Eticlopride  (Synonyms: FLB-131)

Eticlopride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with K_is of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride is an antipsychotic agent^[1].

Eticlopride (1 μM, 6 h) abrogates the action of DA, where DA increases KLF2 expression in HUVEC cells^[2].
Eticlopride (1 μM, 15 min) abolishes heterodimerization of D2R/SSTR2 in rat striatal neurons^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eticlopride (10 mg/kg, i.p.) blocks normal vessel morphologyc restored by DA in orthotopic PC3 and HT29 tumor-bearing animals^[2].
Eticlopride (0.01 or 0.02 mg/kg, i.p.) alleviates cognitive deficits produced by Quinpirole (HY-B1752) in rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

340.85

C₁₇H₂₅ClN₂O₃

84226-12-0

O=C(C1=C(C(CC)=CC(Cl)=C1OC)O)NC[C@H]2N(CCC2)CC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. CHRONIC ETICLOPRIDE AND DOPAMINE DENERVATION INDUCE EQUAL NONADDITIVE INCREASES IN STRIATAL D, RECEPTOR DENSITY: AUTORADIOGRAPHIC EVIDENCE AGAINST THE DUAL MECHANISM HYPOTHESI

  [2]. Chakroborty D, et al. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20730-5.   [Content Brief]

  [3]. Baragli A, et al. Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 Co-immunoprecipitation and fluorescence resonance energy transfer analysis. Cell Signal. 2007 Nov;19(11):2304-16.  [Content Brief]

  [4]. Brown RW, et al. The effects of eticlopride on Morris water task performance in male and female rats neonatally treated with quinpirole. Psychopharmacology (Berl). 2005 Jul;180(2):234-40.  [Content Brief]