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Isoforms Recommended:	RUNX1

Results for "

RUNX1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) HIV (1) mRNA (1) RUNX (7) Small Interfering RNA (siRNA) (4) TGF-beta/Smad (2)
By Research Areas:	Cancer (10) Infection (2) Inflammation/Immunology (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) mRNA (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151411

RUNX1/ETO tetramerization-IN-1	RUNX	Cancer
RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization, exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of *RUNX1/ETO* (EC₅₀=0.25 μM), restores gene expression down-regulated by *RUNX1/ETO. RUNX1/ETO* tetramerization-IN-1 inhibits the proliferation of *RUNX1/ETO*-depending SKNO-1 cells, and reduces the *RUNX1/ETO*-related tumor growth in a mouse model ^[1] .

HY-174367

RUNX1/ETO-IN-1	RUNX Apoptosis	Cancer
RUNX1/ETO-IN-1 is a *RUNX1-ETO* oncogenic fusion protein inhibitor that specifically targets the NHR2 oligomerization domain. RUNX1/ETO-IN-1 directly interacts with the NHR2 (K_D,app = 39 μM). RUNX1/ETO-IN-1 exhibits anti-leukemic activity by inducing apoptosis and promoting differentiation in RUNX1/ETO-translocated AML cells. RUNX1/ETO-IN-1 remains essentially uncharged at physiological pH, demonstrating superior membrane permeability.

HY-108470

Ro5-3335 5+ Cited Publications	RUNX	Cancer
Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation ^[1].

HY-RS16650

Runx1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Cancer
Runx1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Runx1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Runx1 Mouse Pre-designed siRNA Set A Runx1 Mouse Pre-designed siRNA Set A

HY-RS12349

RUNX1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RUNX1 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX1 Human Pre-designed siRNA Set A RUNX1 Human Pre-designed siRNA Set A

HY-RS23085

Runx1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Runx1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Runx1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Runx1 Rat Pre-designed siRNA Set A Runx1 Rat Pre-designed siRNA Set A

HY-124137

Runx1-CBFβ interaction inhibitor 1	RUNX	Cancer
Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC₅₀=3.2 μM) ^[1].

HY-RS12350

RUNX1T1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RUNX1T1 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX1T1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX1T1 Human Pre-designed siRNA Set A RUNX1T1 Human Pre-designed siRNA Set A

HY-174541

*Human RUNX1* mRNA**	mRNA	Cancer
Human RUNX1 mRNA encodes the human RUNX family transcription factor 1 (RUNX1) protein, the alpha subunit of Core binding factor (CBF). RUNX1 can forms the heterodimeri CBF with CBFB and is thought to be involved in the development of normal hematopoiesis.

HY-118365

NSC 140873	RUNX	Infection Cancer
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335) ^[1] .

HY-19149

Ro24-7429	HIV Apoptosis	Infection Inflammation/Immunology Cancer
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects ^[1] .

HY-16786

AI-10-49	RUNX	Inflammation/Immunology Cancer
AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC₅₀ value of 0.26 μM. AI-10-49 can be used for the research of leukemia ^[1].

HY-125966

AI-4-57	RUNX	Cancer
AI-4-57 is an allosteric inhibitor for CBFβ SMMHC-RUNX1 (core binding factor β and the smooth-muscle myosin heavy chain) interaction with an IC₅₀ of 22 μM ^[1].

HY-16268A

Kartogenin sodium Maximum Cited Publications 27 Publications Verification KGN sodium	TGF-beta/Smad	Inflammation/Immunology
Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research ^[1] .

HY-16268

Kartogenin Maximum Cited Publications 27 Publications Verification KGN	TGF-beta/Smad	Inflammation/Immunology
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84458

	RUNX1 Antibody (YA4155) AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; RUNX1	WB, ICC/IF, ELISA	Human
	RUNX1 Antibody (YA4155) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RUNX1.

HY-P80888

	RUNX1/2/3 Antibody (YA086) RUNX1; AML1; RUNX2; OSF2; RUNX3; CBFA3	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	RUNX2 Antibody (YA086) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RUNX2.

HY-P85360

	RUNX1 Antibody (YA5052) RUNX1; AML1; CBFA2; Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha	WB, ICC/IF, ELISA	Human
	RUNX1 Antibody (YA5052) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RUNX1.

HY-P86201

	RUNX1 Antibody (YA5893) RUNX1; AML1; CBFA2; Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	RUNX1 Antibody (YA5893) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RUNX1.

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Runx1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Runx1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Runx1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RUNX1 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Runx1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Runx1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Runx1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX1T1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RUNX1T1 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX1T1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

*Human RUNX1* mRNA**		mRNA
Human RUNX1 mRNA encodes the human RUNX family transcription factor 1 (RUNX1) protein, the alpha subunit of Core binding factor (CBF). RUNX1 can forms the heterodimeri CBF with CBFB and is thought to be involved in the development of normal hematopoiesis.

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