Search Result

Results for "

SOC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) BCL6 (1) Calcium Channel (2) COX (1) CRAC Channel (3) E1/E2/E3 Enzyme (2) EAAT (1) Formyl Peptide Receptor (FPR) (1) Glycosidase (1) HIV (1) Interleukin Related (3) JAK (1) Lipase (1) NF-κB (2) NO Synthase (6) Small Interfering RNA (siRNA) (14) STAT (2) TGF-beta/Smad (1) TNF Receptor (2) TRP Channel (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (8) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (4)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (8) siRNAs (14)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS25028

Socs2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Socs2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Socs2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Socs2 Rat Pre-designed siRNA Set A Socs2 Rat Pre-designed siRNA Set A

HY-RS13553

SOCS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOCS2 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOCS2 Human Pre-designed siRNA Set A SOCS2 Human Pre-designed siRNA Set A

HY-RS13555

SOCS4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOCS4 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOCS4 Human Pre-designed siRNA Set A SOCS4 Human Pre-designed siRNA Set A

HY-RS16260

Socs3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Socs3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Socs3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Socs3 Mouse Pre-designed siRNA Set A Socs3 Mouse Pre-designed siRNA Set A

HY-RS17712

Socs1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Socs1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Socs1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Socs1 Mouse Pre-designed siRNA Set A Socs1 Mouse Pre-designed siRNA Set A

HY-RS13556

SOCS5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOCS5 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOCS5 Human Pre-designed siRNA Set A SOCS5 Human Pre-designed siRNA Set A

HY-RS18546

Socs2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Socs2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Socs2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Socs2 Mouse Pre-designed siRNA Set A Socs2 Mouse Pre-designed siRNA Set A

HY-RS24177

Socs1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Socs1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Socs1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Socs1 Rat Pre-designed siRNA Set A Socs1 Rat Pre-designed siRNA Set A

HY-RS13552

SOCS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOCS1 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOCS1 Human Pre-designed siRNA Set A SOCS1 Human Pre-designed siRNA Set A

HY-RS23359

Socs3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Socs3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Socs3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Socs3 Rat Pre-designed siRNA Set A Socs3 Rat Pre-designed siRNA Set A

HY-RS13557

SOCS6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOCS6 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOCS6 Human Pre-designed siRNA Set A SOCS6 Human Pre-designed siRNA Set A

HY-RS13554

SOCS3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOCS3 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOCS3 Human Pre-designed siRNA Set A SOCS3 Human Pre-designed siRNA Set A

HY-RS13558

SOCS7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOCS7 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOCS7 Human Pre-designed siRNA Set A SOCS7 Human Pre-designed siRNA Set A

HY-103310

MRS1845 1 Publications Verification	Calcium Channel CRAC Channel	Cardiovascular Disease
MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC₅₀ of 1.7 μM . MRS1845 is an ORAI1 inhibitor . MRS1845 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P10373

pJAK2(1001–1013)	JAK	Infection
pJAK2(1001-1013) is a *SOCS1/3* antagonist. pJAK2(1001–1013) plays a positive role in antiviral immune response by inhibiting the negative regulatory effect of *SOCS* proteins and enhancing the JAK/STAT signaling pathway

HY-P2775

β-Glucosidase, almond 1 Publications Verification	Glycosidase	Others
β-Glucosidase, almond is the rate-limiting enzyme in cellulose degradation. β-Glucosidase is a major group among glycoside hydrolases. β-Glucosidase is involved in the degradation of cellulose in soils and has potential for monitoring soil quality .

HY-172535

Lipid OA2 dihydrochloride	Lipase	Inflammation/Immunology Cancer
Lipid OA2 dihydrochloride is an ionizable cationic lipid that can be used to prepare single-component lipid nanoparticles for siRNA delivery. Lipid OA2 dihydrochloride can effectively deliver SOCS1-siRNA to dendritic cells, silence the SOCS1 gene, and enhance their antigen-presenting ability and pro-inflammatory factor secretion capacity .

HY-155335

FPR2 agonist 3	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
FPR2 agonist 3 (compound CMC23) can limit the lactate dehydrogenase release in LPS (HY-D1056) -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6. FPR2 agonist 3 decrease the level of phosphor-STAT3 via the *STAT3/SOCS3* signaling pathway .

HY-141482

WSB1 Degrader 1	E1/E2/E3 Enzyme	Cancer
WSB1 Degrader 1 is a poten and orally active *WSB1 (WD repeat and SOCS* box-containing 1)** degrader. WSB1 Degrader 1 has anticancer metastatic effects .

HY-169908

STAT3-IN-37	STAT	Cancer
STAT3-IN-37 (Compound 101) is the inhibitor for STAT3 with an IC₅₀ of 15 nM (measuring by DNA-HTRF assay) or 2 nM (measuring by human whole blood SOCS3 qPCR assay) .

HY-13812

QNZ 40+ Cited Publications EVP4593	NF-κB TNF Receptor	Neurological Disease Inflammation/Immunology
QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC₅₀s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of *SOC* channel.

HY-RS15395

UBXN11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UBXN11 Human Pre-designed siRNA Set A contains three designed siRNAs for UBXN11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UBXN11 Human Pre-designed siRNA Set A UBXN11 Human Pre-designed siRNA Set A

HY-156395

MN551	E1/E2/E3 Enzyme	Cancer
MN551 is a potent inhibitor of cysteine-directed electrophilic covalent that plays important roles in the biology of SOCS2 and its CRL5 complex, and as E3 ligase handles in proteolysis targeting chimera (PROTACs) to induce targeted protein degradation .

HY-P10385

SPSB2-iNOS inhibitory cyclic peptide-3	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-3 (Compound CP3) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM .

HY-13812R

QNZ (Standard)	NF-κB TNF Receptor	Neurological Disease Inflammation/Immunology
QNZ (Standard) is the analytical standard of QNZ. This product is intended for research and analytical applications. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.

HY-P990001

Anti-Mouse IL-10 Antibody (JES5-2A5)	Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse IL-10 IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for research on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM) .

HY-P10384

SPSB2-iNOS inhibitory cyclic peptide-2	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 (Compound CP2) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 is reduction-resistant and oxidatively stable .

HY-117511

HJC0123	STAT Apoptosis Interleukin Related TGF-beta/Smad	Others
HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates *SOCS3*. HJC0123 can be used in the study of liver fibrosis .

HY-124619

GPI-1046	EAAT HIV	Neurological Disease
GPI-1046 is an orally active, antibiotic-free immunophilin ligand that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens core (NAc-core). GPI-1046 improves human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) by attenuating store-operated calcium (SOC) entry. GPI-1046 has neuroprotective activity .

HY-12521

GSK-5498A 3 Publications Verification	CRAC Channel	Inflammation/Immunology
GSK-5498A is a selective CARC channel inhibitor (IC₅₀: 1 μM). GSK-5498A inhibits mediators release from mast cells and pro-inflammatory cytokines release from T cells. GSK-5498A can be used in the research of inflammatory disorders .

HY-P10385A

SPSB2-iNOS inhibitory cyclic peptide-3 TFA	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-3 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-3 (HY-P10385). SPSB2-iNOS inhibitory cyclic peptide-3 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM .

HY-W009724

2-Aminoethyl diphenylborinate Maximum Cited Publications 52 Publications Verification 2-APB	Calcium Channel TRP Channel CRAC Channel	Cardiovascular Disease Inflammation/Immunology
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca ²⁺ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue .

HY-P10383

SPSB2-iNOS inhibitory cyclic peptide-1	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P10384A

SPSB2-iNOS inhibitory cyclic peptide-2 TFA	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-2 (HY-P10384). SPSB2-iNOS inhibitory cyclic peptide-2 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 TFA is reduction-resistant and oxidatively stable .

HY-172402

Vasoactive intestinal peptide	Interleukin Related COX	Infection
Vasoactive intestinal peptide is an agonist of VPAC1/VPAC2 receptor (G-protein-coupled receptors). Vasoactive intestinal peptide reduces corneal perforation rate, bacterial load, and excessive neutrophil infiltration in Pseudomonas aeruginosa-induced keratitis models. Vasoactive intestinal peptide enhances anti-inflammatory mediators like IL-10 and TGF-β, inhibites pro-inflammatory factors such as IL-1β and TNF-α, and upregulates lipid mediator-related enzymes (SOCS3, COX-2, ALOX12) to promote inflammation resolution. Vasoactive intestinal peptide is promising for research of ocular infectious diseases .

HY-173364

EB-TCIP BAK-04-212	BCL6	Cancer
EB-TCIP (BAK-04-212) is a bivalent molecule comprised of AP1867 (HY-114434) and BI-3812 (HY-111381). EB-TCIP can form a reversible ternary complex between FKBP ^F36V and BCL6 ^BTB. EB-TCIP recruits FKBP12 ^F36V-tagged EWS/FLI1 to DNA sites bound by the transcriptional regulator BCL6, leading to rapid expression of BCL6 target genes (eg: SOCS2 and CXCL11). EWS/FLI1 is a fusion transcription factors in Ewing sarcoma. EB-TCIP can be used for research of deregulated transcription in cancer .

HY-P10383A

SPSB2-iNOS inhibitory cyclic peptide-1 TFA	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-1(HY-P10383). SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

Cat. No.	Product Name	Target	Research Area