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PDE4-IN-29

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-176520
    PDE4-IN-29

    		Phosphodiesterase (PDE) Inflammation/Immunology
    PDE4-IN-29 (Compound 55) is an orally active and selective PDE4 inhibitor (including subtypes such as PDE4A1, PDE4B2, PDE4D3) with IC50s of <5 nM against PDE4D3. PDE4-IN-29 inhibits the degradation of cyclic adenosine monophosphate (cAMP), increases intracellular cAMP levels, suppressing the release of inflammatory factors such as TNF-α. PDE4-IN-29 is promising for research of inflammatory diseases including psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease .
    PDE4-IN-29

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