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Results for "

aglycone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (1) Antibiotic (1) Apoptosis (6) Bacterial (3) Bcl-2 Family (1) Beta-lactamase (1) Caspase (1) COX (3) Cytochrome P450 (1) Drug Derivative (2) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (7) ERK (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) HSV (2) iGluR (2) Insecticide (1) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (1) Lactate Dehydrogenase (1) Na+/K+ ATPase (1) NF-κB (1) NO Synthase (2) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (2) p38 MAPK (3) Parasite (2) Reactive Oxygen Species (ROS) (1) Reference Standards (7) SOD (1) STAT (1) α-synuclein (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Endocrinology (1) Infection (7) Inflammation/Immunology (8) Metabolic Disease (5) Neurological Disease (5)

By Targets:

Adrenergic Receptor (1)

Akt (1)

Antibiotic (1)

Apoptosis (6)

Bacterial (3)

Bcl-2 Family (1)

Beta-lactamase (1)

Caspase (1)

COX (3)

Cytochrome P450 (1)

Drug Derivative (2)

Drug Intermediate (1)

Drug Isomer (1)

Drug Metabolite (1)

Endogenous Metabolite (7)

ERK (1)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (1)

HSV (2)

iGluR (2)

Insecticide (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

JNK (1)

Lactate Dehydrogenase (1)

Na+/K+ ATPase (1)

NF-κB (1)

NO Synthase (2)

Nuclear Factor of activated T Cells (NFAT) (1)

Nucleoside Antimetabolite/Analog (2)

p38 MAPK (3)

Parasite (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (7)

SOD (1)

STAT (1)

α-synuclein (1)

By Research Areas:

Cancer (13)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (7)

Inflammation/Immunology (8)

Metabolic Disease (5)

Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13250B

*Silvestrol aglycone* (enantiomer)**	Drug Isomer	Cancer
Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol .

HY-135115

Oleuropein Aglycone 3,4-DHPEA-EA	α-synuclein HDAC Adrenergic Receptor	Inflammation/Immunology
Oleuropein Aglycone (3,4-DHPEA-EA) is a polyphenol and the aglycone form of oleuropein (HY-N0292), formed by enzymatic, acidic or acetylated hydrolysis of oleuropein. Dietary intake of oleuropein Aglycone (50 mg/kg diet) increases the number of neuronal autophagic vesicles, reverses cognitive deficits in the TgCRND8 transgenic mouse model of Alzheimer's disease, and reduces the levels of histone deacetylase 2 (HDAC2) in the cortex and hippocampus. Oleuropein Aglycone increases urinary norepinephrine, interscapular brown adipose tissue epinephrine, and UCP1 protein levels, and reduced plasma leptin levels and total abdominal adipose tissue weight in a rat model of high-fat diet-induced obesity. Oleuropein Aglycone also reduced lung neutrophil infiltration, lipid peroxidation, and IL-1β levels in a mouse model of carrageenan-induced pleurisy.

HY-137970

Spinosyn D aglycone A-83543D aglycone	Parasite	Infection
Spinosyn D aglycone is an aglycone form of the insecticide Spinosyn D (HY-125326). Unlike spinosyn D, spinosyn D aglycone is not lethal to H. virescens (tobacco budworm) neonate larvae (LC50=>64 ppm).

HY-125550

Doramectin aglycone	Drug Derivative	Others
Doramectin aglycone is an active compound.

HY-156133

Dihydrospinosyn A aglycone	Others	Others
Dihydrospinosyn A aglycone (compound 2) is a derivative of spinosyn A aglycone with a hydrolyzed C9- and C17-glycosidic bond.

HY-N11996

Aloenin aglycone	NO Synthase NF-κB	Others
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC₅₀: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .

HY-155252

Spinosyn A aglycone (-)-Spinosyn A aglycon	Insecticide	Others
Spinosyn A aglycone ((-)-Spinosyn A aglycon) is an aglycone form of the insecticide Spinosyn A (HY-B0767). Spinosyn A aglycone is an acid degradation product produced by hydrolysis of both saccharide groups on spinosyn A .

HY-N10257

Burnettramic acid A aglycone	Endogenous Metabolite	Others
Burnettramic acid A aglycone is a fungal metabolite found in Aspergillus burnettii .

HY-N8308

Momordicoside I aglycone	Others	Others
Momordicoside I aglycone is a Triterpenoids product that can be isolated from the herbs of Mormodica charantia L. .

HY-N12923

IB-96212 aglycone	Others	Others
IB-96212 aglycone (Compound 2) is the hydrolyzate of IB-96212 (HY-161239A) .

HY-13250

Silvestrol aglycone	Drug Derivative	Cancer
Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC₅₀s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity .

HY-106048R

*Bredinin aglycone* (Standard)** 5-Hydroxy-1H-imidazole-4-carboxamide (Standard); FF-10501 (Standard)	Reference Standards Nucleoside Antimetabolite/Analog	Others
Bredinin aglycone (Standard) is the analytical standard of Bredinin aglycone. This product is intended for research and analytical applications. Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues[1].

HY-106048

Bredinin aglycone 5-Hydroxy-1H-imidazole-4-carboxamide; FF-10501	Nucleoside Antimetabolite/Analog	Others
Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues .

HY-N1375

Qingyangshengenin	Others	Cancer
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-121309S1

Doxorubicinone-13C,d3 Adriamycin aglycone-¹³C,d₃; Adriamycinone-¹³C,d₃	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
Doxorubicinone- ¹³C,d₃ (Adriamycin aglycone- ¹³C,d₃) is ¹³C labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-121309

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	Endogenous Metabolite	Cancer
Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-121416

Jurubidine	Others	Others
Jurubidine is a novel and potent cyclised aglycone .

HY-141441

Novobiocic acid	Bacterial	Infection
Novobiocic acid is an aglycone form of the antibiotic Novobiocin (HY-B0425).

HY-N7954

Neopanaxadiol	Others	Neurological Disease
Neopanaxadiol, an aglycone of protopanaxadiol type ginsenosides, has the potential for Alzheimer's disease research .

HY-N0798

20(R)-Protopanaxatriol 1 Publications Verification 20(R)-APPT	Others	Others
20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

HY-N12749

16-Anhydro Digitalin	Others	Cardiovascular Disease
16-Anhydro Digitalin (compound 11) is a cardiac glycoside with a 16-dehydroisosyringyl aglycone structure .

HY-121309R

Doxorubicinone (Standard) Adriamycin aglycone (Standard); Adriamycinone (Standard)	Reference Standards Endogenous Metabolite	Cancer
Doxorubicinone (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-N3932

Garjasmin	Others	Others
Garjasmin (compound 1) is a kind of iridoid aglycone. Garjasmin can be isolated from the flowers of Gardenia jasminoides Ellis .

HY-N3434

Kaempferol 3,7,4'-trimethyl ether	Others	Others
Kaempferol 3,7,4'-trimethyl ether is a flavonol aglycone isolated from the leaves of Siparuna gigantotepala, has antioxidant activity .

HY-N6073

Soyasapogenol A	Apoptosis HSV	Infection Metabolic Disease Inflammation/Immunology Cancer
Soyasapogenol A is a triterpenoid aglycone of soyasaponins. Soyasapogenol A has activities such as anti-inflammation, anti-cancer, hepatoprotection and anti-HSV-1. Soyasapogenol A can be used in the research of tumors and immune inflammatory diseases .

HY-N1098

Velutin	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway .

HY-N13220

Soybean Extract	Others	Endocrinology
Soybean Extract is a soybean extract, and its components include: Isoflavone. Soybean Extract has an increased content of isoflavone aglycones after biotransformation, which is an estrogen-like bioactive compound with effective type I collagen enhancement. .

HY-N0798R

20(R)-Protopanaxatriol (Standard) 20(R)-APPT (Standard)	Reference Standards Others	Others
20(R)-Protopanaxatriol (Standard) is the analytical standard of 20(R)-Protopanaxatriol. This product is intended for research and analytical applications. 20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

HY-137968

Avermectin B1a aglycon	Parasite	Infection
Avermectin B1a aglycon is an aglycone derivative of Avermectin B1a (HY-15308), an antiparasitic agent that paralyzes nematodes. Avermectin B1a aglycon hyperpolarizes P. crassipes muscle fibers, with a minimum effective concentration of 0.1 μM .

HY-N7497

Protoescigenin	Others	Others
Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .

HY-135738

Convicine	Drug Intermediate	Others
Convicine is a pyrimidine glycoside. Convicine, as well as Vicine, is the precursor of the aglycones Divicine and Isouramil. Convicine is the main factors of favism, which is a genetic condition leading to severe hemolysis after faba bean ingestion. Convicine can be isolated from the faba bean .

HY-N11975

Glycyrrhizin-6′,6′′-dimethylester	Others	Others
Glycyrrhizin-6′,6′′-dimethylester (compound 23) is a licorice saponin isolated from licorice root. Glycyrrhizin-6′,6′′-dimethylester can participate as an aglycone in the generation of methyl glucuronate, producing similar threshold sweetness, licorice, and bitterness .

HY-121309S

Doxorubicinone-d3 Adriamycin aglycone-d₃; Adriamycinone-d₃	Endogenous Metabolite	Cancer
Doxorubicinone-d₃ is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human?DNA topoisomerase I?and?topoisomerase II?inhibitor with?IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-N6833R

Rebaudioside M (Standard)	Reference Standards Others	Others
Rebaudioside M (Standard) is the analytical standard of Rebaudioside M. This product is intended for research and analytical applications. Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M is more than 350 times sweeter than sucrose .

HY-W008226

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone	Cytochrome P450 Bacterial Antibiotic	Infection Metabolic Disease
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

HY-N6073R

Soyasapogenol A (Standard)	Reference Standards Apoptosis HSV	Infection Metabolic Disease Inflammation/Immunology Cancer
Soyasapogenol A (Standard) is the analytical standard of Soyasapogenol A (HY-N6073). This product is intended for research and analytical applications. Soyasapogenol A is a triterpenoid aglycone of soyasaponins. Soyasapogenol A has activities such as anti-inflammation, anti-cancer, hepatoprotection and anti-HSV-1. Soyasapogenol A can be used in the research of tumors and immune inflammatory diseases .

HY-N11976

Glycyrrhizin-6′′-methylester	Others	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

HY-N7497R

Protoescigenin (Standard)	Reference Standards Others	Others
Protoescigenin (Standard) is the analytical standard of Protoescigenin. This product is intended for research and analytical applications. Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .

HY-N2093

Vicine 2 Publications Verification	Drug Metabolite	Cardiovascular Disease Metabolic Disease
Vicine, an alkaloid glycoside found mainly in fava beans, is toxic in individuals who have a hereditary loss of the enzyme glucose-6-phosphate dehydrogenase and may cause haemolytic anaemia.Vicine is an inactive compound that is hydrolysed by the intestinal microflora to a highly reactive free radical generating compound, the aglycone divicine when Vicine enters the body through food .

HY-N6833

Rebaudioside M	Others	Metabolic Disease Inflammation/Immunology Cancer
Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage .

HY-N15596

Cotylenol (-)-Cotylenol	Endogenous Metabolite	Others
Cotylenol is a fungal metabolite with oxygen functions. Cotylenol can be isolated from the culture filtrate of fungal strain, 501-7 w. Cotylenol has optically activity and leaf growth activity. Cotylenol induces the lysozyme activity at concentrations above 50 μg/mL. Cotylenol is a diterpene containing one methoxyl group and three hydroxyl groups, and can be used for synthesis of Cotylenin A (HY-169843) as an aglycone part .

HY-121125

Aucubigenin	Others	Others
Aucubigenin, the aglycone of the iridoid glycoside aucubin, has been characterized through X-ray diffraction analysis. Its crystal structure reveals monoclinic symmetry with specific conformations adopted by its cyclopentane and pyran rings. The study also determined the absolute configurations of both aucubin and aucubigenin. Significant O-H O hydrogen bonding interactions were observed in the crystal lattices of both compounds, highlighting their structural stability and potential for intermolecular interactions .

HY-N2072

Crocetin 1 Publications Verification Transcrocetin; trans-Crocetin	iGluR Apoptosis COX p38 MAPK	Neurological Disease Inflammation/Immunology Cancer
Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia .

HY-E70130

Snailase, Snail gastrointestinal	Others	Others
Snailase, Snail gastrointestinal is an enzyme mixture composed of more than 20 enzymes, which is often used for enzymatic hydrolysis of purified flavonoid glycosides. Snailase can be obtained from the digestive tract and includes cellulase, sucrase, hemicellulase, pectinase, polygalacturonase, protease, etc .

HY-N2072R

Crocetin (Standard) Transcrocetin (Standard); trans-Crocetin (Standard)	iGluR Reference Standards Apoptosis COX p38 MAPK	Neurological Disease Inflammation/Immunology Cancer
Crocetin (Standard) (TransCrocetin (Standard) ) is an aglycone of crocin. Crocetin (Standard) is orally active and brain-penetrant. Crocetin (Standard) shows strong NMDA receptor affinity and channel opening activity. Crocetin (Standard) can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin (Standard) can inhibit apoptosis and activation of MAPK. Crocetin (Standard) can delay delays brain and body aging. Crocetin (Standard) can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia .

HY-N2736

3′,4′,7-Trihydroxyflavone	Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family	Infection Neurological Disease Inflammation/Immunology
3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC₅₀ = 1.89 μM) and COX-1 (IC₅₀ = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H₂O₂-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice .

HY-129236

Hellebrin	Na+/K+ ATPase Apoptosis	Cancer
Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways .

HY-N0467

Rebaudioside C Dulcoside B	Endogenous Metabolite	Neurological Disease
Rebaudioside C (Dulcoside B) is an orally effective natural sweetener that cannot pass the blood-brain barrier and selectively binds to human sweet taste receptors (TAS1R2/TAS1R3). The sweetness of Rebaudioside C is about 20-30 times that of sucrose, and its sweetness activity depends on the C-16/C-17 double bond structure and specific aglycones. The glycoside structure in the Rebaudioside C molecule can bind to the sweet taste receptor, activate the taste signal transduction pathway, and produce sweetness perception .

Cat. No.	Product Name	Category	Target	Chemical Structure