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  5. Sortilin Antibody (YA3243)

Sortilin Antibody (YA3243)

Cat. No.: HY-P83498
COA
SDS
User Guide for Antibodies Technical Support

Sortilin Antibody (YA3243) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3243), targeting Sortilin, with a predicted molecular weight of 92 kDa (observed band size: 92 kDa). Sortilin Antibody (YA3243) can be used for WB, IHC-P experiment in human, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Sortilin Antibody (YA3243) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3243), targeting Sortilin, with a predicted molecular weight of 92 kDa (observed band size: 92 kDa). Sortilin Antibody (YA3243) can be used for WB, IHC-P experiment in human, rat background.
Background

Sortilin functions as a sorting receptor in the Golgi compartment and a clearance receptor on the cell surface. It mediates protein transport from the Golgi apparatus to lysosomes via an M6PR-independent pathway: lysosomal proteins bind to the receptor in the Golgi, and the resulting complex is transported to acidic prelysosomal compartments where low pH triggers dissociation (by similar: the receptor recycles back to the Golgi via retromer binding). It also facilitates Golgi-to-endosome transport, promotes neuronal apoptosis by internalizing proBDNF/proNGFB, and acts as a neurotensin receptor. During osteogenic differentiation, it scavenges extracellular LPL to aid matrix mineralization. In adipocytes, it likely contributes to forming GLUT4 storage vesicles (GSVs) for insulin-responsive glucose uptake. Potential involvement in ER-to-Golgi transport is also suggested.
Gene ID
SwissProt ID
Synonyms
100 kDa NT receptor; Glycoprotein 95; Gp95; LDLCQ6; Neurotensin receptor 3; NT3; NTR3; SORT 1; Sortilin 1
Molecular Weight

Predicted band size: 92 kDa; Observed band size: 92 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Neuroscience
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Recombinant protein of human Sortilin/NT3
Database

Entrez Gene: 6272 Human ; 20661 Mouse ; 83576 Rat

SwissProt: Q99523 Human ; Q6PHU5 Mouse ; O54861 Rat

OMIM: 602458 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

Sortilin Antibody (YA3243) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sortilin Antibody (YA3243)
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HY-P83498
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