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Results for "

Trypsin-like proteasome

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Proteasome (12) Apoptosis (2) Biochemical Assay Reagents (2) Isotope-Labeled Compounds (1) Ser/Thr Protease (2)
By Research Areas:	Cancer (4) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Proteasome Polo-like Kinase (PLK) NOD-like Receptor (NLR) Toll-like Receptor (TLR) C-type Lectin-like Receptors (CTLRs) Human leukocyte immunoglobulin (Ig)-like receptors (LILR) KLF ANGPTL PERK ULK METTL3 HRASLS MASTL CDKL ADAMTS IGF-1R LOX-1 FLT3 Nuclear Hormone Receptor 4A/NR4A Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134961

Z-Ala-Arg-Arg-AMC 1 Publications Verification Fluorogenic proteasome Substrate; Z-ARR-AMC	Proteasome	Others
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .

HY-115391

Boc-LRR-AMC 1 Publications Verification Boc-Leu-Arg-Arg-AMC	Biochemical Assay Reagents	Others
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-18741

VR23 1 Publications Verification	Proteasome Apoptosis	Metabolic Disease Cancer
VR23 is a small molecule that potently inhibits the activities of **trypsin-like proteasomes (IC₅₀*=1 nM), chymotrypsin-like* proteasomes (IC₅₀=50-100 nM), and caspase-like proteasomes (IC₅₀=3 μM).

HY-137281

HMB-Val-Ser-Leu-VE	Ser/Thr Protease	Others
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC₅₀ of 0.033 μM .

HY-P11311

NC-002	Proteasome	Cancer
NC-002, a cell-permeable peptide, is a **Trypsin-like proteasome** inhibitor without inhibition of lysosomal cysteine proteases. NC-002 is the epoxyketone derivative of Leupeptin (HY-18234). NC-002 sensitizes myeloma cells to Bortezomib (HY-10227) and Carfilzomib (HY-10455). NC-002 can be used for cancers research .

HY-P4514

Z-Gly-Gly-Arg-βNA	Proteasome	Others
Z-Gly-Gly-Arg-βNA is the synthetic peptide substrate of trypsin-like activities of the proteasome .

HY-126874

Tyropeptin A-4 TP-101	Proteasome	Others
Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity .

HY-P5280

Ac-KQL-AMC	Ser/Thr Protease	Others
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .

HY-135070

Ac-RLR-AMC Ac-Arg-Leu-Arg-AMC	Proteasome	Others
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .

HY-135070B

Ac-RLR-AMC TFA Ac-Arg-Leu-Arg-AMC TFA	Proteasome	Others
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .

HY-W753820A

Boc-LRR-AMC TFA Boc-Leu-Arg-Arg-AMC TFA	Biochemical Assay Reagents	Others
Boc-LRR-AMC TFA (Boc-Leu-Arg-Arg-AMC TFA) is the TFA salt form of Boc-LRR-AMC (HY-115391). Boc-LRR-AMC TFA is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-W720448

VR23-d8	Isotope-Labeled Compounds Proteasome Apoptosis	Metabolic Disease
VR23-d₈ is the deuterium labeled VR23 (HY-18741). VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC₅₀=1 nM), chymotrypsin-like proteasomes (IC₅₀=50-100 nM), and caspase-like proteasomes (IC₅₀=3 μM).

HY-10985

Marizomib Maximum Cited Publications 16 Publications Verification Salinosporamide A; NPI-0052	Proteasome	Cancer
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, *pan-proteasome* inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-150602

20S Proteasome activator 1	Proteasome	Neurological Disease
20S Proteasome activator 1 is a potent 20S proteasome activator with EC₂₀₀ values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases .

HY-P11331

Az-NC-002	Proteasome	Others
Az-NC-002 is a Proteasome trypsin-like site (β2) and immunoproteasome β2i-specific active probe. Az-NC-002 has weak off-target effects with no significant inhibition for Cathepsin D (HY-P2750), but this inhibition reacts outside of the active site or influence on a small fraction of the enzyme .

HY-120722

TCH-165 1 Publications Verification	Proteasome	Cancer
TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation .

Cat. No.	Product Name	Target	Research Area

HY-134961

Z-Ala-Arg-Arg-AMC 1 Publications Verification Fluorogenic proteasome Substrate; Z-ARR-AMC	Proteasome	Others
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .

HY-115391

Boc-LRR-AMC 1 Publications Verification Boc-Leu-Arg-Arg-AMC	Biochemical Assay Reagents	Others
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-137281

HMB-Val-Ser-Leu-VE	Ser/Thr Protease	Others
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC₅₀ of 0.033 μM .

HY-P11311

NC-002	Proteasome	Cancer
NC-002, a cell-permeable peptide, is a **Trypsin-like proteasome** inhibitor without inhibition of lysosomal cysteine proteases. NC-002 is the epoxyketone derivative of Leupeptin (HY-18234). NC-002 sensitizes myeloma cells to Bortezomib (HY-10227) and Carfilzomib (HY-10455). NC-002 can be used for cancers research .

HY-P4514

Z-Gly-Gly-Arg-βNA	Proteasome	Others
Z-Gly-Gly-Arg-βNA is the synthetic peptide substrate of trypsin-like activities of the proteasome .

HY-P5280

Ac-KQL-AMC	Ser/Thr Protease	Others
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .

HY-135070

Ac-RLR-AMC Ac-Arg-Leu-Arg-AMC	Proteasome	Others
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .

HY-135070B

Ac-RLR-AMC TFA Ac-Arg-Leu-Arg-AMC TFA	Proteasome	Others
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .

HY-W753820A

Boc-LRR-AMC TFA Boc-Leu-Arg-Arg-AMC TFA	Biochemical Assay Reagents	Others
Boc-LRR-AMC TFA (Boc-Leu-Arg-Arg-AMC TFA) is the TFA salt form of Boc-LRR-AMC (HY-115391). Boc-LRR-AMC TFA is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-P11331

Az-NC-002	Proteasome	Others
Az-NC-002 is a Proteasome trypsin-like site (β2) and immunoproteasome β2i-specific active probe. Az-NC-002 has weak off-target effects with no significant inhibition for Cathepsin D (HY-P2750), but this inhibition reacts outside of the active site or influence on a small fraction of the enzyme .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10985

Marizomib 15+ Cited Publications Salinosporamide A; NPI-0052	Marine natural products Source classification Marine microorganism	Proteasome
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, *pan-proteasome* inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

Cat. No.	Product Name	Chemical Structure

HY-W720448

VR23-d8
VR23-d₈ is the deuterium labeled VR23 (HY-18741). VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC₅₀=1 nM), chymotrypsin-like proteasomes (IC₅₀=50-100 nM), and caspase-like proteasomes (IC₅₀=3 μM).

Cat. No.	Product Name		Classification

HY-P11331

Az-NC-002		Azide
Az-NC-002 is a Proteasome trypsin-like site (β2) and immunoproteasome β2i-specific active probe. Az-NC-002 has weak off-target effects with no significant inhibition for Cathepsin D (HY-P2750), but this inhibition reacts outside of the active site or influence on a small fraction of the enzyme .

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Trypsin-like proteasome

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products