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Results for "

RSV Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RSV (58) 5-HT Receptor (1) Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (1) CRM1 (1) DNA/RNA Synthesis (6) Drug Metabolite (2) Enterovirus (1) HCV (3) HSV (1) IFNAR (2) IGF-1R (1) Influenza Virus (6) Lactate Dehydrogenase (1) MDM-2/p53 (1) NF-κB (1) Reference Standards (1) SARS-CoV (3) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (4) Infection (62) Inflammation/Immunology (4) Metabolic Disease (1)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: RSV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149648

JNJ-8003	RSV	Infection
JNJ-8003 is a potent inhibitor of RSV Polymerase. JNJ-8003 inhibits nucleotide polymerization of RNA transcription and replication at the early stages .

HY-123475A

Sisunatovir hydrochloride 3 Publications Verification RV521 hydrochloride	RSV	Infection
Sisunatovir (RV521) hydrochloride is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC₅₀ values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir hydrochloride inhibits RSV infection and reduces virus titers in the lungs of mice .

HY-123475

Sisunatovir 3 Publications Verification RV521	RSV	Infection
Sisunatovir (RV521) is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC₅₀ values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir inhibits RSV infection and reduces virus titers in the lungs of mice .

HY-146108

RSV-IN-5	RSV	Infection
RSV-IN-5 (Compound 4) is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus (RSV) fusion proteins. RSV-IN-5 exhibits potent anti-RSV activities against not only wild-type A2 F protein (EC₅₀=2.0 nM), but also D486N-mutant F protein (EC₅₀=8.1 nM) .

HY-12993B

RSV604 (R enantiomer) A-60444 (R enantiomer)	RSV	Infection
RSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is an inhibitor of respiratory syncytial virus (RSV) replication. R-enantiomer is less active against RSV.

HY-119375

*Syncytial Virus Inhibitor-1*	Bacterial	Infection
Syncytial Virus Inhibitor-1 is a potent, orally bioavailable respiratory syncytial virus (RSV) fusion inhibitor with EC₅₀s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively .

HY-130627

RSV/IAV-IN-2	RSV Influenza Virus	Infection
RSV/IAV-IN-2 (compound 14c) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-2 has lesser cytotoxicity than the clinical agent, Ribavirin. RSV/IAV-IN-2 has the potential for the research of RSV and/or IAV infections .

HY-130626

RSV/IAV-IN-1	RSV Influenza Virus	Infection
RSV/IAV-IN-1 (compound 14e) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-1 has lesser cytotoxicity than the clinical agent, Ribavirin. RSV/IAV-IN-1 has the potential for the research of RSV and/or IAV infections .

HY-171983

RSV-IN-13	RSV	Infection
RSV-IN-13 (compound 24) is a selective *RSV* fusion protein inhibitor with antiviral activity. RSV-IN-13 has an EC₅₀ of 444.2 nM against RSV A2 strain and a CC₉₀ of 23.7 μM in HepG2 cells. RSV-IN-13 can block the virus from entering host cells. RSV-IN-13 can be used to study RSV infection .

HY-114721

BTA-9881 MEDI-564	RSV	Infection
BTA-9881 (MEDI-564) is a *RSV* inhibitor, with an EC₅₀: 48 nM, 59 nM and 160 nM for RSV A2, RSV Long, and RSV B1. BTA-9881 has favorable pharmacokinetics property .

HY-143495

RSV-IN-3	RSV Influenza Virus	Infection
RSV-IN-3 (Compound 1) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-3 shows anti-RSV activity (EC₅₀ = 32.70 μM) .

HY-143496

RSV-IN-4	RSV Influenza Virus	Infection
RSV-IN-4 (Compound 2) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-4 shows anti-RSV activity (EC₅₀ = 11.76 μM) .

HY-154967

RSV L-protein-IN-4	RSV	Infection
RSV L-protein-IN-4 (Compound C) is a noncompetitive RSV polymerase inhibitor (IC₅₀: 0.88 μM). RSV L-protein-IN-4 shows antiviral activity against RSV strains (EC₅₀: 0.25 μM) .

HY-154964

RSV L-protein-IN-2	RSV	Infection
RSV L-protein-IN-2 (Compound A) is a noncompetitive RSV polymerase inhibitor (IC₅₀: 4.5 μM). RSV L-protein-IN-2 shows antiviral activity against long RSV strains (EC₅₀: 1.3 μM) .

HY-154968

RSV L-protein-IN-5	RSV	Infection
RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC₅₀=0.1 μM). RSV L-protein-IN-5 inhibits Polymerase (IC₅₀=0.66 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection .

HY-115574

RSV L-protein-IN-1	RSV	Infection
RSV L-protein-IN-1 (compound D) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC₅₀=0.021 μM). RSV L-protein-IN-1 inhibits Polymerase (IC₅₀=0.089 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-1 shows moderate cytotoxicity (CC50=8.4 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection .

HY-12993

RSV604 2 Publications Verification A-60444	RSV	Infection
RSV604 (A-60444) is an inhibitor of respiratory syncytial virus (RSV) replication. RSV604 targets the nucleocapsid protein, with a K_d of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (average EC₅₀s=0.8 μM) .

HY-172452

RSV L-protein-6	RSV	Infection
RSV L-protein-6 (Compound 19a) is a respiratory syncytial virus polymerase inhibitor, with an IC₅₀ of 13 nM in SPA primer extensions enzymatic assay. RSV L-protein-6 can inhibit RSV replication in Hela cells .

HY-143494

RSV/IAV-IN-3	RSV Influenza Virus	Infection
RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza A virus (IAV) with EC₅₀ values of 2.92 µM and 1.90 µM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC₅₀ values of 3.25 µM and 1.50 µM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC₅₀ of 3.89 µM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage .

HY-147346

Zelicapavir 1 Publications Verification EDP-938; RSV-IN-7	RSV	Infection
Zelicapavir (RSV-IN-7) (example 253) is an orally active *RSV* inhibitor (EC₅₀: < 0.4 μΜ) .

HY-154966

RSV L-protein-IN-3	RSV	Infection
RSV L-protein-IN-3 is a wild-type *RSV* polymerase inhibitor with an IC₅₀ value of 10.4 μM and an EC₅₀ value of 2.1 μM (against RSV). RSV L-protein-IN-3 has lesser cytotoxicity than the clinical agent, Ribavirin (HY-B0434) .

HY-102038

PC786 1 Publications Verification	RSV	Infection
PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against *RSV-A* (IC₅₀ <0.09 to 0.71 nM) and *RSV-B* (IC₅₀, 1.3 to 50.6 nM) .

HY-12983

ALS-8112 3 Publications Verification	RSV	Infection
ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC₅₀ of 0.02 μM.

HY-109142

Ziresovir 4 Publications Verification AK0529; RO-0529	RSV	Infection
Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC₅₀=3 nM) and highlights pharmacokinetics in animal species .

HY-168616

CL-A3-7	RSV IGF-1R	Infection
CL-A3-7 is a virus-cell fusion inhibitor targeting the *RSV* F protein. It exerts its effect by blocking the interaction between the virus and the host IGF1R, effectively inhibiting infections of both wild-type *RSV* and the K394R variant. It is applicable to anti-RSV drug development and resistance-related research .

HY-111296

YM 53403	RSV	Infection
YM 53403 is an anti-respiratory syncytial virus (RSV) agent, with an EC₅₀ of 0.20 μM. YM 53403 potently inhibits the replication of RSV strains belonging to both A and B subgroups .

HY-156442

MEDS433	Lactate Dehydrogenase	Infection
MEDS433 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC₅₀ of 1.2 nM. MEDS433 exerts a potent antiviral activity against RSV-A and RSV-B in the one-digit nanomolar range. MEDS433 induces the expression of antiviral proteins encoded by interferon stimulated genes (ISGs) able to reduce RSV replication .

HY-124052

AZ-27	RSV	Infection
AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various *RSV* polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter .

HY-161771

JNJ-7184	RSV	Infection
JNJ-7184 is a non-nucleoside inhibitor of the *RSV*-Large (L) polymerase, with the pEC₅₀ and pCC₅₀ of 7.86 and 4.29 in Hela cells, respectively. JNJ-7184 prevents *RSV* replication and transcription by inhibiting initiation or early elongation .

HY-12983A

Lumicitabine 1 Publications Verification ALS-008176; ALS-8176	RSV	Infection
Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.

HY-11098

JNJ 2408068 R170591	RSV	Infection
JNJ 2408068 is a potent *RSV* (respiratory syncytial virus) inhibitor. JNJ 2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg .

HY-158824A

Asvasiran sodium ALN-RSV01 sodium	Small Interfering RNA (siRNA) RSV	Infection
Asvasiran sodium is a siRNA that targets the respiratory syncytial virus (RSV) N gene and inhibits viral replication.

HY-158824

Asvasiran ALN-RSV01	Small Interfering RNA (siRNA) RSV	Infection
Asvasiran is a siRNA that targets the respiratory syncytial virus (RSV) N gene and inhibits viral replication.

HY-120632

BMS-433771	RSV	Infection
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC₅₀ of 20 nM. BMS-433771 can be used for the research of respiratory tract disease .

HY-120632A

BMS-433771 dihydrochloride hydrate	RSV	Infection
BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC₅₀ of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease .

HY-142009

Antiviral agent 10	RSV	Infection
Antiviral agent 10 is an anti-viral agent that can inhibit respiratory syncytial virus (RSV) .

HY-100285

RD3-0028	RSV	Infection
RD3-0028 is a potent and selective inhibitor of *RSV* replication with an EC₅₀ of 4.5 μM.

HY-11097

TMC353121 5+ Cited Publications	RSV	Infection
TMC353121 is a potent respiratory syncytial virus (RSV) fusion inhibitor with pEC₅₀ of 9.9.

HY-112673

RSV-IN-1	RSV	Infection
RSV-IN-1 is a human respiratory syncytical virus (hRSV) inhibitor, with an IC₅₀ of 0.11 μM.

HY-W013605A

4-Methoxycinnamaldehyde p-Methoxycinnamaldehyde	RSV	Infection
4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC₅₀ of 0.055 μg/mL .

HY-109004

Enzaplatovir BTA-C585	RSV	Infection
Enzaplatovir (BTA-C585) is an orally bioavailable Inhibitor for respiratory syncytial virus (RSV) infection .

HY-16727

Presatovir 4 Publications Verification GS-5806	RSV	Infection
Presatovir (GS-5806) is an orally bioavailable *RSV* fusion inhibitor with a mean EC₅₀ value of 0.43 nM .

HY-112180

Rilematovir 4 Publications Verification JNJ-678; JNJ-53718678	RSV	Infection
Rilematovir (JNJ-678) is a novel fusion protein inhibitor. Rilematovir has the potential for respiratory syncytial virus (RSV) research.

HY-12994

VP-14637 MDT-637	RSV	Infection
MDT-637 (VP 14637) is a novel *respiratory syncytial virus (RSV) fusion* inhibitor with an IC₅₀ of 1.42 ng/mL.

HY-122587

AVG-233	DNA/RNA Synthesis RSV	Infection
AVG-233 is a potent, orally active RNA dependent RNA polymerase (RdRp) inhibitor. AVG-233 prevents initiation of the viral polymerase complex at the promoter. AVG-233 binding site is present in the L_1-1749 fragment. AVG-233 has nanomolar activity against both RSV strains and clinical RSV isolates (EC₅₀=0.14-0.31 μM). AVG-233 can be used for research of respiratory syncytial virus (RSV) .

HY-W013605AR

4-Methoxycinnamaldehyde (Standard) p-Methoxycinnamaldehyde (Standard)	Reference Standards RSV	Infection
4-Methoxycinnamaldehyde (Standard) is the analytical standard of 4-Methoxycinnamaldehyde. This product is intended for research and analytical applications. 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].

HY-19874

RFI-641	RSV	Infection
RFI-641 is a selective inhibitor of the respiratory syncytial virus (RSV), with an IC₅₀ of 50 nM. RFI-641 inhibit binding and fusion of enveloped virus via interaction with the viral fusion protein .

HY-104032

*Ac-CoA Synthase Inhibitor1* 4 Publications Verification	RSV	Infection Metabolic Disease
Ac-CoA Synthase Inhibitor1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC₅₀ of 0.6 μM . Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV) .

HY-124512

Quercetin pentaacetate Pentaacetylquercetin	RSV	Infection Inflammation/Immunology
Quercetin pentaacetate could interact with F-protein with lower binding energy and better stability to block viral adhesion. Quercetin pentaacetate interacts with RSV and inhibit the viral adhesion on cell surface .

HY-W251428

Phosphatidylglycerols (egg) sodium salt Egg PG	Biochemical Assay Reagents	Others
Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .

Cat. No.	Product Name	Type

HY-W251428

Phosphatidylglycerols (egg) sodium salt

Egg PG

Drug Delivery

Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013605A

4-Methoxycinnamaldehyde p-Methoxycinnamaldehyde	Infection Structural Classification Classification of Application Fields Araceae Ketones, Aldehydes, Acids Source classification Acorus gramineus Soland. Plants Disease Research Fields	RSV
4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC₅₀ of 0.055 μg/mL .

HY-N6771

Cyclopiazonic acid 4 Publications Verification	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Disease Research Fields Indole Alkaloids	Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

HY-W013605AR

4-Methoxycinnamaldehyde (Standard) p-Methoxycinnamaldehyde (Standard)	Structural Classification Araceae Ketones, Aldehydes, Acids Source classification Acorus gramineus Soland. Plants	Reference Standards RSV
4-Methoxycinnamaldehyde (Standard) is the analytical standard of 4-Methoxycinnamaldehyde. This product is intended for research and analytical applications. 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].

HY-N15215

Antiviral agent 64	Structural Classification Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Enterovirus Influenza Virus RSV HSV
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits *RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC₅₀* of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

Cat. No.	Product Name	Chemical Structure

HY-W013403S

2'-Deoxy-2'-fluorouridine-d2

2'-Deoxy-2'-fluorouridine-d₂ is the deuterium labeled 2'-Deoxy-2'-fluorouridine . 2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

Cat. No.	Product Name		Classification