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Withania

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) Cholinesterase (ChE) (1) Drug Derivative (1) Drug Metabolite (1) Ferroptosis (2) GABA Receptor (1) HIV (1) iGluR (2) NF-κB (2) PKA (1) Reference Standards (3) RET (1) Transferrin Receptor (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (8)
Click Chemistry:	Azide (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N5120

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Cholinesterase (ChE)	Cancer
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .

HY-N10884

Withasomniferolide A	Others	Others
Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

HY-N10887

Withasomniferolide B	GABA Receptor	Neurological Disease
Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

HY-138146

4-Dehydrowithaferin A 4-oxo Withaferin A	Drug Derivative	Cancer
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

HY-N5046

27-O-Acetyl-withaferin A	Others	Inflammation/Immunology
27-O-Acetyl-withaferin A is found in Withania aristata .

HY-N5069

2,3-Didehydrosomnifericin	Bacterial	Others
2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera .

HY-N8693

Withanoside IV	Others	Others
Withanoside IV is a Steroids product that can be isolated from the herbs of Withania somnifera .

HY-N5131

3β-Methoxy-2,3-dihydrowithaferin A Quresimin A	Others	Others
3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera .

HY-N11702

Kaempferol-3-O-robinoside-7-O-glucoside	Others	Others
Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera .

HY-N5113

6α-Chloro-5β-hydroxywithaferin A	Bacterial	Others
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .

HY-N2065

Withaferin A 5+ Cited Publications	NF-κB Ferroptosis	Inflammation/Immunology Cancer
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N2065R

Withaferin A (Standard)	Reference Standards NF-κB Ferroptosis	Inflammation/Immunology Cancer
Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N15635

Withacoagin (+)-Withacoagin	HIV	Infection Metabolic Disease Inflammation/Immunology
Withacoagin is a withanolide that can be isolated from the roots of Withania coagulans. Withacoagin has various biological activites such as adaptogenic, anti-inflammatory, and antioxidant properties. Withacoagin regulates the activity of various enzymes and pathways related to oxidative stress and inflammation. Withacoagin can attenuates HIV-1 infection .

HY-N8671R

Withanoside V (Standard)	Reference Standards Others	Neurological Disease
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

HY-N8671

Withanoside V	Others	Neurological Disease
Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

HY-N10889

Sominone	Drug Metabolite RET	Neurological Disease
Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-129692

Withanone 1 Publications Verification	iGluR	Neurological Disease Cancer
Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

HY-P10928

BCY17901 TFA	Transferrin Receptor	Neurological Disease Cancer
BCY17901 TFA is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .

HY-P10928A

BCY17901	Transferrin Receptor	Neurological Disease Cancer
BCY17901 is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .

HY-129692R

Withanone (Standard)	Reference Standards iGluR	Neurological Disease Cancer
Withanone (Standard) is the analytical standard of Withanone (HY-129692). This product is intended for research and analytical applications. Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

HY-P10319

RI-STAD-2	PKA	Cardiovascular Disease Cancer
RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer .

Cat. No.	Product Name	Target	Research Area

HY-P10928

BCY17901 TFA	Transferrin Receptor	Neurological Disease Cancer
BCY17901 TFA is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .

HY-P10928A

BCY17901	Transferrin Receptor	Neurological Disease Cancer
BCY17901 is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .

HY-P10319

RI-STAD-2	PKA	Cardiovascular Disease Cancer
RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer .

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Cholinesterase (ChE)
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .

Withasomniferolide A	Structural Classification Source classification Withania somnifera Plants Solanaceae Steroids	Others
Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

Withasomniferolide B	Structural Classification Source classification Withania somnifera Plants Solanaceae Steroids	GABA Receptor
Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

4-Dehydrowithaferin A 4-oxo Withaferin A	Quinones Structural Classification Classification of Application Fields Source classification Benzene Quinones Withania somnifera Solanaceae Plants Disease Research Fields Cancer	Drug Derivative
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

27-O-Acetyl-withaferin A	other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Steroids	Others
27-O-Acetyl-withaferin A is found in Withania aristata .

2,3-Didehydrosomnifericin	Structural Classification other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Steroids	Bacterial
2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera .

Withanoside IV	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	Others
Withanoside IV is a Steroids product that can be isolated from the herbs of Withania somnifera .

3β-Methoxy-2,3-dihydrowithaferin A Quresimin A	other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Steroids	Others
3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera .

Kaempferol-3-O-robinoside-7-O-glucoside	Structural Classification Flavonoids Flavones Source classification Withania somnifera Plants Solanaceae	Others
Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera .

6α-Chloro-5β-hydroxywithaferin A	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Withania somnifera Plants Solanaceae Disease Research Fields	Bacterial
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .

Withaferin A 5+ Cited Publications	Structural Classification other families Classification of Application Fields Source classification Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids	NF-κB Ferroptosis
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

Withaferin A (Standard)	Structural Classification other families Source classification Withania somnifera Solanaceae Plants Steroids	Reference Standards NF-κB Ferroptosis
Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

Withacoagin (+)-Withacoagin	Structural Classification Natural Products Source classification Solanaceae Plants Withania coagulans (Stocks) Dunal	HIV
Withacoagin is a withanolide that can be isolated from the roots of Withania coagulans. Withacoagin has various biological activites such as adaptogenic, anti-inflammatory, and antioxidant properties. Withacoagin regulates the activity of various enzymes and pathways related to oxidative stress and inflammation. Withacoagin can attenuates HIV-1 infection .

Withanoside V (Standard)	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	Reference Standards Others
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

Withanoside V	Structural Classification Source classification Withania somnifera Plants Solanaceae Steroids	Others
Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

Sominone	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	Drug Metabolite RET
Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

Withanone 1 Publications Verification	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	iGluR
Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

Withanone (Standard)	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	Reference Standards iGluR
Withanone (Standard) is the analytical standard of Withanone (HY-129692). This product is intended for research and analytical applications. Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

Cat. No.	Product Name		Classification

HY-P10928

BCY17901 TFA		Azide
BCY17901 TFA is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .

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Withania

Inhibitors & Agonists

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