SORT

By Targets:	Autophagy (1) Bacterial (1) Carboxypeptidase (1) Cytochrome P450 (1) Drug Metabolite (1) Endogenous Metabolite (1) Fluorescent Dye (1) Fungal (1) Lipocalin Family (1) Liposome (1) Neurotensin Receptor (9) Notch (1) PI3K (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (7) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (5)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153688

SORT-PGRN interaction inhibitor 3	Neurotensin Receptor	Neurological Disease
SORT-PGRN interaction inhibitor 3 (Compound 13) is a *SORT-PGRN* interaction inhibitor (IC₅₀: 0.17 μM). SORT-PGRN interaction inhibitor 3 can be used for research of neurodegenerative diseases .

HY-159878

SORT1-IN-5	Neurotensin Receptor	Cancer
SORT1-IN-5 (compound 3) is a blood-brain barrier permeable *SORT1* inhibitor. SORT1-IN-5 is an MSOH salt with limited oral bioavailability .

HY-159868

SORT1-IN-1	Neurotensin Receptor	Cancer
SORT1-IN-1 (compound 2) is a *SORT1* inhibitor .

HY-159875

SORT1-IN-2	Neurotensin Receptor	Cancer
SORT1-IN-2 (compound 6) is a *SORT1* inhibitor .

HY-159876

SORT1-IN-3	Neurotensin Receptor	Cancer
SORT1-IN-3 (compound 5) is a blood-brain barrier permeable *SORT1* inhibitor .

HY-159877

SORT1-IN-4	Neurotensin Receptor	Cancer
SORT1-IN-4 (compound 6) is a blood-brain barrier permeable *SORT1* inhibitor .

HY-153687

SORT-PGRN interaction inhibitor 2	Neurotensin Receptor	Neurological Disease
SORT-PGRN interaction inhibitor 2 is a *SORT-PGRN* inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research .

HY-RS13575

SORT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SORT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SORT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SORT1 Human Pre-designed siRNA Set A SORT1 Human Pre-designed siRNA Set A

HY-RS27567

Sort1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sort1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sort1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sort1 Rat Pre-designed siRNA Set A Sort1 Rat Pre-designed siRNA Set A

HY-RS21049

Sort1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sort1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sort1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sort1 Mouse Pre-designed siRNA Set A Sort1 Mouse Pre-designed siRNA Set A

HY-115213

SORT-PGRN interaction inhibitor 1	Neurotensin Receptor	Neurological Disease
SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC₅₀ of 2 μM .

HY-122245

Sortin2	Fungal	Cancer
Sortin2 is a synthetic compound and a Yeast vacuolar protein sorting* (vps)* inhibitor . Sortin2 can affect protein targeting to the vacuole in Saccharomyces cerevisiae .

HY-12827

Sortin1	Carboxypeptidase	Others
Sortin1 is a vacuolar protein sorting inhibitor that targets carboxypeptidase Y (CPY). Sortin1 is a soluble and membrane vacuolar marker molecule in plants and yeast .

HY-163324A

2-Me PeER	Cytochrome P450	Others
2-Me PeER is a rhodamine dye-based fluorescent probe that detects CYP3A4 activity. In fluorescence-activated cell sorting (FACS) based on CYP3A4 activity, homogeneous and functional human induced pluripotent stem cell (hiPSC)-derived hepatocytes and intestinal epithelial cells can be obtained with the aid of 2-Me PeER .

HY-132975

PrDiAzK	Bacterial	Others
PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT) . PrDiAzK is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1581

BODIPY 505/515-8-C3-COOH	Fluorescent Dye	Others
BODIPY 505/515-8-C3-COOH is a green fluorescing derivative, as a fluorescent dye for imaging lipid droplets in nannochloropsis. BODIPY 505/515-8-C3-COOH can be used for the research of flow cytometric high-throughput screening and cell sorting .

HY-153686

BVFP	Neurotensin Receptor	Neurological Disease
BVFP binds to the PGRN_588–593 peptide with a K_d of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis .

HY-W339816

(S,R)-Bis(monomyristoylglycero)phosphate ammonium	Lipocalin Family Endogenous Metabolite	Others
(S,R)-Bis(monomyristoylglycero)phosphate ammonium actively contributes to cargo sorting by promoting the degradation and sorting of lipids, and it plays a critical role in the sorting of polyunsaturated fatty acids (PUFAs) within acidic organelles. This phospholipid features two phosphate-linked glycerol molecules arranged in a unique sn-1 glycerophospho-sn-1′ glycerol stereoconformation, with each glycerol molecule esterified to a myristic acid. Typically, it is found in the intraluminal vesicles (ILVs) of late endosomes and lysosomes.

HY-W747072

3-Sulfo-taurocholic Acid Disodium Salt 3-Sulfocholyl Taurine; TCA3S	Drug Metabolite	Metabolic Disease
3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.

HY-177069

4A3-SC7	Liposome	Others
4A3-SC7 is a polymer of 4A3 amine and is an ionizable lipid component. 4A3-SC7 can be used to prepare lipid nanoparticles (LNPs) to construct a selective organ targeting (SORT) LNP platform .

HY-101920

Autophinib 5+ Cited Publications	Autophagy PI3K	Neurological Disease Cancer
Autophinib is a potent, selective autophagy inhibitor with IC₅₀s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive *Vacuolar Protein Sorting* 34 (VPS34) inhibitor with an IC₅₀ of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34** .

HY-N9790

Procyanidin B2 3,3'-di-O-gallate	Notch	Others
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway .

HY-120821

Endosidin-2 1 Publications Verification ES2	Others	Others
Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting) .

Cat. No.	Product Name

HY-L209

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library	1,998 compounds
The Ancient Chinese Classical Formulas, released by the State Administration of Traditional Chinese Medicine, selects the classic prescriptions from more than 100,000 prescriptions contained in more than 100 representative ancient medical books. Experts said that the classic prescription derived from ancient books, with thousands of years of human experience, is widely used in common diseases, frequented diseases, chronic diseases and other fields, and its development and utilization can fill the gap in medical drugs for some diseases in China, and effectively alleviate the increasingly severe medical needs brought by a series of social problems such as aging and chronic diseases in China. MCE has collected and sorted out these monomer compounds from the sources of ancient Chinese classical formulas, including licorice, ginseng, pinellia and other traditional Chinese medicine sources, which help to provide new ideas and new strategies for modern drug development. MCE ancient Chinese classical formulas traditional Chinese medicine active compound library has 1,998 traditional Chinese medicine monomer compound, which can be used in the research fields of new drug development and drug target identification.

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

1,998 compounds

The Ancient Chinese Classical Formulas, released by the State Administration of Traditional Chinese Medicine, selects the classic prescriptions from more than 100,000 prescriptions contained in more than 100 representative ancient medical books. Experts said that the classic prescription derived from ancient books, with thousands of years of human experience, is widely used in common diseases, frequented diseases, chronic diseases and other fields, and its development and utilization can fill the gap in medical drugs for some diseases in China, and effectively alleviate the increasingly severe medical needs brought by a series of social problems such as aging and chronic diseases in China. MCE has collected and sorted out these monomer compounds from the sources of ancient Chinese classical formulas, including licorice, ginseng, pinellia and other traditional Chinese medicine sources, which help to provide new ideas and new strategies for modern drug development.

MCE ancient Chinese classical formulas traditional Chinese medicine active compound library has 1,998 traditional Chinese medicine monomer compound, which can be used in the research fields of new drug development and drug target identification.

HY-L140

Withdrawn Drug Compound Library	217 compounds
Withdrawal or delisting drugs refer to drugs that are recalled or discontinued from the market due to low efficiency, serious side effects, financial and regulatory problems and other reasons. Once the drug is withdrawn from the market, it will cause heavy losses to the original research company that invested a lot of time, finance and other costs to develop the drug. Adverse drug reaction (ADR) is the main reason for drug withdrawal from the market. ADR refers to the unexpected effects caused by the reasons such as the target-directed interaction during the treatment. However, studying the mechanism of these ADRs may just be a breakthrough in finding new indications. For example, thalidomide, the protagonist of the drug damage event that caused numerous "seal babies" deformed infants, was found to be due to the degradation of a transcription factor - SALL4 after delisting, which made thalidomide have a new clinical application. In 1998, it was approved by FDA for the treatment of leprosy nodular erythema, and in 2006, it was approved for the treatment of multiple myeloma. ADR study of delisted drugs can not only avoid the loss of drug development in advance but also bring hope to new indications. MCE has sorted out 217 drug compounds withdrawn from the market through FDA, EMA and other authoritative platforms. Each compound has withdrawal records in at least one country/market. It is a useful tool for conducting research on drug side effects or drug toxicity mechanisms and discovering new indications of drugs.

Withdrawn Drug Compound Library

217 compounds

Withdrawal or delisting drugs refer to drugs that are recalled or discontinued from the market due to low efficiency, serious side effects, financial and regulatory problems and other reasons. Once the drug is withdrawn from the market, it will cause heavy losses to the original research company that invested a lot of time, finance and other costs to develop the drug.

Adverse drug reaction (ADR) is the main reason for drug withdrawal from the market. ADR refers to the unexpected effects caused by the reasons such as the target-directed interaction during the treatment. However, studying the mechanism of these ADRs may just be a breakthrough in finding new indications. For example, thalidomide, the protagonist of the drug damage event that caused numerous "seal babies" deformed infants, was found to be due to the degradation of a transcription factor - SALL4 after delisting, which made thalidomide have a new clinical application. In 1998, it was approved by FDA for the treatment of leprosy nodular erythema, and in 2006, it was approved for the treatment of multiple myeloma. ADR study of delisted drugs can not only avoid the loss of drug development in advance but also bring hope to new indications.

MCE has sorted out 217 drug compounds withdrawn from the market through FDA, EMA and other authoritative platforms. Each compound has withdrawal records in at least one country/market. It is a useful tool for conducting research on drug side effects or drug toxicity mechanisms and discovering new indications of drugs.

Cat. No.	Product Name	Type

HY-D1581

BODIPY 505/515-8-C3-COOH	Fluorescent Dyes/Probes
BODIPY 505/515-8-C3-COOH is a green fluorescing derivative, as a fluorescent dye for imaging lipid droplets in nannochloropsis. BODIPY 505/515-8-C3-COOH can be used for the research of flow cytometric high-throughput screening and cell sorting .

Cat. No.	Product Name	Target	Research Area

HY-P5481

DABCYL-LPETG-EDANS	Peptides	Others
DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)

HY-P5067

EAK16-II	Peptides	Others
EAK16-II is an amphipathic peptide that inhibits the self-sorting of EAKIIH6 in a concentration-dependent manner .

Cat. No.	Product Name	Target	Research Area

HY-P991011

Nivisnebart	Inhibitory Antibodies	Inflammation/Immunology
HY-P991011 is an *SORT1*-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9790

Procyanidin B2 3,3'-di-O-gallate	Structural Classification Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	Notch
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway .

Species:	Human (2)
Tag:	His (2) Avi (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P78773

	*Sortilin/SORT1 Protein, Human (HEK293, His)* SORTilin; SORT1; 100 kDa NT receptor; Glycoprotein 95; Gp95; Gp95LDLCQ6; Neurotensin receptor 3; NT3NTR3; Ntr3; SORTilin 1;	Human	HEK293
	The Sortilin/SORT1 protein acts as a sorting receptor in the Golgi apparatus and as a clearance receptor on the cell surface. It plays a crucial role in protein transport to lysosomes, independent of M6PR. Sortilin/SORT1 Protein, Human (HEK293, His) is the recombinant human-derived Sortilin/SORT1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78775

	*Sortilin/SORT1 Protein, Human (Biotinylated, HEK293, His-Avi)* SORTilin; SORT1; 100 kDa NT receptor; Glycoprotein 95; Gp95; Gp95LDLCQ6; Neurotensin receptor 3; NT3NTR3; Ntr3; SORTilin 1;	Human	HEK293
	The Sortilin/SORT1 protein acts as a sorting receptor in the Golgi apparatus and as a clearance receptor on the cell surface. It plays a crucial role in protein transport to lysosomes, independent of M6PR. Sortilin/SORT1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Sortilin/SORT1 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83498

	Sortilin Antibody (YA3243) 100 kDa NT receptor; Glycoprotein 95; Gp95; LDLCQ6; Neurotensin receptor 3; NT3; NTR3; SORT 1; SORTilin 1	WB, IHC-P	Human, Rat
	Sortilin Antibody (YA3243) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3243), targeting Sortilin, with a predicted molecular weight of 92 kDa (observed band size: 92 kDa). Sortilin Antibody (YA3243) can be used for WB, IHC-P experiment in human, rat background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-132975

PrDiAzK		Alkynes
PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT) . PrDiAzK is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS13575

SORT1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SORT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SORT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27567

Sort1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Sort1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sort1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21049

Sort1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sort1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sort1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides