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Results for "

RNA ligand

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (2) RNA MTase (1) Small Interfering RNA (siRNA) (2) Target Protein Ligand-Linker Conjugates (2) AAK1 (1) Amyloid-β (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (1) CCR (2) CDK (1) Cyclin G-associated Kinase (GAK) (1) DNA Methyltransferase (1) Early 2 Factor (E2F) (1) Fluorescent Dye (1) G-quadruplex (2) Galectin (1) HBV (2) Ligands for Target Protein for PROTAC (2) LIM Kinase (LIMK) (1) Liposome (2) NF-κB (1) PROTACs (6) Salt-inducible Kinase (SIK) (1) SARS-CoV (1) Toll-like Receptor (TLR) (2) Wee1 (1)
By Research Areas:	Cancer (10) Infection (6) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (3)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Aptamers (2) Cationic Lipids (2) siRNA drugs (1) siRNAs (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Click Chemistry

Oligonucleotides

Targets Recommended: RNA MTase Target Protein Ligand-Linker Conjugates DNA/RNA Synthesis Small Interfering RNA (siRNA) E3 Ligase Ligand-Linker Conjugates mRNA PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136277

DFHO	Fluorescent Dye	Others
DFHO is a fluorogenic ligand of Corn fluorogenic aptamer. The RNA aptamer, Corn binds DFHO with a K_d value of 70 nM and converts it to a fluorescent form, enabling RNA imaging in cells .

HY-134581A

Enpatoran hydrochloride Maximum Cited Publications 10 Publications Verification M5049 hydrochloride	Toll-like Receptor (TLR)	Inflammation/Immunology
Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC₅₀s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research .

HY-176802

Oxide-DFHBI-demethyl-C6-NH2	Target Protein Ligand-Linker Conjugates	Cancer
Oxide-DFHBI-demethyl-C6-NH2 is a *Target Protein Ligand-Linker Conjugate* that incorporates a target aptamer ligand (HY-176801) and a PROTAC linker (HY-79577), which recruits E3 ligases. Oxide-DFHBI-demethyl-C6-NH2 can be used for synthesis of RNA aptamer-based PROTAC Dth (HY-175397) .

HY-175761

Riboswit-modulator-1	Others	Others
Riboswit-modulator-1 (Compound A1), a covalent RNA ligand, is a Flavin mononucleotide (FMN) riboswitch modulator. Riboswit-modulator-1 modifies unpaired guanine residues (G11 and G62) proximal to the FMN-binding site through a proximity-driven mechanism, and interferes with its conformational transitions. Riboswit-modulator-1 acts as a negative antagonist by eliciting the opposite effect of the natural effector molecule .

HY-168460

RNA recruiter 2	DNA/RNA Synthesis	Cancer
RNA recruiter 2 is a QSOX1 mRNA ligand. RNA recruiter 2 can serve as a ligand for target RNA (Ligands for Target RNA for RIBOTAC) for the development of RIBOTAC RNA degraders with antitumor activity. RNA recruiter 2 can be used for the synthesis of F1-RIBOTAC (HY-171148) .

HY-168457

*RNase L ligand* 2**	SARS-CoV	Others
RNase L ligand 2 (compound 6) is the Rnase L ligand part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNase L ligand 2 can be used in the synthesis of RIBOTAC .

HY-168455

RNAse L RIBOTAC	PROTACs	Infection
RNAse L RIBOTAC (compound C64) is an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. (Blue: RNA ligand (HY-168456); Black: linker (HY-130591); Pink: Rnase L ligand (HY-168457))

HY-176801

Oxide-DFHBI-demethyl	Ligands for Target Protein for PROTAC	Cancer
Oxide-DFHBI-demethyl is a target aptamer ligand (Ligand for Target Protein for PROTAC). Oxide-DFHBI-demethyl can be used for synthesis of RNA aptamer-based PROTAC Dth (HY-175397) .

HY-168456

RNA recruiter 1	Ligands for Target Protein for PROTAC	Infection
RNA recruiter 1 is the RNA ligand of RNAse L RIBOTAC (HY-168456), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNA recruiter 1 can be utilized in the synthesis of RIBOTAC .

HY-175397

Dth DFHBI-thalidomide	PROTACs NF-κB Early 2 Factor (E2F)	Cancer
Dth is a RNA aptamer-based PROTAC degrader. Dth can degrade a range of endogenous proteins (such as mCherry, p50, p65 and E2F1) by simply replacing the 3′ module on the RNA scaffold with the corresponding RNA aptamer of target protein (target aptamer) . Pink: Target aptamer ligand (HY-176801); Blue: CRBN ligase ligand (HY-41547); Black: linker (HY-79577).

HY-168458

RNA recruiter-linker 1	Target Protein Ligand-Linker Conjugates	Infection
RNA recruiter-linker 1 is the RNA ligand-linker part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNA recruiter-linker 1 can be utilized in the synthesis of RIBOTAC .

HY-160155

Cholesteryl-Teg azide	Biochemical Assay Reagents	Others
Cholesteryl-Teg azide is a cholesterol azide and can be used as a ligand for bioconjugation. Cholesteryl-Teg azide can modify RNA strands .

HY-121295

Roseoflavin	Bacterial	Infection
Roseoflavin, a natural pigment originally isolated from Streptomyces davawensis, is an antimetabolite analog of Riboflavin and flavin mononucleotide that has antimicrobial properties .

HY-148859

AA-T3A-C12	Liposome	Metabolic Disease Inflammation/Immunology
AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts .

HY-112680

Carboxypyridostatin	G-quadruplex	Neurological Disease
Carboxypyridostatin is a G-quadruplex ligand. Carboxypyridostatin has a highly molecular specificity to *RNA* on DNA G4s and reduces ATF-5 protein. Carboxypyridostatin reduces cell proliferation and hinders stress granule (SG) formation .

HY-171148

F1-RIBOTAC	PROTACs	Cancer
F1-RIBOTAC is a ribonuclease-targeting chimeras (RIBOTACs). F1-RIBOTAC decreases QSOX1-a mRNA expression level in an RNase L-dependent manner. F1-RIBOTAC can be used for the research of cancer . (Pink: RNA ligand (HY-168460); Black: linker (HY-W008005); Blue: RNase L ligand (HY-168452))

HY-112680A

Carboxy pyridostatin trifluoroacetate salt 4 Publications Verification	G-quadruplex	Neurological Disease
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to *RNA* on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation .

HY-134581

Enpatoran Maximum Cited Publications 10 Publications Verification M5049	Toll-like Receptor (TLR)	Inflammation/Immunology
Enpatoran (M5049) is a potent, orally active and dual TLR7/8 inhibitor with IC₅₀s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran is inactive against TLR3, TLR4 and TLR9. Enpatoran can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran exhibits excellent pharmacokinetic properties in vivo. Enpatoran can be used for both innate and adaptive autoimmunity blocking research .

HY-148100A

Emapticap pegol sodium NOX-E36 sodium	CCR	Cancer
Emapticap pegol sodium is a inhibitor of pro-inflammatory *chemokine C-C motif-ligand* 2** (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

HY-148100

Emapticap pegol NOX-E36	CCR	Inflammation/Immunology Cancer
Emapticap pegol is a inhibitor of pro-inflammatory *chemokine C-C motif-ligand* 2** (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

HY-153898

rTRD01	Amyloid-β	Neurological Disease
rTRD01 is a TDP-43 ligand that binds to TDP-43’s RRM1 and RRM2 domains (K_d=89 uM for TDP-43_102–269). rTRD01 partially disrupts TDP-43’s interaction with the hexanucleotide RNA repeat of the disease-linked c9orf72 gene. rTRD01 can be used for the research of neurodegenerative diseases .

HY-158301

MY-1B 1 Publications Verification	DNA Methyltransferase RNA MTase	Others
MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC₅₀: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes .

HY-170872

PT-129	PROTACs DNA/RNA Synthesis	Cancer
PT-129 is an RPOTAC degrader targeting the NTF2 domain (protein-RNA interaction site) of G3BP1/2, which mediates the disassembly of intracellular stress granules. PT-129 can inhibit the formation of stress granules in stressed cells and disassemble existing stress granules, and can disrupt the transmission of ATF4, thereby inhibiting the proliferation of cancer cells. Stress granules (SGs) are membrane-less cytoplasmic compartments formed under stress stimuli. SGs promote the transmission of ATF4 from fibroblasts to tumor cells through a migratory effect, mediating fibroblast-related tumor growth. And G3BP1/2 is a central protein of the SGs network, and the inhibition of G3BP1/2 may reduce the stress resistance of cancer cells in the tumor microenvironment. PT-129 is composed of a target protein ligand (red part) G3BP1/2-Targeting ligand-1 (HY-170873), an E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a PROTAC linker (black part) Amino-PEG3-C2-acid (HY-W040165); among them, the E3 ligase ligand + linker form a complex Thalidomide-NH-PEG3-propionic acid (HY-136166) .

HY-147266A

Elebsiran VIR-2218	HBV Small Interfering RNA (siRNA)	Infection
Elebsiran (VIR-2218) is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran can be used for the study of chronic HBV/HDV infections .

HY-147266

Elebsiran sodium VIR-2218 sodium	Small Interfering RNA (siRNA) HBV	Infection
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .

HY-176259

F3-PEG8-RiboTAC	PROTACs Galectin Apoptosis	Cancer
F3-PEG8-RiboTAC is a RiboTAC that can specifically degrade the mRNA of the oncogene LGALS1. F3-PEG8-RiboTAC can induce tumor cell apoptosis and inhibit invasion. F3-PEG8-RiboTAC has anti-tumor activity and can be used in the research of tumors such as leukemia and triple-negative breast cancer. (RNase L ligand (HY-177030); RNA binder (HY-177031); Linker (HY-W019798)) .

HY-154974

LNP Lipid-8	Liposome	Cancer
LNP Lipid-8 (11-A-M) is an ionizable single-tail multi-head lipid that can be used as a lipid nanoparticle (LNP) to deliver siRNA to T cells without targeting ligands. LNP Lipid-8 is more selective for T cells than other cell types such as hepatocytes. LNP Lipid-8 selectively delivers siRNA/sgRNA to T cells (especially CD8 ⁺ T cells) through endogenous lipid transport pathways, and can enter cells and release RNA through endocytosis to achieve gene silencing. LNP Lipid-8 loaded with GFP siRNA (siGFP) significantly led to GFP gene silencing in mouse models. LNP Lipid-8 showed good efficacy and safety in both cells and animals, without obvious liver targeting and toxicity. LNP Lipid-8 can be used for RNA delivery research in the fields of tumor immunotherapy and T cell-mediated autoimmune diseases .

HY-148062

RSS0680	PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1	Others
RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC with protein kinase degradation activity (Pink: FLT3-IN-17 (HY-148070); Black: Linker (HY-W041970); Blue: E3 ligase Ligand (HY-112078)). RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].

Cat. No.	Product Name	Type

HY-136277

DFHO	Fluorescent Dyes/Probes
DFHO is a fluorogenic ligand of Corn fluorogenic aptamer. The RNA aptamer, Corn binds DFHO with a K_d value of 70 nM and converts it to a fluorescent form, enabling RNA imaging in cells .

Cat. No.	Product Name	Type

HY-148859

AA-T3A-C12	Drug Delivery
AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts .

Cat. No.	Product Name		Classification

HY-168457

*RNase L ligand* 2**		Azide
RNase L ligand 2 (compound 6) is the Rnase L ligand part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNase L ligand 2 can be used in the synthesis of RIBOTAC .

HY-168458

RNA recruiter-linker 1		Alkynes
RNA recruiter-linker 1 is the RNA ligand-linker part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNA recruiter-linker 1 can be utilized in the synthesis of RIBOTAC .

Cat. No.	Product Name		Classification

HY-148859

AA-T3A-C12		Cationic Lipids
AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts .

HY-148100A

Emapticap pegol sodium NOX-E36 sodium		Aptamers
Emapticap pegol sodium is a inhibitor of pro-inflammatory *chemokine C-C motif-ligand* 2** (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

HY-148100

Emapticap pegol NOX-E36		Aptamers
Emapticap pegol is a inhibitor of pro-inflammatory *chemokine C-C motif-ligand* 2** (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

HY-147266

Elebsiran sodium VIR-2218 sodium		siRNAs siRNA drugs
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .

HY-154974

LNP Lipid-8		Cationic Lipids
LNP Lipid-8 (11-A-M) is an ionizable single-tail multi-head lipid that can be used as a lipid nanoparticle (LNP) to deliver siRNA to T cells without targeting ligands. LNP Lipid-8 is more selective for T cells than other cell types such as hepatocytes. LNP Lipid-8 selectively delivers siRNA/sgRNA to T cells (especially CD8 ⁺ T cells) through endogenous lipid transport pathways, and can enter cells and release RNA through endocytosis to achieve gene silencing. LNP Lipid-8 loaded with GFP siRNA (siGFP) significantly led to GFP gene silencing in mouse models. LNP Lipid-8 showed good efficacy and safety in both cells and animals, without obvious liver targeting and toxicity. LNP Lipid-8 can be used for RNA delivery research in the fields of tumor immunotherapy and T cell-mediated autoimmune diseases .

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