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Results for "

PDH

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

2

Antibodies

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134908
    DHNA

    1,4-Dihydroxy-6-naphthoic acid

    		 PDHK Cardiovascular Disease
    DHNA (KIS20) is a PDH kinase 4 (PDK4) inhibitor with an IC50 of 18 μM. DHNA can be used for the study of heart failure .
    DHNA
  • HY-P2804
    GAPDH, rabbit muscle
    1 Publications Verification

    GADPH; G3PDH; Glyceraldehyde phosphate dehydrogenase

    		 Endogenous Metabolite Others
    Glyceraldehyde phosphate dehydrogenase (EC 1.2.1.12) is the target of anti-thymocyte and anti-apoptotic agents. Glyceraldehyde phosphate dehydrogenase catalyzes the chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals .
    GAPDH, rabbit muscle
  • HY-W009213
    3-Nitrophenyl disulfide

    Bis(3-nitrophenyl) disulfide; Nitrophenide

    		 Parasite Infection
    3-Nitrophenyl disulfide (Bis(3-Nitrophenyl) disulfide) is an inhibitor of mannitol-1-phosphate dehydrogenase (M1PDH) with IC50 of 3 μM. 3-Nitrophenyl disulfide has antiparasitic activity .
    3-Nitrophenyl disulfide
  • HY-149814
    PDK-IN-1

    		PDHK HSP Cancer
    PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass .
    PDK-IN-1
  • HY-161048
    PDH E1-IN-1

    		PDHK Others
    PDH E1-IN-1 (compound 24) is a selective TPP-competitive PDH E1 with an IC50 value of 0.99 μM .
    PDH E1-IN-1
  • HY-162586
    PDHK-IN-7

    		PDHK Cancer
    PDHK-IN-7 (compound 32) is an inhibitor of pyruvate dehydrogenase kinase with an IC50 value of 17 nM.PDHK-IN-7 activates PDH in rat livers and has a glucose-lowering effect in Zucker fatty rats .
    PDHK-IN-7
  • HY-175770
    mIDH1-IN-2

    		Isocitrate Dehydrogenase (IDH) PDK-1 Apoptosis Cancer
    mIDH1-IN-2 is a brain-penetrant isocitrate dehydrogenase 1 (IDH1) inhibitor. mIDH1-IN-2 shows subnanomolar potency against IDH1 R132H and R132C (IC50 = 80.0 and 58.0 nM) and minimal activity against wt-IDH1/2. mIDH1-IN-2 also inhibits PDK1 (IC50 = 0.61 μM) and reduces PDH phosphorylation dose-dependently. mIDH1-IN-2 can inhibit cells proliferation, induces S phase arrest and promotes apoptosis. mIDH1-IN-2 can be used for the research of cancer, such as glioma .
    mIDH1-IN-2
  • HY-N15518
    Pipcroside C

    		PDHK Bacterial Infection
    Pipcroside C is found in P. crocatum Ruiz & Pav. Pipcroside C is a PDH inhibitor (IC50: 80.25 µM). Pipcroside C has antibacterial activity and is used in the study of oral infections .
    Pipcroside C
  • HY-N15517
    Pipcroside B

    		PDHK Bacterial Infection
    Pipcroside B is found in P. crocatum Ruiz & Pav. Pipcroside B is a PDH inhibitor (IC50: 99.82 µM). Pipcroside B has antibacterial activity and is used in the study of oral infections .
    Pipcroside B
  • HY-RS10285
    PDP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PDP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PDP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PDP1 Human Pre-designed siRNA Set A
    PDP1 Human Pre-designed siRNA Set A
  • HY-Y0445A
    Sodium dichloroacetate
    20+ Cited Publications

    		 PDK-1 NKCC PDHK Reactive Oxygen Species (ROS) Apoptosis Cancer
    Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na +-K +-2Cl − cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers .
    Sodium dichloroacetate
  • HY-W587796
    6-Phosphoglucono-δ-lactone

    6-PGδL; 6-Phosphonoglucono-D-lactone

    		 Endogenous Metabolite PDI Cardiovascular Disease Metabolic Disease Cancer
    6-Phosphoglucono-δ-lactone (6-PGδL) is a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD). 6-Phosphoglucono-δ-lactone is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP). 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research .
    6-Phosphoglucono-δ-lactone

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