PGK 1

Isoforms Recommended:	PGK1

By Targets:	Phosphoglycerate Kinase (PGK) (2) Apoptosis (1) CDK (2) Fungal (1) Keap1-Nrf2 (1) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Infection (1) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: Phosphoglycerate Kinase (PGK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W195984

Z57346765 1 Publications Verification	Phosphoglycerate Kinase (PGK)	Cancer
Z57346765 is a PGK1-specific inhibitor that reduces the activity of metabolic enzymes in PGK1 glycolysis and inhibits PGK1-dependent cell proliferation. Z57346765 exerts inhibitory effects against clear cell renal cell carcinoma (KIRC) .

HY-134205A

CBR-470-1 2 Publications Verification	Keap1-Nrf2	Neurological Disease Metabolic Disease
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP ⁺-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .

HY-15154

NG 52 Maximum Cited Publications 15 Publications Verification Compound 52	CDK	Cancer
NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC₅₀s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC₅₀ of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .

HY-127162

Prostaglandin K1 PGK1	Prostaglandin Receptor	Others
Prostaglandin K1 (compound 46) is a structurally modified analog of prostacyclin (prostanoid) with an EC₅₀ of 2800 nM for EP1 and a K_i of 2800 nM .

HY-RS16592

Pgk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pgk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pgk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pgk1 Mouse Pre-designed siRNA Set A Pgk1 Mouse Pre-designed siRNA Set A

HY-RS23026

Pgk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pgk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pgk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pgk1 Rat Pre-designed siRNA Set A Pgk1 Rat Pre-designed siRNA Set A

HY-RS10384

PGK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PGK1 Human Pre-designed siRNA Set A contains three designed siRNAs for PGK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PGK1 Human Pre-designed siRNA Set A PGK1 Human Pre-designed siRNA Set A

HY-N8540

Ilicicolin H	Phosphoglycerate Kinase (PGK) Fungal Apoptosis	Infection Cancer
Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC₅₀ = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC₅₀ = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with K_D of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection .

HY-15154R

NG 52 (Standard)	CDK	Cancer
NG 52 (Standard) is the analytical standard of NG 52. This product is intended for research and analytical applications. NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8540

Ilicicolin H	Natural Products Microorganisms Source classification	Phosphoglycerate Kinase (PGK) Fungal Apoptosis
Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC₅₀ = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC₅₀ = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with K_D of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74634

	PGK1 Protein, Mouse (sf9, His) Phosphoglycerate kinase 1; Primer recognition protein 2; PGK1; PGKA	Mouse	Sf9 insect cells
	The PGK1 protein catalyzes the conversion of 1,3-bisphosphoglycerate into 3-phosphoglycerate and plays a central role in ATP production.It also acts as a polymerase alpha cofactor protein and may be involved in primer recognition.PGK1 Protein, Mouse (sf9, His) is the recombinant mouse-derived PGK1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P71049

	PGK1 Protein, Human (HEK293, His) Phosphoglycerate kinase 1; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PGK1; PGKA	Human	HEK293
	The PGK1 protein plays a key role in the glycolysis pathway by catalyzing one of two ATP-generating reactions, promoting the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. In addition to its glycolytic function, PGK1 appears to act as a cofactor protein for polymerase α, playing a role in primer recognition. PGK1 Protein, Human (HEK293, His) is the recombinant human-derived PGK1 protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P80784

	PGK1 Antibody PGKA; MIG10; HEL-S-68p	WB, ICC/IF, FC	Human, Mouse, Rat
	PGK1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PGK1.

HY-P80784A

	PGK1 Antibody (YA862) PGKA; MIG10; HEL-S-68p	WB, ICC/IF	Human, Mouse, Rat
	PGK1 Antibody (YA862) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PGK1.

HY-P87724

	PGK1 Antibody (YA7409)	WB, IHC, ICC/IF, ELISA	Human, Mouse, Rat

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Cat. No.	Product Name		Classification

HY-RS16592

Pgk1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pgk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pgk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23026

Pgk1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pgk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pgk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10384

PGK1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PGK1 Human Pre-designed siRNA Set A contains three designed siRNAs for PGK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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