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VASOACTIVE Intestinal Polypeptide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PACAP Receptor (5) Adenylate Cyclase (1) Apoptosis (2) CGRP Receptor (1) CMV (1) IPK Superfamily (2) PD-1/PD-L1 (1) SARS-CoV (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (2) Infection (3) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Targets Recommended: PACAP Receptor CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4195A

[K15,R16,L27]VIP(1-7)/GRF(8-27) acetate	IPK Superfamily	Metabolic Disease
[K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate) is the acetate of [K15,R16,L27]VIP(1-7)/GRF(8-27) (HY-P4195). [K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate), a VIP₁ selective agonist, exhibits IC₅₀ values of binding of 2 nM, 1 nM, 30,000 nM for the human VIP₁, rat VIP₁, rat VIP₂ receptors, respectively . VIP: VASOACTIVE Intestinal Polypeptide

HY-P0012A

Aviptadil acetate 2 Publications Verification VASOACTIVE Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

HY-P1072

PHM-27 (human)	CGRP Receptor	Cardiovascular Disease Metabolic Disease
PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC₅₀ of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism .

HY-P0012

Aviptadil 2 Publications Verification VASOACTIVE Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

HY-P0221C

PACAP (1-38) free acid	PACAP Receptor	Endocrinology
PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

HY-P1158

[Ala2,8,9,11,19,22,24,25,27,28]-VIP	Adenylate Cyclase	Neurological Disease
[Ala2,8,9,11,19,22,24,25,27,28]-VIP is an analog vasoactive intestinal polypeptide (VIP) with high affinity and selectivity for human VIP/pituitary adenylate cyclase-activating polypeptide 1 (hVPAC1). VIP is a widespread neurotransmitter .

HY-P4195

[K15,R16,L27]VIP(1-7)/GRF(8-27)	IPK Superfamily	Metabolic Disease
[K15,R16,L27]VIP(1-7)/GRF(8-27), a VIP₁ selective agonist, exhibits IC₅₀ values of binding of 2 nM, 1 nM, 30,000 nM for the human VIP₁, rat VIP₁, rat VIP₂ receptors, respectively . VIP: VASOACTIVE Intestinal Polypeptide

HY-P1767

Prepro VIP (81-122), human	PACAP Receptor	Cardiovascular Disease
Prepro VIP (81-122), human is a prepro-vasoactive intestinal polypeptide (VIP) derived peptide, corresponding to residues 81-122. Peptide histidine valine 42 (PHV-42) has been designated to correspond exactly to Prepro VIP (81-122), which reduces both the force and frequency of spontaneous contractions of isolated rat uterus .

HY-P11288

ANT308	PACAP Receptor Apoptosis	Cancer
ANT308 is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 significantly enhances the activation and proliferation of T cells. ANT308 inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 can be used for the studies of acute myeloid leukemia (AML) and uveal melanoma (UVM) .

HY-P0221B

PACAP (1-38) free acid TFA	PACAP Receptor	Endocrinology
PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

HY-P11288A

ANT308 TFA	PACAP Receptor Apoptosis	Cancer
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 TFA significantly enhances the activation and proliferation of T cells. ANT308 TFA inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 TFA can be used for the study of acute myeloid leukemia (AML) and uveal melanoma (UVM) .

HY-P5005

VIPhyb	CMV PD-1/PD-L1	Infection Inflammation/Immunology Cancer
VIPhyb is a vasoactive intestinal polypeptide (VIP) receptor antagonist. VIPhyb can inhibit VIP signaling, increase T-cell immunity and downregulate PD1. VIPhyb can inhibit cancer cell proliferation. VIPhyb can reduce inflammatory cytokine expression. VIPhyb can enhance viral clearance. VIPhyb can be used for the researches of cancer, infection and inflammation and immunology, such as non-small cell lung cancer (NSCLC), cytomegalovirus infection and colitis .

Cat. No.	Product Name	Target	Research Area

HY-P4195A

[K15,R16,L27]VIP(1-7)/GRF(8-27) acetate	IPK Superfamily	Metabolic Disease
[K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate) is the acetate of [K15,R16,L27]VIP(1-7)/GRF(8-27) (HY-P4195). [K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate), a VIP₁ selective agonist, exhibits IC₅₀ values of binding of 2 nM, 1 nM, 30,000 nM for the human VIP₁, rat VIP₁, rat VIP₂ receptors, respectively . VIP: VASOACTIVE Intestinal Polypeptide

HY-P0012A

Aviptadil acetate 2 Publications Verification VASOACTIVE Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

HY-P1072

PHM-27 (human)	CGRP Receptor	Cardiovascular Disease Metabolic Disease
PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC₅₀ of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism .

HY-P0012

Aviptadil 2 Publications Verification VASOACTIVE Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

HY-P0221C

PACAP (1-38) free acid	PACAP Receptor	Endocrinology
PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

HY-P1158

[Ala2,8,9,11,19,22,24,25,27,28]-VIP	Adenylate Cyclase	Neurological Disease
[Ala2,8,9,11,19,22,24,25,27,28]-VIP is an analog vasoactive intestinal polypeptide (VIP) with high affinity and selectivity for human VIP/pituitary adenylate cyclase-activating polypeptide 1 (hVPAC1). VIP is a widespread neurotransmitter .

HY-P4195

[K15,R16,L27]VIP(1-7)/GRF(8-27)	IPK Superfamily	Metabolic Disease
[K15,R16,L27]VIP(1-7)/GRF(8-27), a VIP₁ selective agonist, exhibits IC₅₀ values of binding of 2 nM, 1 nM, 30,000 nM for the human VIP₁, rat VIP₁, rat VIP₂ receptors, respectively . VIP: VASOACTIVE Intestinal Polypeptide

HY-P4013

[Arg15,20,21, Leu17] VIP-Gly-Lys-Arg-NH2	Peptides	Inflammation/Immunology
[Arg15,20,21, Leu17] VIP-Gly-Lys-Arg-NH2 is a vasoactive intestinal polypeptide (VIP) analog with relaxant effects .

HY-P1761

Prepro VIP (111-122), human	Peptides	Neurological Disease
Prepro VIP (111-122), human is a prepro-vasoactive intestinal polypeptide (VIP)-derived peptide, corresponding to residues 111-122. VIP is present in the peripheral and the central nervous systems where it functions as a nonadrenergic, noncholinergic neurotransmitter or neuromodulator .

HY-P1767

Prepro VIP (81-122), human	PACAP Receptor	Cardiovascular Disease
Prepro VIP (81-122), human is a prepro-vasoactive intestinal polypeptide (VIP) derived peptide, corresponding to residues 81-122. Peptide histidine valine 42 (PHV-42) has been designated to correspond exactly to Prepro VIP (81-122), which reduces both the force and frequency of spontaneous contractions of isolated rat uterus .

HY-P11288

ANT308	PACAP Receptor Apoptosis	Cancer
ANT308 is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 significantly enhances the activation and proliferation of T cells. ANT308 inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 can be used for the studies of acute myeloid leukemia (AML) and uveal melanoma (UVM) .

HY-P0221B

PACAP (1-38) free acid TFA	PACAP Receptor	Endocrinology
PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .

HY-P11288A

ANT308 TFA	PACAP Receptor Apoptosis	Cancer
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 TFA significantly enhances the activation and proliferation of T cells. ANT308 TFA inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 TFA can be used for the study of acute myeloid leukemia (AML) and uveal melanoma (UVM) .

HY-P5005

VIPhyb	CMV PD-1/PD-L1	Infection Inflammation/Immunology Cancer
VIPhyb is a vasoactive intestinal polypeptide (VIP) receptor antagonist. VIPhyb can inhibit VIP signaling, increase T-cell immunity and downregulate PD1. VIPhyb can inhibit cancer cell proliferation. VIPhyb can reduce inflammatory cytokine expression. VIPhyb can enhance viral clearance. VIPhyb can be used for the researches of cancer, infection and inflammation and immunology, such as non-small cell lung cancer (NSCLC), cytomegalovirus infection and colitis .

Species:	Human (2)
Tag:	His (1) Fc (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71061

	VIP Protein, Human (HEK293, His) 1 Publications Verification VASOACTIVE Intestinal peptide; VIP; Intestinal peptide PHV-42; Peptide histidine methioninamide 27; VASOACTIVE Intestinal Polypeptide	Human	HEK293
	VIP is a neuropeptide that induces vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, enhances glycogenolysis, and relaxes tracheal, gastric, and gallbladder smooth muscles. PHM and PHV-related peptides also have vasodilatory properties. VIP Protein, Human (HEK293, His) is the recombinant human-derived VIP protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76128

	VIPR2 Protein, Human (HEK293, Fc) VASOACTIVE Intestinal Polypeptide receptor 2; VIP-R-2; PACAP-R3; VPAC2; VIPR2	Human	HEK293
	VIPR2 protein, serving as a receptor for Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activating Peptide (PACAP-38 and -27), activates adenylyl cyclase and can also couple with phospholipase C. Its versatile signaling pathways emphasize its pivotal role in transducing signals from VIP and PACAP, participating in cellular processes regulated by cyclic AMP and phosphoinositide signaling cascades. VIPR2 Protein, Human (HEK293, Fc) is the recombinant human-derived VIPR2 protein, expressed by HEK293 , with C-mFc labeled tag.

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HY-P87143

	VIP Antibody (YA6836) Peptide histidine methioninamide 27 antibody; Peptide histidine valine 42 antibody; PHM27 antibody; PHV42 antibody; Prepro V; IP : antibody; VASOACTIVE Intestinal peptide antibody; VASOACTIVE Intestinal Polypeptide antibody; V; IP : antibody; V; IP : peptides antibody; V; IP : peptides precursor antibody; Peptide histidine methioninamide 27 antibody; Peptide histidine valine 42 antibody; PHM27 antibody; PHV42 antibody; Prepro V; IP : antibody; VASOACTIVE Intestinal peptide antibody; VASOACTIVE Intestinal Polypeptide antibody; V; IP : antibody; V; IP : peptides antibody; V; IP : peptides precursor antibody; VIP_HUMAN antibody;	IHC-F, IHC-P	Human, Mouse, Rat
	VIP Antibody (YA6836) is a Rat -derived and non-conjugated monoclonal antibody, targeting to VIP.

HY-P81526

	VPAC2 Antibody (YA1271) VIP2R; VIPR2; VASOACTIVE Intestinal Polypeptide receptor 2; VIP-R-2; Helodermin-preferring VIP receptor; Pituitary adenylate cyclase-activating Polypeptide type III receptor (PACAP type III receptor; PACAP-R-3; PACAP-R3); VPAC2	IHC-P	Human
	VPAC2 Antibody (YA1271) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VPAC2.

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