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Results for "

TGFα

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (1) PKC (1)
By Research Areas:	Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-165060

(±)2-(14,15-Epoxyeicosatrienoyl) glycerol (±)2-14,15-EG	DNA/RNA Synthesis	Metabolic Disease
(±)2-(14,15-Epoxyeicosatrienoyl) glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol activates the metalloprotease ADAM17, which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway .

HY-N16121

12-Deoxyphorbol 13-isobutyrate	PKC	Neurological Disease
12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research .

Cat. No.	Product Name

HY-L124

Anti-Prostate Cancer Compound Library	2,953 compounds
Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment. MCE offers a unique collection of 2,953 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

Anti-Prostate Cancer Compound Library

2,953 compounds

Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment.

MCE offers a unique collection of 2,953 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N16121

12-Deoxyphorbol 13-isobutyrate	Structural Classification Euphorbia triangularis Desf. Terpenoids Source classification Diterpenoids Euphorbiaceae Plants	PKC
12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research .

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