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Results for "

Zn2

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

10

Fluorescent Dye

4

Biochemical Assay Reagents

1

Peptides

2

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0156
    ZnAF-1

    		Fluorescent Dye Others
    ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection . ZnAF-1 can bind Zn(II) with a 1 : 1 stoichiometry .
    ZnAF-1
  • HY-108699
    TM-N1324

    		GHSR Neurological Disease Endocrinology
    TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn 2+, and 280 nM/180 nM in the absence of Zn 2+ for human/murine GPR39.
    TM-N1324
  • HY-129200
    Aspergillomarasmine A

    		Endogenous Metabolite Others
    Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .
    Aspergillomarasmine A
  • HY-137159
    Bestatin methyl ester

    		Aminopeptidase Cancer
    Bestatin methyl ester is a cell permeable Zn2+-binding aminopeptidases inhibitor. Bestatin methyl ester inhibits spore cell differentiation .
    Bestatin methyl ester
  • HY-D0157
    ZnAF-2

    		Biochemical Assay Reagents Others
    ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .
    ZnAF-2
  • HY-10528R
    Tasquinimod (Standard)

    ABR-215050 (Standard)

    		 HDAC Cancer
    Tasquinimod (Standard) is the analytical standard of Tasquinimod. This product is intended for research and analytical applications. Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor[1][2][3].
    Tasquinimod (Standard)
  • HY-B0600R
    Tafluprost (Standard)

    		Prostaglandin Receptor Cardiovascular Disease Others
    Tafluprost (Standard) is the analytical standard of Tafluprost. This product is intended for research and analytical applications. Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma [2] [4] .
    Tafluprost (Standard)
  • HY-D0158
    ZnAF-2 DA

    		Biochemical Assay Reagents Others
    ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).
    ZnAF-2 DA
  • HY-D1894
    5-Br-PAPS

    		Fluorescent Dye Others
    5-Br-PAPS is a highly specific Zn 2+ metallochromic indicator. 5-Br-PAPS is used in assays for measuring free Zn 2+ by forming a deeply colored red Zn 2+ complex .
    5-Br-PAPS
  • HY-D1264
    PMQA

    Zn-green

    		 Fluorescent Dye Others
    PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn 2+-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn 2+ in living cells .
    PMQA
  • HY-W002356
    2-Pyridinecarbothioamide

    		Drug Intermediate Others
    2-Pyridinecarbothioamide is a building block, that can be used for synthesis of Zn 2+ responsive fluorescent probe .
    2-Pyridinecarbothioamide
  • HY-D0982
    Zinquin

    		Fluorescent Dye Others
    Zinquin is a fluorescent sensor and used to observe reactive Zn 2+.λex/λem=368/490 nm.
    Zinquin
  • HY-171029
    C902

    		Amino Acid Derivatives Others
    C902 is a cysteine residue in the RAG1 protein, that binds to Zn 2+ ion and contributes to the DNA cleavage .
    C902
  • HY-D1441
    Zinquin AM ester

    		Fluorescent Dye Others
    Zinquin AM ester is an AM ester form of Zinquin. Zinquin, a fluorescent dye, is a commonly used sensor for cellular Zn 2+ status .
    Zinquin AM ester
  • HY-162158
    DA ZP1

    		Fluorescent Dye Others
    DA ZP1 is a fluorogenic Zn(II) sensor (Kd Zn 2+ = 0.6 nM) . Ex / Em = 490 / 522 nm
    DA ZP1
  • HY-E70199
    Aminopeptidase N (rat)

    APN/CD13

    		 Others Others
    A Aminopeptidase N (rat) (APN/CD13) is a Zn 2+ dependent membrane-bound ectopeptidase that degrades preferentially proteins and peptides with a N-terminal neutral amino acid .
    Aminopeptidase N (rat)
  • HY-119287
    TSQ

    		Fluorescent Dye Others
    TSQ is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λmax ~470 nm). TSQ can combine with Zn 2+ in the presence of Ca 2+ and Mg 2+ to produce blue fluorescence .
    TSQ
  • HY-B1159S
    Nitroxoline-d4

    8-Hydroxy-5-nitroquinoline-d4; 5-Nitro-8-quinolinol-d4

    		 Bacterial Autophagy Antibiotic Infection Cancer
    Nitroxoline-d4 is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe 2+ and Zn 2+ ions from the biofilm matrix[1][2].
    Nitroxoline-d4
  • HY-146669
    BChE-IN-6

    		Cholinesterase (ChE) Neurological Disease
    BChE-IN-6 (compound 12) is a potent BChE inhibitor, with a Ki of 0.182 μM. BChE-IN-6 shows chelating capacity on Zn 2+. BChE-IN-6 can be used for Alzheimer’s disease (AD) research .
    BChE-IN-6
  • HY-124171
    Zinquin ethyl ester
    1 Publications Verification

    		 Fluorescent Dye Others
    Zinquin ethyl ester is a fluorescent derivative of Zinquin and is a fluorescent probe of cytosolic zinc ion. Zinquin ethyl ester is able to penetrate cell membranes and is lipophilic and zinc-sensitive. Zinquin ethyl ester can combine with Zn 2+ in the cell to produce blue fluorescence .
    Zinquin ethyl ester
  • HY-P1285
    Conantokin R

    Con-R

    		 iGluR Neurological Disease
    Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn 2+ and Mg 2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity [2].
    Conantokin R
  • HY-16074
    ATN-224
    4 Publications Verification

    Bis(choline)tetrathiomolybdate

    		 SOD Cancer
    ATN-224 is an orally active Cu 2+/Zn 2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5 nM.
    ATN-224
  • HY-10528
    Tasquinimod
    5+ Cited Publications

    ABR-215050

    		 HDAC Cancer
    Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn 2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor [2] .
    Tasquinimod
  • HY-D0159
    ZnAF-1F

    		Fluorescent Dye Others
    ZnAF-1F is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn 2+ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm [2] .
    ZnAF-1F
  • HY-100202
    TPEN
    Maximum Cited Publications
    15 Publications Verification

    TPEDA

    		 Reactive Oxygen Species Apoptosis Autophagy Cancer
    TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn 2+, but a lower affinity for Mg 2+ and Ca 2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis [2] .
    TPEN
  • HY-170697
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-Hydroxyethyl)-docosapentaenamide

    		Drug Metabolite Neurological Disease
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-6 fatty acid with a hydroxyethylamide group attached at the alpha chain.
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-Hydroxyethyl)-docosapentaenamide
  • HY-D0159A
    ZnAF-1F tetraTFA

    		Fluorescent Dye Others
    ZnAF-1F tetraTFA is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F tetraTFA can be used as fluorescent probes for Zn 2+ in cells. ZnAF-1F tetraTFA shows λ excitation of 489 nm and λ emission of 514 nm [2] .
    ZnAF-1F tetraTFA
  • HY-N15079
    Arphamenine B

    		Bacterial Infection
    Arphamenine B is a Zn 2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B enhances the immune response and is used to characterize novel proteases [2] .
    Arphamenine B
  • HY-136887
    Arphamenine B hemisulfate

    		Bacterial Infection
    Arphamenine B hemisulfate is a Zn 2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B hemisulfate is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B hemisulfate enhances the immune response and is used to characterize novel proteases [2] .
    Arphamenine B hemisulfate
  • HY-B0600
    Tafluprost

    AFP-168; MK2452

    		 Prostaglandin Receptor Cardiovascular Disease Others
    Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn 2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma [2] .
    Tafluprost
  • HY-10528S
    Tasquinimod-d3

    ABR-215050-d3

    		 HDAC Isotope-Labeled Compounds Cancer
    Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn 2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor [2] .
    Tasquinimod-d3
  • HY-W011060
    Cryptand 2.2.2

    4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane

    		 Biochemical Assay Reagents Others
    Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .
    Cryptand 2.2.2
  • HY-101200
    Linsidomine hydrochloride

    SIN-1 chloride

    		 Apoptosis Autophagy Reactive Oxygen Species Annexin A NF-κB Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Linsidomine hydrochloride (SIN-1 chloride) is a spontaneous ROS/RNS generator and peroxynitrite donor. Linsidomine hydrochloride is a vasodilator and platelet aggregation inhibitor. Linsidomine hydrochloride induces oxidative stress-induced chondrocyte apoptosis and necrosis. Linsidomine hydrochloride inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of Linsidomine hydrochloride shows protective effects on Zn 2+ treated nerve cells [2] .
    Linsidomine hydrochloride
  • HY-158779
    Sulfane sulfur probe 4

    SSP4

    		 Fluorescent Dye Others
    Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (Ex/Em=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe 2+, Fe 3+, Mg 2+, Ca 2+, and Zn 2+) .
    Sulfane sulfur probe 4
  • HY-136894
    Rhod-5N

    		Fluorescent Dye Others
    Rhod-5N is a calcium-binding fluorescent dye composed of a BAPTA chelating group and a rhodamine fluorophore. Rhod-5N is often added to MOPS buffer to complex and indicate cation content. The selectivity of Rhod-5N for Cd 2+ is higher than other interfering cations ((Na+, K+, Mg 2+, Ca 2+, Zn 2+) except Pb 2+), and the detection limit is 3.1 μg/L [2].
    Rhod-5N
  • HY-126849
    3-Morpholinosydnonimine

    SIN-1; Linsidomine

    		 Reactive Oxygen Species Apoptosis Annexin A NF-κB Autophagy Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    3-Morpholinosydnonimine (SIN-1) is a spontaneous ROS/RNS generator and peroxynitrite donor. 3-Morpholinosydnonimine is a vasodilator and platelet aggregation inhibitor. 3-Morpholinosydnonimine induces oxidative stress-induced chondrocyte apoptosis and necrosis. 3-Morpholinosydnonimine inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of 3-Morpholinosydnonimine shows protective effects on Zn 2+ treated nerve cells [2] .
    3-Morpholinosydnonimine
  • HY-101200R
    Linsidomine hydrochloride (Standard)

    SIN-1 chloride (Standard)

    		 Apoptosis Autophagy Reactive Oxygen Species Annexin A NF-κB Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Linsidomine (hydrochloride) (Standard) is the analytical standard of Linsidomine (hydrochloride). This product is intended for research and analytical applications. Linsidomine hydrochloride (SIN-1 chloride) is a spontaneous ROS/RNS generator and peroxynitrite donor. Linsidomine hydrochloride is a vasodilator and platelet aggregation inhibitor. Linsidomine hydrochloride induces oxidative stress-induced chondrocyte apoptosis and necrosis. Linsidomine hydrochloride inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of Linsidomine hydrochloride shows protective effects on Zn 2+ treated nerve cells [2] .
    Linsidomine hydrochloride (Standard)
  • HY-W011060R
    Cryptand 2.2.2 (Standard)

    4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)

    		 Biochemical Assay Reagents Others
    Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .
    Cryptand 2.2.2 (Standard)
  • HY-126823
    Phen Green SK diacetate (5/6-mixture)
    5+ Cited Publications

    PGSK diacetate (5/6-mixture)

    		 Fluorescent Dye Others
    Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe 2+, Cd 2+, Co 2+, Ni 2+, Zn 2+, etc. Phen green SK (PGSK) diacetate chelates Fe 2+, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively [2] .
    Phen Green SK diacetate (5/6-mixture)
  • HY-162812
    H3R antagonist 4

    		Apoptosis Cholinesterase (ChE) Tau Protein Ferroptosis Histamine Receptor Neurological Disease
    H3R antagonist 4 (compound 11L) was a dual inhibitor of cholinesterase and histamine receptor (H3R), with corresponding IC50 of 7.04 μM (eeAChE), 9.73 μM (hAChE)(reversible) and 1.09 nM (H3R) , respectively. H3R antagonist 4 inhibited the aggregation of Aβ1-42 induced by itself and Cu 2+ (95.48% and 88.63%) , and degraded the Aβ1-42 fibrils induced by itself and Cu 2+ (80.16% and 89.30%) . H3R antagonist 4 chelate biometals such as Cu 2+, Zn 2+, Al 3+, and Fe 2+. H3R antagonist 4 significantly reduced tau protein hyperphosphorylation induced by Aβ1-42 and inhibited RSL-3-induced apoptosis and ferroptosis in PC12 cells. H3R antagonist 4 had the best blood-brain barrier permeability and intestinal absorption in hCMEC/D3 and hPepT1-MDCK cells.H3R antagonist 4 ameliorates learning and memory impairment in a mouse model of Alzheimer's disease induced by scopolamine (HY-N0296) .
    H3R antagonist 4

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