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Y strain

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21

Inhibitors & Agonists

7

Fluorescent Dye

1

Natural
Products

7

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-20349
    Monobehenin

    		Bacterial Infection
    Monobehenin, an bacterial biofilm formation inhibitor, has strong inhibitory activity toward bacterial biofilm formation of S. mutans, X. oryzae, and Y. enterocolitica in a strain specific manner .
    Monobehenin
  • HY-148323
    Anti-Trypanosoma cruzi agent-4

    		Parasite Infection
    Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of Trypanosoma cruzi. Anti-Trypanosoma cruzi agent-4 can be used for the research of infection .
    Anti-Trypanosoma cruzi agent-4
  • HY-162680
    OSC-GCDI(P)

    		Influenza Virus Infection
    OSC-GCDI(P) is a broad-spectrum orally active anti-influenza virus agent that exhibits significant inhibitory effects against both wild-type and Oseltamivir (HY-13317) resistant (H275Y) influenza virus strains in mouse infection models. OSC-GCDI(P) is capable of preventing not only wild-type influenza viruses but also OS-resistant variants with NA(H275Y) .
    OSC-GCDI(P)
  • HY-116528
    GCA-186

    		HIV Infection
    GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively .
    GCA-186
  • HY-152161
    HIV-1 inhibitor-51

    		HIV Reverse Transcriptase Infection
    HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (KD=2.50 μM) and inhibitory activity (IC50=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC50s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056) .
    HIV-1 inhibitor-51
  • HY-175491
    HIV-1-IN-85

    		HIV Reverse Transcriptase Infection
    HIV-1-IN-85 is an orally active HIV-1 inhibitor (IC50 = 72 nM). HIV-1-IN-85 exhibits strong inhibitory activity against wild-type (WT) HIV-1 and NNRTI-resistant single mutant strains (L100I, K103N, Y181C, Y188L, E138K) and moderate efficacy against double mutant strains (F227L+V106A, RES056). HIV-1-IN-85 shows good in vivo safety in ICR mice. HIV-1-IN-85 can be used for the study of HIV-1 infection .
    HIV-1-IN-85
  • HY-172408
    NNRT-IN-6

    		Reverse Transcriptase HIV Infection
    NNRT-IN-6 (Compound 13a) is the non-nucleoside reverse transcriptase inhibitor (NNRT) for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 0.41 μM. NNRT-IN-6 inhibits HIV-1 wildtype and mutant strains L100I, K103N, Y181C, Y188L, E138K, F227L/V106A and RES056 with EC50 of 6.2-250 nM .
    NNRT-IN-6
  • HY-175667
    NNRT-IN-12

    		HIV Reverse Transcriptase Infection
    NNRT-IN-12 (compound 19) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC50 value of 0.107 μM for WT HIV-1 RT. NNRT-IN-12 shows anti-HIV-1 activity with EC50 value of 14.1, 5.03, 7.64, 27.1 nM for L100I, K103N, Y181C, Y188L mutant HIV-1 strains, respectively. NNRT-IN-12 shows cytotoxicity .
    NNRT-IN-12
  • HY-175351
    HIV-1-IN-83

    		HIV Reverse Transcriptase Infection
    HIV-1-IN-83 (Compound 18E) is a HIV-1 non-nucleoside reverse transcriptase inhibitor with an IC50 of 0.45 μM for wild-type HIV-1 non-nucleoside reverse transcriptase. HIV-1-IN-83 has potent antiviral activity against both HIV-1 wild-type and mutant strains and improves antidrug resistance for Y188L and RES056 mutant strains. HIV-1-IN-83 has no significant toxicity up to 11.088 μM .
    HIV-1-IN-83
  • HY-N16422
    Mer-NF5003E

    		HIV HIV Protease Infection
    Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC50=50 μM). Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C). Mer-NF5003E is promising for research of HIV infections .
    Mer-NF5003E
  • HY-146365
    HIV-1 inhibitor-30

    		HIV Infection Inflammation/Immunology
    HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS .
    HIV-1 inhibitor-30
  • HY-146019A
    HIV-1 inhibitor-25

    		HIV Infection
    HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS .
    HIV-1 inhibitor-25
  • HY-D2886
    RB-PEG-N3 (MW 400)

    Rhodamine B-PEG-N3 (MW 400)

    		 Fluorescent Dye Others
    RB-PEG-N3 (MW 400) (Rhodamine B-PEG-N3 (MW 400)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 400) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
    RB-PEG-N3 (MW 400)
  • HY-D2886H
    RB-PEG-N3 (MW 10000)

    Rhodamine B-PEG-N3 (MW 10000)

    		 Fluorescent Dye Others
    RB-PEG-N3 (MW 10000) (Rhodamine B-PEG-N3 (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
    RB-PEG-N3 (MW 10000)
  • HY-178031
    HIV-1-IN-87

    		HIV Infection
    HIV-1-IN-87 (Compound 11x) is a dual-site HIV-1 inhibitor targeting the non-nucleoside reverse transcriptase inhibitor binding pocket (NNIBP) and its adjacent site (NNIAS). HIV-1-IN-87 has potent antiviral activities against wild-type and mutant strains (such as L100I, K103N and Y181C) (EC50s: 4.1-150 nM). HIV-1-IN-87 can be used for HIV-1 infections like acquired immune deficiency syndrome (AIDS) research .
    HIV-1-IN-87
  • HY-D2886A
    RB-PEG-N3 (MW 600)

    Rhodamine B-PEG-N3 (MW 600)

    		 Fluorescent Dye Others
    RB-PEG-N3 (MW 600) (Rhodamine B-PEG-N3 (MW 600)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 600) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
    RB-PEG-N3 (MW 600)
  • HY-D2886B
    RB-PEG-N3 (MW 1000)

    Rhodamine B-PEG-N3 (MW 1000)

    		 Fluorescent Dye Others
    RB-PEG-N3 (MW 1000) (Rhodamine B-PEG-N3 (MW 1000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 1000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
    RB-PEG-N3 (MW 1000)
  • HY-D2886C
    RB-PEG-N3 (MW 2000)

    Rhodamine B-PEG-N3 (MW 2000)

    		 Fluorescent Dye Others
    RB-PEG-N3 (MW 2000) (Rhodamine B-PEG-N3 (MW 2000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 2000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
    RB-PEG-N3 (MW 2000)
  • HY-D2886E
    RB-PEG-N3 (MW 5000)

    Rhodamine B-PEG-N3 (MW 5000)

    		 Fluorescent Dye Others
    RB-PEG-N3 (MW 5000) (Rhodamine B-PEG-N3 (MW 5000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 5000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
    RB-PEG-N3 (MW 5000)
  • HY-D2886D
    RB-PEG-N3 (MW 3400)

    Rhodamine B-PEG-N3 (MW 3400)

    		 Fluorescent Dye Others
    RB-PEG-N3 (MW 3400) (Rhodamine B-PEG-N3 (MW 3400)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and azide group (N3). RB-PEG-N3 (MW 3400) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 546/610 nm) .
    RB-PEG-N3 (MW 3400)
  • HY-144123
    HIV-1 inhibitor-16

    		HIV Infection
    HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity .
    HIV-1 inhibitor-16

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