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Results for "

PP2A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (13) Atg8/LC3 (1) Autophagy (2) Bacterial (1) c-Myc (1) DNA/RNA Synthesis (1) Endogenous Metabolite (4) ERK (3) FOXO (1) GSK-3 (1) Isotope-Labeled Compounds (1) JNK (1) Liposome (1) MASTL (2) Mitochondrial Metabolism (1) p38 MAPK (1) Phosphatase (38) PKC (4) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Small Interfering RNA (siRNA) (3) Tau Protein (1) Topoisomerase (1) YAP (1) α-synuclein (2)
By Research Areas:	Cancer (38) Endocrinology (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (9)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Phospholipids (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113976A

Endothall Endothal	Phosphatase	Cancer
Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy .

HY-131443

TRC-766 DBK-766	Phosphatase	Others
TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase .

HY-156420

ATUX-1215	Phosphatase Apoptosis	Inflammation/Immunology Cancer
ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals. ATUX-1215 can slow the progression of lung fibrosis .

HY-137552

MKI-1 1 Publications Verification MASTL Kinase Inhibitor-1	MASTL	Cancer
MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC₅₀ of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer .

HY-139296

PP2A Cancerous-IN-1	Akt	Cancer
PP2A Cancerous-IN-1 is a strong and potent *CIP2A* (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities . PP2A Cancerous-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-113976AR

Endothall (Standard) Endothal (Standard)	Reference Standards Phosphatase	Cancer
Endothall (Standard) is the analytical standard of Endothall. This product is intended for research and analytical applications. Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy .

HY-149097

ITH12711	Phosphatase	Neurological Disease
ITH12711 is a *PP2A* ligand. ITH12711 is able to cross the blood-brain barrier (BBB). ITH12711 exerts neuroprotection via restoration of PP2A-phosphatase activity .

HY-P11336

Oscillamide C	Phosphatase	Cancer
Oscillamide C (Compound 2), a ureido-containing cyclic peptide, is a Protein phosphatase 1 (PP1) and Protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 0.90 and 1.33 μM for PP1 and PP2A, respectively. Oscillamide C can be isolated from the cyanobacteria Planktothrix agardhii and P. rubescens. Oscillamide C can be used for cancers research .

HY-P11336A

Oscillamide C TFA	Phosphatase	Cancer
Oscillamide C (TFA) (Compound 2), a ureido-containing cyclic peptide, is a Protein phosphatase 1 (PP1) and Protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 0.90 and 1.33 μM for PP1 and PP2A, respectively. Oscillamide C (TFA) can be isolated from the cyanobacteria Planktothrix agardhii and P. rubescens. Oscillamide C (TFA) can be used for cancers research .

HY-P11219

TAT-PDHPS1	YAP	Cancer
TAT-PDHPS1 is a YAP inhibitor composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), an essential activator of protein phosphatase 2A (PP2A), leading to increased YAP phosphorylation, which inactivates YAP and suppresses the expression of its downstream target genes. TAT-PDHPS1 is potentially useful in ovarian cancer research .

HY-123794

MP07-66	Phosphatase	Cancer
MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to *PP2A* reactivation .

HY-106702A

Fostriecin PD 110161; CL 1565A; CI-920	Antibiotic Bacterial Topoisomerase Phosphatase	Infection
Fostriecin is a triene antibiotic. Fostriecin is a topoisomerase II and protein phosphatase PP2A inhibitor .

HY-12833

AMZ30 1 Publications Verification	Phosphatase Akt ERK	Others
AMZ30 is selective protein phosphatase methylesterase-1(PME-1) inhibitor with IC₅₀s of 600 nM and 3.5 µM in human cell lysates and in HEK 293T cells, respectively. AMZ30 shows >100-fold selectivity relative to other serine hydrolases. AMZ30 reduces the demethylated form of *PP2A* in living cells. AMZ30 attenuates muscle cell differentiation. AMZ30 increases the resistance of U87MG and U251MG glioblastoma cells to t-BHP-induced oxidative stress. AMZ30can be used for the study of glioblastoma ^[2] .

HY-W328402

(Rac)-LB-100	Phosphatase	Cancer
(Rac)-LB-100 is the racemate of LB-100. LB-100 is a protein phosphatase 2A (PP2A) inhibitor .

HY-145232

PhosTAC7 3 Publications Verification	Phosphatase Tau Protein	Neurological Disease Cancer
PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, FOXO3a protein, and tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases (Alzheimer's disease) ^[2].

HY-120272

SMAP-2 DT-1154	Phosphatase	Cancer
SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity ^[2].

HY-101180

C2 Ceramide 2 Publications Verification Ceramide 2	Phosphatase Mitochondrial Metabolism Apoptosis Autophagy	Metabolic Disease Endocrinology
C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates *PP2A* and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss ^[2] .

HY-N6785

Okadaic acid Maximum Cited Publications 18 Publications Verification	Phosphatase Apoptosis	Neurological Disease Cancer
Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for *PP2A* (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation ^[2].

HY-112929

DT-061 15+ Cited Publications	Phosphatase	Cancer
DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis .

HY-126730

Rubratoxin A	Phosphatase	Cancer
Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A) with an IC₅₀ of 170 nM. Rubratoxin A causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts .

HY-18983

Calyculin A Maximum Cited Publications 18 Publications Verification (-)-Calyculin A	Phosphatase	Cancer
Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 2 nM and 0.5-1 nM, respectively .

HY-18597

LB-100 5+ Cited Publications	Phosphatase	Cancer
LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC₅₀ of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells ^[2] .

HY-W072940

Anticancer agent 7	Phosphatase FOXO	Cancer
Anticancer agent 7 (Example 5) modulates *PP2A, and induces FOXOl transcription factor translocation to the nucleus. Anticancer agent 7 inhibits the proliferation of H1650 lung cancer cell with an IC₅₀* of 5 μM .

HY-137135A

Cantharidic acid disodium	Phosphatase Apoptosis	Cancer
Cantharidic acid disodium is the hydrolysis product of the acid anhydride Cantharidin that induces apoptosis in various human cancer cells. Cantharidic acid disodium is a selective protein phosphatase 2 (PP2A) and PP1 inhibitor withIC₅₀ values of 50 nM and 600 nM, respectively ^[2].

HY-172143

ATUX-8385	Phosphatase	Neurological Disease Cancer
ATUX-8385 is a potent *PP2A* activator. ATUX-8385 binds to PR65 subunit. ATUX-8385 has the potential for the research of cancers and chronic conditions such as Alzheimer’s disease and chronic obstructive pulmonary disease .

HY-101047

D-erythro-Sphingosine 4 Publications Verification Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator ^[2] .

HY-176749

HUP-46	α-synuclein Atg8/LC3 Autophagy	Neurological Disease
HUP-46 is a BBB-penatrable modulator of αSyn dimerization and autophagy. HUP-46 reduces the ratio of pPP2A/PP2A, increases the autophagy marker LC3BII levels, and decreases αSyn dimerization. HUP-46 can be used for research of neurodegenerative diseases .

HY-135699

TD52 2 Publications Verification	Apoptosis Phosphatase Akt	Cancer
TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity . TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-135699A

TD52 dihydrochloride 2 Publications Verification	Akt Phosphatase Apoptosis	Cancer
TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity . TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-135284

FTY720-Mitoxy	Phosphatase	Neurological Disease Inflammation/Immunology
FTY720-Mitoxy is a fingolimod hydrochloride (HY-12005) derivative with neuroprotective and *PP2A* activating activities. FTY720-Mitoxy has the property of targeting mitochondria. In addition, FTY720-Mitoxy protects neurons by reducing inflammatory responses and is used in the study of neurodegenerative diseases such as Parkinson's disease .

HY-101047S

D-erythro-Sphingosine-d7 Erythrosphingosine-d₇; erythro-C18-Sphingosine-d₇; trans-4-Sphingenine-d₇	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator ^[2] .

HY-147071

1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine DAPE	Liposome	Metabolic Disease
1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE) is a phospholipid phosphatidylethanolamine. Unlike other phospholipid phosphatidylethanolamines, 1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine has no significant effect on protein phosphatase PP2A activity and does not inhibit insulin-stimulated GLUT4 translocation .

HY-137135

Cantharidic acid	Phosphatase Apoptosis ERK p38 MAPK JNK	Cancer
Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway .

HY-113612A

Cytostatin sodium	Apoptosis Phosphatase	Cancer
Cytostatin sodium is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC₅₀ value of 210 nM. Cytostatin sodium exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin sodium can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin sodium belongs to the family of natural product fosriecin ^[2] .

HY-101047R

D-erythro-Sphingosine (Standard) Erythrosphingosine (Standard); erythro-C18-Sphingosine (Standard); trans-4-Sphingenine (Standard)	Reference Standards PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine (Standard) is the analytical standard of D-erythro-Sphingosine. This product is intended for research and analytical applications. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-E70743

MASTL Recombinant Human Active Protein Kinase	MASTL	Cancer
MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase. MASTL Recombinant Human Active Protein Kinase is a recombinant MASTL protein that can be used to study MASTL-related functions .

HY-113612

Cytostatin	Phosphatase Apoptosis	Cancer
Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC₅₀ value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin ^[2] .

HY-157673

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine 16:1 PE	Phosphatase Apoptosis	Cancer
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance *PP2A* and PTP1B activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells .

HY-101047S1

D-erythro-Sphingosine-13C2,d2 Erythrosphingosine-¹³C₂,d₂; erythro-C18-Sphingosine-¹³C₂,d₂; trans-4-Sphingenine-¹³C₂,d₂	Isotope-Labeled Compounds PKC Endogenous Metabolite Phosphatase	Cancer
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator ^[2] .

HY-N0743

Senkyunolide A 3 Publications Verification	α-synuclein	Neurological Disease Inflammation/Immunology Cancer
Senkyunolide A is a phthalide, anti-tumor cell proliferation agent with anticancer activity. Senkyunolide A protects neurons from corticosterone (HY-B1618)-induced apoptosis by decreasing protein phosphatase *PP2A* and α-synuclein phosphorylation and protein level. Senkyunolide A also inhibits osteoarthritis through the NLRP3 signaling pathway and suppresses the expression of CD137, a diagnostic biomarker for atherosclerosis ^[2] .

HY-112929B

(1S,2S,3R)-DT-061 1 Publications Verification	Phosphatase	Cancer
(1S,2S,3R)-DT-061 is an enantiomer of DT-061 (HY-112929). DT-061 is an orally active activator of protein phosphatase 2A (PP2A). (1S,2S,3R)-DT-061 can be used as a negative control in the research of KRAS-mutant and MYC-driven lung cancer tumorigenesis .

HY-163828

PPA24	Apoptosis Phosphatase c-Myc GSK-3 ERK Reactive Oxygen Species (ROS)	Cancer
PPA24 is a PP2A activator with a K_D of 8.465 μM for PP2ACα. PPA24 induces cancer cell death via apoptosis. PP2ACα induces ROS generation and decreases the level of c-Myc expression. PPA24 can be used to study colorectal cancer (CRC), Folinic acid (HY-17556), 5-Fluorouracil (HY-90006), and Oxaliplatin (HY-17371) (FOLFOX)-resistant CRC, and melanoma cancer ^[2] .

HY-P11334

Cyanostatin B	Aminopeptidase Phosphatase Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis	Cancer
Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC₅₀ = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC₅₀ value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability. ^[2].

HY-N6785A

Okadaic acid sodium	Phosphatase Apoptosis	Neurological Disease Cancer
Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for *PP2A* (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation ^[2].

HY-115760

Okadaic acid ammonium salt	Phosphatase	Neurological Disease Cancer
Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity for *PP2A* (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation ^[2].

HY-RS21174

Ppp2ca Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ppp2ca Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppp2ca gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ppp2ca Mouse Pre-designed siRNA Set A Ppp2ca Mouse Pre-designed siRNA Set A

HY-RS18724

Ppp2r1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ppp2r1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppp2r1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ppp2r1a Mouse Pre-designed siRNA Set A Ppp2r1a Mouse Pre-designed siRNA Set A

HY-RS11412

PTPA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTPA Human Pre-designed siRNA Set A contains three designed siRNAs for PTPA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTPA Human Pre-designed siRNA Set A PTPA Human Pre-designed siRNA Set A

HY-N4317

Ethoxysanguinarine 1 Publications Verification	Apoptosis	Cancer
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth .

Cat. No.	Product Name

HY-L081

Phosphatase Inhibitor Library

159 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 159 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Cat. No.	Product Name	Type

HY-157673

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine 16:1 PE	Drug Delivery
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance *PP2A* and PTP1B activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells .

Cat. No.	Product Name	Target	Research Area

HY-P11336

Oscillamide C	Phosphatase	Cancer
Oscillamide C (Compound 2), a ureido-containing cyclic peptide, is a Protein phosphatase 1 (PP1) and Protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 0.90 and 1.33 μM for PP1 and PP2A, respectively. Oscillamide C can be isolated from the cyanobacteria Planktothrix agardhii and P. rubescens. Oscillamide C can be used for cancers research .

HY-P11336A

Oscillamide C TFA	Phosphatase	Cancer
Oscillamide C (TFA) (Compound 2), a ureido-containing cyclic peptide, is a Protein phosphatase 1 (PP1) and Protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 0.90 and 1.33 μM for PP1 and PP2A, respectively. Oscillamide C (TFA) can be isolated from the cyanobacteria Planktothrix agardhii and P. rubescens. Oscillamide C (TFA) can be used for cancers research .

HY-P11219

TAT-PDHPS1	YAP	Cancer
TAT-PDHPS1 is a YAP inhibitor composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), an essential activator of protein phosphatase 2A (PP2A), leading to increased YAP phosphorylation, which inactivates YAP and suppresses the expression of its downstream target genes. TAT-PDHPS1 is potentially useful in ovarian cancer research .

HY-P11334

Cyanostatin B	Aminopeptidase Phosphatase Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis	Cancer
Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC₅₀ = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC₅₀ value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability. ^[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6785

Okadaic acid Maximum Cited Publications 18 Publications Verification	Animals Ketones, Aldehydes, Acids Marine natural products Source classification Other marine organisms	Phosphatase Apoptosis
Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for *PP2A* (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation ^[2].

HY-101047

D-erythro-Sphingosine 4 Publications Verification Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator ^[2] .

HY-N0743

Senkyunolide A 3 Publications Verification	Natural Products Classification of Application Fields Source classification Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields Cancer	α-synuclein
Senkyunolide A is a phthalide, anti-tumor cell proliferation agent with anticancer activity. Senkyunolide A protects neurons from corticosterone (HY-B1618)-induced apoptosis by decreasing protein phosphatase *PP2A* and α-synuclein phosphorylation and protein level. Senkyunolide A also inhibits osteoarthritis through the NLRP3 signaling pathway and suppresses the expression of CD137, a diagnostic biomarker for atherosclerosis ^[2] .

HY-N4317

Ethoxysanguinarine 1 Publications Verification	Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Papaveraceae Cancer	Apoptosis
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth .

HY-106702A

Fostriecin PD 110161; CL 1565A; CI-920	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Topoisomerase Phosphatase
Fostriecin is a triene antibiotic. Fostriecin is a topoisomerase II and protein phosphatase PP2A inhibitor .

HY-101047R

D-erythro-Sphingosine (Standard) Erythrosphingosine (Standard); erythro-C18-Sphingosine (Standard); trans-4-Sphingenine (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Standard) is the analytical standard of D-erythro-Sphingosine. This product is intended for research and analytical applications. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-113612

Cytostatin	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Phosphatase Apoptosis
Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC₅₀ value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin ^[2] .

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HY-P703178

	PPP2R5A Protein, Human (His, Strep) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha; PPP2R5A; Homo sapiens; Human; PR61alpha;	Human	E. coli
	PPP2R5A Protein, Human (His, Strep) is the recombinant human-derived PPP2R5A, expressed by E. coli , with Strep, His labeled tag. ,

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HY-101047S

D-erythro-Sphingosine-d7
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator ^[2] .

HY-101047S1

D-erythro-Sphingosine-13C2,d2
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator ^[2] .

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HY-P80284

	PP2A alpha + beta Antibody (YA123)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
	PP2A alpha + beta Antibody (YA123) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PP2A alpha + beta.

HY-P82190

	SET Antibody (YA1935) 2PP2A; IGAAD; TAF-I; I2PP2A; IPP2A2; PHAPII; TAF-IBETA	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	SET Antibody (YA1935) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SET.

HY-P83111

	*Phospho-PP2A* alpha (Tyr307) Antibody (YA2856)** PPP2CA; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; RP-C	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-PP2A alpha (Tyr307) Antibody (YA2856) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PP2A alpha (Tyr307).

HY-P86411

	PP2A alpha/beta Antibody (YA6103) PP2A A; PP2A alpha; PP2A B; PP2A beta; PP2A-alpha; PP2A-beta; PP2AA_HUMAN; PP2Aalpha; PP2AB_HUMAN; PP2Abeta; PP2Ac; PP2CA; PP2Calpha; PP2CB; PPP2CA; PPP2CB; Protein phosphatase 2 catalytic subunit alpha isoform; Protein phosphatase 2 catalytic subunit beta isoform; Protein phosphatase type 2A catalytic subunit; Replication protein C; RP C; RP-C; RPC; Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine protein phosphatase 2A catalytic subunit beta isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PP2A alpha/beta Antibody (YA6103) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PP2A alpha/beta.

HY-P85454

	PP2A alpha Antibody (YA5146) PPP2CA; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; RP-C	WB, ICC/IF	Human, Mouse, Bovine, Chicken, Dog, Pig, Rabbit, Zebrafish
	PP2A alpha Antibody (YA5146) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PP2A alpha.

HY-P81948

	PP2A alpha/beta Antibody (YA1693) PPP2CA; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; RP-C	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
	PP2A alpha/beta Antibody (YA1693) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PP2A alpha/beta.

HY-P85517

	PP2A alpha + beta Antibody (YA5209) PP2A beta; PP2A-beta; PP2AB_HUMAN; PP2Abeta; PP2CB; PPp2cb; Protein phosphatase 2; formerly 2A; , catalytic subunit, beta isoform; Protein phosphatase 2 catalytic subunit beta isozyme; Protein phosphatase 2, catalytic subunit, beta isoform; Protein phosphatase 2A catalytic subunit beta isoform; Protein phosphatase type 2A catalytic subunit; Serine/threonine protein phosphatase 2A catalytic subunit beta; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform.	WB, IP	Human, Mouse, Rat
	PP2A alpha + beta Antibody (YA5209) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PP2A alpha + beta.

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Cat. No.	Product Name		Classification

HY-135699

TD52 2 Publications Verification		Alkynes
TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity . TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-135699A

TD52 dihydrochloride 2 Publications Verification		Alkynes
TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity . TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139296

PP2A Cancerous-IN-1		Alkynes
PP2A Cancerous-IN-1 is a strong and potent *CIP2A* (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities . PP2A Cancerous-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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HY-147071

1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine DAPE		Phospholipids
1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE) is a phospholipid phosphatidylethanolamine. Unlike other phospholipid phosphatidylethanolamines, 1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine has no significant effect on protein phosphatase PP2A activity and does not inhibit insulin-stimulated GLUT4 translocation .

HY-157673

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine 16:1 PE		Phospholipids
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance *PP2A* and PTP1B activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells .

HY-RS21174

Ppp2ca Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ppp2ca Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppp2ca gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18724

Ppp2r1a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ppp2r1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppp2r1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11412

PTPA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTPA Human Pre-designed siRNA Set A contains three designed siRNAs for PTPA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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