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Y2 receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Arrestin (1) DNA/RNA Synthesis (1) Endogenous Metabolite (3) GABA Receptor (1) GCGR (1) GLP Receptor (1) Na+/Ca2+ Exchanger (1) Neuropeptide Y Receptor (27) P2X Receptor (2) P2Y Receptor (24) Reference Standards (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (9) Endocrinology (6) Inflammation/Immunology (12) Metabolic Disease (11) Neurological Disease (19)
Oligonucleotides:	Nucleotide Analogs (2)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10148

N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) Ac-[Leu28,31]-NPY (24-36)	Neuropeptide Y Receptor	Neurological Disease
N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) is a selective agonist of neuropeptide Y Y2 receptor. N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) attenuates cardiac vagal action in anaesthetised rats .

HY-107732

JNJ-5207787	Neuropeptide Y Receptor	Neurological Disease
JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y₂ receptor (Y₂) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC₅₀s of 7.0 and 7.1 for human Y₂ receptor and rat Y₂ receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y₁, Y₄, and Y₅ receptors .

HY-14450

JNJ-31020028 1 Publications Verification	Neuropeptide Y Receptor	Neurological Disease Endocrinology
JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC₅₀ values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease .

HY-P1011

Neuropeptide Y (13-36), porcine NPY 13-36	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (13-36), porcine is a selective neuropeptide Y₂ receptor agonist .

HY-P4805

Peptide YY (13-36) (canine, mouse, porcine, rat)	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (13-36) (canine, mouse, porcine, rat) is a *Y₂ receptor* subtype agonist .**

HY-101986C

BIIE-0246 dihydrochloride AR-H 053591 dihydrochloride	Neuropeptide Y Receptor	Neurological Disease
BIIE-0246 dihydrochloride (AR-H 053591 dihydrochloride) is a potent and highly selective non-peptide neuropeptide Y (NPY) Y₂ receptor antagonist, with an IC₅₀ value of 15 nM .

HY-P2703

Peptide YY (pig)	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system .

HY-118198

NPY Y2 antagonist 1	Neuropeptide Y Receptor	Others
NPY Y2 antagonist 1 (compound 36) is a pyridine-type, selective *neuropeptide Y receptor* (NPY) Y2** antagonist .

HY-P3676

Neuropeptide Y (3-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36 .

HY-P1818

Neuropeptide Y (22-36)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y₂ receptor and retains subnanomolar affinity for the Y₂ receptor .

HY-P1480

Neuropeptide Y (13-36), amide, human Neuropeptide Y (13-36), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (13-36), amide, human is a selective neuropeptide Y₂ receptor agonist .

HY-107735

CYM 9484	Neuropeptide Y Receptor	Neurological Disease
CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC₅₀ value of 19 nM .

HY-P1021

Peptide YY (PYY) (3-36), porcine	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), porcine is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

HY-P1021A

Peptide YY (PYY) (3-36), porcine TFA 3 Publications Verification	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), porcine TFA is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite .

HY-107723

CGP71683 hydrochloride CGP71683A	Neuropeptide Y Receptor	Neurological Disease Endocrinology
CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a K_i of 1.3 nM, and shows no obvious activity at Y1 receptor (K_i, >4000 nM) and Y2 receptor (K_i, 200 nM) in cell membranes.

HY-107479

(R)-JNJ-31020028	Neuropeptide Y Receptor	Neurological Disease
(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC₅₀ values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects .

HY-107731

SF 11	Neuropeptide Y Receptor	Neurological Disease
SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC₅₀=199 nM). Antidepressant-like activity .

HY-P2543

Neuropeptide Y (3-36) (human, rat)	Neuropeptide Y Receptor	Metabolic Disease
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor .

HY-P11291

NNC0165-1273	Neuropeptide Y Receptor	Endocrinology
NNC0165-1273 is an analog of gut hormone peptide YY (PYY_3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research .

HY-P10000

Peptide YY (PYY) (3-36), Human	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion .

HY-P3677

Neuropeptide Y (2-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. Neuropeptide Y (2-36) (porcine) is also a rat neuropeptide receptor agonist, with EC₅₀ values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. Neuropeptide Y (2-36) (porcine) can be used in studies related to obesity and eating disorders .

HY-P11044

GEP12	GCGR Neuropeptide Y Receptor	Metabolic Disease
GEP12 is a *GLP-1R/Y1-R/Y2-R* tri-receptor agonist peptide with an EC₅₀ of 17.3 nM and an IC₅₀ of 19.2 nM for receptor binding. GEP12 may promote glycemic control and weight loss .

HY-P11043

GEP44	GLP Receptor Neuropeptide Y Receptor Arrestin	Metabolic Disease
GEP44 is a peptide biased triple agonist targeting *Glucagon-like peptide 1 receptor* (GLP-1R), neuropeptide Y1 Receptor (Y1-R)*, and neuropeptide Y2 Receptor* (Y2-R). GEP44 induces Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets by counteracting effects of Y1-R and GLP-1R agonism. GEP44 promotes insulin-independent Y1-R-mediated glucose uptake in muscle tissue and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 can be used for obesity and type 2 diabetes mellitus research .

HY-P1322

[D-Trp34]-Neuropeptide Y	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats .

HY-P1322A

[D-Trp34]-Neuropeptide Y TFA	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats .

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8) .

HY-137616C

Rp-dUTPαS tetrasodium	P2Y Receptor	Cancer
Rp-dUTPαS (tetrasodium) is an isomer of the sulfur-containing nucleoride dUTP-α-S and an agonist of the purinergic P2Y₂ receptor. Rp-dUTPαS (tetrasodium) selectively induces inositol phosphate accumulation in P2Y₂-expressing 1321N1 cells with an EC₅₀ of 12.5 μM .

HY-B0606

Diquafosol tetrasodium 5 Publications Verification INS365	P2Y Receptor	Inflammation/Immunology
Diquafosol tetrasodium is a *P2Y2* receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.

HY-137612

Sp-UTP-α-S Uridine 5'-O-1-thiotriphosphate	P2Y Receptor	Cancer
Sp-UTP-α-S is a *P2Y2* and P2Y4 receptor activator. Sp-UTP-α-S can be used in cancer research .

HY-137612C

Rp-UTP-α-S tetrasodium Rp-Uridine 5'-O-(1-thiotriphosphate) tetrasodium	P2Y Receptor	Cancer
Rp-UTP-α-S (tetrasodium) is a nucleotide agonist of purinergic *P2Y₂* and P2Y₄ receptors. Rp-UTP-α-S (tetrasodium) can induce inositol phosphate accumulation in P2Y₂ or P2Y₄ expressing 1321N1 cells with EC₅₀ values of 5.4 and 27 μM .

HY-132240

SF-22	Neuropeptide Y Receptor	Neurological Disease
SF-22 is a potent and brain-penetrant antagonist of neuropeptide Y receptor (Y2R), with the IC₅₀ value of 750 nM. SF-22 plays an important role in neurological disease .

HY-107372

Uridine triphosphate UTP; Uridine 5'-triphosphate	Endogenous Metabolite DNA/RNA Synthesis P2Y Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Uridine triphosphate (UTP) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors .

HY-108649A

MRS2768 tetrasodium salt	P2Y Receptor	Cardiovascular Disease
MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro .

HY-137606

Uridine adenosine tetraphosphate UP4A	P2X Receptor	Cardiovascular Disease
Uridine adenosine tetraphosphate (UP4A) is an endothelium-derived vasoconstrictor that primarily acts through the P2X1 receptor and possibly through the *P2Y2* and P2Y4 receptors. Uridine adenosine tetraphosphate can be used in the study of cardiovascular diseases .

HY-154840

4-Thiouridine 5′-triphosphate tetralithium 4-Thio-UTP tetralithium	P2Y Receptor	Inflammation/Immunology
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent *P2Y₂* and P2Y₄ receptor agonist, with EC₅₀s of 35 and 350 nM for *hP2Y₂* and hP2Y₄, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex .

HY-154840A

4-Thiouridine 5′-triphosphate tetrasodium 4-Thio-UTP tetrasodium	P2Y Receptor	Inflammation/Immunology
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium is a potent *P2Y₂* and P2Y₄ receptor agonist, with EC₅₀s of 35 and 350 nM for *hP2Y₂* and hP2Y₄, respectively. 4-Thiouridine 5′-triphosphate tetrasodium can be used in the study of crosslinking experiments, labeling of transcriptional complex .

HY-W013093

Uridine triphosphate trisodium salt 4 Publications Verification UTP trisodium salt; Uridine 5'-triphosphate trisodium salt	Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors .

HY-108651

Uridine-5'-O-(3-thiotriphosphate) trisodium UTPγS trisodium	P2Y Receptor	Metabolic Disease
Uridine-5'-O-(3-thiotriphosphate) trisodium, a stable analogue of UTP, is a potent agonist of the *P2Y2* and P2Y4 receptors with increased metabolic stability .

HY-101044

PPADS tetrasodium 5+ Cited Publications	P2X Receptor Na+/Ca2+ Exchanger	Neurological Disease
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca ²⁺ exchanger in guinea pig airway smooth muscle .

HY-13104

MRS 2578 Maximum Cited Publications 10 Publications Verification	P2Y Receptor Apoptosis	Cardiovascular Disease
MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC₅₀s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors .

HY-137603

Uridine-5'-O-3-thiotriphosphate UTPγS	P2Y Receptor	Metabolic Disease
Uridine-5'-O-(3-thiotriphosphate) (UTPγS), a stable analogue of UTP, is a potent agonist of the *P2Y2* and P2Y4 receptors with increased metabolic stability .

HY-110089

mrs 4062 TFA	P2Y Receptor	Inflammation/Immunology
mrs 4062 (TFA) is a selective P2Y₄ receptor agonist with an EC₅₀ of 23 nM. mrs 4062 (TFA) has EC₅₀s of 640 nM and 740 nM for P2Y₂ and P2Y₆, respectively .

HY-110092A

PSB-1114 triethylamine	P2Y Receptor	Cancer
PSB-1114 triethylamine is a potent, enzymatically stable, and subtype-selective *P2Y₂* receptor agonist with an EC₅₀ of 134 nM. PSB-1114 triethylamine displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors .

HY-110092

PSB-1114 tetrasodium	P2Y Receptor	Metabolic Disease
PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective **P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀** of 7.0 μM) receptors .

HY-134369

Ap4C tetrasodium	P2Y Receptor	Others Inflammation/Immunology
Ap4C tetrasodium is a dinucleoside polyphosphate containing purine and pyrimidine base moieties. Ap4C tetrasodium acts as a signaling molecule by binding to specific P2Y receptors, activating *P2Y2* and P2Y4 receptors in platelets, leading to platelet aggregation and other cellular responses. Ap4C tetrasodium can be used for research in inflammation and blood coagulation .

HY-13104R

MRS 2578 (Standard)	P2Y Receptor Apoptosis	Cardiovascular Disease
MRS 2578 (Standard) is the analytical standard of MRS 2578. This product is intended for research and analytical applications. MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors .

HY-W013093R

Uridine triphosphate trisodium salt (Standard) UTP trisodium salt (Standard); Uridine 5'-triphosphate trisodium salt (Standard)	Reference Standards Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Uridine triphosphate (trisodium salt) (Standard) is the analytical standard of Uridine triphosphate (trisodium salt). This product is intended for research and analytical applications. Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors .

HY-110322A

PPTN 2 Publications Verification	P2Y Receptor	Inflammation/Immunology
PPTN, a chemical probe, is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .

HY-110322

PPTN hydrochloride 2 Publications Verification	P2Y Receptor	Inflammation/Immunology
PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity .

HY-103055

PPTN mesylate	P2Y Receptor	Inflammation/Immunology
PPTN mesylate is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN mesylate exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .

Cat. No.	Product Name	Target	Research Area

HY-P10148

N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) Ac-[Leu28,31]-NPY (24-36)	Neuropeptide Y Receptor	Neurological Disease
N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) is a selective agonist of neuropeptide Y Y2 receptor. N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) attenuates cardiac vagal action in anaesthetised rats .

HY-P1011

Neuropeptide Y (13-36), porcine NPY 13-36	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (13-36), porcine is a selective neuropeptide Y₂ receptor agonist .

HY-P1480

Neuropeptide Y (13-36), amide, human Neuropeptide Y (13-36), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (13-36), amide, human is a selective neuropeptide Y₂ receptor agonist .

HY-P1021A

Peptide YY (PYY) (3-36), porcine TFA 3 Publications Verification	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), porcine TFA is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite .

HY-P2543

Neuropeptide Y (3-36) (human, rat)	Neuropeptide Y Receptor	Metabolic Disease
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor .

HY-P4805

Peptide YY (13-36) (canine, mouse, porcine, rat)	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (13-36) (canine, mouse, porcine, rat) is a *Y₂ receptor* subtype agonist .**

HY-P2703

Peptide YY (pig)	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system .

HY-P3676

Neuropeptide Y (3-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36 .

HY-P1818

Neuropeptide Y (22-36)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y₂ receptor and retains subnanomolar affinity for the Y₂ receptor .

HY-P1021

Peptide YY (PYY) (3-36), porcine	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), porcine is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

HY-P11291

NNC0165-1273	Neuropeptide Y Receptor	Endocrinology
NNC0165-1273 is an analog of gut hormone peptide YY (PYY_3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research .

HY-P10000

Peptide YY (PYY) (3-36), Human	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion .

HY-P3677

Neuropeptide Y (2-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. Neuropeptide Y (2-36) (porcine) is also a rat neuropeptide receptor agonist, with EC₅₀ values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. Neuropeptide Y (2-36) (porcine) can be used in studies related to obesity and eating disorders .

HY-P11044

GEP12	GCGR Neuropeptide Y Receptor	Metabolic Disease
GEP12 is a *GLP-1R/Y1-R/Y2-R* tri-receptor agonist peptide with an EC₅₀ of 17.3 nM and an IC₅₀ of 19.2 nM for receptor binding. GEP12 may promote glycemic control and weight loss .

HY-P11043

GEP44	GLP Receptor Neuropeptide Y Receptor Arrestin	Metabolic Disease
GEP44 is a peptide biased triple agonist targeting *Glucagon-like peptide 1 receptor* (GLP-1R), neuropeptide Y1 Receptor (Y1-R)*, and neuropeptide Y2 Receptor* (Y2-R). GEP44 induces Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets by counteracting effects of Y1-R and GLP-1R agonism. GEP44 promotes insulin-independent Y1-R-mediated glucose uptake in muscle tissue and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 can be used for obesity and type 2 diabetes mellitus research .

HY-P1322

[D-Trp34]-Neuropeptide Y	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats .

HY-P1322A

[D-Trp34]-Neuropeptide Y TFA	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats .

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8) .

Cat. No.	Compare	Product Name	Species	Source

HY-P702389

	NPY2R Protein, Human (Cell-Free, His) Neuropeptide Y receptor type 2; NPY-Y2 receptor; Y2 receptor	Human	E. coli Cell-free
	NPY2R, the neuropeptide Y (NPY) and peptide YY (PYY) receptors, exhibit different affinities for pancreatic peptides. Preferences in descending order include PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [ Pro -34] PYY and NPY free acids. NPY2R Protein, Human (Cell-Free, His) is the recombinant human-derived NPY2R protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

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HY-W013093

Uridine triphosphate trisodium salt 4 Publications Verification UTP trisodium salt; Uridine 5'-triphosphate trisodium salt		Nucleotide Analogs
Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors .

HY-107372

Uridine triphosphate UTP; Uridine 5'-triphosphate		Nucleotide Analogs
Uridine triphosphate (UTP) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors .

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Y2 receptor

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