2. Search Result
Search Result
Results for "

RNAP

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Peptides

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P10857
    Microcin J25

    MccJ25

    		 Bacterial Antibiotic Infection
    Microcin J25 (MccJ25) is a cyclic peptide antibiotic consisting of 21 unmodified amino acid residues. Microcin J25 inhibits DNA-dependent RNA polymerase (RNAP) of Gram-negative bacteria. Microcin J25 has antibacterial activity .
    Microcin J25
  • HY-125650
    Pseudouridimycin
    1 Publications Verification

    PUM

    		 Antibiotic DNA/RNA Synthesis Bacterial Nucleoside Antimetabolite/Analog Infection
    Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis .
    Pseudouridimycin
  • HY-169079
    RNAP-NusG-IN-1

    		Bacterial Infection
    RNAP-NusG-IN-1 is an RNAP-NusG inhibitor. RNAP-NusG-IN-1 has antibacterial activity against Gram-positive bacteria, with the strongest activity against Streptococcus pneumoniae, showing an MIC value of 1 μg/mL .
    RNAP-NusG-IN-1
  • HY-171647
    RNAP-σ interaction inhibitor-1

    		Bacterial Antibiotic DNA/RNA Synthesis Infection
    RNAP-σ interaction inhibitor1 (compound 5d) is an inhibitor of RNA polymerase-sigma factors interaction. RNAP-σ interaction inhibitor-1 exhibits the activity against Streptococci with MIC values of 1-2 µg/mL .
    RNAP-σ interaction inhibitor-1
  • HY-171648
    RNAP-σ interaction inhibitor-2

    		Bacterial Antibiotic DNA/RNA Synthesis Infection
    RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor of RNA polymerase-sigma factors interaction. RNAP-σ interaction inhibitor-2 exhibits the activity against S. aureus with MIC values of 2 µg/mL .
    RNAP-σ interaction inhibitor-2
  • HY-P10980
    Citrocin

    		Bacterial Infection
    Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli .
    Citrocin
  • HY-125650A
    Pseudouridimycin TFA

    PUM TFA

    		 Antibiotic DNA/RNA Synthesis Bacterial Nucleoside Antimetabolite/Analog Infection
    Pseudouridimycin (PUM) TFA is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis .
    Pseudouridimycin TFA
  • HY-173481
    CDK9-IN-37

    		CDK Cancer
    CDK9-IN-37 (Compound 24) is a CDK9 inhibitor (EC50: 5.5 nM) with weak inhibition on other CDK isoforms, showing high selectivity. CDK9-IN-37 has significant antiproliferative activity against acute myeloid leukemia MOLM-13 cells (IC50: 0.034 μM). CDK9-IN-37 inhibits the CDK9 signaling pathway, reduces the phosphorylation level of RNAP II CTD (Ser2), downregulates the anti-apoptotic protein McI-1, induces cell apoptosis, and arrests the cell cycle at the G2/M phase. CDK9-IN-37 can be used in the study of acute myeloid leukemia (AML) .
    CDK9-IN-37

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: