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X-ray Crystallography

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Biochemical Assay Reagents (1) Casein Kinase (1) Cathepsin (1) Cholecystokinin Receptor (1) HIV Protease (1) Interleukin Related (1) Orphan Nuclear Receptor (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147105

LRH-1 modulator-1	Orphan Nuclear Receptor Interleukin Related	Inflammation/Immunology
LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa .

HY-111333

Pyrroxamycin Dioxapyrrolomycin; LL-F42248α; AL-R2081	Bacterial	Infection
Pyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin.

HY-P2138

U-85548E	HIV Protease	Others
U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.

HY-W250179

Hexaethylene glycol monohexadecyl ether Polyoxyethylene (6) cetyl ether	Biochemical Assay Reagents	Others
Hexaethylene glycol monohexadecyl ether, is a nonionic surfactant belonging to the polyethylene glycol (PEG) ether family. It has a hydrophilic head and a lipophilic tail, which makes it suitable for a wide range of applications. Specifically, Hexaethylene glycol monohexadecyl ether is commonly used in membrane protein research, for solubilization and stabilization of proteins, and for structural analysis techniques such as X-ray crystallography and electron microscopy. Additionally, Hexaethylene glycol monohexadecyl ether is used in a variety of other industrial and research applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Its unique properties make it ideal for facilitating interactions between molecules with different physicochemical properties.

HY-119642

Kopsinine	Others	Others
Kopsinine is an indole alkaloid extracted from periwinkle flowers .

HY-164634

CLIK-148	Cathepsin Cholecystokinin Receptor	Neurological Disease Metabolic Disease Cancer
CLIK-148 is a highly selective, irreversible and orally active cysteine protease inhibitor, primarily targeting Cathepsin L. CLIK-148 effectively inhibits the Cathepsin L-dependent degradation of HMG-CoA reductase in the endoplasmic reticulum (ER) membrane. CLIK-148 inhibits the processing of proCCK by Cathepsin L, thereby reducing the production of CCK8 (HY-P0093). CLIK-148 inhibits the degradation of type I collagen by osteoclasts' secreted Cathepsin L, reducing tumor-induced bone metastasis and malignant hypercalcemia. CLIK-148 can be used for the studies of bone metabolism disorders and regulation of neuropeptide processing .

HY-123853

CAM4066	Casein Kinase	Cancer
CAM4066 is a potent CK2α inhibitor, with an IC₅₀ value of 300 nM. CAM4066 exhibits high selectivity, with IC₅₀ values of 22.35, 43.55, and > 50 μM for HIPK3, DAPK3, and CLK2, respectively. CAM4066 shows no cell activity. CAM4066 can be used for the development of highly potent CK2 inhibitors .

Cat. No.	Product Name	Type

HY-W250179

Hexaethylene glycol monohexadecyl ether Polyoxyethylene (6) cetyl ether	Biochemical Assay Reagents
Hexaethylene glycol monohexadecyl ether, is a nonionic surfactant belonging to the polyethylene glycol (PEG) ether family. It has a hydrophilic head and a lipophilic tail, which makes it suitable for a wide range of applications. Specifically, Hexaethylene glycol monohexadecyl ether is commonly used in membrane protein research, for solubilization and stabilization of proteins, and for structural analysis techniques such as X-ray crystallography and electron microscopy. Additionally, Hexaethylene glycol monohexadecyl ether is used in a variety of other industrial and research applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Its unique properties make it ideal for facilitating interactions between molecules with different physicochemical properties.

Hexaethylene glycol monohexadecyl ether

Polyoxyethylene (6) cetyl ether

Biochemical Assay Reagents

Hexaethylene glycol monohexadecyl ether, is a nonionic surfactant belonging to the polyethylene glycol (PEG) ether family. It has a hydrophilic head and a lipophilic tail, which makes it suitable for a wide range of applications. Specifically, Hexaethylene glycol monohexadecyl ether is commonly used in membrane protein research, for solubilization and stabilization of proteins, and for structural analysis techniques such as X-ray crystallography and electron microscopy. Additionally, Hexaethylene glycol monohexadecyl ether is used in a variety of other industrial and research applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Its unique properties make it ideal for facilitating interactions between molecules with different physicochemical properties.

Cat. No.	Product Name	Target	Research Area

HY-P2138

U-85548E	HIV Protease	Others
U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.

HY-P2435

Bz-Nle-Lys-Arg-Arg-AMC	Peptides	Others
Bz-Nle-Lys-Arg-Arg-AMC can be used for protease activity assay. In 0.1mL Tris-HCl buffer (50 mM, pH 7.8), Bz-Nle-Lys-Arg-Arg-AMC was hydrolyzed, and the release rate of AMC was observed .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111333

Pyrroxamycin Dioxapyrrolomycin; LL-F42248α; AL-R2081	Microorganisms Antibiotics Source classification	Bacterial
Pyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin.

HY-119642

Kopsinine	Apocynaceae Terpenoids Source classification Diterpenoids Vinca erecta Regel & Schmalh. Plants	Others
Kopsinine is an indole alkaloid extracted from periwinkle flowers .

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X-ray Crystallography

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

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Natural
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