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STK-899704

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-120339
    STK899704

    		Microtubule/Tubulin FAK MEK ERK MMP Caspase PARP Apoptosis MDM-2/p53 Cancer
    STK899704 is a tubulin inhibitor. STK899704 inhibits microtubule polymerization, leading to microtubule depolymerization. STK899704 exhibits broad-spectrum inhibitory activity against various cancer cell lines, including cervical cancer, breast cancer, and lung cancer, with IC50 values ​​ranging from 0.2 to 1.0 μM. STK899704 disrupts the mitotic spindle structure, inducing G2/M phase cell cycle arrest. STK899704 inhibits the migration ability of HT29 cells by downregulating the FAK-MEK-ERK signaling pathway, thereby suppressing the expression and activity of MMP-2 and MMP-9. STK899704 activates caspase-3/7/8/9, leading to PARP cleavage and inducing apoptosis. STK899704 induces cellular senescence through the p53 pathway. STK899704 exhibits significant anti-tumor effects in mouse skin cancer. STK899704 can be used in research on skin cancer, lung cancer, colon cancer, and other cancers .
    STK899704

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