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Pathways Recommended: PI3K/Akt/mTOR
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PI3K/mTOR-IN-17

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174855
    PI3K/mTOR-IN-17

    		PI3K mTOR Apoptosis Bcl-2 Family MDM-2/p53 Caspase Cancer
    PI3K/mTOR-IN-17 is a dual PI3K and mTOR inhibitor with IC50 values of 1.21 μM (PI3K), and 0.21 μM (mTOR). PI3K/mTOR-IN-17 induces cells caspase-mediated apoptosis by arresting their growth in the G1-phase. PI3K/mTOR-IN-17 upregulates the levels of caspases-3, 7, 8, and 9, p53 expression and Bax/Bcl-2 ratio. PI3K/mTOR-IN-17 suppresses the PI3K/mTOR signaling pathway. PI3K/mTOR-IN-17 can be used for research of cancer, such as non-small cell lung cancer (NSCLC) .
    PI3K/mTOR-IN-17
  • HY-170656
    PI3K/mTOR Inhibitor-17

    		PI3K mTOR Cancer
    PI3K/mTOR Inhibitor-17 (compound 5nh) is a potent inhibitor of PI3K/mTOR, with the inhibitor of 0.45 and 2.9 nM for PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-17 plays an important role in cancer research .
    PI3K/mTOR Inhibitor-17
  • HY-162025
    mTOR inhibitor-17

    		mTOR PI3K Cancer
    mTOR inhibitor-17 (Compound 9e) is a selective inhibitor for mTOR. mTOR inhibitor-10 inhibits mTOR and PI3K-α, with IC50 of 0.68 and 1359 nM. mTOR inhibitor-10 inhibits proliferation of LNCaP with IC50 of 40 nM .
    mTOR inhibitor-17

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