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Results for "

PDI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PDI (17) Antibiotic (3) Apoptosis (3) Bacterial (3) Biochemical Assay Reagents (1) Integrin (1) Phosphatase (1) Small Interfering RNA (siRNA) (7)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (3)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (3) siRNAs (7)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: PDI

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124866

PDI-IN-3	PDI	Neurological Disease
PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability .

HY-W107464

G6PDi-1 3 Publications Verification	PDI	Metabolic Disease Inflammation/Immunology
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀ of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .

HY-114086

ML359	PDI	Cardiovascular Disease
ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC₅₀ of 250 nM. ML359 can prevent thrombus formation in vivo .

HY-100430

CCF642	Apoptosis PDI	Cancer
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-111117

3-Methyltoxoflavin 1 Publications Verification	PDI	Cancer
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC₅₀ of 170 nM.

HY-110172

PDI-IN-1	PDI	Cancer
PDI-IN-1 (Compound P1) is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 1.7 μM. PDI-IN-1 has anti-cancer activity.

HY-163351

PDI-IN-2	PDI	Cancer
PDI-IN-2 (Compound 22) is a *PDI* or recombinant *PDI* inhibitor with IC₅₀ values of 0.62 and 0.63 μM, respectively. PDI-IN-2 has antitumor activity .

HY-170655

PDI-IN-4	PDI Integrin	Cardiovascular Disease
PDI-IN-4 (Compound 14d) is an inhibitor of protein disulfide isomerase, with an IC₅₀ value of 0.48 μM. PDI-IN-4 suppresses platelet aggregation and thrombus formation by attenuating GPIIb/IIIa activation without significantly causing cytotoxicity. PDI-IN-4 can be used in research on thrombosis .

HY-RS10265

PDIA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PDIA2 Human Pre-designed siRNA Set A contains three designed siRNAs for PDIA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PDIA2 Human Pre-designed siRNA Set A PDIA2 Human Pre-designed siRNA Set A

HY-RS10267

Pdia3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pdia3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdia3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pdia3 Mouse Pre-designed siRNA Set A Pdia3 Mouse Pre-designed siRNA Set A

HY-125832

PBDB-T	Biochemical Assay Reagents	Others
PBDB-T is a wide bandgap polymer donor in Perylene diimide (PDI)-based polymer solar cells (PSCs) .

HY-100433

PACMA 31 1 Publications Verification	PDI	Cancer
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-142127

Ribostamycin Vistamycin; SF-733	Bacterial Antibiotic PDI	Infection
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of *PDI* .

HY-RS25269

P4hb Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P4hb Rat Pre-designed siRNA Set A contains three designed siRNAs for P4hb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

P4hb Rat Pre-designed siRNA Set A P4hb Rat Pre-designed siRNA Set A

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Bacterial Antibiotic PDI	Infection
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

HY-107193

Bacitracin 1 Publications Verification	Bacterial Antibiotic PDI	Infection Cancer
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

HY-RS18831

Padi2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Padi2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Padi2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Padi2 Mouse Pre-designed siRNA Set A Padi2 Mouse Pre-designed siRNA Set A

HY-122895

E64FC26 2 Publications Verification	Apoptosis PDI	Cancer
E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity .

HY-RS09960

PADI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PADI1 Human Pre-designed siRNA Set A contains three designed siRNAs for PADI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PADI1 Human Pre-designed siRNA Set A PADI1 Human Pre-designed siRNA Set A

HY-RS18780

P4hb Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P4hb Mouse Pre-designed siRNA Set A contains three designed siRNAs for P4hb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

P4hb Mouse Pre-designed siRNA Set A P4hb Mouse Pre-designed siRNA Set A

HY-100432

LOC14 2 Publications Verification	PDI	Neurological Disease Inflammation/Immunology
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC₅₀ and K_d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .

HY-117570

KSC-34	PDI	Neurological Disease
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC₅₀ of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family . KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-122895A

(E/Z)-E64FC26	Apoptosis PDI	Cancer
(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity .

HY-116748

(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane	PDI Phosphatase
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pK_a value (8.3) and high reduction potential (-0.24 V), capable of mimicking *PDI* activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research .

HY-RS09945

P4HB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P4HB Human Pre-designed siRNA Set A contains three designed siRNAs for P4HB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

P4HB Human Pre-designed siRNA Set A P4HB Human Pre-designed siRNA Set A

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Resistance Selection Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic PDI
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

Bacitracin 1 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Source classification Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Disease Research Fields Cancer	Bacterial Antibiotic PDI
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

Ribostamycin Vistamycin; SF-733	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic PDI
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of *PDI* .

Species:	Human (8) Mouse (3) Cynomolgus (2)
Tag:	His (12) GST (1)
Source:	HEK293 (5) sf9 insect cells (1) Sf9 insect cells (2) E. coli (4) sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71087

	P4HB Protein, Human (HEK293, His) Protein Disulfide-Isomerase; PDI; Cellular Thyroid Hormone-Binding Protein; Prolyl 4-Hydroxylase Subunit Beta; p55; P4HB; ERBA2L; PDI; PDIA1; PO4DB	Human	HEK293
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (HEK293, His) is the recombinant human-derived P4HB protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78767

	PADI2 Protein, Mouse (HEK293, His) PADI2; PAD-H19; KIAA0994; PAD2; PDI2	Mouse	HEK293
	Padi2 Protein functions as an enzyme that catalyzes the deimination process, specifically targeting arginine residues within proteins. PADI2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PADI2 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78767A

	PADI2 Protein, Mouse (HEK293, N-His) PADI2; PAD-H19; KIAA0994; PAD2; PDI2	Mouse	HEK293
	Padi2 Protein functions as an enzyme that catalyzes the deimination process, specifically targeting arginine residues within proteins. PADI2 Protein, Mouse (HEK293, N-His) is the recombinant mouse-derived PADI2, expressed by HEK293 , with N-10*His labeled tag. ,

HY-P74658

	P4HB Protein, Mouse (HEK293, His) Protein disulfide-isomerase; PDI; ERp59; p55; P4HB; PDIa1	Mouse	HEK293
	P4HB proteins are versatile and multifunctional, coordinating disulfide bond catalysis at the cell surface and inside the cell.It exhibits reductase activity, cleaves disulfide bonds, induces structural modifications, and functions as a chaperone to inhibit aggregation of misfolded proteins.P4HB Protein, Mouse (HEK293, His) is the recombinant mouse-derived P4HB protein, expressed by HEK293 , with C-His labeled tag.

HY-P701030

	PADI4 Protein, Human (Biotinylated, His) Protein-arginine deiminase type-4; HL-60 PAD; HL60 PAD; HL-60; PAD; PAD4; PADI5; PDI5	Human	E. coli
	The PADI4 protein catalyzes the citrullination of arginine residues in proteins such as histones, contributing to the histone code and stem cell regulation. PADI4 Protein, Human (Biotinylated, His) is the recombinant human-derived PADI4 protein, expressed by E. coli , with N-His labeled tag.

HY-P704834

	PAD1 Protein, Human (sf9, His) PAD1; PDI1	Human	sf9 insect cells
	PAD1 Protein, Human (sf9, His) is the recombinant human-derived PAD1 protein, expressed by sf9 insect cells, with N-His tag.

HY-P703022

	PAD1 Protein, Human (Active, sf9, GST) PAD1; PDI1	Human	Sf9 insect cells
	PAD1 Protein, Human (Active, sf9, GST) is the recombinant human-derived PAD1, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P78575

	PADI2 Protein, Cynomolgus (sf9, His) PADI2; PAD-H19; KIAA0994; PAD2; PDI2	Cynomolgus	sf9 insect cells
	The PADI2 protein plays a key role in cellular processes by catalyzing the deimination of protein arginine residues. This enzymatic activity, called citrullination, involves the conversion of arginine to citrulline, affecting the structure and function of the target protein. PADI2 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived PADI2 protein, expressed by sf9 insect cells , with N-His labeled tag.

HY-P78738

	PADI2 Protein, Human (HEK293, His) PADI2; PAD-H19; KIAA0994; PAD2; PDI2	Human	HEK293
	The PADI2 protein serves as a catalyst for the deimination process, specifically targeting arginine residues within proteins and facilitating their conversion. PADI2 Protein, Human (HEK293, His) is the recombinant human-derived PADI2 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P704161

	PADI3 Protein, Human (sf9, His) PAD3; PDI3; UHS1; Protein-arginine deiminase type-3	Human	Sf9 insect cells
	PADI3 Protein, Human (sf9, His) is the recombinant human-derived PADI3 protein, expressed by Sf9 insect cells, with N-His tag.

HY-P70990

	PADI4 Protein, Human (His) 1 Publications Verification Protein-Arginine Deiminase Type-4; HL-60 PAD; Peptidylarginine Deiminase IV; Protein-arginine Deiminase type IV; PADI4; PADI5; PDI5	Human	E. coli
	PADI4 is a hydrolase that converts arginine residues in histones to citrulline. PADI4 promotes tumor progression by up-regulating the cytokine receptor CXCR2. PADI4 can also cause inflammation and immune responses. PADI4 Protein, Human (His) is the recombinant human-derived PADI4 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703812

	PADI4 Protein, Cynomolgus (His) Protein-Arginine Deiminase Type-4; HL-60 PAD; Peptidylarginine Deiminase IV; Protein-arginine Deiminase type IV; PADI4; PADI5; PDI5	Cynomolgus	E. coli
	PADI4 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived PADI4 protein, expressed by E. coli, with N-His tag.

HY-P71917

	P4HB Protein, Human (His) 1 Publications Verification Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide Isomerase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_HUMAN; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp	Human	E. coli
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (His) is the recombinant human-derived P4HB protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81758

	P4HB Antibody (YA1503) P4HB; DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	P4HB Antibody (YA1503) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1503), targeting P4HB, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). P4HB Antibody (YA1503) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P86343

	PDI Antibody (YA6035)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PDI Antibody (YA6035) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDI. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P82048

	ERp29 Antibody (YA1793) ERp28; ERP29_HUMAN; ERp31; HEL S 107; PDI-DB; PDIA9	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	ERp29 Antibody (YA1793) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1793), targeting ERp29, with a predicted molecular weight of 29 kDa (observed band size: 29 kDa). ERp29 Antibody (YA1793) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P83984

	P4HB Antibody (YA3681) DSI,GIT,PDI,PHDB,PDIA1,PO4DB,PO4HB,PROHB,CLCRP1,ERBA2L,P4Hbeta	WB, IHC-P, FC, ELISA	Human
	P4HB Antibody (YA3681) is a mouse-derived and non-conjugated IgG2a antibody, targeting to P4HB. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.

HY-P83985

	P4HB Antibody (YA3682) DSI,GIT, PDI,PHDB, PDIA1,PO4DB, PO4HB,PROHB,CLCRP1, ERBA2L,P4Hbeta	WB, IHC-P, ICC/IF, FC, ELISA	Human
	P4HB Antibody (YA3682) is a mouse-derived and non-conjugated IgG2a antibody, targeting to P4HB. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human.