SCC

By Targets:	Adenylate Cyclase (1) Antibiotic (1) Apoptosis (2) Biochemical Assay Reagents (1) c-Met/HGFR (1) Cdc42-binding kinase (1) Chloride Channel (2) Drug Derivative (1) EGFR (1) Endogenous Metabolite (2) ERK (1) HSP (1) JNK (1) Liposome (1) MDM-2/p53 (1) Neuropeptide FF Receptor (1) p38 MAPK (1) PERK (1) Phosphodiesterase (PDE) (1) Reference Standards (1) Small Interfering RNA (siRNA) (2) TNF Receptor (1)
By Research Areas:	Cancer (6) Endocrinology (3) Infection (2) Inflammation/Immunology (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116000

Glumetinib 1 Publications Verification Gumarontinib; SCC244	c-Met/HGFR	Cancer
Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC₅₀ of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3. Antitumor activity .

HY-103192

MDL12330A 3 Publications Verification RMI12330A	Adenylate Cyclase Phosphodiesterase (PDE)	Others
MDL12330A (RMI12330A) is an adenyl cyclase inhibitor. MDL12330A inhibits the vasopressin action on the short-circuit current (SCC). MDL12330A is also an inhibitor of cAMP phosphodiesterase .

HY-111424

BDP9066	Cdc42-binding kinase	Cancer
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC₅₀ of 64 nM for MRCKβ in SCC12 cells, K_i values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

HY-10984A

(S)-Pomalidomide (S)-CC-4047	Endogenous Metabolite	Cancer
(S)-Pomalidomide ((S)-CC-4047) is an angiogenesis-inhibiting drug with growth-inhibitory activity against B-cell tumors. (S)-Pomalidomide can induce complete tumor regression in BurK_itt lymphoma cells. (S)-Pomalidomide serves as an immunomodulator with potential applications in inhibiting hematological malignancies .

HY-172526

*4A3-SCC-10*	Liposome	Cancer
4A3-SCC-10 is a biodegradable ionizable lipid containing disulfide bonds. 4A3-SCC-10 can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. 4A3-SCC-10 can be used for broad applications such as gene editing, vaccine, and cancer detection .

HY-125049

Kijanimicin Sch 25663	Endogenous Metabolite Antibiotic	Infection
Kijanimicin (Sch 25663) is an antibiotic produced by Actinomadura kijaniata SCC 1256 .

HY-170843

Antitumor agent-198	Apoptosis	Cancer
Antitumor agent-198 (Compound A3) exhibits cytotoxicity in head and neck squamous cell carcinoma (HNSCC) cells, that inhibits the proliferation of CAL27, HN6, HN30, SCC9 and SCC25 with IC₅₀ of 4 nM-77 nM. Antitumor agent-198 inhibits the HNSCC cell migration, arrests the cell cycle, and induces apoptosis .

HY-101595

RPH-2823	Drug Derivative	Others
RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance .

HY-RS17479

Cyp11a1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cyp11a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cyp11a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cyp11a1 Mouse Pre-designed siRNA Set A Cyp11a1 Mouse Pre-designed siRNA Set A

HY-P10780

RFRP-3 (mouse) Neuropeptide NPVF (mouse)	Neuropeptide FF Receptor Apoptosis MDM-2/p53 PERK	Endocrinology
RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development .

HY-114664

KNK423	HSP	Infection Cancer
KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research .

HY-RS12711

SERPINB3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SERPINB3 Human Pre-designed siRNA Set A contains three designed siRNAs for SERPINB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SERPINB3 Human Pre-designed siRNA Set A SERPINB3 Human Pre-designed siRNA Set A

HY-A0234R

Stepronin (Standard) Prostenoglycine (Standard); TTPG (Standard); Tiase (Standard)	Chloride Channel Reference Standards	Endocrinology
Stepronin (Standard) is the analytical standard of Stepronin. This product is intended for research and analytical applications. Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl ^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .

HY-A0234

Stepronin 1 Publications Verification Prostenoglycine; TTPG; Tiase	Chloride Channel	Endocrinology
Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl ^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .

HY-15495B

(3S)-Tanzisertib hydrochloride (3S)-CC-930 hydrochloride	JNK ERK p38 MAPK EGFR TNF Receptor	Inflammation/Immunology
(3S)-Tanzisertib (hydrochloride) ((3S)-CC-930 (hydrochloride)) is an orally active JNK inhibitor (IC₅₀ values for JNK1, JNK2, and JNK3 are 61, 7, and 6 nM, respectively). (3S)-Tanzisertib (hydrochloride) selectively inhibits ERK1, p38α, and EGFR (IC₅₀ = 0.48, 3.4, and 0.38 μM, respectively). (3S)-Tanzisertib (hydrochloride) inhibits LPS-induced TNFα production in an acute rat PK-PD model. (3S)-Tanzisertib (hydrochloride) can be used in idiopathic pulmonary fibrosis (IPF) research .

HY-W127393

N-Nonanoyl-L-homoserine lactone	Biochemical Assay Reagents	Others
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

Cat. No.	Product Name	Type

HY-W127393

N-Nonanoyl-L-homoserine lactone	Biochemical Assay Reagents
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

N-Nonanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

Cat. No.	Product Name	Target	Research Area

HY-P10780

RFRP-3 (mouse) Neuropeptide NPVF (mouse)	Neuropeptide FF Receptor Apoptosis MDM-2/p53 PERK	Endocrinology
RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125049

Kijanimicin Sch 25663	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields Other Antibiotics	Endogenous Metabolite Antibiotic
Kijanimicin (Sch 25663) is an antibiotic produced by Actinomadura kijaniata SCC 1256 .

Cat. No.	Compare	Product Name	Species	Source

HY-P76682

	TNFAIP8 Protein, Human (His) Tumor necrosis factor alpha-induced protein 8; MDC-3.13; NDED; SCC-S2; TNF-induced protein GG2-1	Human	E. coli
	TNFAIP8 Protein functions as a negative regulator of apoptosis, inhibiting caspase-8 activity and suppressing TNF-mediated apoptosis without affecting procaspase-8 processing.This control prevents BID cleavage and subsequent caspase-3 activation, contributing to cellular survival mechanisms.TNFAIP8's role highlights its potential significance in apoptosis regulation and its implications for tumor development.TNFAIP8 Protein, Human (His) is the recombinant human-derived TNFAIP8 protein, expressed by E.coli , with N-His labeled tag.

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HY-P83240

	Rad21 Antibody (YA2985) RAD21; HR21; KIAA0078; NXP1; Double-strand-break repair protein rad21 homolog; hHR21; Nuclear matrix protein 1; NXP-1; SCC1 homolog	WB, FC	Human, Mouse, Rat
	Rad21 Antibody (YA2985) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2985), targeting Rad21, with a predicted molecular weight of 72 kDa (observed band size: 72,128 kDa). Rad21 Antibody (YA2985) can be used for WB, FC experiment in human, mouse, rat background.

HY-P81223

	CYP11A1 Antibody 1 Publications Verification Cholesterol 20 22 desmolase antibody Cholesterol desmolase antibody; Cholesterol monooxygenase (side chain cleaving) antibody; Cholesterol side chain cleavage enzyme antibody; Cholesterol side chain cleavage enzyme mitochondrial antibody; Cholesterol side-chain cleavage enzyme antibody; CP11A_HUMAN antibody; CYP11A antibody; CYP11A1 antibody; CYPXIA1 antibody; Cytochrome P450 11A1 antibody; Cytochrome P450 11A1 mitochondrial antibody; Cytochrome P450 family 11 subfamily A polypeptide 1 antibody; Cytochrome P450 subfamily XIA antibody; Cytochrome P450(SCC) antibody; Cytochrome P450C11A1 antibody; mitochondrial antibody; P450SCC antibody; Steroid 20 22 lyase antibody;	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	CYP11A1 Antibody is an unconjugated, approximately 53 kDa, rabbit-derived, anti-CYP11A1 polyclonal antibody. CYP11A1 Antibody can be used for: WB,IHC-F,IHC-P,ICC/IF expriments in human, mouse, rat background without labeling.

HY-P81402

	SA2 Antibody (YA1147) SA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; stag2; Stromal antigen 2	IHC-P	Human
	SA2 Antibody (YA1147) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1147), targeting SA2. SA2 Antibody (YA1147) can be used for IHC-P experiment in human background.

HY-P81855

	TNFAIP8 Antibody (YA1600) TNF alpha-induced protein 8; NDED; SCC-S2	WB, IP	Human
	TNFAIP8 Antibody (YA1600) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1600), targeting TNFAIP8, with a predicted molecular weight of 23 kDa (observed band size: 21-23 kDa). TNFAIP8 Antibody (YA1600) can be used for WB, IP experiment in human background.

HY-P83849

	RAD21 Antibody (YA3546) HR21; MCD1; NXP1; SCC1; CDLS4; hHR21; HRAD21	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
	RAD21 Antibody (YA3546) is a mouse-derived and non-conjugated IgG1 antibody, targeting to RAD21. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, rat, monkey.

HY-P86621

	Rad21 Antibody (YA6313) RAD21; HR21; KIAA0078; NXP1; Double-strand-break repair protein rad21 homolog; hHR21; Nuclear matrix protein 1; NXP-1; SCC1 homolog	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Rad21 Antibody (YA6313) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rad21. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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HY-RS17479

Cyp11a1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cyp11a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cyp11a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12711

SERPINB3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SERPINB3 Human Pre-designed siRNA Set A contains three designed siRNAs for SERPINB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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