (3)

Potassium Channel (1)

Reference Standards (13)

Sigma Receptor (2)

By Research Areas:

Cancer (19)

Cardiovascular Disease (35)

Endocrinology (52)

Inflammation/Immunology (4)

Metabolic Disease (7)

Neurological Disease (73)

127

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Adrenergic Receptor 5 alpha Reductase IFNAR α-synuclein PGC-1α

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0659

Brimonidine 5 Publications Verification UK 14304; AGN190342	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0659A

Brimonidine tartrate 5 Publications Verification UK 14304 tartrate; AGN190342 tartrate	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-W702712

3-Hydroxy xylazine	Adrenergic Receptor	Neurological Disease
3-Hydroxy xylazine is a metabolite of the α2-adrenergic receptor agonist Xylazine.

HY-17034BS

Medetomidine-d3 hydrochloride MPV785-d₃	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine-d₃ (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor .

HY-116222

A 53693	Fluorescent Dye	Endocrinology
A 53693 is a rigid catecholamine with selective adrenergic agonist activity. A 53693 has affinity for certain rat alpha-2 receptor subtypes. A 53693 shows high selectivity for alpha-2 receptors and, in contrast, has low affinity for alpha-1 receptors. A 53693 is used as a probe in biological studies to explore the molecular interactions of alpha agonist compounds .

HY-103208

Benalfocin hydrochloride	Adrenergic Receptor	Metabolic Disease
Benalfocin is a novel selective alpha-2 adrenergic receptor antagonist. Benalfocin reduces blood pressure and heart rate. Benalfocin can be used in the study of cardiovascular effects .

HY-W042920A

TDIQ hydrochloride	Adrenergic Receptor	Neurological Disease
TDIQ hydrochloride is an analog of Amphetamine with high affinity for α2-adrenergic receptor. TDIQ hydrochloride is a selective α2-adrenoceptor ligand with the K_i values of 75 nM, 95 nM, and 65 nM for α2A-, α2B-, and α2C-adrenergic receptors, respectively .

HY-19057

Vatinoxan MK-467; L-659066	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Vatinoxan (MK-467) is an **alpha 2-adrenergic receptor antagonist. The peripheral selectivity of Vatinoxan determines that it has limited penetration across the blood-brain barrier and therefore has low concentrations in the central nervous system. Vatinoxan antagonizes alpha 2-adrenergic receptor** receptors by binding to them, thereby reducing or preventing cardiovascular effects caused by α2-adrenergic agonists. Vatinoxan can be used in studies of cardiovascular effects, sedation and analgesia .

HY-B0659S

Brimonidine-d4	Adrenergic Receptor	Endocrinology
Brimonidine-d₄ is the deuterium labeled Brimonidine. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-107358A

Lidamidine hydrochloride WHR-1142A	Adrenergic Receptor	Others
Lidamidine hydrochloride (WHR-1142A) is an *α2-adrenergic* receptor agonist and antidiarrheal agent .

HY-B0194A

Tizanidine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

HY-U00402

Fenmetozole Tosylate	Adrenergic Receptor	Neurological Disease Endocrinology
Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, and acts as an antidepressant agent.

HY-101610

OPC-28326	Adrenergic Receptor	Cardiovascular Disease Endocrinology
OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with K_i of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.

HY-105960

Fenmetozole	Adrenergic Receptor	Cardiovascular Disease
Fenmetozole is an antagonist of ethanol, and also antagonizes α2-adrenergic receptor, which has antidepressant effect .

HY-105960A

Fenmetozole hydrochloride	Adrenergic Receptor	Neurological Disease
Fenmetozole hydrochloride is an antagonist of ethanol, and also antagonizes α2-adrenergic receptor, which has antidepressant effect .

HY-103212B

Azepexole B-HT 933	Adrenergic Receptor	Neurological Disease
Azepexole (B-HT 933) is a selective α2 adrenergic inducer with over 300-fold selectivity for α2 adrenergic receptors over α1 adrenergic receptors. Azepexole can be used to study the biological functions of α2 adrenergic receptors and inhibition of related diseases. Azepexole may also play a role in regulating mood and improving cognitive function .

HY-B0659R

Brimonidine (Standard) UK 14304 (Standard); AGN190342 (Standard)	Reference Standards Adrenergic Receptor	Endocrinology Cancer
Brimonidine (Standard) is the analytical standard of Brimonidine. This product is intended for research and analytical applications. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-107358

Lidamidine WHR-1142A free base	Adrenergic Receptor	Metabolic Disease
Lidamidine (WHR-1142A free base) is an *α2-adrenergic* receptor agonist and antidiarrheal agent .

HY-U00371

AR-08	Adrenergic Receptor	Neurological Disease Endocrinology
AR-08 is an agonist of α2-adrenergic receptor, used for the treatment of attention deficit hyperactivety disorder (ADHD).

HY-106444A

Fipamezole hydrochloride MPV-1730 hydrochloride; JP-1730 hydrochloride	Adrenergic Receptor	Neurological Disease
Fipamezole hydrochloride is a potent and orally active α2-adrenergic receptor antagonist with K_i values of 9.2 nM, 17 nM, and 55 nM for human α2A, α2B, and α2C, receptors, respectively. Fipamezole hydrochloride is an anti-dyskinetic agent, and can be used for the study of Parkinson's disease .

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-106617A

Etoperidone hydrochloride	5-HT Receptor Adrenergic Receptor	Neurological Disease
Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows K_d values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .

HY-106617

Etoperidone	5-HT Receptor Adrenergic Receptor	Neurological Disease
Etoperidone, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone shows K_d values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .

HY-106444

Fipamezole MPV 1730; JP-1730	Adrenergic Receptor	Neurological Disease
Fipamezole (MPV 1730; JP-1730) is a potent and orally active α2-adrenergic receptor antagonist with K_i values of 9.2 nM, 17 nM, and 55 nM for human α2A, α2B, and α2C, receptors, respectively. Fipamezole is an anti-dyskinetic agent, and can be used for the study of Parkinson's disease .

HY-B0659AR

Brimonidine tartrate (Standard) UK 14304 tartrate (Standard); AGN190342 tartrate (Standard)	Reference Standards Adrenergic Receptor	Endocrinology Cancer
Brimonidine (tartrate) (Standard) is the analytical standard of Brimonidine (tartrate). This product is intended for research and analytical applications. Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-129697

3-Hydroxy Medetomidine 3-OH Medetomidine; Medetomidine metabolite MIII	Drug Metabolite	Metabolic Disease
3-Hydroxy Medetomidine (3-OH Medetomidine; Medetomidine metabolite MIII) is a metabolite of the α2-adrenergic receptor agonist medetomidine.

HY-B1696

Methyldopate	Adrenergic Receptor	Cardiovascular Disease
Methyldopate is an ethyl ester proagent of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research .

HY-B1696A

Methyldopate hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Methyldopate hydrochloride is an ethyl ester hydrochloride proagent of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate hydrochloride has the potential for severe hypertension research .

HY-103413

Eticlopride hydrochloride	Dopamine Receptor	Neurological Disease
Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with K_is of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride hydrochloride is an antipsychotic agent .

HY-121129

Eticlopride FLB-131	Dopamine Receptor	Neurological Disease
Eticlopride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with K_is of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride is an antipsychotic agent .

HY-112074

Tiamenidine HOE 440	Adrenergic Receptor	Cardiovascular Disease
Tiamenidine (HOE 440) is an orally active α2-adrenergic receptor agonist with antihypertensive effect. Tiamenidine is used as an antihypertensive agent for hypertension research .

HY-B0225AS

Methyldopa-d3 hydrochloride L-(-)-α-Methyldopa-d₃ hydrochloride; MK-351-d₃ hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa-d₃ (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-U00117

Lusaperidone R107474	Adrenergic Receptor	Neurological Disease Endocrinology
Lusaperidone (R107474) is an α2 **adrenergic receptor antagonist with K_i**s of 0.13 and 0.15 nM for α2A and α2C, respectively.

HY-B0225BR

Methyldopa hydrate (Standard) L-(-)-α-Methyldopa hydrate (Standard); MK-351 hydrate (Standard)	Reference Standards Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225R

Methyldopa (Standard)	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (Standard) is the analytical standard of Methyldopa. This product is intended for research and analytical applications. Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0194S

Tizanidine-d4	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Tizanidine-d₄ is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons .

HY-106874A

Delequamine hydrochloride RS-15385-197 hydrochloride	Adrenergic Receptor	Neurological Disease
Delequamine (RS-15385-197) hydrochloride is an orally active and selective α2-adrenergic receptor antagonist with a pK_i of 9.5 for α2-adrenoceptors in rat cortex. Delequamine hydrochloride shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine hydrochloride can be used for the study of erectile dysfunction .

HY-106874

Delequamine RS-15385-197	Adrenergic Receptor	Neurological Disease
Delequamine (RS-15385-197) is an orally active and selective α2-adrenergic receptor antagonist with a pK_i of 9.5 for α2-adrenoceptors in rat cortex. Delequamine shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine can be used for the study of erectile dysfunction .

HY-136693

L-654284	Adrenergic Receptor	Neurological Disease
L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows K_i values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a K_i of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system .

HY-12710A

Rauwolscine hydrochloride α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a K_i of 12 nM.

HY-U00123

Guanoxabenz Hydroxyguanabenz	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Guanoxabenz is an α2 adrenergic receptor agonist, with a K_i of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor .

HY-U00244

Benzquinamide P2647; BZQ; Benzoquinamide	Adrenergic Receptor	Metabolic Disease Endocrinology
Benzquinamide (P2647) is an antiemetic which can bind to the *α_2A, α_2B, and α_2C* **adrenergic receptors** (α2-AR) with K_i values of 1,365, 691, and 545 nM, respectively.

HY-100300

AGN 192836	Adrenergic Receptor	Cardiovascular Disease Endocrinology
AGN 192836 is a potent and selective α2 adrenergic agonist with EC₅₀s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.

HY-162620

α2A-AR agonist 1	Adrenergic Receptor	Cancer
α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC₅₀ of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED₅₀ of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes .

HY-U00123A

Guanoxabenz hydrochloride Hydroxyguanabenz hydrochloride	Adrenergic Receptor	Neurological Disease
Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a K_i of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor .

HY-12717

Phentolamine 5 Publications Verification	Adrenergic Receptor	Endocrinology Cancer
Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction .

HY-14607

Besipirdine hydrochloride HP 749	Potassium Channel	Neurological Disease
Besipirdine (hydrochloride) is a potassium channel blocker with cholinergic and adrenergic activity. The cholinergic activity of Besipirdine (hydrochloride) involves stimulating phosphatidylinositol turnover and reducing potassium currents. The adrenergic activity of Besipirdine (hydrochloride) involves stimulating norepinephrine release, which is attributed to the inhibition of presynaptic α2-adrenergic receptors and the inhibition of norepinephrine uptake. Besipirdine (hydrochloride) may be used in research for Alzheimer's disease .

HY-159639

BAY-2925976	Androgen Receptor	Neurological Disease
BAY-2925976 is an *α2C adrenergic* receptor (ARα2C)** antagonist that can be used for the study of obstructive sleep apnea (OSA) .

Cat. No.	Product Name	Target	Research Area

HY-P3641A

Kisspeptin 13 TFA	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .

HY-P3641

Kisspeptin 13	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Hippocastanaceae Source classification Aesculus hippocastanum Plants Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-A0066A

Tolazoline hydrochloride Imidaline hydrochloride; NSC35110 hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Source classification Alpinia officinarum Hance Plants Disease Research Fields Endocrinology Zingiberaceae	Adrenergic Receptor
Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-13715

Norepinephrine Maximum Cited Publications 46 Publications Verification Levarterenol; L-Noradrenaline	Cardiovascular Disease Structural Classification Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715A

Norepinephrine hydrochloride Maximum Cited Publications 46 Publications Verification Levarterenol hydrochloride; L-Noradrenaline hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Mimosa pudica Linn. Leguminosae Other Alkaloids Source classification Phenols Polyphenols Plants Disease Research Fields Endocrinology	Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715B

Norepinephrine bitartrate monohydrate Maximum Cited Publications 46 Publications Verification Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate	Structural Classification Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225BR

Methyldopa hydrate (Standard) L-(-)-α-Methyldopa hydrate (Standard); MK-351 hydrate (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Adrenergic Receptor Endogenous Metabolite
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225R

Methyldopa (Standard)	Structural Classification Ketones, Aldehydes, Acids Hippocastanaceae Aesculus hippocastanum Source classification Plants	Adrenergic Receptor Endogenous Metabolite
Methyldopa (Standard) is the analytical standard of Methyldopa. This product is intended for research and analytical applications. Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-12710A

Rauwolscine hydrochloride α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride	Alkaloids other families Classification of Application Fields Neurological Disease Source classification Plants Disease Research Fields Endocrinology Indole Alkaloids	Adrenergic Receptor
Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a K_i of 12 nM.

HY-13715C

Norepinephrine tartrate Maximum Cited Publications 46 Publications Verification Levarterenol tartrate; L-Noradrenaline tartrate	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α₁, α₂, β₁ receptors .

HY-A0066AR

Tolazoline hydrochloride (Standard) Imidaline hydrochloride (Standard); NSC35110 hydrochloride (Standard)	Alkaloids Other Alkaloids Source classification Alpinia officinarum Hance Plants Zingiberaceae	Reference Standards Adrenergic Receptor
Tolazoline (hydrochloride) (Standard) is the analytical standard of Tolazoline hydrochloride (HY-A0066A). This product is intended for research and analytical applications. Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-13715AR

Norepinephrine hydrochloride (Standard) Levarterenol hydrochloride (Standard); L-Noradrenaline hydrochloride (Standard)	Alkaloids Mimosa pudica Linn. Leguminosae Other Alkaloids Source classification Phenols Polyphenols Plants	Reference Standards Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (hydrochloride) (Standard) is the analytical standard of Norepinephrine (hydrochloride). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors[1][2][3][4].

HY-13715R

Norepinephrine (Standard) Levarterenol (Standard); L-Noradrenaline (Standard)	Structural Classification Phenols Polyphenols Endogenous metabolite	Reference Standards Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Standard) is the analytical standard of Norepinephrine. This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715BR

Norepinephrine bitartrate monohydrate (Standard) Levarterenol bitartrate monohydrate (Standard); L-Noradrenaline bitartrate monohydrate (Standard)	Structural Classification Source classification Phenols Endogenous metabolite	Reference Standards Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (bitartrate monohydrate) (Standard) is the analytical standard of Norepinephrine (bitartrate monohydrate). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors .

HY-A0019

Paliperidone 3 Publications Verification 9-Hydroxyrisperidone	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-101392A

Harmane hydrochloride	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Rauwolfia canescens	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-A0019R

Paliperidone (Standard) 9-Hydroxyrisperidone (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Reference Standards Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

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HY-P702203

	ADRA2A-VLPs Protein, Human (HEK293, His) alpha-2A adrenergic receptor; alpha-2 adrenergic receptor subtype C10; alpha-2A adrenoreceptor; alpha-2A adrenoceptor; alpha-2AAR	Human	HEK293
	ADRA2A-VLPs Protein, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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Cat. No.	Product Name	Chemical Structure

HY-B0194S

Tizanidine-d4
Tizanidine-d₄ is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons .

HY-12715S

Yohimbine-13C,d3
Yohimbine- ¹³C,d₃ is the ¹³C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.

HY-B2169S2

Melperone-d4 hydrochloride

Melperone-d₄ hydrochloride is the deuterium labeled Melperone hydrochloride (HY-103109) . Melperone hydrochloride is a butyrophenone with atypical antipsychotic properties. Melperone hydrochloride is a multireceptor antagonist with K_ds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone hydrochloride has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with K_d values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone hydrochloride can be used for the study of schizophrenia, and agitation in the elderly .

HY-15394S1

(Rac)-Rotigotine-d3 hydrochloride

(Rac)-Rotigotine-d₃ hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-12717AS

Phentolamine-d4 hydrochloride

Phentolamine-d₄ (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction .

HY-17034BS

Medetomidine-d3 hydrochloride
Medetomidine-d₃ (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor .

HY-B0659S

Brimonidine-d4
Brimonidine-d₄ is the deuterium labeled Brimonidine. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0225AS

Methyldopa-d3 hydrochloride
Methyldopa-d₃ (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-13715S

(Rac)-Norepinephrine-d3 formate
(Rac)-Norepinephrine-d₃ (formate) is deuterium labeled Norepinephrine. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors .

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine .

HY-A0019S

Paliperidone-d4
Paliperidone-d₄ is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride

(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W748758

(Z)-Thiothixene-d8

(Z)-Thiothixene-d₈ (NSC 108165-d₈; Navan-d₈; Navane-d₈) is the deuterium labeled Thiothixene (HY-A0139). Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.

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