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Pathways Recommended: PROTAC
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PROTAC c-Met degrader-6

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175321
    PROTAC c-Met degrader-6

    		PROTACs c-Met/HGFR Apoptosis Cancer
    PROTAC c-Met degrader-6 is a potent and orally active c-Met PROTACdegrader. PROTAC c-Met degrader-6 significantly induces the degradation of the c-Met protein with DC50s of 0.52 nM and 0.45 nM in EBC-1 and Hs746T. PROTAC c-Met degrader-6 almost abrogates the migratory and invasion abilities of tumor cells and significantly induces the apoptosis and blocks the cell cycle in the G0/G1 phase. PROTAC EGFR degrader 14 can be used for the study of various cancers such as non-small cell lung cancer and stomach cancer (Pink: Target protein ligand: (HY-W425461); Blue: E3 ligand (HY-14658); Black: Linker (HY-20797), Target protein ligand + Linker (HY-175337)) .
    PROTAC c-Met degrader-6
  • HY-175337
    c-Met ligand-Linker Conjugate 2

    		Target Protein Ligand-Linker Conjugates c-Met/HGFR Cancer
    c-Met ligand-Linker Conjugate 2 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC c-Met degrader-6 (HY-175321). PROTAC c-Met degrader-6 is a c-Met PROTAC degrader with anti-tumor activity [1] .
    c-Met ligand-Linker Conjugate 2

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