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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

TREM2 Antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (1) Prostaglandin Receptor (1) Ser/Thr Kinase (1) TREM receptor (6)
By Research Areas:	Cancer (2) Inflammation/Immunology (4) Neurological Disease (2)

7

Inhibitors & Agonists

6

Inhibitory Antibodies

1

Antibodies

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) Antibody-Oligonucleotide Conjugates (AOCs) ADC Linker PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Anti-TREM2 Antibody (AL2p-58)	TREM receptor	Inflammation/Immunology
Anti-TREM2 Antibody (AL2p-58) is a humanized IgG1 monoclonal antibody that targets *TREM2*. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

PY314	TREM receptor	Inflammation/Immunology
PY314 is a humanized antibody expressed in CHO, targeting *TREM2*. PY314 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for PY314 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

AL002	TREM receptor	Neurological Disease
AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and a *TREM2* agonist antibody for use in neurological disease research .

Iluzanebart VGL101	Ser/Thr Kinase TREM receptor	Inflammation/Immunology
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) .

EOS006215 EOS-215	TREM receptor	Cancer
EOS006215 is a humanized monoclonal antibody inhibitor targeting *TREM-2. EOS006215 reprograms TREM2* ⁺ macrophages, significantly blocks their pleiotropic pro-tumoral functions and overcomes resistance. EOS215 decreases metastasis burden in orthotopic 4T1 triple negative breast cancer mice model and significantly inhibits tumor growth in anti-PD-1 resistant mice model. EOS006215 can be used to study advanced malignant solid neoplasm, such as triple negative breast cancer (TNBC) .

DNL-919 TAK-920	TREM receptor	Neurological Disease
DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting *TREM-2*. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

EP4 receptor antagonist 7	Prostaglandin Receptor Interleukin Related	Inflammation/Immunology Cancer
EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC₅₀ value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC₅₀ value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD ⁸⁺ T cells into tumors in a CT26 murine colon cancer model .

Cat. No.	Product Name	Target	Research Area

Anti-TREM2 Antibody (AL2p-58)	TREM receptor	Inflammation/Immunology
Anti-TREM2 Antibody (AL2p-58) is a humanized IgG1 monoclonal antibody that targets *TREM2*. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

PY314	TREM receptor	Inflammation/Immunology
PY314 is a humanized antibody expressed in CHO, targeting *TREM2*. PY314 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for PY314 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

AL002	TREM receptor	Neurological Disease
AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and a *TREM2* agonist antibody for use in neurological disease research .

Iluzanebart VGL101	Ser/Thr Kinase TREM receptor	Inflammation/Immunology
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) .

EOS006215 EOS-215	TREM receptor	Cancer
EOS006215 is a humanized monoclonal antibody inhibitor targeting *TREM-2. EOS006215 reprograms TREM2* ⁺ macrophages, significantly blocks their pleiotropic pro-tumoral functions and overcomes resistance. EOS215 decreases metastasis burden in orthotopic 4T1 triple negative breast cancer mice model and significantly inhibits tumor growth in anti-PD-1 resistant mice model. EOS006215 can be used to study advanced malignant solid neoplasm, such as triple negative breast cancer (TNBC) .

DNL-919 TAK-920	TREM receptor	Neurological Disease
DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting *TREM-2*. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Compare	Product Name	Application	Reactivity

	**TREM2 Antibody** 2 Publications Verification TREM2; TREM-2; TREM2a; TREM2b; TREM2c; triggering receptor expressed on myeloid cells 2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	TREM2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TREM2.

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