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Isoforms Recommended:	TRPM

Results for "

TRPM8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) Calcium Channel (1) CGRP Receptor (1) Drug Metabolite (1) Endogenous Metabolite (6) Insulin Receptor (1) Isotope-Labeled Compounds (2) Parasite (1) Small Interfering RNA (siRNA) (3) TRP Channel (37)
By Research Areas:	Cancer (16) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (8) Metabolic Disease (4) Neurological Disease (19)
Oligonucleotides:	Flavoring Agents (1) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145124

TRPM8 antagonist 3	TRP Channel	Others
TRPM8 antagonist 3 is a novel *TRPM8* blocker with an IC₅₀ value of 11 nM.

HY-112430

TRPM8 antagonist 2 1 Publications Verification	TRP Channel	Neurological Disease
TRPM8 antagonist 2 is a potent and selective *TRPM8* antagonist, with an IC₅₀ of 0.2 nM, used in the research of neuropathic pain syndromes.

HY-W014325

TRPM8 agonist WS-3 Framidice 3	TRP Channel Endogenous Metabolite	Metabolic Disease Cancer
TRPM8 agonist WS-3 is an agonist of *TRPM8* with an EC₅₀ of 3.7 μM.

HY-130074

FEMA 4809	TRP Channel	Neurological Disease
FEMA 4809 is a TRPM8 receptor agonist (EC₅₀=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception .

HY-18662

RQ-00203078 4 Publications Verification	TRP Channel	Neurological Disease Cancer
RQ-00203078 is a highly selective, potent and orally active *TRPM8* antagonist with IC₅₀s of 5.3 nM and 8.3 nM for rat and human *TRPM8* channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels .

HY-W014325R

TRPM8 agonist WS-3 (Standard) Framidice 3 (Standard)	TRP Channel Endogenous Metabolite	Metabolic Disease Cancer
TRPM8 agonist WS-3 (Standard) is the analytical standard of TRPM8 agonist WS-3. This product is intended for research and analytical applications. TRPM8 agonist WS-3 is an agonist of TRPM8 with an EC50 of 3.7 μM.

HY-RS15118

TRPM8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPM8 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPM8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPM8 Human Pre-designed siRNA Set A TRPM8 Human Pre-designed siRNA Set A

HY-RS16771

Trpm8 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trpm8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpm8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trpm8 Mouse Pre-designed siRNA Set A Trpm8 Mouse Pre-designed siRNA Set A

HY-RS23211

Trpm8 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trpm8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpm8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trpm8 Rat Pre-designed siRNA Set A Trpm8 Rat Pre-designed siRNA Set A

HY-108461

TRPM8-IN-1	TRP Channel	Neurological Disease
TRPM8-IN-1 (example 14) is an inhibitor of transient receptor potential melastatin-8 (TRPM8) channels, IC₅₀<5 μM .

HY-109087

Elismetrep MT-8554	TRP Channel	Cardiovascular Disease Neurological Disease
Elismetrep (MT-8554) is a *TRPM8* antagonist. Elismetrep reduces the frequency of vasomotor symptoms. Elismetrep can be used for study of pain .

HY-100345

AMTB hydrochloride 1 Publications Verification	TRP Channel	Neurological Disease Cancer
AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC₅₀ of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (Na_V) .

HY-11062

Icilin 1 Publications Verification AG-3-5	TRP Channel	Neurological Disease Inflammation/Immunology
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC₅₀=1.4 μM). Icilin is a "super-cooling agent" . Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response .

HY-110181

M8-B	TRP Channel	Metabolic Disease
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb) .

HY-115506

PF-05105679	TRP Channel	Neurological Disease
PF-05105679 is an orally active and selective *TRPM8* antagonist with an IC₅₀ of 103 nM. PF-05105679 has the potential for cold-related pain .

HY-N1369S1

Menthol-d2	Calcium Channel Isotope-Labeled Compounds	Neurological Disease
Menthol-d₂ is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .

HY-N9484S

Menthofuran-13C2	Drug Metabolite Isotope-Labeled Compounds	Others
Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and *TRPM8* modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-112703

AMG 333	TRP Channel	Cardiovascular Disease Neurological Disease
AMG 333 is an orally active and highly selective *TRPM8* antagonist with an IC₅₀ of 13 nM.

HY-104061

AMG8788	TRP Channel	Others
AMG8788 is a potent, selective, orally active antagonist of *TRPM8* with an IC₅₀ of 63.2 nM .

HY-104062

AMG9678	TRP Channel	Others
AMG9678 is a potent, selective, orally active antagonist of *TRPM8* with an IC₅₀ of 31.2 nM .

HY-N7536

Voacangine	TRP Channel	Others
Voacangine is an antagonist for TRPV1 and *TRPM8* but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to *TRPM8* (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced *TRPM8* activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-104059

AMG2850	TRP Channel	Inflammation/Immunology
AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist .

HY-16162

D-3263	TRP Channel	Cancer
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

HY-16162A

D-3263 hydrochloride 1 Publications Verification	TRP Channel	Cancer
D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) *TRPM8* agonist.

HY-126593

Cryosim-3	TRP Channel	Others
Cryosim-3 is a selective TRPM8 receptor agonist. Cryosim-3 increases tear secretion and relieves ocular discomfort in animal models .

HY-N7117

1,4-Cineole	TRP Channel Endogenous Metabolite	Inflammation/Immunology Cancer
1,4-Cineole is a widely distributed, natural, oxygenated monoterpene . 1,4-Cineole, present in Rhododendron anthopogonoides, activates both human *TRPM8* and human TRPA1 .

HY-108449

Acoltremon 1 Publications Verification WS-12; AR-15512; AVX-012	TRP Channel	Cancer
Acoltremon (WS-12; AR-15512) is a potent and selective *TRPM8* agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .

HY-75161

(-)-Menthol 1 Publications Verification	TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-110199

TC-I 2014	TRP Channel	Neurological Disease
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC₅₀ values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models .

HY-N7117R

1,4-Cineole (Standard)	TRP Channel Endogenous Metabolite	Inflammation/Immunology Cancer
1,4-Cineole (Standard) is the analytical standard of 1,4-Cineole. This product is intended for research and analytical applications. 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene . 1,4-Cineole, present in Rhododendron anthopogonoides, activates both human TRPM8 and human TRPA1 .

HY-75161R

(-)-Menthol (Standard)	TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-19960

BCTC 4 Publications Verification	TRP Channel Insulin Receptor CGRP Receptor	Neurological Disease Metabolic Disease Cancer
BCTC is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects .

HY-19976

RN-1747 2 Publications Verification	TRP Channel	Cardiovascular Disease
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC₅₀ values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC₅₀ of 4 μM .

HY-160900

RN-1665	TRP Channel	Others
RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively .

HY-B0985A

Phenazopyridine 2 Publications Verification	TRP Channel	Neurological Disease
Phenazopyridine is a competitive SARM1 inhibitor, with IC₅₀ 145 μM. Phenazopyridine is a *TRPM8* antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-B0985

Phenazopyridine hydrochloride 2 Publications Verification	TRP Channel	Neurological Disease
Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC₅₀ 145 μM. Phenazopyridine hydrochlorideis a *TRPM8* antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .

HY-101507

Zerencotrep Maximum Cited Publications 10 Publications Verification Pico145; HC-608	TRP Channel	Cancer
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC₅₀s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

HY-W014394

Vanillyl butyl ether	TRP Channel Parasite	Infection Cardiovascular Disease
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether exhibits mutually inhibitory effects on mammalian TRPV1 and *TRPM8* channels. Vanillyl butyl ether shows repellency activity against Tribolium castaneum, T. confusum and L. bostrychophila. Vanillyl butyl ether acts as a mild warming agent, providing a warming sensation and enhancing blood circulation .

HY-B0985R

Phenazopyridine (hydrochloride) (Standard)	TRP Channel	Neurological Disease
Phenazopyridine (hydrochloride) (Standard) is the analytical standard of Phenazopyridine (hydrochloride). This product is intended for research and analytical applications. Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC₅₀ 145 μM. Phenazopyridine hydrochlorideis a *TRPM8* antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .

HY-15056

AMG 9090	TRP Channel	Inflammation/Immunology
AMG 9090 is characterized as a compound that acts as a partial agonist of rat TRPA1 channels, demonstrating pharmacological activity in pain and inflammation models. TRPA1 is pivotal in sensing reactive compounds, triggering pain responses in humans and rodents. AMG 9090, along with other trichloro(sulfanyl)ethyl benzamides (TCEB compounds), shows differential effects on human and rat TRPA1 channels: it acts as a potent antagonist of human TRPA1 activated by AITC and noxious cold, whereas it behaves as a partial agonist at rat TRPA1. This suggests AMG 9090's potential as a therapeutic agent targeting TRPA1-mediated pain and inflammation, with additional inhibitory activity against TRPM8 noted .

HY-B1173

(+)-Camphor D-(+)-Camphor; (1R)-(+)-Camphor	Bacterial	Neurological Disease Inflammation/Immunology Cancer
(+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, *TRPM8) and an inhibitor of TRPA1* channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-B1173R

(+)-Camphor (Standard) D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)	Bacterial	Neurological Disease Inflammation/Immunology Cancer
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, *TRPM8) and an inhibitor of TRPA1* channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-144372

TRPV1 antagonist 3	TRP Channel	Neurological Disease
TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC₅₀ of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7536

Voacangine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids	TRP Channel
Voacangine is an antagonist for TRPV1 and *TRPM8* but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to *TRPM8* (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced *TRPM8* activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-N7117

1,4-Cineole	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Ericaceae Plants Rhododendron anthopogonoides Maxim. Inflammation/Immunology Disease Research Fields Cancer	TRP Channel Endogenous Metabolite
1,4-Cineole is a widely distributed, natural, oxygenated monoterpene . 1,4-Cineole, present in Rhododendron anthopogonoides, activates both human *TRPM8* and human TRPA1 .

HY-75161

(-)-Menthol 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite Disease Research Fields Cancer	TRP Channel Endogenous Metabolite
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-75161R

(-)-Menthol (Standard)	Structural Classification Other Monoterpenes Human Gut Microbiota Metabolites Microorganisms Terpenoids Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite	TRP Channel Endogenous Metabolite
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-N8264

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Moringaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-W014394

Vanillyl butyl ether	Cardiovascular Disease Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	TRP Channel Parasite
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether exhibits mutually inhibitory effects on mammalian TRPV1 and *TRPM8* channels. Vanillyl butyl ether shows repellency activity against Tribolium castaneum, T. confusum and L. bostrychophila. Vanillyl butyl ether acts as a mild warming agent, providing a warming sensation and enhancing blood circulation .

HY-B1173

(+)-Camphor D-(+)-Camphor; (1R)-(+)-Camphor	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Plants Lauraceae Cinnamomum camphora Disease Research Fields	Bacterial
(+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, *TRPM8) and an inhibitor of TRPA1* channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-N7117R

1,4-Cineole (Standard)	Structural Classification Other Monoterpenes Terpenoids Ericaceae Plants Rhododendron anthopogonoides Maxim.	TRP Channel Endogenous Metabolite
1,4-Cineole (Standard) is the analytical standard of 1,4-Cineole. This product is intended for research and analytical applications. 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene . 1,4-Cineole, present in Rhododendron anthopogonoides, activates both human TRPM8 and human TRPA1 .

HY-B1173R

(+)-Camphor (Standard) D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)	Structural Classification Other Monoterpenes Terpenoids Source classification Plants Lauraceae Cinnamomum camphora	Bacterial
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, *TRPM8) and an inhibitor of TRPA1* channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

Cat. No.	Product Name	Chemical Structure

HY-N1369S1

Menthol-d2
Menthol-d₂ is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .

HY-N9484S

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81864

	TRPM8 Antibody (YA1609) LTrpC6; MGC2849; Transient receptor potential p8; Trp p8; TRPM8; TRPP8	WB, ICC/IF	Human, Mouse
	TRPM8 Antibody (YA1609) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1609), targeting TRPM8, with a predicted molecular weight of 128 kDa (observed band size: 128 kDa). TRPM8 Antibody (YA1609) can be used for WB, ICC/IF experiment in human, mouse background.

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Cat. No.	Product Name		Classification

HY-75161

(-)-Menthol 1 Publications Verification		Flavoring Agents
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-RS15118

TRPM8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TRPM8 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPM8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16771

Trpm8 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Trpm8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpm8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23211

Trpm8 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Trpm8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpm8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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TRPM8

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