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Results for "

SRI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arrestin (2) Beta-secretase (1) c-Met/HGFR (2) CDK (1) CFTR (2) Dopamine Receptor (1) Dopamine Transporter (3) Drug Derivative (2) ERK (1) HIV (2) HIV Protease (1) HuR (2) Isotope-Labeled Compounds (1) LRRK2 (1) MMP (1) Opioid Receptor (1) RET (1) Serotonin Transporter (1) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (3) Wnt (1)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150089

SRI-37240	CFTR	Inflammation/Immunology
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .

HY-142114

SRI-37330 3 Publications Verification	Arrestin	Metabolic Disease
SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research .

HY-141623

SRI-37330 hydrochloride 3 Publications Verification	Arrestin	Metabolic Disease
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research .

HY-148853

SRI-42127 1 Publications Verification	HuR	Others
SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes .

HY-175661

SRI-22136	Opioid Receptor Beta-secretase	Neurological Disease
SRI-22136 is a Delta Opioid Receptor (DOR) antagonist that can cross blood-brain barrier with a IC₅₀ of 0.42 nM. SRI-22136 does not have agonistic activity but antagonistic activity against DOR, MOR (IC₅₀ = 370 nM), KOR (IC₅₀ = 54 nM) and can avoid addiction/aversion effects. SRI-22136 can effectively inhibit the BACE1 activity induced by DADLE (a DOR agonist) (HY-105343) (IC₅₀ = 120 nM). SRI-22136 prevents completely Alzheimer’s-like pathology in mouse model. SRI-22136 can used for the study of Alzheimer’s disease .

HY-126158

SRI-29574	Dopamine Transporter Serotonin Transporter	Neurological Disease
SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC₅₀=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT .

HY-112580

SRI-31040	Drug Derivative	Others
SRI-31040 is an active compound.

HY-175535

SRI-32743	HIV Protease HIV Dopamine Transporter	Infection Neurological Disease
SRI-32743 is an allosteric human dopamine transporter (hDAT) modulator (IC₅₀=9.86 μM). SRI-32743 is promising for research of HIV-Tat-induced neurotoxicity .

HY-175534

SRI-45949	Dopamine Receptor HIV	Infection Neurological Disease
SRI-45949 is an allosteric modulator of the HIV-DAT-Tat interaction. SRI-45949 has IC₅₀ values of 9.56 μM and 9.34 μM for [ ³H]DA uptake and [ ³H]WIN35,428 binding, respectively. SRI-45949 can be used in research related to HIV-associated neurocognitive disorders .

HY-100347S

SRI-011381-d5	Isotope-Labeled Compounds TGF-beta/Smad	Neurological Disease
SRI-011381-d₅ is the deuterium labeled SRI-011381 (HY-100347). SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

HY-117902

SRI-31142	Dopamine Transporter	Neurological Disease
SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine .

HY-75368

SRI-31255	LRRK2	Neurological Disease
SRI-31255 is an orally active LRRK2 inhibitor with IC₅₀ values of 520 and 427 nM for human wild-type (WT) and mutant G2019S, respectively. SRI-31255 exerts neuroprotective effects by binding to the ATP-binding pocket of LRRK2, inhibiting kinase activity. SRI-31255 can be used as a lead compound for the development of LRRK2-targeted drugs for the treatment of Parkinson's disease .

HY-150090

SRI-41315 1 Publications Verification	CFTR	Inflammation/Immunology
SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity .

HY-117002

SRI 37892	Wnt	Cancer
SRI 37892 is a small molecule compound inhibitor of Frizzled protein 7 (Fzd7) with inhibitory activity against cancer cell proliferation (IC₅₀=2μM). SRI 37892 significantly blocks Wnt/Fzd7 signaling. SRI 3789 can be used in the research of developing cancer therapeutic agents [1].

HY-100347A

SRI-011381 hydrochloride Maximum Cited Publications 51 Publications Verification	TGF-beta/Smad	Neurological Disease
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

HY-100347

SRI-011381 Maximum Cited Publications 51 Publications Verification	TGF-beta/Smad	Neurological Disease
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

HY-114363

SRI 31215	c-Met/HGFR	Cancer
SRI 31215 is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC₅₀ values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer .

HY-114363A

SRI 31215 TFA 2 Publications Verification	c-Met/HGFR	Cancer
SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC₅₀ values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer .

HY-123600

SRI-29329	CDK	Others
SRI-29329 is a specific CLK inhibitor, with IC₅₀ values of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively .

HY-160783

SRI-43265	HuR	Cancer
SRI-43265 (compound 40) is an inhibitor of human antigen R protein (HuR) dimerization, and HuR multimers have been implicated in cancer and inflammatory pathogenesis .

HY-147251

SRI 6409-94	Drug Derivative	Others
SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity .

HY-RS13767

SRI Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SRI Human Pre-designed siRNA Set A contains three designed siRNAs for SRI gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SRI Human Pre-designed siRNA Set A SRI Human Pre-designed siRNA Set A

HY-RS17159

Sri Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sri Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sri gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sri Mouse Pre-designed siRNA Set A Sri Mouse Pre-designed siRNA Set A

HY-RS23609

Sri Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sri Rat Pre-designed siRNA Set A contains three designed siRNAs for Sri gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sri Rat Pre-designed siRNA Set A Sri Rat Pre-designed siRNA Set A

HY-19956

GI254023X 15+ Cited Publications GI4023; SRI028594	MMP	Cancer
GI254023X is a potent MMP9 and ADAM10 inhibitor with IC₅₀s of 2.5 and 5.3 nM, respectively.

HY-N9533

16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid	Others	Others
16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid is a lanostanoid that can be found in the Sri Lankan basidiomycete Ganoderma applanatum .

HY-178061

APS03118	ERK RET	Cancer
APS03118 is an orally active, potent and selective rearranged during transfection (RET) inhibitor. APS03118 broadly inhibits RET fusions and mutations (including G810, V804, L730, and Y806 variants), with IC₅₀ values predominantly below 1 nM (0.095 nM for WT; ranging from 0.00438 to 5.72 nM for mutants), and demonstrates marked superiority against RET G810 mutations. APS03118 inhibits the entire RET signaling pathway (including RET, Shc, and ERK1/2), with >20-fold selectivity over most off-target kinases (except FLT3 and YES). APS03118 induces complete tumor regression in KIF5B-RET and CCDC6-RET V804 M patient derived xenografts (PDXs) and significantly prolongs survival in an intracranial CCDC6-RET metastasis mice model. APS03118 can be used for selective RET inhibitor (SRI)-resistant, RET-driven cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9533

16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Other Diseases Disease Research Fields	Others
16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid is a lanostanoid that can be found in the Sri Lankan basidiomycete Ganoderma applanatum .

Species:	Human (3)
Tag:	His (1) Tag Free (1) GST (2)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P77211

	*Sorcin/SRI* Protein, Human (sf9, His-GST)** 22 kDa protein; CP22; V19	Human	Sf9 insect cells
	The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (sf9, His-GST) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P77210

	*Sorcin/SRI* Protein, Human (sf9)** 22 kDa protein; CP22; V19	Human	Sf9 insect cells
	The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (sf9) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with tag free.

HY-P700311

	*Sorcin/SRI* Protein, Human (E.coli, GST)** 22 kDa protein; CP22; V19	Human	E. coli
	The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (E.coli, GST) is the recombinant human-derived Sorcin/SRI protein, expressed by E. coli , with N-GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-100347S

SRI-011381-d5
SRI-011381-d₅ is the deuterium labeled SRI-011381 (HY-100347). SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

SRI Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SRI Human Pre-designed siRNA Set A contains three designed siRNAs for SRI gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sri Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sri Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sri gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sri Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Sri Rat Pre-designed siRNA Set A contains three designed siRNAs for Sri gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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