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Results for "

PS1

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Natural
Products

3

Isotope-Labeled Compounds

3

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-50882
    ELN318463

    		γ-secretase Neurological Disease
    ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1 [1] .
    ELN318463
  • HY-139973
    OAB-14

    		Amyloid-β Neurological Disease
    OAB-14, is a Bexarotene (HY-14171) derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice [1] .
    OAB-14
  • HY-119165
    GSM-1

    		γ-secretase Neurological Disease
    GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1) [1] .
    GSM-1
  • HY-N1414A
    3′,6-Disinapoylsucrose
    1 Publications Verification

    		 Bcl-2 Family Apoptosis Neurological Disease
    3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to Bcl-2 in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway [1] .
    3′,6-Disinapoylsucrose
  • HY-161723
    LH2-051

    		Dopamine Transporter CDK Neurological Disease
    LH2-051, a lysosome-enhancing compound (LYEC), is a brain-penetrant dopamine transporter (DAT) inhibitor (Ki: 0.95 μM). LH2-051 inhibits DAT-mediated dopamine uptake with an IC50 of 3.0 μM. LH2-051 promotes nuclear translocation of TFEB and lysosome biogenesis. LH2-051 improves the memory of amyloid precursor protein (APP)/Presenilin 1 (PS1) mice. LH2-051 can be used for the study of Alzheimer’s disease [1].
    LH2-051
  • HY-50882A
    ELN318463 racemate

    		γ-secretase Neurological Disease
    ELN318463 racemate is the racemate of ELN318463. ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1 [1] .
    ELN318463 racemate
  • HY-118243
    KMS88009

    		Amyloid-β Others
    KMS88009 is a potent small molecule that directly interferes with the formation of amyloid-β oligomers, thereby preserving cognitive behavior when used preventively and reversing cognitive behavior decline when used therapeutically. Oral administration of KMS88009 around the onset of Alzheimer's disease symptoms significantly reduced the assembly of amyloid-β oligomers and improved cognitive behavior in the APP/PS1 double transgenic mouse model. This unique dual mode of action suggests that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. In an evaluation, the physicochemical properties, pharmacokinetics and toxicity of this anti-amyloidogenic small molecule KMS88009 were studied, as well as post-mortem analysis of APP/PS1 TG mice after behavioral testing.
    KMS88009
  • HY-18157
    SCH 900229

    		Amyloid-β Neurological Disease
    SCH 900229 is a potent γ-secretase inhibitor with selective activity against PS1. The Aβ40 IC50 value of SCH 900229 is 1.3 nM, showing its excellent ability in reducing Aβ. SCH 900229 has shown good Aβ-lowering effects after oral administration in preclinical animal models. SCH 900229 has been advanced to human clinical trials for further development of compounds for the inhibition of Alzheimer's disease [1].
    SCH 900229
  • HY-161953
    O-GlcNAcase-IN-2

    		OGA Neurological Disease
    O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC50=4.93 nM). O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects [1].
    O-GlcNAcase-IN-2
  • HY-176271
    MAO-B-IN-45

    		Ferroptosis Monoamine Oxidase Glutathione Peroxidase Reactive Oxygen Species (ROS) Tau Protein Amyloid-β Neurological Disease
    MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain.
    MAO-B-IN-45
  • HY-RS18076
    Psen1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Psen1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Psen1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Psen1 Mouse Pre-designed siRNA Set A
    Psen1 Mouse Pre-designed siRNA Set A
  • HY-RS11276
    PSEN1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PSEN1 Human Pre-designed siRNA Set A contains three designed siRNAs for PSEN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PSEN1 Human Pre-designed siRNA Set A
    PSEN1 Human Pre-designed siRNA Set A
  • HY-157623
    16:0 Lyso PS

    1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium

    		 Biochemical Assay Reagents
    16:0 Lyso PS (1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine (sodium)) is a kind of biochemical reagent.
    16:0 Lyso PS
  • HY-126213
    1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium

    18:1 Lyso-PS

    		 NADPH Oxidase Inflammation/Immunology
    Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following activation of the NADPH oxidase and lyso-PS signaling. Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium through the macrophage G2A functions to enhance existing receptor/ligand systems for resolution of neutrophilic inflammation [1].
    1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium
  • HY-147072
    1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium

    18:0 -18:2 PS

    		 Liposome Others
    1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium is a glycerophospholipid [1].
    1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium
  • HY-143675S
    1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9

    		Isotope-Labeled Compounds Others
    1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9 is the deuterium labeled 1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS .
    1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9
  • HY-167592S
    17:0-20:3 PS-d5

    1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(-d5)-3-phospho- L-serine sodium

    		 Isotope-Labeled Compounds Others
    17:0-20:3 PS-d5 (1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phospho- L-serine (sodium)) is deuterium labeled 17:0-20:3 PS .
    17:0-20:3 PS-d5
  • HY-W011338
    Benzyl butyl phthalate
    1 Publications Verification

    		 Aryl Hydrocarbon Receptor Cancer
    Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) [1] .
    Benzyl butyl phthalate
  • HY-W011338S
    Benzyl butyl phthalate-d4

    		Aryl Hydrocarbon Receptor Cancer
    Benzyl butyl phthalate-d4 is the deuterium labeled Benzyl butyl phthalate [1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .
    Benzyl butyl phthalate-d4
  • HY-W011338R
    Benzyl butyl phthalate (Standard)

    		Reference Standards Aryl Hydrocarbon Receptor Cancer
    Benzyl butyl phthalate (Standard) is the analytical standard of Benzyl butyl phthalate. This product is intended for research and analytical applications. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) [1] .
    Benzyl butyl phthalate (Standard)

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