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SMARCB1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Epigenetic Reader Domain (1) Histone Methyltransferase (3) PROTACs (1) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CFT8634 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
CFT8634 is an orally bioavailable PROTAC BRD9 targeted degrader based on the E3 ubiquitin ligase CRBN mechanism. CFT8634 can be used for the study of synovial sarcoma and SMARCB1-deficient solid tumors (Pink: BRD9 ligand (HY-169988); Blue: E3 ligase ligand (HY-169989); Black: linker (HY-169991). CFT8634 is a heterobifunctional molecule that binds to BRD9 at one end and recruits CRBN at the other end, which can inhibit the growth of tumor cells that depend on BRD9. CFT8634 can be used for the study of SMARCB1-related cancers (such as synovial sarcoma and malignant rhabdoid tumor) ^[1] .

DM-01	Histone Methyltransferase	Cancer
DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors ^[1].

Tazemetostat 70+ Cited Publications EPZ-6438; E-7438	Histone Methyltransferase Apoptosis	Cancer
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat also inhibits EZH1 with an IC₅₀ of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells ^[1].

Tazemetostat (Standard) EPZ-6438 (Standard); E-7438 (Standard)	Reference Standards Histone Methyltransferase Apoptosis	Cancer
Tazemetostat (Standard) is the analytical standard of Tazemetostat. This product is intended for research and analytical applications. Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat also inhibits EZH1 with an IC₅₀ of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells ^[1].

Smarcb1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smarcb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smarcb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smarcb1 Mouse Pre-designed siRNA Set A Smarcb1 Mouse Pre-designed siRNA Set A

Smarcb1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smarcb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smarcb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smarcb1 Rat Pre-designed siRNA Set A Smarcb1 Rat Pre-designed siRNA Set A

SMARCB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMARCB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMARCB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMARCB1 Human Pre-designed siRNA Set A SMARCB1 Human Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Application	Reactivity

	SMARCB1 Antibody (YA2018) SMARCB1; BAF47; hSNF5; INI1; RDT; RTPS1; Sfh1p; SMARCB1; SNF5 homolog; SNF5L1; Snr1; SWI/SNF comp	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
	SMARCB1 Antibody (YA2018) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2018), targeting SMARCB1, with a predicted molecular weight of 44 kDa (observed band size: 44 kDa). SMARCB1 Antibody (YA2018) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse background.

	SMARCB1 Antibody (YA5650)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	SMARCB1 Antibody (YA5650) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to INI-1. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse.

	SMARCB1 Antibody (YA5649) BAF47; BRG1-associated factor 47; hSNF5; INI1; Integrase interactor 1 protein; Malignant rhabdoid tumor suppressor; RDT; RTPS1; Sfh1p; SMARCB1; SNF5 homolog; SNF5_HUMAN; SNF5L1; Snr1; Sucrose nonfermenting yeast homolog like 1; SWI/SNF complex component SNF5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI10; Transcription factor TYE4; Transcription regulatory protein SNF5; TYE4	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	SMARCB1 Antibody (YA5649) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to INI-1. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse.

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Smarcb1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Smarcb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smarcb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smarcb1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Smarcb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smarcb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMARCB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SMARCB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMARCB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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