Search Result
Results for "
SUB1
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
312
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B0389S1
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Glucose-d<SUB>1SUB>; D-(+)-Glucose-d<SUB>1SUB>; Dextrose-d<SUB>1SUB>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
Cancer
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D-Glucose-d is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
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- HY-RS25282
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Rpo2tc1
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Small Interfering RNA (siRNA)
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Others
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Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Sub1 Rat Pre-designed siRNA Set A
Sub1 Rat Pre-designed siRNA Set A
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- HY-RS13999
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P15; PC4; p14
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Small Interfering RNA (siRNA)
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Others
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SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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SUB1 Human Pre-designed siRNA Set A
SUB1 Human Pre-designed siRNA Set A
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- HY-RS18793
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P9; P15; Pc4; Rpo2tc1
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Small Interfering RNA (siRNA)
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Others
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Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Sub1 Mouse Pre-designed siRNA Set A
Sub1 Mouse Pre-designed siRNA Set A
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- HY-RS00945
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LSC; GEF1; IMD62; LBCL2; SUB1.5; P115-RHOGEF
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Small Interfering RNA (siRNA)
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Others
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ARHGEF1 Human Pre-designed siRNA Set A contains three designed siRNAs for ARHGEF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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ARHGEF1 Human Pre-designed siRNA Set A
ARHGEF1 Human Pre-designed siRNA Set A
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- HY-P10215
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Parasite
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Infection
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Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively [1].
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- HY-B0389S3
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Glucose-d<SUB>1SUB>-1; D-(+)-Glucose-d<SUB>1SUB>-1; Dextrose-d<SUB>1SUB>-1
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Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-W016577S4
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- HY-W099504S2
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- HY-N0210S6
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- HY-41700S2
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- HY-N0378S5
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- HY-B0389S4
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Glucose-d<SUB>1SUB>-2; D-(+)-Glucose-d<SUB>1SUB>-2; Dextrose-d<SUB>1SUB>-2
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d1-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-B0389S7
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Glucose-d<SUB>1SUB>-3; D-(+)-Glucose-d<SUB>1SUB>-3; Dextrose-d<SUB>1SUB>-3
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Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-B0389S2
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Glucose-d<SUB>12SUB>-1; D-(+)-Glucose-d<SUB>12SUB>-1; Dextrose-d<SUB>12SUB>-1
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d12-12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-B0389S23
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Glucose-d<SUB>2SUB>-1; D-(+)-Glucose-d<SUB>2SUB>-1; Dextrose-d<SUB>2SUB>-1
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Endogenous Metabolite
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Metabolic Disease
Cancer
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D-Glucose-d2-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol
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- HY-B0389S8
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Glucose-d<SUB>1SUB>-4; D-(+)-Glucose-d<SUB>1SUB>-4; Dextrose-d<SUB>1SUB>-4
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-19696S2
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Tauroursodeoxycholic acid-d<SUB>4SUB>-1; TUDCA-d<SUB>4SUB>-1; UR 906-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
ERK
Caspase
Endogenous Metabolite
Apoptosis
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Cancer
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Tauroursodeoxycholate-d4-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
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- HY-B0228S7
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- HY-109037S2
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MYK461-d<SUB>1SUB>; SAR439152-d<SUB>1SUB>
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Isotope-Labeled Compounds
Myosin
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Cardiovascular Disease
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Mavacamten-d1 (MYK461-d1; SAR439152-d1) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
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- HY-Y0001S1
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Carboxycyclopropane-d<SUB>1SUB>; Cyclopropionic acid-d<SUB>1SUB>
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Isotope-Labeled Compounds
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Others
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Cyclopropane-1-carboxylic Acid-d1 is the deuterium labeled Cyclopropane-1-carboxylic Acid [1].
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- HY-B0763S2
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KC-404-d<SUB>7SUB>-1; AV-411-d<SUB>7SUB>-1; MN-166-d<SUB>7SUB>-1
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Phosphodiesterase (PDE)
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Inflammation/Immunology
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Ibudilast-d7-1 is the deuterium labeled Ibudilast [1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
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- HY-B0141S6
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- HY-B0511S
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- HY-B1411S1
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- HY-B0152S
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6-Aminopurine-d<SUB>1SUB>; Vitamin B4-d<SUB>1SUB>
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DNA/RNA Synthesis
Endogenous Metabolite
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Cancer
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Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis [1] .
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- HY-B0479S1
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Thiophenicol-d<SUB>3SUB>-1; Dextrosulphenidol-d<SUB>3SUB>-1
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Isotope-Labeled Compounds
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Infection
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Thiamphenicol-d3-1 (Thiophenicol-d3-1; Dextrosulphenidol-d3-1) is the deuterium-labeled Thiamphenicol (HY-B0479) [1]. Thiamphenicol (Thiophenicol)，a methyl-sulfonyl derivative of Chloramphenicol，is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit，leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative，Gram-positive aerobic and anaerobic bacteria) .
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- HY-23188
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Loratidine-d<SUB>5SUB>-1; SCH 29851-d<SUB>5SUB>-1
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Isotope-Labeled Compounds
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Others
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Loratadine-d5-1 is a deuterated labeled Loratadine (HY-17043). Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
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- HY-N2037AS1
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Norcoclaurine-d<SUB>4SUB>-1 hydrochloride; Demethyl-Coclaurine-d<SUB>4SUB>-1 hydrochloride
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Isotope-Labeled Compounds
MAP3K
MDM-2/p53
Apoptosis
ROS Kinase
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Infection
Cardiovascular Disease
Endocrinology
Cancer
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Higenamine-d4-1 (Norcoclaurine-d4-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases [1] .
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- HY-B0234S4
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E1-d<SUB>2SUB>-1; Oestrone-d<SUB>2SUB>-1
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
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Endocrinology
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Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells [1] .
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- HY-17043S2
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- HY-14648S5
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Hexadecadrol-d<SUB>3SUB>-1; Prednisolone F-d<SUB>3SUB>-1
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Isotope-Labeled Compounds
Antibiotic
Autophagy
Glucocorticoid Receptor
SARS-CoV
ADC Cytotoxin
Mitophagy
Complement System
Bacterial
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Cancer
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Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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- HY-14648S1
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- HY-14649S6
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Vitamin A acid-d<SUB>3SUB>-1; all-trans-Retinoic acid-d<SUB>3SUB>-1; ATRA-d<SUB>3SUB>-1
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Isotope-Labeled Compounds
RAR/RXR
PPAR
Endogenous Metabolite
Autophagy
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Metabolic Disease
Cancer
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Retinoic acid-d3-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha [1] .
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- HY-13966S
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2-DG-d<SUB>1SUB>; 2-Deoxy-D-arabino-hexose-d<SUB>1SUB>; D-Arabino-2-deoxyhexose-d<SUB>1SUB>
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Isotope-Labeled Compounds
Apoptosis
Hexokinase
HSV
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Cancer
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2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase [1] .
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- HY-100442S1
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ABR-215757-d<SUB>5SUB>-1; ABR 25757-d<SUB>5SUB>-1
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SARS-CoV
Isotope-Labeled Compounds
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Metabolic Disease
Inflammation/Immunology
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Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice [1] .
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- HY-70057S1
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FCE 26743-d<SUB>4SUB>-1; EMD 1195686-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
Monoamine Oxidase
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Neurological Disease
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Safinamide-d4-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 μM) over MAO-A (IC50=580 μM) [1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8?μM) than at resting (IC50=262?μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al .
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- HY-50898S3
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GW572016-d<SUB>4SUB>-1; GW2016-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
EGFR
Autophagy
Ferroptosis
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Cancer
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Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively [1].
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- HY-B0400S7
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Sorbitol-d<SUB>1SUB>-2; D-Glucitol-d<SUB>1SUB>-2
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Endogenous Metabolite
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Others
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D-Sorbitol-d-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
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- HY-G0016S1
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- HY-B0400S8
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Sorbitol-d<SUB>2SUB>-1; D-Glucitol-d<SUB>2SUB>-1
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Endogenous Metabolite
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Others
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D-Sorbitol-d2-1 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
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- HY-10162S3
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AZD2281-d<SUB>4SUB>-1; KU0059436-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
PARP
Autophagy
Mitophagy
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Cancer
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Olaparib-d4-1 (AZD2281-d4-1) is the deuterium labeled Olaparib (HY-10162). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator [1] .
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- HY-13593S1
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CB-1348-d<SUB>8SUB>-1; WR-139013-d<SUB>8SUB>-1
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Isotope-Labeled Compounds
DNA Alkylator/Crosslinker
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Cancer
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Chlorambucil-d8-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease [1] .
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- HY-B0801S4
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MDL-16455-d<SUB>3SUB>-1; Terfenadine carboxylate-d<SUB>3SUB>-1
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Histamine Receptor
Isotope-Labeled Compounds
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Inflammation/Immunology
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Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research [1] .
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- HY-10585S4
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VPA-d<SUB>4SUB>-1; 2-Propylpentanoic Acid-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
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Cancer
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Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches [1] .
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- HY-15592S2
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GSK-1265744-d<SUB>3SUB>-1; S/GSK1265744-d<SUB>3SUB>-1
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Isotope-Labeled Compounds
HIV Integrase
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Infection
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Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research [1]
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- HY-A0095S1
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BIMT-17-d<SUB>4SUB>-1; BIMT-17BS-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
5-HT Receptor
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Neurological Disease
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Flibanserin-d4-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD) [1] .
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- HY-W778692
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1-Linoleoyl-rac-glycerol-d<SUB>5SUB>; 1-Monolinolein-d<SUB>5SUB>
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Isotope-Labeled Compounds
Interleukin Related
Phospholipase
Apolipoprotein
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Metabolic Disease
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1-Linoleoyl Glycerol-d5 (1-Linoleoyl-rac-glycerol-d5; 1-Monolinolein-d5) is the deuterium labeled 1-Linoleoyl Glycerol (HY-111346). 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6) [1] .
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- HY-108506S2
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BIA 2-005-d<SUB>4SUB>-1; GP 47779-d<SUB>4SUB>-1
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Isotope-Labeled Compounds
Sodium Channel
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Neurological Disease
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Licarbazepine-d4-1 is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects [1].
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- HY-B1716S1
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L-5-HTP-d<SUB>3SUB>-1; Oxitriptan-d<SUB>3SUB>-1
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Endogenous Metabolite
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Metabolic Disease
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L-5-Hydroxytryptophan-d3-1 is the deuterium labeled L-5-Hydroxytryptophan [1]. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia .
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- HY-13331S2
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Cortexolone 17 alpha-propionate-d<SUB>5SUB>-1; Cortexolone 17α-propionate-d<SUB>5SUB>-1; CB-03-01-d<SUB>5SUB>-1
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Isotope-Labeled Compounds
Androgen Receptor
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Endocrinology
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Clascoterone-d5-1 (Cortexolone 17 alpha-propionate-d5-1) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist [1].
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- HY-B1659S3
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- HY-B0158S4
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- HY-B0389S18
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Glucose-13C<SUB>3SUB>-1; D-(+)-Glucose-13C<SUB>3SUB>-1; Dextrose-13C<SUB>3SUB>-1
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-B0389S25
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Glucose-13C,d<SUB>1SUB>; D-(+)-Glucose-13C,d<SUB>1SUB>; Dextrose-13C,d<SUB>1SUB>
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Endogenous Metabolite
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Metabolic Disease
Cancer
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D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
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- HY-B0492S
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- HY-141636S
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1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d<SUB>9SUB>-1; PAPC-d<SUB>9SUB>-1; PC(16:0/20:4)-d<SUB>9SUB>-1
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Isotope-Labeled Compounds
Endogenous Metabolite
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Cardiovascular Disease
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1-PalMitoyl-2-arachidoyllecithin-d9-1 (1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d9-1) is deuterium labeled 1-PalMitoyl-2-arachidoyllecithin. 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells [1].
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- HY-B0892S4
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- HY-W032013S3
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Octanol-d<SUB>5SUB>
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Calcium Channel
Endogenous Metabolite
Isotope-Labeled Compounds
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Others
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|
1-Octanol-d5 is deuterated labeled 1-Octanol (HY-W032013). 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents [1]. 1-Octanol is a highly attractive biofuel with diesel-like properties .
|
-
- HY-W032013S
-
|
Octanol-d<SUB>17SUB>
|
Calcium Channel
Endogenous Metabolite
|
Metabolic Disease
|
|
1-Octanol-d17 is the deuterium labeled 1-Octanol [1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .
|
-
- HY-W087024S
-
-
- HY-W032013S1
-
|
Octanol-d<SUB>2SUB>
|
Calcium Channel
Endogenous Metabolite
|
Metabolic Disease
|
|
1-Octanol-d2 is the deuterium labeled 1-Octanol [1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .
|
-
- HY-Y0308S
-
|
Exsiccated sodium phosphate-d<SUB>1SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
Phosphate dibasic-d2 (sodium) is the deuterium labeled Sodium phosphate dibasic [1].
|
-
- HY-W720915
-
|
1-Dodecylbenzene-d<SUB>5SUB>; 1-Phenyl-n-dodecane-d<SUB>5SUB>; 1-Phenyldodecane-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
N-Dodecylbenzene-d5 (1-Dodecylbenzene-d5; 1-Phenyl-n-dodecane-d5; 1-Phenyldodecane-d5) is the deuterium labeled N-Dodecylbenzene (HY-Y1052).
|
-
- HY-66008S1
-
|
N-Acetyl-5-aminosalicylic acid-d<SUB>3SUB>-1; N-Acetyl-ASA-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
Drug Metabolite
|
Inflammation/Immunology
Cancer
|
|
N-Acetyl mesalazine-d3-1 (N-Acetyl-5-aminosalicylic acid-d3-1) is deuterium labeled N-Acetyl mesalazine (HY-66008). N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer [1].
|
-
- HY-B0158S3
-
-
- HY-A0042S2
-
|
CGP 33101-15N,d<SUB>2SUB>-1; E 2080-15N,d<SUB>2SUB>-1; RUF 331-15N,d<SUB>2SUB>-1
|
Isotope-Labeled Compounds
Sodium Channel
|
Neurological Disease
|
|
Rufinamide- 15N,d2-1 (CGP 33101- 15N,d2-1) is 15N- and deuterium-labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na + current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome [1] .
|
-
- HY-Y1004S4
-
-
- HY-B0111S1
-
-
- HY-N0131S1
-
-
- HY-N0210S5
-
-
- HY-Y1004S3
-
-
- HY-122426S1
-
-
- HY-N0717S8
-
-
- HY-124891S
-
|
N-Phenylpyrrole-d<SUB>9SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Phenylpyrrole-d9 (N-Phenylpyrrole-d9) is the deuterium labeled 1-Phenylpyrrole (HY-124891). 1-Phenylpyrrole (N-Phenylpyrrole) has dual fluorescent properties. 1-Phenylpyrrole displays a single band in nonpolar solvents and a second red-shifted fluorescent band in polar solvents [1].
|
-
- HY-W004263S
-
|
Arachidyl alcohol-d<SUB>41SUB>
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
1-Eicosanol-d41 (Arachidyl alcohol-d41) is the deuterium labeled 1-Eicosanol (HY-W004263) [1]. 1-Eicosanol is a natural compound with antioxidant activity found in Justicia insularis leaves. 1-Eicosanol can be used as an antioxidant .
|
-
- HY-W004293S
-
-
- HY-W004292S1
-
|
Undecyl alcohol-d<SUB>4SUB>
|
Isotope-Labeled Compounds
Drug Derivative
Insecticide
|
Infection
|
|
1-Undecanol-d4 (Undecyl alcohol-d4) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps [1] .
|
-
- HY-152070S1
-
-
- HY-135810S1
-
|
Desethylhydroxychloroquine-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
Influenza Virus
Parasite
|
Infection
Inflammation/Immunology
|
|
Cletoquine-d4-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment [1] .
|
-
- HY-W004292S
-
|
Undecyl alcohol-d<SUB>23SUB>
|
Isotope-Labeled Compounds
Drug Derivative
Insecticide
|
Infection
|
|
1-Undecanol-d23 (Undecyl alcohol-d23) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps [1] .
|
-
- HY-B0412S4
-
-
- HY-90006S
-
|
5-FU-d<SUB>1SUB>
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
HIV
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer [1] . 5-Fluorouracil also inhibits HIV .
|
-
- HY-B0122SS1
-
-
- HY-18341S4
-
|
Levothyroxine-13C<SUB>6SUB>-1; T4-13C<SUB>6SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
Thyroid Hormone Receptor
|
Endocrinology
|
|
L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) [1] .
|
-
- HY-Y1139S
-
|
Heptanedioic acid-d<SUB>4SUB>; 1,5-Pentanedicarboxylic acid-d<SUB>4SUB>; 1,7-Heptanedioic acid-d<SUB>4SUB>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Pimelic acid-d4 is the deuterium labeled Pimelic acid [1]. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.
|
-
- HY-113139S
-
-
- HY-17386S2
-
-
- HY-W032013S2
-
|
Octanol-d<SUB>2SUB>-1
|
Calcium Channel
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
|
1-Octanol-d2-1 is deuterated labeled 1-Octanol (HY-W032013). 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents [1]. 1-Octanol is a highly attractive biofuel with diesel-like properties .
|
-
- HY-13956A
-
|
(R)-U 72107-d<SUB>1SUB>
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
(R)-Pioglitazone-d1 ((R)-U 72107-d1) is a stabilized and deuterated R-enantiomer of pioglitazone, exhibiting pharmacological properties that are beneficial for NASH treatment, including modulation of mitochondrial function, non-steroidal anti-inflammatory effects, and glucose-lowering capabilities.
|
-
- HY-145119AS
-
|
VV116; GS-621763-d<SUB>1SUB> hydrobromide
|
SARS-CoV
RSV
Influenza Virus
|
Infection
|
|
Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 [1] .
|
-
- HY-113136S
-
|
N1-Methylguanosine-d<SUB>3SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
1-Methylguanosine-d3 (N1-Methylguanosine-d3) is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker [1] .
|
-
- HY-B0901S1
-
-
- HY-153939S
-
|
RG7388-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
|
Cancer
|
|
Idasanutlin-d3-1 (RG7388-d3-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia [1] .
|
-
- HY-19822S1
-
|
RAD1901-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Cancer
|
|
Elacestrant-d4-1 is the deuterium labeled Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively [1] .
|
-
- HY-W032015S3
-
-
- HY-B0114S1
-
|
GP 47680-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
Sodium Channel
Apoptosis
|
Neurological Disease
Cancer
|
|
Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker [1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .
|
-
- HY-N1380S4
-
|
2-Methoxyphenol-d<SUB>4SUB>-1
|
COX
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Guaiacol-d4-1 is the deuterium labeled Guaiacol [1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation [1]. Anti-inflammatory activity .
|
-
- HY-W101642S
-
-
- HY-76025S
-
|
p-Dibromobenzene-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
1,4-Dibromobenzene-d4 is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans [1].
|
-
- HY-W752616
-
|
Monoisopropanolamine-d<SUB>6SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
1-Aminopropan-2-ol-d6 (Monoisopropanolamine-d6) is the deuterium labeled 1-Aminopropan-2-ol (HY-W015969). 1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas [1].
|
-
- HY-12987S2
-
-
- HY-W711089
-
|
MC-4379-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
Herbicide
|
Others
|
|
Bifenox-d3-1 (Modown-d3; MC-4379-d3) is the deuterium labeled Bifenox (HY-136513). Bifenox (Modown; MC-4379) is a potent herbicide. Bifenox increases the ROS production. Bifenox causes cellular membrane disruption, inhibition of photosynthesis [1].
|
-
- HY-B0113S1
-
|
H 16868-d<SUB>3SUB>-1
|
Proton Pump
Autophagy
Bacterial
Phospholipase
|
Infection
Metabolic Disease
Cancer
|
|
Omeprazole-d3-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM [1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
|
-
- HY-B0561S2
-
-
- HY-W016577S3
-
-
- HY-B0258S1
-
-
- HY-145119S
-
|
VV116 free base; GS-621763-d<SUB>1SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119) [1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .
|
-
- HY-B0223S4
-
|
SKF-62979-d<SUB>3SUB>-1
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Albendazole-d3-1 (SKF-62979-d3-1) is the deuterium labeled Albendazole (HY-B0223). Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells [1] .
|
-
- HY-14281S2
-
-
- HY-B0196S1
-
-
- HY-W099521S
-
-
- HY-15917S1
-
|
DTTl-d<SUB>10SUB>-1
|
Isotope-Labeled Compounds
Disulfidptosis
|
Cancer
|
|
DL-dithiothreitol-d10-1 is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond [1] .
|
-
- HY-B0451AS3
-
-
- HY-B0740S3
-
|
MK130-d<SUB>3SUB>-1 hydrochloride
|
Isotope-Labeled Compounds
5-HT Receptor
Parasite
|
Infection
Neurological Disease
|
|
Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases [1]
|
-
- HY-17376S1
-
|
SCH 58235-d<SUB>4SUB>-1
|
Keap1-Nrf2
Autophagy
|
Cardiovascular Disease
Cancer
|
|
Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
|
-
- HY-15780S1
-
|
OPC-34712-d<SUB>8SUB>-1
|
Isotope-Labeled Compounds
Dopamine Receptor
Adrenergic Receptor
5-HT Receptor
|
Neurological Disease
|
|
Brexpiprazole-d8-1 (OPC-34712-d8-1) is the deuterium labeled Brexpiprazole (HY-15780) [1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM) .
|
-
- HY-13678S1
-
|
SM 7338-d<SUB>6SUB>-1
|
Bacterial
Antibiotic
|
Infection
|
|
Meropenem-d6-1 (SM 7338-d6-1) is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) [1].
|
-
- HY-10846S1
-
|
OPC-67683-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
|
Cancer
|
|
Delamanid-d4-1 is deuterated labeled Delamanid.Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids [1].
|
-
- HY-14956S1
-
|
TG-873870-d<SUB>3SUB>-1
|
Bacterial
|
Inflammation/Immunology
|
|
Nemonoxacin-d3-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia [1] .
|
-
- HY-17430S1
-
-
- HY-B0197S
-
|
GR-85548A-d<SUB>3SUB>-1
|
5-HT Receptor
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
Naratriptan-d3 (GR-85548A-d3) is the deuterium labeled Naratriptan (HY-B0197). Naratriptan is a selective 5-HT1B/1D receptor agonist. Naratriptan is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors (EC50=0.11 μM for dog basilar artery). Naratriptan also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. Naratriptan is mainly used in the research of acute migraine, targeting cranial vascular and neuroinflammatory mechanisms [1] .
|
-
- HY-W014559S3
-
-
- HY-W099504S1
-
-
- HY-10284S3
-
-
- HY-W014286S
-
-
- HY-W654010
-
|
SM-13496-d<SUB>8SUB>-1 hydrochloride
|
Isotope-Labeled Compounds
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Lurasidone-d8-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM [1].
|
-
- HY-B1565S
-
-
- HY-122272S2
-
-
- HY-W012477S
-
|
Photoinitiator-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Hydroxycyclohexyl phenyl ketone-d5 (Photoinitiator-184-d5) is the deuterium labeled 1-Hydroxycyclohexyl phenyl ketone (HY-W012477) [1].
|
-
- HY-Y0921S1
-
|
1,2-(RS)-Propanediol-d<SUB>2SUB>; 1,2-Propylene glycol-d<SUB>2SUB>; Propylene glycol-d<SUB>2SUB>
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Neurological Disease
|
|
(±)-1,2-Propanediol-d2 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
|
-
- HY-Y0921S
-
|
1,2-(RS)-Propanediol-d<SUB>8SUB>; 1,2-Propylene glycol-d<SUB>8SUB>; Propylene glycol-d<SUB>8SUB>
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Neurological Disease
|
|
(±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
|
-
- HY-Y0921S2
-
|
1,2-(RS)-Propanediol-d<SUB>6SUB>; 1,2-Propylene glycol-d<SUB>6SUB>; Propylene glycol-d<SUB>6SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
|
(±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
|
-
- HY-W765245
-
|
Sirolimus-13C,d<SUB>3SUB>-1; AY-22989-13C,d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
Fungal
mTOR
Bacterial
Autophagy
Endogenous Metabolite
FKBP
Antibiotic
|
Cancer
|
|
Rapamycin- 13C,d3-1 (Sirolimus- 13C,d3-1) is the deuterium labeled and 13C-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 [1]. Rapamycin is an autophagy activator, an immunosuppressant .
|
-
- HY-41676S
-
|
1-Chloro-4-benzonitrile-d<SUB>4SUB>; 1-Chloro-4-cyanobenzene-d<SUB>4SUB>; 1-Cyano-4-chlorobenzene-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
4-Chlorobenzonitrile-d4 is the deuterium labeled 4-Chlorobenzonitrile [1].
|
-
- HY-Y0678S
-
|
Trimethyl phloroglucinol-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
1,3,5-Trimethoxybenzene-d3 (Trimethyl phloroglucinol-d3) is the deuterium labeled 1,3,5-Trimethoxybenzene (HY-Y0678). 1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor [1].
|
-
- HY-N1429S2
-
|
12-Deoxycholyltaurine-d<SUB>4SUB>-1 sodium
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties [1] .
|
-
- HY-W004051S
-
-
- HY-W013049S4
-
|
Behenic acid-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Metabolic Disease
Cancer
|
|
Docosanoic acid-d4-1 (Behenic acid-d4-1) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans [1] .
|
-
- HY-N7092S18
-
-
- HY-W130478S
-
-
- HY-W865379
-
-
- HY-W012856S
-
-
- HY-13631ES2
-
|
MC-GGFG-DXD-d<SUB>4SUB>-1
|
Drug-Linker Conjugates for ADC
Isotope-Labeled Compounds
|
Others
|
|
Deruxtecan-d4-1 is the deuterium labeled Adenosine Deruxtecan (HY-13631E) [1]. Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
|
-
- HY-B0228S
-
-
- HY-N0384S4
-
|
Vanilacetic acid-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency [1].
|
-
- HY-N0210S11
-
-
- HY-B1812S4
-
|
1,2-Dimethoxybenzene-d<SUB>2SUB>-1
|
Isotope-Labeled Compounds
Cytochrome P450
|
Others
|
|
Veratrole-d2-1 is the deuterium labeled Veratrole (HY-B1812). Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii [1] .
|
-
- HY-W142175S
-
|
1-Phenyl-1-butyne-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Butynylbenzene-d5 is the deuterium labeled 1-Butynylbenzene [1]. 1-Butynylbenzene-d5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N0210S7
-
-
- HY-W016931S
-
-
- HY-W017554S
-
-
- HY-N0210S8
-
-
- HY-W015849S
-
-
- HY-W017522S5
-
|
Hexanedioic acid-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
HSV
|
Infection
Metabolic Disease
|
|
Adipic acid-d4-1 (Hexanedioic acid-d4-1) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc [1] .
|
-
- HY-34487S3
-
|
Resorcinol dimethyl ether-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,3-Dimethoxybenzene-d3 (Resorcinol dimethyl ether-d3) is the deuterium labeled 1,3-Dimethoxybenzene (HY-34487). 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds [1].
|
-
- HY-109506S3
-
|
129Y83-d<SUB>9SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
DPPC-d9-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers [1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice .
|
-
- HY-66011AS3
-
|
BAY 12-8039-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Moxifloxacin-d3-1 hydrochloride (BAY 12-8039-d3-1) is a deuterium labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia [1] .
|
-
- HY-W719338
-
|
(±)-Pentane-1,2-diol<SUB>7SUB>; 1,2-Dihydroxypentane<SUB>7SUB>; 1,2-Pentylene glycol<SUB>7SUB>; Diol PD<SUB>7SUB>; Hydrolite 5<SUB>7SUB>; NSC 513<SUB>7SUB>; 1,2-Pentanediol<SUB>7SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
Pentane-1,2-diol-d7 ((±)-Pentane-1,2-diol-d7; 1,2-Dihydroxypentane-d7; 1,2-Pentylene glycol-d7; Diol PD-d7; Hydrolite 5-d7; NSC 513-d7; 1,2-Pentanediol-d7) is the deuterium labeled Pentane-1,2-diol (HY-Y1249).
|
-
- HY-15025S2
-
|
UK-92480-d<SUB>3SUB>N<SUB>-1
|
Phosphodiesterase (PDE)
|
Cancer
|
|
Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
|
-
- HY-W094751S
-
-
- HY-W052227S
-
-
- HY-W700931
-
|
Dimethylcarbitol-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Methoxy-2-(2-methoxyethoxy)ethane-d6 (Dimethylcarbitol-d6) is the deuterium labeled 1-Methoxy-2-(2-methoxyethoxy)ethane (HY-Y1227).
|
-
- HY-W016152S
-
|
m-Methoxyphenyl bromide-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-3-methoxybenzene-d3 is the deuterium labeled 1-Bromo-3-methoxybenzene. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified [1].
|
-
- HY-114041S1
-
|
RvE1-d<SUB>4SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production [1] .
|
-
- HY-W342440S
-
-
- HY-107343S1
-
|
Ethyl docosahexaenoate-d<SUB>5SUB>-1
|
Isotope-Labeled Compounds
|
Others
|
|
Docosahexaenoic acid ethyl ester-d5-1 is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects [1] .
|
-
- HY-W725429
-
|
Naphthalene-1,5-diol-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,5-Dihydroxynaphthalene-d6 (Naphthalene-1,5-diol-d6) is the deuterium labeled 1,5-Dihydroxynaphthalene (HY-Y0825).
|
-
- HY-Y1805S
-
|
Tetralin solvent-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4-Tetrahydronaphthalene-d4 (Tetralin solvent-d4) is the deuterium labeled 1,2,3,4-Tetrahydronaphthalene (HY-Y1805) [1].
|
-
- HY-W712592
-
|
N-Ethylsuccinimide-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Ethylpyrrolidine-2,5-dione-d5 (N-Ethylsuccinimide-d5) is the deuterium labeled 1-Ethylpyrrolidine-2,5-dione (HY-W353513).
|
-
- HY-W699416
-
|
Naphthalene-1-carboxylic acid-d<SUB>7SUB>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
1-Naphthoic acid-d7 (Naphthalene-1-carboxylic acid-d7) is the deuterium labeled 1-Naphthoic acid (HY-Y0236). Naphthalene-1-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W012934S
-
|
N-Ethyl-pyrrolidone-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Ethylpyrrolidin-2-one-d5 (N-Ethyl-pyrrolidone-d5) is deuterium labeled 1-Ethylpyrrolidin-2-one [1].
|
-
- HY-112530S
-
|
DSPE-d<SUB>70SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis
|
-
- HY-W011883S
-
|
3,5-DIBROMOFLUOROBENZENE-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,3-Dibromo-5-fluorobenzene-d3 is the deuterium labeled 1,3-Dibromo-5-fluorobenzene [1].
|
-
- HY-128429S
-
|
(E)-2-Hexenal-d<SUB>2SUB>-1
|
Isotope-Labeled Compounds
Fungal
Biochemical Assay Reagents
|
Infection
|
|
trans-2-Hexenal-d2-1 is the deuterium labeled trans-2-Hexenal (HY-128429). trans-2-Hexenal ((E)-2-Hexenal) is a volatile compound widely present in fresh plants, vegetables, and fruits, with a unique leafy aroma. trans-2-Hexenal has antifungal activity and can also inhibit the germination of soybean seeds and the growth of seedlings. In addition, trans-2-Hexenal can be used to determine low-molecular-weight carbonyl compounds that are reactive with biological nucleophiles in biological samples [1].
|
-
- HY-W740373
-
|
N-Methyl-4-piperidinol-d<SUB>4SUB>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
1-Methylpiperidin-4-ol-d4 (N-Methyl-4-piperidinol-d4) is the deuterium labeled 1-Methylpiperidin-4-ol (HY-W018626). 1-Methylpiperidin-4-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N0215S13
-
|
(S)-2-Amino-3-phenylpropionic acid-d<SUB>1SUB>
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals [1] .
|
-
- HY-W131797
-
-
- HY-W009719S
-
|
2,3-DICHLOROBROMOBENZENE-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-2,3-dichlorobenzene-d3 is the deuterium labeled 1-Bromo-2,3-dichlorobenzene [1].
|
-
- HY-113482S
-
-
- HY-Y0566S
-
|
Triethylenediamine-d<SUB>12SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,4-Diazabicyclo[2.2.2]octane-d12 is the deuterium labeled 1,4-Diazabicyclo[2.2.2]octane [1].
|
-
![1,4-Diazabicyclo[2.2.2]octane-d12](//file.medchemexpress.eu/product_pic/hy-y0566s.gif)
- HY-W654320
-
-
- HY-11018S1
-
-
- HY-113424AS
-
|
DOPC-d<SUB>9SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
1,2-Dioleoyl-sn-glycero-3-phosphocholine-d9 is deuterium labeled 1,2-Dioleoyl-sn-glycero-3-phosphocholine. 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid and is commonly used alone, or with other components, in the generation of micelle
|
-
- HY-W011885S
-
|
N-Lauryl-2-pyrrolidone-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Dodecylpyrrolidin-2-one-d6 (N-Lauryl-2-pyrrolidone-d6) is deuterium-labeled 1-Dodecylpyrrolidin-2-one (HY-W011885) [1].
|
-
- HY-N9933S
-
-
- HY-W716213
-
|
2',4'-Dimethoxyacetophenone-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(2,4-Dimethoxyphenyl)ethanone-d6 (2',4'-Dimethoxyacetophenone-d6) is the deuterium labeled 1-(2,4-Dimethoxyphenyl)ethanone (HY-W040456).
|
-
- HY-W009981S
-
|
2,4-Difluorobromobenzene-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-2,4-difluorobenzene-d3 is the deuterium labeled 1-Bromo-2,4-difluorobenzene [1].
|
-
- HY-79779S1
-
|
α,4-Dibromotoluene-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-4-(bromomethyl)benzene-d4 is the deuterium labeled 1-Bromo-4-(bromomethyl)benzene [1].
|
-
- HY-130462S1
-
|
POPC-d<SUB>82SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d82 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for
|
-
- HY-W654353
-
|
T-α-MCA-d<SUB>4SUB>-1 sodium
|
Isotope-Labeled Compounds
FXR
Endogenous Metabolite
|
Others
|
|
Tauro-α-muricholic acid-d4-1 (sodium) is deuterium labeled Tauro-α-muricholic acid (sodium). Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal [1] .
|
-
- HY-B0402S
-
|
1-Adamantanamine-d<SUB>15SUB>; 1-Aminoadamantane-d<SUB>15SUB>
|
Influenza Virus
Orthopoxvirus
SARS-CoV
Apoptosis
|
Infection
Neurological Disease
Cancer
|
|
Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent [1] .
|
-
- HY-W768340
-
|
D-(+)-Saccharose-13C<SUB>6SUB>-1
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al [1].
|
-
- HY-B0228S8
-
-
- HY-B0402S1
-
|
1-Adamantanamine-d<SUB>6SUB>; 1-Aminoadamantane-d<SUB>6SUB>
|
Apoptosis
CDK
SARS-CoV
Bcl-2 Family
Influenza Virus
Orthopoxvirus
|
Cancer
|
|
Amantadine-d6 is the deuterium labeled Amantadine [1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
|
-
- HY-W017142S
-
|
3-(Benzyloxy)-2-propanol-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(Benzyloxy)propan-2-ol-d6 (3-(Benzyloxy)-2-propanol-d6) is the deuterium labeled 1-(Benzyloxy)propan-2-ol (HY-W017142).
|
-
- HY-130462S
-
|
POPC-d<SUB>31SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d31 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for
|
-
- HY-79779S
-
|
α,4-Dibromotoluene-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-4-(bromomethyl)benzene-d6 is the deuterium labeled 1-Bromo-4-(bromomethyl)benzene [1].
|
-
- HY-B0762S1
-
|
O-Acetyl-L-carnitine-d<SUB>3SUB>-1 hydrochloride
|
Isotope-Labeled Compounds
Caspase
Apoptosis
|
Neurological Disease
|
|
Acetyl-L-carnitine-d3-1 (O-Acetyl-L-carnitine-d3-1) hydrochloride is the deuterium labeled Acetyl-L-carnitine hydrochloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression [1] .
|
-
- HY-W015784S
-
-
- HY-W700950
-
|
1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(4-Chlorophenyl)cyclobutanecarbonitrile-d6 (1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile-d6) is the deuterium labeled 1-(4-Chlorophenyl)cyclobutanecarbonitrile (HY-W010002).
|
-
- HY-W097453S2
-
-
- HY-W1115209
-
|
2,4,6-Tribromoiodobenzene-d<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,3,5-Tribromo-2-iodobenzene-d2 (2,4,6-Tribromoiodobenzene-d2) is a deuterium labeled 1,3,5-Tribromo-2-iodobenzene.
|
-
- HY-W110726S1
-
-
- HY-W014431S
-
|
3-Fluoro-5-bromochlorobenzene-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-3-chloro-5-fluorobenzene-d3 is the deuterium labeled 1-Bromo-3-chloro-5-fluorobenzene [1].
|
-
- HY-W015824S3
-
-
- HY-N0210S12
-
-
- HY-W013376S
-
|
1-(Diphenylmethyl)piperazine-d<SUB>8SUB>; 1-Benzhydrylpiperazine-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Norcyclizine-d8 is the deuterium labeled Norcyclizine [1].
|
-
- HY-W110726S
-
-
- HY-W777094
-
|
Tetraethoxy C methyl propane-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Acetyl-4-(4-hydroxyphenyl)piperazine-d8 (Tetraethoxy C methyl propane-d8) is the deuterium labeled 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone (HY-W014037).
|
-
- HY-W105111S
-
|
2,3,5-Trichlorobromobenzene-d<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-2,3,5-trichlorobenzene-d2 is the deuterium labeled 1-Bromo-2,3,5-trichlorobenzene [1].
|
-
- HY-N7092S23
-
|
D(-)-Fructose-13C<SUB>3SUB>-1
|
Isotope-Labeled Compounds
|
Others
|
|
D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-B0151S2
-
|
3β-Hydroxy-5-pregnen-20-one-d<SUB>4SUB>-1
|
Cannabinoid Receptor
TRP Channel
Endogenous Metabolite
Autophagy
|
Neurological Disease
|
|
Pregnenolone-d4-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication [1] . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .
|
-
- HY-Y0921S3
-
|
1,2-(RS)-Propanediol-13C<SUB>3SUB>; 1,2-Propylene glycol-13C<SUB>3SUB>; Propylene glycol-13C<SUB>3SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
|
(±)-1,2-Propanediol- 13C3 is 13C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish [1] .
|
-
- HY-Y0219S1
-
-
- HY-B0896S1
-
|
Glyceryl triacetate-d<SUB>5SUB>; 1,2,3-Triacetoxypropane-d<SUB>5SUB>
|
Isotope-Labeled Compounds
Fungal
Endogenous Metabolite
|
Others
|
|
Triacetin-d5 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
|
-
- HY-W013504S
-
|
4-Bromo-α,α,α-trifluorotoluene-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-4-(trifluoromethyl)benzene-d4 is the deuterium labeled 1-Bromo-4-(trifluoromethyl)benzene [1].
|
-
- HY-B0896S2
-
|
Glyceryl triacetate-d<SUB>9SUB>; 1,2,3-Triacetoxypropane-d<SUB>9SUB>
|
Fungal
Endogenous Metabolite
|
Others
|
|
Glyceryl Triacetate-d9 is the deuterium labeled Triacetin [1]. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
|
-
- HY-115702S
-
|
PAF C-16-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine-d4 is the deuterium labeled 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine [1].
|
-
- HY-Y1275S
-
|
NMP-d<SUB>9SUB>; 1-Methyl-2-pyrrolidinone-d<SUB>9SUB>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Cancer
|
|
N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals [1] .
|
-
- HY-W192474S
-
-
- HY-Y0743S
-
-
- HY-W013948S
-
|
Propanal, (2,4-dinitrophenyl)hydrazone-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(2,4-Dinitrophenyl)-2-propylidenehydrazine-d3 is the deuterium labeled 1-(2,4-Dinitrophenyl)-2-propylidenehydrazine [1].
|
-
- HY-W654409
-
|
Hexafluoroisopropyl alcohol-d<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,1,1,3,3,3-Hexafluoropropan-2-ol-d2 (Hexafluoroisopropyl alcohol-d2) is deuterium labeled 1,1,1,3,3,3-Hexafluoropropan-2-ol [1].
|
-
- HY-114293S4
-
|
Acetyl-CoA-13C<SUB>2SUB>-1 sodium
|
Isotope-Labeled Compounds
Autophagy
Endogenous Metabolite
Oxidative Phosphorylation
|
Cardiovascular Disease
|
|
Acetyl coenzyme A- 13C2-1 sodium (Acetyl-CoA- 13C2-1 sodium) is the 13C-labeled Acetyl coenzyme A (HY-114293). Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis [1] .
|
-
- HY-W009293S
-
|
N-(4,4-Difluorobenzhydryl)piperazine-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(Bis(4-fluorophenyl)methyl)piperazine-d4 (N-(4,4-Difluorobenzhydryl)piperazine-d4) is the deuterium labeled 1-(Bis(4-fluorophenyl)methyl)piperazine.
|
-
- HY-W777599
-
|
(Rac)-Naproxen-13C,d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
|
Others
|
|
(±)-Naproxen- 13C,d3-1 ((Rac)-Naproxen- 13C,d3-1) is 13C and deuterium labeled (±)-Naproxen [1].
|
-
- HY-122426S2
-
|
Undecyl bromide-d<SUB>4SUB>; undecane, 1-bromo-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromoundecane-d4 is the deuterium labeled 1-Bromoundecane [1].
|
-
- HY-W756596
-
|
3-Chloropropane-1,2-diyl dioctanoate-d<SUB>5SUB>
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
1,2-Dioctanoyl-3-chloropropanediol-d5 is deuterium labeled 1,2-Dioctanoyl-3-chloropropanediol. 1,2-Dioctanoyl-3-chloropropanediol (3-Chloropropane-1,2-diyl dioctanoate) is an ester product [1].
|
-
- HY-W012652S
-
|
Quinoxaline, 1,2,3,4-tetrahydro-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4-Tetrahydroquinoxaline-d4 (Quinoxaline, 1,2,3,4-tetrahydro-d4) is the deuterium labeled 1,2,3,4-Tetrahydroquinoxaline.
|
-
- HY-145473S
-
|
15(S)-HETE-SAPE; 15(S)-Hydroxyeicosatetraenoic acid-SAPE-d<SUB>11SUB>; 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d<SUB>11SUB>
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 (15(S)-HETE-SAPE-d11) is deuterium labeled 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 (HY-N6687) by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes [1].
|
-
- HY-Y0531S
-
-
- HY-N0537S12
-
-
- HY-146829S
-
|
15:0-18:1-PA-d<SUB>7SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate-d7 (sodium) is deuterium labeled 1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate (sodium).
|
-
- HY-N0229S4
-
|
L-2-Aminopropionic acid-13C,d<SUB>1SUB>
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-Alanine- 13C,d is the 13C- and deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-D0837S
-
|
Glyoxaline-d<SUB>4SUB>; 1,3-Diaza-2,4-cyclopentadiene-d<SUB>4SUB>
|
Endogenous Metabolite
|
Others
|
|
Imidazole-d4 is the deuterium labeled Imidazole [1].
|
-
- HY-N0537S13
-
-
- HY-10003S
-
|
1-hydroxycholecalciferol-d<SUB>7SUB>; 1.alpha.-Hydroxyvitamin D3-d<SUB>7SUB>
|
Isotope-Labeled Compounds
VD/VDR
|
Metabolic Disease
|
|
Alfacalcidol-d7 is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis [1] .
|
-
- HY-W754348
-
|
1-(2,6-Dimethylphenoxy)acetone-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(2,6-Dimethylphenoxy)propan-2-one-d5 (1-(2,6-Dimethylphenoxy)acetone-d5) is the deuterium labeled 1-(2,6-Dimethylphenoxy)propan-2-one (HY-W270592).
|
-
- HY-15029S1
-
-
- HY-W768181
-
-
- HY-16504S
-
-
- HY-142555S
-
|
Sodium 4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl sulfate-d<SUB>6SUB> (1:1)
|
Isotope-Labeled Compounds
|
Others
|
|
Bisphenol A monosulfate-d6 (sodium) is the deuterium labeled Bisphenol A monosulfate sodium [1].
|
-
- HY-100441S1
-
-
- HY-W654074
-
|
1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate-d<SUB>5SUB>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Metabolic Disease
|
|
1,2-Dilauroyl-3-chloropropanediol-d5 (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate-d5) is the deuterium labeled 1,2-Dilauroyl-3-chloropropanediol (HY-W587507). 1,2-Dilauroyl-3-chloropropanediol (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate) is an ester product.
|
-
- HY-W010265S
-
|
1-Phenylbutan-1-one-d<SUB>5SUB>; 1-Phenyl-1-butanone-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
Butyrophenone-d5 is the deuterium labeled Butyrophenone [1].
|
-
- HY-W767978
-
|
6-Acetyl-4,4-dimethylthio-chroman-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(4,4-Dimethylthiochroman-6-yl)ethanone-d8 (6-Acetyl-4,4-dimethylthio-chroman-d8) is the deuterium labeled 1-(4,4-Dimethylthiochroman-6-yl)ethanone (HY-I0187).
|
-
- HY-W770203
-
|
DG(18:1/0:0/18:2)-d<SUB>5SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
1-Oleoyl-2-linoleoyl-rac-glycerol-d5 (DG(18:1/0:0/18:2)-d5) is the deuterium labeled 1-Oleoyl-2-linoleoyl-rac-glycerol (HY-W777107). 1-Oleoyl-2-linoleoyl-rac-glycerol (DG(18:1/0:0/18:2)) is a diacylglycerol, which is composed of a linoleic acid and an oleic acid. 1-Oleoyl-2-linoleoyl-rac-glycerol can be found in dry-cured ham, and acts as the food additive [1].
|
-
- HY-B0456S1
-
|
Vitamin B2-13C<SUB>4SUB>,15N<SUB>2SUB>-1; E101-13C<SUB>4SUB>,15N<SUB>2SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-109541S2
-
|
DMPC-d<SUB>9SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>9SUB>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Colfosceril miristate-d9 (DMPC-d9) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-W101971S
-
|
1-(4-Chlorophenyl)-2-methyl-2-propanol-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(4-Chlorophenyl)-2-methylpropan-2-ol-d6 (1-(4-Chlorophenyl)-2-methyl-2-propanol-d6) is the deuterium labeled 1-(4-Chlorophenyl)-2-methylpropan-2-ol (HY-W101971).
|
-
- HY-Y1039S
-
|
1-Monostearin-d<SUB>40SUB>; 2,3-dihydroxypropyl stearate-d<SUB>40SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Stearoyl-rac-glycerol-d40 is the deuterium labeled 1-Stearoyl-rac-glycerol [1].
|
-
- HY-109541S5
-
|
DMPC-d<SUB>67SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>67SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-W743123
-
|
1,3-Dipalmitoylglycerol-d<SUB>5SUB>; Glycerol 1,3-dipalmitate-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,3-Dipalmitin-d5 (1,3-Dipalmitoylglycerol-d5) is a deuterium labeled 1,3-Dipalmitin (HY-128792). 1,3-Dipalmitin (1,3-Dipalmitoylglycerol) is a cerebroside that can be found in Typhonium giganteum Engl [1].
|
-
- HY-109541S3
-
|
DMPC-d<SUB>13SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>13SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
Colfosceril miristate-d13 (DMPC-d13) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-B0166S8
-
|
L-Ascorbate-1; Vitamin C-13C<SUB>6SUB>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
Reactive Oxygen Species (ROS)
Calcium Channel
Apoptosis
|
Cancer
|
|
L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) [1]. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
|
-
- HY-109541S
-
|
DMPC-d<SUB>58SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>58SUB>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Colfosceril miristate-d58 (DMPC-d58) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-Y1039S1
-
|
1-Monostearin-d<SUB>35SUB>; 2,3-dihydroxypropyl stearate-d<SUB>35SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Stearoyl-rac-glycerol-d35 is the deuterium labeled 1-Stearoyl-rac-glycerol.
|
-
- HY-W751665
-
|
N-Benzyl-3-carboethoxy-4-piperidone hydrochloride-d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(Adamantan-1-yl)ethan-1-one-d3 (N-Benzyl-3-carboethoxy-4-piperidone hydrochloride-d3) is the deuterium labeled 1-(Adamantan-1-yl)ethan-1-one (HY-W067624).
|
-
- HY-109541S1
-
|
DMPC-d<SUB>4SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Colfosceril miristate-d4 (DMPC-d4) is deuterium labeled Colfosceril miristate. Colfosceril miristate is a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-109541S4
-
|
DMPC-d<SUB>63SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>63SUB>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Colfosceril miristate-d63 (DMPC-d63) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-Y1217S1
-
|
Hydroxycyclohexane-d<SUB>11SUB>; NSC 54711-d<SUB>11SUB>; Naxol-d<SUB>11SUB>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
1-Cyclohexanol-d11 is the deuterium labeled 1-Cyclohexanol (HY-Y1217). 1-Cyclohexanol (Hydroxycyclohexane) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-114553S
-
|
5F-PB-223-Carboxyindolemetabolite-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid-d5 (5F-PB-223-Carboxyindolemetabolite-d5) is deuterium labeled 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid [1].
|
-
- HY-W777649
-
-
- HY-Y1217S
-
|
Hydroxycyclohexane-d<SUB>12SUB>; NSC 54711-d<SUB>12SUB>; Naxol-d<SUB>12SUB>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
1-Cyclohexanol-d12 is the deuterium labeled 1-Cyclohexanol (HY-Y1217). 1-Cyclohexanol (Hydroxycyclohexane) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-W777620
-
|
rac-Cotinine-13C,d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone- 13C,d3 (rac-Cotinine- 13C,d3) is the deuterium and 13C-labeled 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (HY-W588192).
|
-
- HY-78004S1
-
|
Dibenzil-d<SUB>4SUB>; s-Diphenylethane-d<SUB>4SUB>; Bibenzyl-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Diphenylethane-d4 (Dibenzil-d4; s-Diphenylethane-d4; Bibenzyl-d4) is the deuterium labeled Bibenzyl (HY-78004) [1].
|
-
- HY-131325S
-
|
N2,N4-Diethyl-6-(methoxy-d<SUB>3SUB>)-1,3,5-triazine-2,4-diamine
|
Isotope-Labeled Compounds
|
Others
|
|
Simeton-d3 (N2,N4-Diethyl-6-(methoxy-d3)-1,3,5-triazine-2,4-diamine) is deuterium labeled Simeton [1].
|
-
- HY-12516S2
-
|
Org-2969-13C<SUB>2SUB>,d<SUB>2SUB>-1
|
Isotope-Labeled Compounds
Progesterone Receptor
|
Others
|
|
Desogestrel- 13C2,d2-1 (Org-2969- 13C2,d2-1) is the deuterium labeled and 13C-labeled Desogestrel (HY-12516). Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups [1] .
|
-
- HY-Y1641S
-
|
Ethylene dithioglycol-d<SUB>4SUB>; Ethylene glycol-d4, dithio-; Ethylenedithiol-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Ethanedithiol-d4 is the deuterium labeled 1,2-Ethanedithiol [1].
|
-
- HY-W709612
-
|
N-Desmethyl regorafenib N-oxide-d<SUB>3SUB>-1
|
Isotope-Labeled Compounds
VEGFR
Raf
c-Kit
Drug Metabolite
|
Cancer
|
|
Regorafenib N-oxide and N-desmethyl (M5)-d3-1 (N-Desmethyl regorafenib N-oxide-d3-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 [1].
|
-
- HY-W392083S1
-
|
(1,3E,5Z)-UNDECATRIENE-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
(1,3E,5Z)-Undeca-1,3,5-triene-d5 is deuterated labeled (1,3E,5Z)-Undeca-1,3,5-triene.
|
-
- HY-Y1309S1
-
-
- HY-W392083S
-
|
(1,3E,5E)-UNDECATRIENE-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
(1,3E,5E)-Undeca-1,3,5-triene-d5 is deuterated labeled (1,3E,5E)-Undeca-1,3,5-triene.
|
-
- HY-Y1309S
-
|
Furro ER-d<SUB>8SUB>; NSC 9586-d<SUB>8SUB>; Nako TRB-d<SUB>8SUB>
|
Endogenous Metabolite
|
Others
|
|
1-Naphthol-d8 is the deuterium labeled 1-Naphthol [1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe .
|
-
- HY-W050145S
-
|
1,6-Anhydro-β-D-glucopyranose-d<SUB>7SUB>; 1,6-Anhydro-β-D-glucose-d<SUB>7SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Levoglucosan-d7 is the deuterium labeled Levoglucosan. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature [1] .
|
-
- HY-125771S
-
|
18:0 Lyso-PC-d<SUB>35SUB>; LPC(18:0)-d<SUB>35SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
HDAC
STAT
Apoptosis
|
Cancer
|
|
1-Stearoyl-sn-glycero-3-phosphocholine-d35 is deuterium labeled 1-Stearoyl-sn-glycero-3-phosphocholine (HY-125771). 1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells [1].
|
-
- HY-146737S
-
|
TG(15:0/15:0/15:0)-d<SUB>5SUB>; 1,2,3-Tripentadecanoyl glycerol-d<SUB>5SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
Tripentadecanoin-d5 is the deuterium labeled Tripentadecanoin.
|
-
- HY-W777706
-
|
1-(3,4-Dimethylphenyl)ethanol-13C,d<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(3,4-Dimethylphenyl)ethan-1-ol- 13C,d3 (1-(3,4-Dimethylphenyl)ethanol- 13C,d3) is the deuterium labeled and 13C-labeled 1-(3,4-Dimethylphenyl)ethan-1-ol (HY-W340128).
|
-
- HY-Y0727S
-
|
1,5-Pentanedibromide-d<SUB>4SUB>; Pentamethylene bromide-d<SUB>4SUB>; Pentamethylene dibromide-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,5-Dibromopentane-d4 is the deuterium labeled 1,5-Dibromopentane [1].
|
-
- HY-34444S
-
|
Bondelane A-d<SUB>8SUB>; Cyclic tetramethylene sulfone-d<SUB>8SUB>; Cyclotetramethylene sulfone-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan [1].
|
-
- HY-W048482S
-
|
DMT-2'O-TBDMS-rU phosphoramidite-13C<SUB>2SUB>,d<SUB>1SUB>
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-Y0727S1
-
|
1,5-Pentanedibromide-d<SUB>10SUB>; Pentamethylene bromide-d<SUB>10SUB>; Pentamethylene dibromide-d<SUB>10SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,5-Dibromopentane-d10 is the deuterium labeled 1,5-Dibromopentane [1].
|
-
- HY-W040193S6
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>13SUB>; DSPC-d<SUB>13SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d13 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-W040193S2
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>79SUB>; DSPC-d<SUB>79SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-W040193S5
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>9SUB>; DSPC-d<SUB>9SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc
|
-
- HY-Y1772S
-
|
p-Iodotoluene-d<SUB>7SUB>; p-Methyliodobenzene-d<SUB>7SUB>; p-Tolyl iodide-d<SUB>7SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Iodo-4-methylbenzene-d7 is the deuterium labeled 1-Iodo-4-methylbenzene [1].
|
-
- HY-128792S
-
|
Glyceryl 1,3-dipalmitate-d6; 1,3-Dipalmitoyl-glycerol-d6; Glycerol 1,3-Dipalmitate-d<SUB>62SUB>
|
Isotope-Labeled Compounds
Others
|
Others
|
|
1,3-Dipalmitin-d6 (Glyceryl 1,3-dipalmitate-d6) is deuterium labeled 1,3-Dipalmitin. 1,3-Dipalmitin (1,3-Dipalmitoylglycerol) is a cerebroside that can be found in Typhonium giganteum Engl [1] [1] .
|
-
- HY-W040193S1
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>74SUB>; DSPC-d<SUB>74SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-Y1044S
-
|
1,5-Pentamethylene glycol-d<SUB>10SUB>; Pentamethylene glycol-d<SUB>10SUB>; Pentylene glycol-d<SUB>10SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,5-Dihydroxypentane-d10 is the deuterium labeled 1,5-Dihydroxypentane [1].
|
-
- HY-Y0093S
-
|
α,ω-Nonanediol-d<SUB>14SUB>; 1,9-Dihydroxynonane-d<SUB>14SUB>; Nonamethylene Glycol-d<SUB>14SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
NSC 5416-d14 is the deuterium labeled NSC 5416 [1].
|
-
- HY-W040193S
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>70SUB>; DSPC-d<SUB>70SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70 is the deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system [1] .
|
-
- HY-W749377
-
|
Toluene, 2,3,4,5,6-pentabromo-13C<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,5-Pentabromo-6-methylbenzene- 13C6 (Toluene, 2,3,4,5,6-pentabromo- 13C6) is the 13C-labeled 1,2,3,4,5-Pentabromo-6-methylbenzene (HY-W274110).
|
-
- HY-W699983
-
|
Glyoxaline-15N<SUB>2SUB>; 1,3-Diaza-2,4-cyclopentadiene-15N<SUB>2SUB>
|
Isotope-Labeled Compounds
Thrombopoietin Receptor
Ser/Thr Protease
Xanthine Oxidase
|
Neurological Disease
Inflammation/Immunology
|
|
Imidazole- 15N2 (Glyoxaline- 15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease [1] .
|
-
- HY-W040193S3
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>83SUB>; DSPC-d<SUB>83SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system [1] .
|
-
- HY-113123S1
-
|
14:0 Lyso PC-d<SUB>7SUB>; 1-myristoyl-sn-glycero-3-phosphatidylcholine-d<SUB>7SUB>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
LysoPC(14:0/0:0)-d7 (14:0 Lyso PC-d7) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect [1] .
|
-
- HY-W285163S
-
|
Formyl Ciprofloxacin-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
|
-
- HY-12650S
-
|
DS5565-13C<SUB>2SUB>,d<SUB>1SUB> (Mixture of Diastereomers)
|
Isotope-Labeled Compounds
|
Others
|
|
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS [1].
|
-
- HY-W040193S4
-
|
1,2-Distearoyl-sn-glycero-3-PC-d<SUB>4SUB>; DSPC-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d4 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc
|
-
- HY-Y0860S
-
|
1,6-Dibromohexane-d<SUB>12SUB>; Hexamethylene dibromide-d<SUB>12SUB>; NSC 7306-d<SUB>12SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,6-Dibromo-n-hexane-d12 is the deuterium labeled 1,6-Dibromo-n-hexane [1].
|
-
- HY-Y0659S
-
|
1,2,3,4-Tetrahydroquinoline-d<SUB>2SUB>; 3,4-Dihydro-2H-quinoline-d<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4-Hydroquinoline-d2 (1,2,3,4-Tetrahydroquinoline-d2) is the deuterium labeled 1,2,3,4-Hydroquinoline.
|
-
- HY-W013053S
-
|
DBA-d<SUB>14SUB>; 1,2,5,6-Dibenzanthracene-d<SUB>14SUB>; Benzo[k]tetraphene-d<SUB>14SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
Dibenz[a,h]anthracene-d14 is the deuterium Dibenz[a,h]anthracene.
|
-
![Dibenz[a,h]anthracene-d14](//file.medchemexpress.eu/product_pic/hy-w013053s.gif)
- HY-W242724
-
|
1,4-Dibromobutane-d<SUB>8SUB>; Tetramethylene Bromide-d<SUB>8SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d8 is the deuterium labeled 1,4-Dibromo-butane [1].
|
-
- HY-W762019S
-
|
1,2,3,4,7,8-HxCDD-13C<SUB>12SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,7,8-Hexachloro dibenzo-p-dioxin- 13C12 (1,2,3,4,7,8-HxCDD- 13C12) is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin [1].
|
-
- HY-W662572S
-
|
N-(5,7-Dimethoxy-d<SUB>6SUB>[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide
|
Isotope-Labeled Compounds
|
Others
|
|
Pyroxsulam-d6 (N-(5,7-Dimethoxy-d6[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide) is deuterium labeled N-(5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide [1].
|
-
- HY-41681S
-
|
1-Chloro-6-hexanol-d<SUB>6SUB>; 1-Chloro-6-hydroxyhexane-d<SUB>6SUB>; 6-Chlorohexanol-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
6-Chloro-1-hexanol-d6 is the deuterium labeled 6-Chloro-1-hexanol [1].
|
-
- HY-W050145S2
-
|
1,6-Anhydro-β-D-glucopyranose-13C<SUB>6SUB>; 1,6-Anhydro-β-D-glucose-13C<SUB>6SUB>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Levoglucosan- 13C6 is the 13C labeled Levoglucosan [1]. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature .
|
-
- HY-151997S
-
|
1,2-Olein-3-laurin-13C3; TG(18:1/18:1/12:0)-13C<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dioleoyl-3-lauroyl-rac-glycerol- 13C3 is the 13C-labeled 1,2-Dioleoyl-3-lauroyl-rac-glycerol (HY-165089), 1,2-Dioleoyl-3-lauroyl-rac-glycerol (1,2-Olein-3-laurin) is a triglyceride identified by specific analytical methods in human milk, infant formula, other mammalian milk, and vegetable oils, with specific structural and distribution characteristics.
|
-
- HY-W766078
-
|
1-b-D-Arabinofuranosyluracil-13C,15N<SUB>2SUB>; Uracil 1-β-D-arabinofuranoside-13C,15N<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Infection
Cardiovascular Disease
Cancer
|
|
1-beta-D-Arabinofuranosyluracil- 13C, 15N2 (1-b-D-Arabinofuranosyluracil- 13C, 15N2; Uracil 1-β-D-arabinofuranoside- 13C, 15N2) is the 13C- and 15N-labeled labeled 1-beta-D-Arabinofuranosyluracil (HY-N6652). 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties [1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .
|
-
- HY-Y0219S
-
|
s-Triazole13C<SUB>2SUB>,15N<SUB>3SUB>; Pyrrodiazole13C<SUB>2SUB>,15N<SUB>3SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128 [1].
|
-
- HY-A0052S
-
|
Telaprevir, (R)-d<SUB>4SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4 is deuterated labeled (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide.
|
-
![(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4](//file.medchemexpress.eu/product_pic/hy-a0052s.gif)
- HY-Y0045S
-
|
1-(1,3-Thiazol-2-yl)ethanone-13C<SUB>2SUB>; 1-(Thiazol-2-yl)ethanone-13C<SUB>2SUB>; Methyl 2-thiazolyl ketone-13C<SUB>2SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Acetylthiazole- 13C2 is 13C labeled 2-Acetylthiazole (HY-Y0045). 2-Acetylthiazole (1-(1,3-Thiazol-2-yl)ethanone; 1-(Thiazol-2-yl)ethanone; Methyl 2-thiazolyl ketone) is a flavor compound. 2-Acetylthiazole is a kind of biological materials or organic compounds that are widely used in life science research [1].
|
-
- HY-33948S
-
|
1,1-Dimethylethanolamine-d<SUB>6SUB>; 2-Amino-α,α-dimethylethanol-d<SUB>6SUB>; 2-Hydroxy-2-methyl-1-propylamine-d<SUB>6SUB>; 2-Hydroxy-2-methylpropan-1-amine-d<SUB>6SUB>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Amino-2-methylpropan-2-ol-d6 is the deuterium labeled 1-Amino-2-methylpropan-2-ol [1].
|
-
- HY-34123S
-
|
2-(2-Bromoethyl)-1H-isoindole-1,3(2H)-dione-d<SUB>4SUB>; 1-Bromo-2-phthalimidoethane-d<SUB>4SUB>; 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl bromide-d<SUB>4SUB>; 2-(2-Bromoethyl)-2,3-dihydro-1H-isoindole-1,3-dione
|
Isotope-Labeled Compounds
|
Others
|
|
N-(2-Bromoethyl)phthalimide-d4 is the deuterium labeled N-(2-Bromoethyl)phthalimide[1].
|
-
- HY-59354S1
-
|
1,2-Dihydro-3,6-pyridazine-13C<SUB>4SUB>-dione; 3,6-Dihydroxypyridazine-13C<SUB>4SUB>; 3,6-Pyridazine-13C<SUB>4SUB>-diol; Maleic hydrazide-13C<SUB>4SUB>
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Cancer
|
|
1,2-Dihydropyridazine-3,6-dione-3,4,5,6- 13C4 (1,2-Dihydro-3,6-pyridazine- 13C4-dione) is 13C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins [1] .
|
-
- HY-W778954
-
|
(2,2-Dimethyl-[1,3] dioxane-4-yl)-methanol-13C<SUB>3SUB>; (4RS)-2,2-Dimethyl-1,3-dioxolane-4-methanol-13C<SUB>3SUB>; (RS)-Solketal-13C<SUB>3SUB>; (±)-1,2-O-Isopropylideneglycerol-13C<SUB>3SUB>; (±)-2,2-Dimethyl-1,3-dioxolane-4-methanol-13C<SUB>3SUB>; (±)-Glycerol 1,2-acetonide-13C<SUB>3SUB>; Solketa-13C<SUB>3SUB>l
|
Isotope-Labeled Compounds
|
Others
|
|
2,2-Dimethyl-1,3-dioxolane-4-methanol- 13C3 ((2,2-Dimethyl-[1,3] dioxane-4-yl)-methanol- 13C3) is the 13C-labeled 2,2-Dimethyl-1,3-dioxolane-4-methanol (HY-Y1372).
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-109541S2
-
|
DMPC-d<SUB>9SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>9SUB>
|
Drug Delivery
|
|
Colfosceril miristate-d9 (DMPC-d9) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-109541S5
-
|
DMPC-d<SUB>67SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>67SUB>
|
Drug Delivery
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-109541S3
-
|
DMPC-d<SUB>13SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>13SUB>
|
Drug Delivery
|
|
Colfosceril miristate-d13 (DMPC-d13) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-109541S
-
|
DMPC-d<SUB>58SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>58SUB>
|
Drug Delivery
|
|
Colfosceril miristate-d58 (DMPC-d58) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-109541S1
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DMPC-d<SUB>4SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>4SUB>
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Drug Delivery
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Colfosceril miristate-d4 (DMPC-d4) is deuterium labeled Colfosceril miristate. Colfosceril miristate is a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
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- HY-109541S4
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DMPC-d<SUB>63SUB>; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d<SUB>63SUB>
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Drug Delivery
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Colfosceril miristate-d63 (DMPC-d63) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P10215
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Parasite
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Infection
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Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively [1].
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* This product has been "discontinued".
Optimized version of product available:
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-B0389S1
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D-Glucose-d is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
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- HY-B0389S7
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D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-B0389S3
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D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-W016577S4
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1-Bromoheptane-d1 is the deuterium labeled 1-Bromoheptane [1].
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- HY-W099504S2
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1-Heptanol-d1 is the deuterium labeled 1-Heptanol [1].
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- HY-N0210S6
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D-Galactose-d-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-41700S2
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D-Alanine-d is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR [1].
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- HY-N0378S5
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D-Mannitol-d is the deuterium labeled D-Mannitol.
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- HY-B0389S4
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D-Glucose-d1-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-B0389S2
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D-Glucose-d12-12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-B0389S23
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D-Glucose-d2-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol
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- HY-B0389S8
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D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-19696S2
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Tauroursodeoxycholate-d4-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
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- HY-B0228S7
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Adenosine-d-1 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys
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- HY-109037S2
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Mavacamten-d1 (MYK461-d1; SAR439152-d1) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
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- HY-Y0001S1
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Cyclopropane-1-carboxylic Acid-d1 is the deuterium labeled Cyclopropane-1-carboxylic Acid [1].
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- HY-B0763S2
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Ibudilast-d7-1 is the deuterium labeled Ibudilast [1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
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- HY-B0141S6
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Estradiol-d2-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway [1] .
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- HY-B0511S
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Biotin-d2-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.
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- HY-B1411S1
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i-Inositol-d is the deuterium labeled i-Inositol [1].
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- HY-B0152S
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Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis [1] .
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- HY-B0479S1
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Thiamphenicol-d3-1 (Thiophenicol-d3-1; Dextrosulphenidol-d3-1) is the deuterium-labeled Thiamphenicol (HY-B0479) [1]. Thiamphenicol (Thiophenicol)，a methyl-sulfonyl derivative of Chloramphenicol，is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit，leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative，Gram-positive aerobic and anaerobic bacteria) .
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- HY-23188
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Loratadine-d5-1 is a deuterated labeled Loratadine (HY-17043). Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
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- HY-N2037AS1
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Higenamine-d4-1 (Norcoclaurine-d4-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases [1] .
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- HY-B0234S4
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Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells [1] .
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- HY-17043S2
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Loratadine-d4-1 (Loratidine-d4-1) is deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators [1].
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- HY-14648S5
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Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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- HY-14648S1
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Dexamethasone-d5-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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- HY-14649S6
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Retinoic acid-d3-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha [1] .
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- HY-13966S
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2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase [1] .
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- HY-100442S1
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Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice [1] .
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- HY-70057S1
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Safinamide-d4-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 μM) over MAO-A (IC50=580 μM) [1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8?μM) than at resting (IC50=262?μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al .
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- HY-50898S3
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Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively [1].
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- HY-B0400S7
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D-Sorbitol-d-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
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- HY-G0016S1
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N-acetyl Dapsone-d4-1 is the deuterium labeled N-acetyl Dapsone, which is a metabolite of Dapsone.
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- HY-B0400S8
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D-Sorbitol-d2-1 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
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- HY-10162S3
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Olaparib-d4-1 (AZD2281-d4-1) is the deuterium labeled Olaparib (HY-10162). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator [1] .
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- HY-13593S1
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Chlorambucil-d8-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease [1] .
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- HY-B0801S4
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Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research [1] .
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- HY-10585S4
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Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches [1] .
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- HY-15592S2
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Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research [1]
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- HY-A0095S1
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Flibanserin-d4-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD) [1] .
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- HY-W778692
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1-Linoleoyl Glycerol-d5 (1-Linoleoyl-rac-glycerol-d5; 1-Monolinolein-d5) is the deuterium labeled 1-Linoleoyl Glycerol (HY-111346). 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6) [1] .
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- HY-108506S2
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Licarbazepine-d4-1 is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects [1].
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- HY-B1716S1
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L-5-Hydroxytryptophan-d3-1 is the deuterium labeled L-5-Hydroxytryptophan [1]. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia .
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- HY-13331S2
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Clascoterone-d5-1 (Cortexolone 17 alpha-propionate-d5-1) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist [1].
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- HY-B1659S3
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Glycerol-d is the deuterium labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.
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- HY-B0158S4
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Cytidine-d is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol
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- HY-B0389S18
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D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response [1].
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- HY-B0389S25
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D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
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- HY-B0492S
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(rac)-(trans)-Paroxetine-d4 (hydrochloride) is the deuterium labeled (rac)-(trans)-Paroxetine hydrochloride [1].
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- HY-141636S
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1-PalMitoyl-2-arachidoyllecithin-d9-1 (1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d9-1) is deuterium labeled 1-PalMitoyl-2-arachidoyllecithin. 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells [1].
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- HY-B0892S4
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Benzyl alcohol-d1 is the deuterium labeled Benzyl alcohol [1].
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- HY-W032013S3
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1-Octanol-d5 is deuterated labeled 1-Octanol (HY-W032013). 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents [1]. 1-Octanol is a highly attractive biofuel with diesel-like properties .
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- HY-W032013S
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1-Octanol-d17 is the deuterium labeled 1-Octanol [1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .
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- HY-W087024S
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1-Phenylpentane-d5 is the deuterium labeled 1-Phenylpentane [1].
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- HY-W032013S1
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1-Octanol-d2 is the deuterium labeled 1-Octanol [1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .
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- HY-14444S
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Plinabulin-d1 is an active compound.
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- HY-Y0308S
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Phosphate dibasic-d2 (sodium) is the deuterium labeled Sodium phosphate dibasic [1].
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- HY-W720915
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N-Dodecylbenzene-d5 (1-Dodecylbenzene-d5; 1-Phenyl-n-dodecane-d5; 1-Phenyldodecane-d5) is the deuterium labeled N-Dodecylbenzene (HY-Y1052).
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- HY-66008S1
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N-Acetyl mesalazine-d3-1 (N-Acetyl-5-aminosalicylic acid-d3-1) is deuterium labeled N-Acetyl mesalazine (HY-66008). N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer [1].
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- HY-B0158S3
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Cytidine-d2-1 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catech
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- HY-A0042S2
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Rufinamide- 15N,d2-1 (CGP 33101- 15N,d2-1) is 15N- and deuterium-labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na + current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome [1] .
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- HY-Y1004S4
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1-Decanol-d4 is the deuterium labeled 1-Decanol [1].
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- HY-B0111S1
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Drospirenone-d4-1 is deuterium labeled Drospirenone.
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- HY-N0131S1
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Stigmasterol-d5-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases [1].
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- HY-N0210S5
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D-Galactose-d is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-Y1004S3
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1-Decanol-d5 is the deuterium labeled 1-Decanol [1].
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- HY-122426S1
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1-Bromoundecane-d3 is the deuterium labeled 1-Bromoundecane [1].
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- HY-N0717S8
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L-Valine-d is the deuterium labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid [1].
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- HY-124891S
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1-Phenylpyrrole-d9 (N-Phenylpyrrole-d9) is the deuterium labeled 1-Phenylpyrrole (HY-124891). 1-Phenylpyrrole (N-Phenylpyrrole) has dual fluorescent properties. 1-Phenylpyrrole displays a single band in nonpolar solvents and a second red-shifted fluorescent band in polar solvents [1].
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- HY-W004263S
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1-Eicosanol-d41 (Arachidyl alcohol-d41) is the deuterium labeled 1-Eicosanol (HY-W004263) [1]. 1-Eicosanol is a natural compound with antioxidant activity found in Justicia insularis leaves. 1-Eicosanol can be used as an antioxidant .
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- HY-W004293S
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n-Tridecyl Alcohol-d27 is the deuterium labeled 1-Tridecanol [1].
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- HY-W004292S1
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1-Undecanol-d4 (Undecyl alcohol-d4) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps [1] .
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- HY-152070S1
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Demethylmaprotiline-d2-1 is the deuterium labeled Demethylmaprotiline [1].
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- HY-135810S1
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Cletoquine-d4-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment [1] .
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- HY-W004292S
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1-Undecanol-d23 (Undecyl alcohol-d23) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps [1] .
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- HY-B0412S4
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Estriol-d3-1 is the deuterium labeled Estriol.
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-
- HY-90006S
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5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer [1] . 5-Fluorouracil also inhibits HIV .
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- HY-B0122SS1
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Topiramate- 13C6-1 (McN 4853- 13C6-1; RWJ 17021- 13C6-1) is 13C-labeled Topiramate (HY-B0122) [1].
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- HY-18341S4
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L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) [1] .
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- HY-Y1139S
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Pimelic acid-d4 is the deuterium labeled Pimelic acid [1]. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.
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- HY-113139S
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1-Methylinosine-d3 is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA [1].
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- HY-17386S2
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Rosiglitazone-d4-1 (BRL 49653-d4-1) is deuterium-labeled Rosiglitazone (HY-17386) [1].
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- HY-W032013S2
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1-Octanol-d2-1 is deuterated labeled 1-Octanol (HY-W032013). 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents [1]. 1-Octanol is a highly attractive biofuel with diesel-like properties .
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-
- HY-13956A
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(R)-Pioglitazone-d1 ((R)-U 72107-d1) is a stabilized and deuterated R-enantiomer of pioglitazone, exhibiting pharmacological properties that are beneficial for NASH treatment, including modulation of mitochondrial function, non-steroidal anti-inflammatory effects, and glucose-lowering capabilities.
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- HY-145119AS
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Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 [1] .
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- HY-113136S
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1-Methylguanosine-d3 (N1-Methylguanosine-d3) is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker [1] .
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- HY-B0901S1
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Bromperidol-d4-1 is deuterium labeled Bromperidol.
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-
- HY-153939S
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Idasanutlin-d3-1 (RG7388-d3-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia [1] .
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- HY-19822S1
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Elacestrant-d4-1 is the deuterium labeled Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively [1] .
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- HY-W032015S3
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1-Bromooctane-d4 is the deuterium labeled 1-Bromooctane [1].
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- HY-B0114S1
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Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker [1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .
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- HY-N1380S4
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Guaiacol-d4-1 is the deuterium labeled Guaiacol [1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation [1]. Anti-inflammatory activity .
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-
- HY-W101642S
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1,3-Diisopropylbenzene-d18 is the deuterium labeled 1,3-Diisopropylbenzene [1].
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-
- HY-76025S
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1,4-Dibromobenzene-d4 is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans [1].
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- HY-W752616
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1-Aminopropan-2-ol-d6 (Monoisopropanolamine-d6) is the deuterium labeled 1-Aminopropan-2-ol (HY-W015969). 1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas [1].
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- HY-12987S2
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Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5 [1] .
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- HY-W711089
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Bifenox-d3-1 (Modown-d3; MC-4379-d3) is the deuterium labeled Bifenox (HY-136513). Bifenox (Modown; MC-4379) is a potent herbicide. Bifenox increases the ROS production. Bifenox causes cellular membrane disruption, inhibition of photosynthesis [1].
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- HY-B0113S1
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Omeprazole-d3-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM [1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
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- HY-B0561S2
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Spironolactone-d3-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes [1] .
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- HY-W016577S3
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1-Bromoheptane-d7 is the deuterium labeled 1-Bromoheptane [1].
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- HY-B0258S1
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Gemfibrozil-d6-1 (CI-719-d6-1) is the deuterium labeled Gemfibrozil (HY-B0258). Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively [1].
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- HY-145119S
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GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119) [1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .
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- HY-B0223S4
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Albendazole-d3-1 (SKF-62979-d3-1) is the deuterium labeled Albendazole (HY-B0223). Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells [1] .
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- HY-14281S2
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Trilostane-d3-1 (Win 24540-d3-1) is deuterium-labeled Trilostane (HY-14281) [1].
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- HY-B0196S1
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Venlafaxine-d6-1 is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant [1].
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- HY-W099521S
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1-Chlorooctane-d17 is the deuterium labeled 1-Chlorooctane [1].
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- HY-15917S1
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DL-dithiothreitol-d10-1 is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond [1] .
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- HY-B0451AS3
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Dopamine-d2-1 (hydrochloride) is the deuterium labeled Dopamine hydrochloride [1].
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- HY-B0740S3
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Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases [1]
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- HY-17376S1
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Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
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- HY-15780S1
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Brexpiprazole-d8-1 (OPC-34712-d8-1) is the deuterium labeled Brexpiprazole (HY-15780) [1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM) .
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- HY-13678S1
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Meropenem-d6-1 (SM 7338-d6-1) is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) [1].
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- HY-10846S1
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Delamanid-d4-1 is deuterated labeled Delamanid.Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids [1].
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- HY-14956S1
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Nemonoxacin-d3-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia [1] .
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- HY-17430S1
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Amprenavir-d4-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.
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- HY-B0197S
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Naratriptan-d3 (GR-85548A-d3) is the deuterium labeled Naratriptan (HY-B0197). Naratriptan is a selective 5-HT1B/1D receptor agonist. Naratriptan is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors (EC50=0.11 μM for dog basilar artery). Naratriptan also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. Naratriptan is mainly used in the research of acute migraine, targeting cranial vascular and neuroinflammatory mechanisms [1] .
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- HY-W014559S3
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1-Bromononane-d4-1 is the deuterium labeled 1-Bromononane [1].
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- HY-W099504S1
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1-Heptanol-d7 is the deuterium labeled 1-Heptanol [1].
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- HY-10284S3
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Linagliptin-d3-1 (BI 1356-d3-1) is the deuterium labeled Linagliptin (HY-10284). Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM [1].
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- HY-W014286S
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1,3-Diphenylurea-d10 is the deuterium labeled 1,3-Diphenylurea [1].
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- HY-W654010
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Lurasidone-d8-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM [1].
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- HY-B1565S
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UV Absorber 326-d3 (Bumetrizole-d3-1) is deuterium labeled UV Absorber 326 [1].
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- HY-122272S2
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Paroxetine-d6-1 is a deuterated labeled Paroxetine [1]. Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .
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- HY-W012477S
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1-Hydroxycyclohexyl phenyl ketone-d5 (Photoinitiator-184-d5) is the deuterium labeled 1-Hydroxycyclohexyl phenyl ketone (HY-W012477) [1].
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- HY-Y0921S1
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(±)-1,2-Propanediol-d2 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
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- HY-Y0921S
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(±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
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- HY-Y0921S2
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(±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents [1] .
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- HY-W765245
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Rapamycin- 13C,d3-1 (Sirolimus- 13C,d3-1) is the deuterium labeled and 13C-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 [1]. Rapamycin is an autophagy activator, an immunosuppressant .
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- HY-41676S
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4-Chlorobenzonitrile-d4 is the deuterium labeled 4-Chlorobenzonitrile [1].
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- HY-Y0678S
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1,3,5-Trimethoxybenzene-d3 (Trimethyl phloroglucinol-d3) is the deuterium labeled 1,3,5-Trimethoxybenzene (HY-Y0678). 1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor [1].
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- HY-N1429S2
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Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties [1] .
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- HY-W004051S
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1-Bromo-2-chlorobenzene-d4 is the deuterium labeled 1-Bromo-2-chlorobenzene [1].
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- HY-W013049S4
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Docosanoic acid-d4-1 (Behenic acid-d4-1) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans [1] .
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- HY-N7092S18
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D-Fructose-d2-1 is the deuterium labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants [1].
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- HY-W130478S
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1-Phenylhexane-d5 is the deuterium labeled 1-Phenylhexane [1].
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- HY-W865379
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(S)-Avadomide-d1 (SP-3164; CC 122-d1) is deuterated labeled (S)-Avadomide-d1 (HY-W865379).
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- HY-W012856S
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1-Ethyl-3-methylbenzene-d5 is the deuterium labeled 1-Ethyl-3-methylbenzene [1].
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- HY-13631ES2
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Deruxtecan-d4-1 is the deuterium labeled Adenosine Deruxtecan (HY-13631E) [1]. Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
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- HY-B0228S
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Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation [1] .
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- HY-N0384S4
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Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency [1].
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- HY-N0210S11
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D-Galactose-d2-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-B1812S4
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Veratrole-d2-1 is the deuterium labeled Veratrole (HY-B1812). Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii [1] .
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- HY-W142175S
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1-Butynylbenzene-d5 is the deuterium labeled 1-Butynylbenzene [1]. 1-Butynylbenzene-d5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-N0210S7
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D-Galactose-d-2 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-W016931S
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1-Bromo-4-chlorobutane-d8 is the deuterium labeled 1-Bromo-4-chlorobutane [1].
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- HY-W017554S
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1-Chloro-2-methoxybenzene-d3 is the deuterium labeled 1-Chloro-2-methoxybenzene [1].
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- HY-N0210S8
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D-Galactose-d-3 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-W015849S
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1-Fluoro-4-methoxybenzene-d4 is the deuterium labeled 1-Fluoro-4-methoxybenzene [1].
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- HY-W017522S5
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Adipic acid-d4-1 (Hexanedioic acid-d4-1) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc [1] .
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- HY-34487S3
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1,3-Dimethoxybenzene-d3 (Resorcinol dimethyl ether-d3) is the deuterium labeled 1,3-Dimethoxybenzene (HY-34487). 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds [1].
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- HY-109506S3
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DPPC-d9-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers [1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice .
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- HY-66011AS3
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Moxifloxacin-d3-1 hydrochloride (BAY 12-8039-d3-1) is a deuterium labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia [1] .
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-
- HY-W719338
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Pentane-1,2-diol-d7 ((±)-Pentane-1,2-diol-d7; 1,2-Dihydroxypentane-d7; 1,2-Pentylene glycol-d7; Diol PD-d7; Hydrolite 5-d7; NSC 513-d7; 1,2-Pentanediol-d7) is the deuterium labeled Pentane-1,2-diol (HY-Y1249).
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-
- HY-15025S2
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Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
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-
- HY-W094751S
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1-Pyrenamin-d9 is the deuterium labeled 1-Pyrenamin [1].
|
-
- HY-W052227S
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Fmoc-DL-Ala-OH-d is the deuterium labeled DL-Alanine-2-N-fmoc.
|
-
- HY-W700931
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1-Methoxy-2-(2-methoxyethoxy)ethane-d6 (Dimethylcarbitol-d6) is the deuterium labeled 1-Methoxy-2-(2-methoxyethoxy)ethane (HY-Y1227).
|
-
- HY-W016152S
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1-Bromo-3-methoxybenzene-d3 is the deuterium labeled 1-Bromo-3-methoxybenzene. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified [1].
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-
- HY-114041S1
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Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production [1] .
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-
- HY-W342440S
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1,1-Diethoxynonane-d10 is a deuterated labeled 1,1-Diethoxynonane [1].
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-
- HY-107343S1
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Docosahexaenoic acid ethyl ester-d5-1 is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects [1] .
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-
- HY-W725429
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1,5-Dihydroxynaphthalene-d6 (Naphthalene-1,5-diol-d6) is the deuterium labeled 1,5-Dihydroxynaphthalene (HY-Y0825).
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-
- HY-Y1805S
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1,2,3,4-Tetrahydronaphthalene-d4 (Tetralin solvent-d4) is the deuterium labeled 1,2,3,4-Tetrahydronaphthalene (HY-Y1805) [1].
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-
- HY-W712592
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1-Ethylpyrrolidine-2,5-dione-d5 (N-Ethylsuccinimide-d5) is the deuterium labeled 1-Ethylpyrrolidine-2,5-dione (HY-W353513).
|
-
- HY-W699416
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1-Naphthoic acid-d7 (Naphthalene-1-carboxylic acid-d7) is the deuterium labeled 1-Naphthoic acid (HY-Y0236). Naphthalene-1-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-W012934S
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1-Ethylpyrrolidin-2-one-d5 (N-Ethyl-pyrrolidone-d5) is deuterium labeled 1-Ethylpyrrolidin-2-one [1].
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-
- HY-112530S
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1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis
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-
- HY-W011883S
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1,3-Dibromo-5-fluorobenzene-d3 is the deuterium labeled 1,3-Dibromo-5-fluorobenzene [1].
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-
- HY-128429S
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trans-2-Hexenal-d2-1 is the deuterium labeled trans-2-Hexenal (HY-128429). trans-2-Hexenal ((E)-2-Hexenal) is a volatile compound widely present in fresh plants, vegetables, and fruits, with a unique leafy aroma. trans-2-Hexenal has antifungal activity and can also inhibit the germination of soybean seeds and the growth of seedlings. In addition, trans-2-Hexenal can be used to determine low-molecular-weight carbonyl compounds that are reactive with biological nucleophiles in biological samples [1].
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-
- HY-W740373
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1-Methylpiperidin-4-ol-d4 (N-Methyl-4-piperidinol-d4) is the deuterium labeled 1-Methylpiperidin-4-ol (HY-W018626). 1-Methylpiperidin-4-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-N0215S13
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L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals [1] .
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-
- HY-W131797
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1-Iodoethane-1,1,2,2,2-d5 is the deuterium labeled 1-Iodoethane [1].
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-
- HY-W009719S
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1-Bromo-2,3-dichlorobenzene-d3 is the deuterium labeled 1-Bromo-2,3-dichlorobenzene [1].
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-
- HY-113482S
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1β-Hydroxydeoxycholic Acid-d5 is the deuterium labeled 1β-Hydroxydeoxycholic Acid [1].
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-
- HY-Y0566S
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1,4-Diazabicyclo[2.2.2]octane-d12 is the deuterium labeled 1,4-Diazabicyclo[2.2.2]octane [1].
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-
- HY-W654320
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Piperin-d10 is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL [1] .
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-
- HY-11018S1
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Risperidone-d4-1 (R 64 766-d4-1) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
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-
- HY-113424AS
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1,2-Dioleoyl-sn-glycero-3-phosphocholine-d9 is deuterium labeled 1,2-Dioleoyl-sn-glycero-3-phosphocholine. 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid and is commonly used alone, or with other components, in the generation of micelle
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-
- HY-W011885S
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1-Dodecylpyrrolidin-2-one-d6 (N-Lauryl-2-pyrrolidone-d6) is deuterium-labeled 1-Dodecylpyrrolidin-2-one (HY-W011885) [1].
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-
- HY-N9933S
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Tauro-β-muricholic acid-d4-1 (T-βMCA-d4-1) sodium is the deuterium labeled Tauro-β-muricholic acid (HY-N9933) [1].
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-
- HY-W716213
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1-(2,4-Dimethoxyphenyl)ethanone-d6 (2',4'-Dimethoxyacetophenone-d6) is the deuterium labeled 1-(2,4-Dimethoxyphenyl)ethanone (HY-W040456).
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-
- HY-W009981S
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1-Bromo-2,4-difluorobenzene-d3 is the deuterium labeled 1-Bromo-2,4-difluorobenzene [1].
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-
- HY-79779S1
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1-Bromo-4-(bromomethyl)benzene-d4 is the deuterium labeled 1-Bromo-4-(bromomethyl)benzene [1].
|
-
- HY-130462S1
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d82 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for
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-
- HY-W654353
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Tauro-α-muricholic acid-d4-1 (sodium) is deuterium labeled Tauro-α-muricholic acid (sodium). Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal [1] .
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-
- HY-B0402S
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Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent [1] .
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-
- HY-W768340
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Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al [1].
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-
- HY-B0228S8
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Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys
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-
- HY-B0402S1
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Amantadine-d6 is the deuterium labeled Amantadine [1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
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-
- HY-W017142S
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1-(Benzyloxy)propan-2-ol-d6 (3-(Benzyloxy)-2-propanol-d6) is the deuterium labeled 1-(Benzyloxy)propan-2-ol (HY-W017142).
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- HY-130462S
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d31 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for
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-
- HY-79779S
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1-Bromo-4-(bromomethyl)benzene-d6 is the deuterium labeled 1-Bromo-4-(bromomethyl)benzene [1].
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-
- HY-B0762S1
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Acetyl-L-carnitine-d3-1 (O-Acetyl-L-carnitine-d3-1) hydrochloride is the deuterium labeled Acetyl-L-carnitine hydrochloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression [1] .
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-
- HY-W015784S
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1,4-Benzenedimethanol-d4 is the deuterium labeled 1,4-Benzenedimethanol [1].
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-
- HY-W700950
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1-(4-Chlorophenyl)cyclobutanecarbonitrile-d6 (1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile-d6) is the deuterium labeled 1-(4-Chlorophenyl)cyclobutanecarbonitrile (HY-W010002).
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-
- HY-W097453S2
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6-(Methylthio)purine-d3-1 is the deuterium labeled 6-(Methylthio)purine [1].
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-
- HY-W1115209
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1,3,5-Tribromo-2-iodobenzene-d2 (2,4,6-Tribromoiodobenzene-d2) is a deuterium labeled 1,3,5-Tribromo-2-iodobenzene.
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-
- HY-W110726S1
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1-Octen-3-one-d3 is deuterated labeled 1-Octen-3-one.
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-
- HY-W014431S
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1-Bromo-3-chloro-5-fluorobenzene-d3 is the deuterium labeled 1-Bromo-3-chloro-5-fluorobenzene [1].
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-
- HY-W015824S3
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DL-Aspartic acid- 13C1 is the 13C labeled DL-Aspartic acid [1].
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- HY-N0210S12
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D-Galactose- 13C,d is the deuterium and 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-W013376S
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Norcyclizine-d8 is the deuterium labeled Norcyclizine [1].
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-
- HY-W110726S
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1-Octen-3-one-d5 is deuterated labeled 1-Octen-3-one.
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-
- HY-W777094
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1-Acetyl-4-(4-hydroxyphenyl)piperazine-d8 (Tetraethoxy C methyl propane-d8) is the deuterium labeled 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone (HY-W014037).
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-
- HY-W105111S
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1-Bromo-2,3,5-trichlorobenzene-d2 is the deuterium labeled 1-Bromo-2,3,5-trichlorobenzene [1].
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-
- HY-N7092S23
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D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
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- HY-B0151S2
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Pregnenolone-d4-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication [1] . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .
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- HY-Y0921S3
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(±)-1,2-Propanediol- 13C3 is 13C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish [1] .
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- HY-Y0219S1
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NSC 83128-d3 is the deuterium labeled NSC 83128 [1].
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- HY-B0896S1
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Triacetin-d5 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-W013504S
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1-Bromo-4-(trifluoromethyl)benzene-d4 is the deuterium labeled 1-Bromo-4-(trifluoromethyl)benzene [1].
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- HY-B0896S2
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Glyceryl Triacetate-d9 is the deuterium labeled Triacetin [1]. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-115702S
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1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine-d4 is the deuterium labeled 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine [1].
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- HY-Y1275S
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N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals [1] .
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- HY-W192474S
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1-(Furan-2-yl)ethane-1-thiol-d3 is deuterated labeled 1-(Furan-2-yl)ethane-1-thiol.
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- HY-Y0743S
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1-(Pyridin-2-yl)ethan-1-one-d6 is deuterated labeled 1-(Pyridin-2-yl)ethan-1-one.
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- HY-W013948S
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1-(2,4-Dinitrophenyl)-2-propylidenehydrazine-d3 is the deuterium labeled 1-(2,4-Dinitrophenyl)-2-propylidenehydrazine [1].
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- HY-W654409
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1,1,1,3,3,3-Hexafluoropropan-2-ol-d2 (Hexafluoroisopropyl alcohol-d2) is deuterium labeled 1,1,1,3,3,3-Hexafluoropropan-2-ol [1].
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- HY-114293S4
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Acetyl coenzyme A- 13C2-1 sodium (Acetyl-CoA- 13C2-1 sodium) is the 13C-labeled Acetyl coenzyme A (HY-114293). Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis [1] .
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- HY-W009293S
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1-(Bis(4-fluorophenyl)methyl)piperazine-d4 (N-(4,4-Difluorobenzhydryl)piperazine-d4) is the deuterium labeled 1-(Bis(4-fluorophenyl)methyl)piperazine.
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-
- HY-W777599
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(±)-Naproxen- 13C,d3-1 ((Rac)-Naproxen- 13C,d3-1) is 13C and deuterium labeled (±)-Naproxen [1].
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- HY-122426S2
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1-Bromoundecane-d4 is the deuterium labeled 1-Bromoundecane [1].
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-
- HY-W756596
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1,2-Dioctanoyl-3-chloropropanediol-d5 is deuterium labeled 1,2-Dioctanoyl-3-chloropropanediol. 1,2-Dioctanoyl-3-chloropropanediol (3-Chloropropane-1,2-diyl dioctanoate) is an ester product [1].
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-
- HY-W012652S
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1,2,3,4-Tetrahydroquinoxaline-d4 (Quinoxaline, 1,2,3,4-tetrahydro-d4) is the deuterium labeled 1,2,3,4-Tetrahydroquinoxaline.
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-
- HY-145473S
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1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 (15(S)-HETE-SAPE-d11) is deuterium labeled 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 (HY-N6687) by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes [1].
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- HY-Y0531S
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1-Adamantanol-d15 is the deuterium labeled 1-Adamantanol [1].
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- HY-N0537S12
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Xylose-d-3 is the deuterium labeled Xylose.
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-
- HY-146829S
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1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate-d7 (sodium) is deuterium labeled 1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate (sodium).
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- HY-N0229S4
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L-Alanine- 13C,d is the 13C- and deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-D0837S
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Imidazole-d4 is the deuterium labeled Imidazole [1].
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- HY-N0537S13
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Xylose-d-4 is the deuterium labeled Xylose.
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- HY-10003S
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Alfacalcidol-d7 is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis [1] .
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- HY-W754348
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1-(2,6-Dimethylphenoxy)propan-2-one-d5 (1-(2,6-Dimethylphenoxy)acetone-d5) is the deuterium labeled 1-(2,6-Dimethylphenoxy)propan-2-one (HY-W270592).
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- HY-15029S1
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(±)-Naproxen-d3-1 is the deuterium labeled (±)-Naproxen [1].
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- HY-W768181
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1,5-Anhydrosorbitol- 13C6 (1,5-Anhydro-D-glucitol- 13C6) is the 13C-labeled 1,5-Anhydrosorbitol (HY-113075). 1,5-Anhydrosorbitol is a short-term marker for glycemic control.
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- HY-16504S
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Treprostinil- 13C2-d1 (Sodium) (UT-15- 13C2-d1(sodium)) is deuterium and 13C labeled Treprostinil (sodium). Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
|
-
- HY-142555S
-
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|
|
Bisphenol A monosulfate-d6 (sodium) is the deuterium labeled Bisphenol A monosulfate sodium [1].
|
-
- HY-100441S1
-
|
|
|
Treprostinil- 13C2,d is the 13C- and deuterium labeled Treprostinil. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
|
-
- HY-W654074
-
|
|
|
1,2-Dilauroyl-3-chloropropanediol-d5 (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate-d5) is the deuterium labeled 1,2-Dilauroyl-3-chloropropanediol (HY-W587507). 1,2-Dilauroyl-3-chloropropanediol (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate) is an ester product.
|
-
- HY-W010265S
-
|
|
|
Butyrophenone-d5 is the deuterium labeled Butyrophenone [1].
|
-
- HY-W767978
-
|
|
|
1-(4,4-Dimethylthiochroman-6-yl)ethanone-d8 (6-Acetyl-4,4-dimethylthio-chroman-d8) is the deuterium labeled 1-(4,4-Dimethylthiochroman-6-yl)ethanone (HY-I0187).
|
-
- HY-W770203
-
|
|
|
1-Oleoyl-2-linoleoyl-rac-glycerol-d5 (DG(18:1/0:0/18:2)-d5) is the deuterium labeled 1-Oleoyl-2-linoleoyl-rac-glycerol (HY-W777107). 1-Oleoyl-2-linoleoyl-rac-glycerol (DG(18:1/0:0/18:2)) is a diacylglycerol, which is composed of a linoleic acid and an oleic acid. 1-Oleoyl-2-linoleoyl-rac-glycerol can be found in dry-cured ham, and acts as the food additive [1].
|
-
- HY-B0456S1
-
|
|
|
Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-109541S2
-
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|
|
Colfosceril miristate-d9 (DMPC-d9) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-W101971S
-
|
|
|
1-(4-Chlorophenyl)-2-methylpropan-2-ol-d6 (1-(4-Chlorophenyl)-2-methyl-2-propanol-d6) is the deuterium labeled 1-(4-Chlorophenyl)-2-methylpropan-2-ol (HY-W101971).
|
-
- HY-Y1039S
-
|
|
|
1-Stearoyl-rac-glycerol-d40 is the deuterium labeled 1-Stearoyl-rac-glycerol [1].
|
-
- HY-109541S5
-
|
|
|
1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67 is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
|
-
- HY-W743123
-
|
|
|
1,3-Dipalmitin-d5 (1,3-Dipalmitoylglycerol-d5) is a deuterium labeled 1,3-Dipalmitin (HY-128792). 1,3-Dipalmitin (1,3-Dipalmitoylglycerol) is a cerebroside that can be found in Typhonium giganteum Engl [1].
|
-
- HY-109541S3
-
|
|
|
Colfosceril miristate-d13 (DMPC-d13) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-B0166S8
-
|
|
|
L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) [1]. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
|
-
- HY-109541S
-
|
|
|
Colfosceril miristate-d58 (DMPC-d58) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-Y1039S1
-
|
|
|
1-Stearoyl-rac-glycerol-d35 is the deuterium labeled 1-Stearoyl-rac-glycerol.
|
-
- HY-W751665
-
|
|
|
1-(Adamantan-1-yl)ethan-1-one-d3 (N-Benzyl-3-carboethoxy-4-piperidone hydrochloride-d3) is the deuterium labeled 1-(Adamantan-1-yl)ethan-1-one (HY-W067624).
|
-
- HY-109541S1
-
|
|
|
Colfosceril miristate-d4 (DMPC-d4) is deuterium labeled Colfosceril miristate. Colfosceril miristate is a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-109541S4
-
|
|
|
Colfosceril miristate-d63 (DMPC-d63) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery [1] .
|
-
- HY-Y1217S1
-
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|
|
1-Cyclohexanol-d11 is the deuterium labeled 1-Cyclohexanol (HY-Y1217). 1-Cyclohexanol (Hydroxycyclohexane) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-114553S
-
|
|
|
1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid-d5 (5F-PB-223-Carboxyindolemetabolite-d5) is deuterium labeled 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid [1].
|
-
- HY-W777649
-
|
|
|
Oxypurinol- 13C, 15N2-1 (Oxipurinol- 13C, 15N2-1) is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol, the major active metabolite of Allopurinoll (HY-B0219), is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout [1].
|
-
- HY-Y1217S
-
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|
|
1-Cyclohexanol-d12 is the deuterium labeled 1-Cyclohexanol (HY-Y1217). 1-Cyclohexanol (Hydroxycyclohexane) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-W777620
-
|
|
|
1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone- 13C,d3 (rac-Cotinine- 13C,d3) is the deuterium and 13C-labeled 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (HY-W588192).
|
-
- HY-78004S1
-
|
|
|
1,2-Diphenylethane-d4 (Dibenzil-d4; s-Diphenylethane-d4; Bibenzyl-d4) is the deuterium labeled Bibenzyl (HY-78004) [1].
|
-
- HY-131325S
-
|
|
|
Simeton-d3 (N2,N4-Diethyl-6-(methoxy-d3)-1,3,5-triazine-2,4-diamine) is deuterium labeled Simeton [1].
|
-
- HY-12516S2
-
|
|
|
Desogestrel- 13C2,d2-1 (Org-2969- 13C2,d2-1) is the deuterium labeled and 13C-labeled Desogestrel (HY-12516). Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups [1] .
|
-
- HY-Y1641S
-
|
|
|
1,2-Ethanedithiol-d4 is the deuterium labeled 1,2-Ethanedithiol [1].
|
-
- HY-W709612
-
|
|
|
Regorafenib N-oxide and N-desmethyl (M5)-d3-1 (N-Desmethyl regorafenib N-oxide-d3-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 [1].
|
-
- HY-W392083S1
-
|
|
|
(1,3E,5Z)-Undeca-1,3,5-triene-d5 is deuterated labeled (1,3E,5Z)-Undeca-1,3,5-triene.
|
-
- HY-Y1309S1
-
|
|
|
1-Naphthol-d7 is the deuterium labeled Naphthol [1].
|
-
- HY-W392083S
-
|
|
|
(1,3E,5E)-Undeca-1,3,5-triene-d5 is deuterated labeled (1,3E,5E)-Undeca-1,3,5-triene.
|
-
- HY-Y1309S
-
|
|
|
1-Naphthol-d8 is the deuterium labeled 1-Naphthol [1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe .
|
-
- HY-W050145S
-
|
|
|
Levoglucosan-d7 is the deuterium labeled Levoglucosan. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature [1] .
|
-
- HY-125771S
-
|
|
|
1-Stearoyl-sn-glycero-3-phosphocholine-d35 is deuterium labeled 1-Stearoyl-sn-glycero-3-phosphocholine (HY-125771). 1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells [1].
|
-
- HY-146737S
-
|
|
|
Tripentadecanoin-d5 is the deuterium labeled Tripentadecanoin.
|
-
- HY-W777706
-
|
|
|
1-(3,4-Dimethylphenyl)ethan-1-ol- 13C,d3 (1-(3,4-Dimethylphenyl)ethanol- 13C,d3) is the deuterium labeled and 13C-labeled 1-(3,4-Dimethylphenyl)ethan-1-ol (HY-W340128).
|
-
- HY-Y0727S
-
|
|
|
1,5-Dibromopentane-d4 is the deuterium labeled 1,5-Dibromopentane [1].
|
-
- HY-34444S
-
|
|
|
1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan [1].
|
-
- HY-W048482S
-
|
|
|
rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-Y0727S1
-
|
|
|
1,5-Dibromopentane-d10 is the deuterium labeled 1,5-Dibromopentane [1].
|
-
- HY-W040193S6
-
|
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d13 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-W040193S2
-
|
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-W040193S5
-
|
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc
|
-
- HY-Y1772S
-
|
|
|
1-Iodo-4-methylbenzene-d7 is the deuterium labeled 1-Iodo-4-methylbenzene [1].
|
-
- HY-128792S
-
|
|
|
1,3-Dipalmitin-d6 (Glyceryl 1,3-dipalmitate-d6) is deuterium labeled 1,3-Dipalmitin. 1,3-Dipalmitin (1,3-Dipalmitoylglycerol) is a cerebroside that can be found in Typhonium giganteum Engl [1] [1] .
|
-
- HY-W040193S1
-
|
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-gly
|
-
- HY-Y1044S
-
|
|
|
1,5-Dihydroxypentane-d10 is the deuterium labeled 1,5-Dihydroxypentane [1].
|
-
- HY-Y0093S
-
|
|
|
NSC 5416-d14 is the deuterium labeled NSC 5416 [1].
|
-
- HY-W040193S
-
|
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70 is the deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system [1] .
|
-
- HY-W749377
-
|
|
|
1,2,3,4,5-Pentabromo-6-methylbenzene- 13C6 (Toluene, 2,3,4,5,6-pentabromo- 13C6) is the 13C-labeled 1,2,3,4,5-Pentabromo-6-methylbenzene (HY-W274110).
|
-
- HY-W699983
-
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|
|
Imidazole- 15N2 (Glyoxaline- 15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease [1] .
|
-
- HY-W040193S3
-
|
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system [1] .
|
-
- HY-113123S1
-
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|
|
LysoPC(14:0/0:0)-d7 (14:0 Lyso PC-d7) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect [1] .
|
-
- HY-W285163S
-
|
|
|
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
|
-
- HY-12650S
-
|
|
|
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS [1].
|
-
- HY-W040193S4
-
|
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d4 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc
|
-
- HY-Y0860S
-
|
|
|
1,6-Dibromo-n-hexane-d12 is the deuterium labeled 1,6-Dibromo-n-hexane [1].
|
-
- HY-Y0659S
-
|
|
|
1,2,3,4-Hydroquinoline-d2 (1,2,3,4-Tetrahydroquinoline-d2) is the deuterium labeled 1,2,3,4-Hydroquinoline.
|
-
- HY-W013053S
-
|
|
|
Dibenz[a,h]anthracene-d14 is the deuterium Dibenz[a,h]anthracene.
|
-
- HY-W242724
-
|
|
|
1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d8 is the deuterium labeled 1,4-Dibromo-butane [1].
|
-
- HY-W762019S
-
|
|
|
1,2,3,4,7,8-Hexachloro dibenzo-p-dioxin- 13C12 (1,2,3,4,7,8-HxCDD- 13C12) is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin [1].
|
-
- HY-W662572S
-
|
|
|
Pyroxsulam-d6 (N-(5,7-Dimethoxy-d6[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide) is deuterium labeled N-(5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide [1].
|
-
- HY-41681S
-
|
|
|
6-Chloro-1-hexanol-d6 is the deuterium labeled 6-Chloro-1-hexanol [1].
|
-
- HY-W050145S2
-
|
|
|
Levoglucosan- 13C6 is the 13C labeled Levoglucosan [1]. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature .
|
-
- HY-151997S
-
|
|
|
1,2-Dioleoyl-3-lauroyl-rac-glycerol- 13C3 is the 13C-labeled 1,2-Dioleoyl-3-lauroyl-rac-glycerol (HY-165089), 1,2-Dioleoyl-3-lauroyl-rac-glycerol (1,2-Olein-3-laurin) is a triglyceride identified by specific analytical methods in human milk, infant formula, other mammalian milk, and vegetable oils, with specific structural and distribution characteristics.
|
-
- HY-W766078
-
|
|
|
1-beta-D-Arabinofuranosyluracil- 13C, 15N2 (1-b-D-Arabinofuranosyluracil- 13C, 15N2; Uracil 1-β-D-arabinofuranoside- 13C, 15N2) is the 13C- and 15N-labeled labeled 1-beta-D-Arabinofuranosyluracil (HY-N6652). 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties [1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .
|
-
- HY-Y0219S
-
|
|
|
NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128 [1].
|
-
- HY-A0052S
-
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|
|
(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4 is deuterated labeled (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide.
|
-
- HY-Y0045S
-
|
|
|
2-Acetylthiazole- 13C2 is 13C labeled 2-Acetylthiazole (HY-Y0045). 2-Acetylthiazole (1-(1,3-Thiazol-2-yl)ethanone; 1-(Thiazol-2-yl)ethanone; Methyl 2-thiazolyl ketone) is a flavor compound. 2-Acetylthiazole is a kind of biological materials or organic compounds that are widely used in life science research [1].
|
-
- HY-33948S
-
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|
|
1-Amino-2-methylpropan-2-ol-d6 is the deuterium labeled 1-Amino-2-methylpropan-2-ol [1].
|
-
- HY-34123S
-
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|
|
N-(2-Bromoethyl)phthalimide-d4 is the deuterium labeled N-(2-Bromoethyl)phthalimide[1].
|
-
- HY-59354S1
-
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|
|
1,2-Dihydropyridazine-3,6-dione-3,4,5,6- 13C4 (1,2-Dihydro-3,6-pyridazine- 13C4-dione) is 13C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins [1] .
|
-
- HY-W778954
-
|
|
|
2,2-Dimethyl-1,3-dioxolane-4-methanol- 13C3 ((2,2-Dimethyl-[1,3] dioxane-4-yl)-methanol- 13C3) is the 13C-labeled 2,2-Dimethyl-1,3-dioxolane-4-methanol (HY-Y1372).
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| Cat. No. |
Product Name |
|
Classification |
-
- HY-RS25282
-
|
Rpo2tc1
|
|
siRNAs
Rat Pre-designed siRNA Sets
|
|
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
- HY-RS13999
-
|
P15; PC4; p14
|
|
siRNAs
Human Pre-designed siRNA Sets
|
|
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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- HY-RS18793
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P9; P15; Pc4; Rpo2tc1
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siRNAs
Mouse Pre-designed siRNA Sets
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Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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- HY-RS00945
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LSC; GEF1; IMD62; LBCL2; SUB1.5; P115-RHOGEF
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siRNAs
Human Pre-designed siRNA Sets
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ARHGEF1 Human Pre-designed siRNA Set A contains three designed siRNAs for ARHGEF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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