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Pathways Recommended: PROTAC
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PROTAC SARS-CoV-2 Degrader-1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174233
    PROTAC SARS-CoV-2 Degrader-1

    		PROTACs SARS-CoV Infection
    PROTAC SARS-CoV-2 Degrader-1 (Compound LLP019) is a PROTAC degrader targeting the SARS-CoV-2 main protease (MPro) with a DC50 value of 4.7 μM. PROTAC SARS-CoV-2 Degrader-1 induces MPro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Degrader-1 is promising for research of COVID-19 and related coronavirus infections. (Pink: DH03 (HY-32717); Black: linker (HY-42149); Blue: Thalidomide-4-O-CH2-COO(t-Bu) (HY-42771) .
    PROTAC SARS-CoV-2 Degrader-1
  • HY-157804
    PROTAC SARS-CoV-2 Mpro degrader-1

    		PROTACs SARS-CoV Infection
    PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity .
    PROTAC SARS-CoV-2 Mpro degrader-1
  • HY-32717
    DH03

    6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinoline-3-carbonitrile

    		 Ligands for Target Protein for PROTAC Infection
    DH03 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). DH03 can serve as an active control for the target protein ligand of PROTAC SARS-CoV-2 Degrader-1 (HY-174233) .
    DH03
  • HY-174235
    Thalidomide-OCH2-amide-PEG2-C2-Boc

    		E3 Ligase Ligand-Linker Conjugates Infection
    Thalidomide-OCH2-amide-PEG2-C2-Boc is an E3 ligase ligand-linker conjugate containing a cereblon (CRBN) ligand for E3 ubiquitin ligase and a linker. Thalidomide-OCH2-amide-PEG2-C2-Boc can be used to synthesize PROTAC SARS-CoV-2 Degrader-1 (HY-174233) .
    Thalidomide-OCH2-amide-PEG2-C2-Boc

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