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Results for "

SHMT

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

3

Recombinant Proteins

6

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129226
    SHMT-IN-2

    		SHMT Endocrinology Cancer
    SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas .
    SHMT-IN-2
  • HY-129651
    SHMT-IN-1

    		SHMT Cancer
    SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). SHMT-IN-1 has antitumor activity .
    SHMT-IN-1
  • HY-148545
    SHMT-IN-3

    		SHMT Cancer
    SHMT-IN-3 (Hit 1) is a SHMT1 and SHMT2 inhibitor with an IC50 of 0.53 µM for human SHMT1. SHMT-IN-3 exhibits noncompetitive inhibition against serine .
    SHMT-IN-3
  • HY-RS17061
    Shmt2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Shmt2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Shmt2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Shmt2 Mouse Pre-designed siRNA Set A
    Shmt2 Mouse Pre-designed siRNA Set A
  • HY-RS12876
    SHMT1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SHMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SHMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SHMT1 Human Pre-designed siRNA Set A
    SHMT1 Human Pre-designed siRNA Set A
  • HY-RS24663
    Shmt1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Shmt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Shmt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Shmt1 Rat Pre-designed siRNA Set A
    Shmt1 Rat Pre-designed siRNA Set A
  • HY-RS18189
    Shmt1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Shmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Shmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Shmt1 Mouse Pre-designed siRNA Set A
    Shmt1 Mouse Pre-designed siRNA Set A
  • HY-RS12877
    SHMT2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SHMT2 Human Pre-designed siRNA Set A contains three designed siRNAs for SHMT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SHMT2 Human Pre-designed siRNA Set A
    SHMT2 Human Pre-designed siRNA Set A
  • HY-162883
    SHMT-IN-4

    		SHMT Others
    SHMT-IN-4 (Compound 9ay) is a herbicide that targets and inhibits serine hydroxymethyltransferase (SHMT1) with an IC50 value of 193.8 g a.i./ha (active ingredient content per hectare). SHMT-IN-4 interferes with amino acid synthesis and metabolism in plants by binding to SHMT1, thereby inhibiting plant growth. Additionally, SHMT-IN-4 shows no significant toxicity to maize and honeybees .
    SHMT-IN-4
  • HY-RS23505
    Shmt2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Shmt2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Shmt2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Shmt2 Rat Pre-designed siRNA Set A
    Shmt2 Rat Pre-designed siRNA Set A
  • HY-112066
    SHIN1
    Maximum Cited Publications
    17 Publications Verification

    RZ-2994

    		 SHMT Cancer
    SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
    SHIN1
  • HY-134978
    (Rac)-SHIN2
    2 Publications Verification

    		 SHMT Bacterial Others
    (Rac)-SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac)-SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac)-SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus .
    (Rac)-SHIN2
  • HY-134978B
    (-)SHIN2

    		SHMT Cancer
    (-)SHIN2 is the isomer of (+)SHIN2 (HY-134978A). (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models . (-)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (-)SHIN2
  • HY-176542
    TD034

    		HDAC YAP Cancer
    TD034 is a selective, reversible and noncovalent HDAC11 inhibitor with an IC50 of 5.1 nM and a Ki of 1.5 nM. TD034 does not inhibit other HDACs or sirtuins. TD034 inhibits the defatty acylation of SHMT2 (HDAC11 substrate). TD034 decreases the YAP1 level via HDAC11 inhibition. TD034 can be used for the study of lung cancer .
    TD034
  • HY-134978A
    (+)SHIN2
    2 Publications Verification

    		 SHMT Cancer
    (+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with 13C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519) . (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (+)SHIN2

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