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acute liver injury model

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Apoptosis (2) Bacterial (1) c-Myc (1) COX (1) CXCR (1) Cyclic GMP-AMP Synthase (1) Drug Derivative (1) Endogenous Metabolite (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (4) FXR (1) G Protein-coupled Receptor Kinase (GRK) (1) Galectin (1) Glutathione Peroxidase (1) GSK-3 (2) Heme Oxygenase (HO) (1) Histone Acetyltransferase (1) Interleukin Related (4) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) LDLR (1) NF-κB (3) NO Synthase (1) p38 MAPK (1) Parasite (1) Phospholipase (1) PROTACs (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) RIP kinase (1) SOD (1) STAT (1) Stearoyl-CoA Desaturase (SCD) (1) Survivin (1) TNF Receptor (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (13) Metabolic Disease (1)

By Targets:

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (2)

Bacterial (1)

c-Myc (1)

COX (1)

CXCR (1)

Cyclic GMP-AMP Synthase (1)

Drug Derivative (1)

Endogenous Metabolite (1)

Fatty Acid Synthase (FASN) (1)

Ferroptosis (4)

FXR (1)

G Protein-coupled Receptor Kinase (GRK) (1)

Galectin (1)

Glutathione Peroxidase (1)

GSK-3 (2)

Heme Oxygenase (HO) (1)

Histone Acetyltransferase (1)

Interleukin Related (4)

Keap1-Nrf2 (1)

Lactate Dehydrogenase (1)

LDLR (1)

NF-κB (3)

NO Synthase (1)

p38 MAPK (1)

Parasite (1)

Phospholipase (1)

PROTACs (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

RIP kinase (1)

SOD (1)

STAT (1)

Stearoyl-CoA Desaturase (SCD) (1)

Survivin (1)

TNF Receptor (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (1)

Inflammation/Immunology (13)

Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Targets Recommended: LXR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-42682

D(+)-Galactosamine hydrochloride 2 Publications Verification D-Galactosamine HCl	Drug Derivative	Inflammation/Immunology
D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure .

HY-42682R

D(+)-Galactosamine hydrochloride (Standard) D-Galactosamine HCl (Standard)	Reference Standards	Inflammation/Immunology
D(+)-Galactosamine (hydrochloride) (Standard) is the analytical standard of D(+)-Galactosamine (hydrochloride). This product is intended for research and analytical applications. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure .

HY-66005

Acetaminophen Maximum Cited Publications 63 Publications Verification Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite Ferroptosis	Inflammation/Immunology Cancer
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .

HY-170362

cGAS-IN-4	Cyclic GMP-AMP Synthase	Inflammation/Immunology
cGAS-IN-4 (Compound 36) is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) with IC₅₀ of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC₅₀ of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A (HY-P2149)-induced acute liver injury in mouse models . orally active, THP-1, C57Bl/6 mouse, orally active

HY-121983

CAY10594 1 Publications Verification	Phospholipase Apoptosis GSK-3 Anaplastic lymphoma kinase (ALK) STAT Interleukin Related G Protein-coupled Receptor Kinase (GRK) CXCR Lactate Dehydrogenase	Inflammation/Immunology Cancer
CAY10594 is an orally active PLD2 inhibitor with an IC₅₀ of 140 nM. CAY10594 has activities such as anti-tumor, anti-oxidation and liver protection. CAY10594 can be used for the research of diseases like breast cancer, acute liver injury and colitis .

HY-N3181

Nodosin	Apoptosis Wnt β-catenin c-Myc Survivin GSK-3 Ferroptosis Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Interleukin Related	Inflammation/Immunology Cancer
Nodosin is an orally active diterpenoid compound that can be isolated from Isodon serra. Nodosin can inhibit the proliferation and induce cell cycle arrest and apoptosis of tumor cells. Nodosin can also inhibit oxidative stress, inflammatory responses, and ferroptosis. Nodosin has anti-inflammatory and anti-tumor activities .

HY-168327

LH10	FXR	Inflammation/Immunology
LH10 is a fexaramine-based agonist for FXR with an EC₅₀ of 0.14 μM. LH10 exhibits liver protection efficacy, ameliorates the alpha naphthylisothiocyanate (ANIT)-induced cholestasis, APAP (HY-66005)-induced acute liver injury and non-alcoholic steatohepatitis (NASH) in mouse models .

HY-169927

Ferroptosis-IN-16	Ferroptosis	Inflammation/Immunology
Ferroptosis-IN-16 (Compound 13l) is a specific inhibitor for ferroptosis with an EC₅₀ of 0.7 nM and 0.9 nM in ES-2 cell and LX-2 cell. Ferroptosis-IN-16 ameliorates Acetaminophen (HY-66005)-induced acute liver injury in mouse model, and exhibits good metabolic stability in mouse liver microsomes .

HY-176274

FASN/SCD-IN-1	Fatty Acid Synthase (FASN) Stearoyl-CoA Desaturase (SCD) Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor SOD LDLR Glutathione Peroxidase	Metabolic Disease Inflammation/Immunology
FASN/SCD-IN-1 is a Silybin (HY-N0779A) derivative, an orally active inhibitor of Fatty Acid Synthase (FASN)/Stearoyl-CoA Desaturase (SCD). FASN/SCD-IN-1 has shown in vitro activity in inhibiting lipid deposition, reducing FASN and SCD transcriptional levels, and exhibiting antioxidant, anti-inflammatory, and anti-fibrotic activities. FASN/SCD-IN-1 has demonstrated significant hepatoprotective effects in a rat model of acute liver injury. FASN/SCD-IN-1 ameliorates the pathological features of MASH liver, including steatosis, inflammation, and fibrosis in a mouse model of myeloproliferative steatohepatitis (MASH). FASN/SCD-IN-1 can be used to study MASH .

HY-N12087

8-Deoxylactucin	NF-κB NO Synthase Reactive Oxygen Species (ROS)	Inflammation/Immunology
8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages with an IC₅₀ value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries .

HY-163897

PROTAC NCOA4 degrader-1	PROTACs Ferroptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology
PROTAC NCOA4 degrader-1 is a VHL-based PROTAC NCOA4 degrader. PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces Fe ²⁺ elevation, ROS production, MDA content and PTGS2 mRNA expression. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl₄-induced acute liver injury model. PROTAC NCOA4 degrader-1 can be used for the researches of inflammation and immunology. (Pink: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B)) .

HY-173235

Galectin-3-IN-6	Galectin	Cardiovascular Disease Inflammation/Immunology Cancer
Galectin-3-IN-6 (Compound 12) is an orally active inhibitor of galectin-3 (Gal-3), with an IC₅₀ value of 12 nM and a K_d value of 13 nM for Gal-3. In a mouse model of acute liver injury and fibrosis induced by CCl4, Galectin-3-IN-6 can significantly reduce the levels of fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, showing significant anti-fibrotic activity. Galectin-3-IN-6 can be used in the research of fibrotic diseases, cancer, and cardiovascular diseases .

HY-175026

RIPK2-IN-8	RIP kinase NF-κB p38 MAPK Interleukin Related	Inflammation/Immunology
RIPK2-IN-8 is an orally active and highly selective RIPK2 inhibitor (IC₅₀ = 11 nM). RIPK2-IN-8 is highly selective for RIPK2 over RIPK1 (IC₅₀ > 30,000 nM) and has a moderate inhibitory effect on RIPK3 (IC₅₀ = 44.61 nM). RIPK2-IN-8 inhibits the NOD2-RIPK2 signaling pathway and the expression of the inflammatory cytokines IL-6 and TNFα, thereby exerting anti-inflammatory effects. RIPK2-IN-8 has demonstrated anti-inflammatory and hepatoprotective effects in an acute liver injury (ALI) model and can be used in ALI research .

D(+)-Galactosamine hydrochloride 2 Publications Verification D-Galactosamine HCl	Microorganisms Source classification Vitis vinifera cv. Zalema Plants Vitaceae Inflammation/Immunology Disease Research Fields Saccharides	Drug Derivative
D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure .

D(+)-Galactosamine hydrochloride (Standard) D-Galactosamine HCl (Standard)	Microorganisms Source classification Vitis vinifera cv. Zalema Plants Vitaceae Saccharides	Reference Standards
D(+)-Galactosamine (hydrochloride) (Standard) is the analytical standard of D(+)-Galactosamine (hydrochloride). This product is intended for research and analytical applications. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure .

Acetaminophen 60+ Cited Publications Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite Ferroptosis
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .

Nodosin	other families Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Plants Disease Research Fields	Apoptosis Wnt β-catenin c-Myc Survivin GSK-3 Ferroptosis Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Interleukin Related
Nodosin is an orally active diterpenoid compound that can be isolated from Isodon serra. Nodosin can inhibit the proliferation and induce cell cycle arrest and apoptosis of tumor cells. Nodosin can also inhibit oxidative stress, inflammatory responses, and ferroptosis. Nodosin has anti-inflammatory and anti-tumor activities .

8-Deoxylactucin	Picria felterrae Lour. Terpenoids Sesquiterpenes Source classification Scrophulariaceae Plants	NF-κB NO Synthase Reactive Oxygen Species (ROS)
8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages with an IC₅₀ value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries .

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acute liver injury model

Inhibitors & Agonists

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