WB | MedChemExpress (MCE) Life Science Reagents

By Targets:	Adrenergic Receptor (1) Akt (1) Antibiotic (1) Apoptosis (2) Bcr-Abl (1) Biochemical Assay Reagents (1) EGFR (1) ERK (1) Fungal (1) G protein-coupled Bile Acid Receptor 1 (1) GLP Receptor (1) LDLR (1) MDM-2/p53 (1) NOD-like Receptor (NLR) (1) P-selectin (1) PD-1/PD-L1 (1) STAT (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163176

WB518	STAT	Inflammation/Immunology
WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739)-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17 .

HY-164546

WB436B	STAT Apoptosis	Cancer
WB436B is a highly selective STAT3 inhibitor. WB436B can selectively inhibit STAT3-Tyr705 phosphorylation and the expression of STAT3 target genes, showing cytotoxic effects on pancreatic cancer cells and inducing apoptosis. WB436B can suppress tumor growth and metastasis in pancreatic cancer mouse models, extending the survival of tumor-bearing mice .

HY-12718A

(±)-WB 4101 hydrochloride	Adrenergic Receptor	Endocrinology
(±)-WB 4101 is a potent antagonist of noradrenaline. (±)-WB 4101 interacts with protein in smooth muscle. (±)-WB 4101 makes drug and receptor bind tightly .

HY-P990202

Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4)	LDLR	Neurological Disease
Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse/rat/human LRP1/CD91. Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) binds to the β chain of LRP1. Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) affects intracellular signaling, lipid homeostasis, and clearance of apoptotic cells by blocking LRP1. Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) can be used for western blot (WB), immunofluorescence (IF) and other detections .

HY-116504

WB-308	EGFR Akt ERK Apoptosis	Cancer
WB-308 is a novel small molecule that was identified as an inhibitor of EGFR by an in vitro EGFR kinase activity system. WB-308 was able to reduce the proliferation and clonogenicity of NSCLC cells, causing G2/M phase arrest and apoptosis. In addition, WB-308 inhibited tumor growth in two in vivo animal models (lung orthotopic transplantation model and patient-derived clonal mouse model). WB-308 impaired the phosphorylation of EGFR, AKT, and ERK1/2 proteins. Compared with Gefitinib, WB-308 had lower cytotoxicity. This study showed that WB-308 is a new EGFR-TKI that may be considered as an alternative to Gefitinib in the clinical treatment of NSCLC.

HY-176494

WB4-24	GLP Receptor	Inflammation/Immunology
WB4-24 is a GLP-1 receptor agonist. WB4-24 increases the release of β-endorphin in microglia. WB4-24 has anti-allergic, anti-inflammatory and analgesic effects in formalin-, carrageenan- and CFA-induced mouse inflammation models .

HY-174266

WB156	MDM-2/p53	Cancer
WB156 is a dual MDM2 and GSPT1 degrader. WB156 can recruit CRBN (Cereblon, a substrate receptor of the E3 ubiquitin-ligase complex) to induce the ubiquitination-proteasome pathway-mediated degradation of MDM2 and GSPT1. WB156 is promising for research of cancers, such as leukemia .

HY-120565

WB403	G protein-coupled Bile Acid Receptor 1	Metabolic Disease
WB403 is a TGR5 activator. WB403 promotes GLP-1 release, improved hyperglycemia, and preserves the mass and function of pancreatic β-cells .

HY-18814

WB-BC-15 WGB-BC-15	Bcr-Abl	Cancer
WB-BC-15 (WGB-BC-15) is a c-Abl kinase inhibitor. WB-BC-15 can increase radiation-induced germ-cell apoptosis, with EC₅₀ of 10.5 μM .

HY-N12913

Antibiotic WB	Antibiotic Fungal	Infection
Antibiotic WB is an antibioticwith antifungal activity and can be isolated from the soil fungus strain 38 .

HY-N10380

Inonotusol F	Others	Metabolic Disease
Inonotusol F is a triterpene isolated from Inonotus obliquus. Inonotusol F shows hepatoprotective effects against D-galactosamine-induced WB-F344 cell damage .

HY-P990169

Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12)	PD-1/PD-L1	Inflammation/Immunology Cancer
Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human phosphorylated PD-1/CD279. Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) can detect the phosphorylated form of the PD-1 ITSM by both western blot and flow cytometry .

HY-158024

NDT-19795	NOD-like Receptor (NLR)	Neurological Disease
NDT-19795 is an effective inhibitor of the NLRP3 inflammasome with an IC₅₀ value of 66 nM in the PBMC method and 4.7 μM in the WB method. NDT-19795 is a carboxylic acid-active substance that can be converted from NT-0796 (HY-156438) within cells. NDT-19795 can be used for the study of neurological diseases .

HY-154818

Bovine Serum Albumin, Acetylated Ac-BSA	Biochemical Assay Reagents	Others
Bovine Serum Albumin, Acetylated (Ac-BSA) is a polypeptide of known structure with strong antigenicity. Bovine Serum Albumin, Acetylated produced a significant immune response, validating the accuracy and reliability of the experimental method. Bovine Serum Albumin, Acetylated can be used as a positive control substance in ELISA or WB experiments, and can be used in experiments with acetylated lysine monoclonal or polyclonal antibodies. Bovine Serum Albumin, Acetylated also improves encapsulation efficiency at low concentrations of PLGA, a polymer for biopharmaceutical delivery with biocompatibility, degradability, and controlled release properties .

HY-P99263

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion .

Cat. No.	Product Name	Type

HY-154818

Bovine Serum Albumin, Acetylated Ac-BSA	Native Proteins
Bovine Serum Albumin, Acetylated (Ac-BSA) is a polypeptide of known structure with strong antigenicity. Bovine Serum Albumin, Acetylated produced a significant immune response, validating the accuracy and reliability of the experimental method. Bovine Serum Albumin, Acetylated can be used as a positive control substance in ELISA or WB experiments, and can be used in experiments with acetylated lysine monoclonal or polyclonal antibodies. Bovine Serum Albumin, Acetylated also improves encapsulation efficiency at low concentrations of PLGA, a polymer for biopharmaceutical delivery with biocompatibility, degradability, and controlled release properties .

Bovine Serum Albumin, Acetylated

Ac-BSA

Native Proteins

Bovine Serum Albumin, Acetylated (Ac-BSA) is a polypeptide of known structure with strong antigenicity. Bovine Serum Albumin, Acetylated produced a significant immune response, validating the accuracy and reliability of the experimental method. Bovine Serum Albumin, Acetylated can be used as a positive control substance in ELISA or WB experiments, and can be used in experiments with acetylated lysine monoclonal or polyclonal antibodies. Bovine Serum Albumin, Acetylated also improves encapsulation efficiency at low concentrations of PLGA, a polymer for biopharmaceutical delivery with biocompatibility, degradability, and controlled release properties .

Cat. No.	Product Name

HY-K1000

WB/IP Lysis Buffer 2 Publications Verification
MCE WB/IP Lysis Buffer is a lysis buffer used to lyse cell or tissue samples under non-denaturing conditions to prepare protein samples. The lysed cell or tissue samples can be used for PAGE, Western Blot, Immunoprecipitation (IP), Co-Immunoprecipitation (Co-IP), ELISA, and other assays.

HY-K1062

Exosome Isolation and Purification Kit (from cell culture media) 1 Publications Verification
MCE Exosome Isolation and Purification Kit provides a simple and effective method to isolate and purify intact exosomes from cell culture media that can be used for electron microscope analysis, NTA analysis, WB, qPCR, etc.

HY-K1011

3-Color Prestained Protein Marker (10-190 kDa) 2 Publications Verification
MCE 3-Color Prestained Protein Marker (10-190 kDa) is a three-color protein standard with 10 prestained proteins ranging from 10 kDa to 190 kDa.

HY-K1028

Transfer Buffer (Semi Dry) Powder (1 L of 1×)
MCE Transfer Buffer (Semi Dry) Powder (1 L of 1×) consists of Tris, Glycine and SDS, and is suitable for Western Blot semi-dry electrophoresis.

HY-K1020

Tris-Glycine-SDS Powder (1 L of 1×)
MCE Tris-Glycine-SDS Powder (1 L of 1×) consists of Tris, Glycine and SDS, and is widely used as an electrophoresis buffer for SDS-PAGE and Western Blot.

HY-K1021

Tris-Glycine Powder (1 L of 1×)
MCE Tris-Glycine Powder (1 L of 1×) consists of Tris and Glycine, and is widely used as an electrophoresis buffer for Native-PAGE.

HY-K1063

Exosome Isolation and Purification Kit (from plasma and serum)
MCE Exosome Isolation and Purification Kit provides a simple and effective method to isolate and purify intact exosomes from plasma and serum that can be used for electron microscope analysis, NTA analysis, WB, qPCR, etc.

HY-K1065

Exosome Isolation and Purification Kit (from body fluids)
MCE Exosome Isolation and Purification Kit provides a simple and effective method to isolate and purify intact exosomes from cerebro-spinal fluid, amniotic fluid, milk, saliva, etc, which can be used for electron microscope analysis, NTA analysis, WB, qPCR, etc.

Cat. No.	Product Name	Target	Research Area

HY-P990202

Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4)	LDLR	Neurological Disease
Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse/rat/human LRP1/CD91. Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) binds to the β chain of LRP1. Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) affects intracellular signaling, lipid homeostasis, and clearance of apoptotic cells by blocking LRP1. Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) can be used for western blot (WB), immunofluorescence (IF) and other detections .

HY-P990169

Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12)	PD-1/PD-L1	Inflammation/Immunology Cancer
Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human phosphorylated PD-1/CD279. Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) can detect the phosphorylated form of the PD-1 ITSM by both western blot and flow cytometry .

HY-P99263

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12913

Antibiotic WB	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Fungal
Antibiotic WB is an antibioticwith antifungal activity and can be isolated from the soil fungus strain 38 .

HY-N10380

Inonotusol F	Natural Products Microorganisms Source classification	Others
Inonotusol F is a triterpene isolated from Inonotus obliquus. Inonotusol F shows hepatoprotective effects against D-galactosamine-induced WB-F344 cell damage .

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WB

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