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Results for "

PCLAF

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149428
    AD4
    1 Publications Verification

    		 PROTACs Cancer
    AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .
    AD4
  • HY-162393
    XL44

    		Apoptosis Cancer
    XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13 Pru and ubiquitin-independent loss of select KEN box containing proteins .
    XL44
  • HY-RS25716
    Pclaf Rat Pre-designed siRNA Set A

    Paf; PAF15; Ns5atp9

    		 Small Interfering RNA (siRNA) Others

    Pclaf Rat Pre-designed siRNA Set A contains three designed siRNAs for Pclaf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pclaf Rat Pre-designed siRNA Set A
    Pclaf Rat Pre-designed siRNA Set A
  • HY-RS19227
    Pclaf Mouse Pre-designed siRNA Set A

    Paf; PAF15; Ns5apt9; Ns5atp9; p15(PAF); mKIAA0101; 2810417H13Rik

    		 Small Interfering RNA (siRNA) Others

    Pclaf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pclaf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pclaf Mouse Pre-designed siRNA Set A
    Pclaf Mouse Pre-designed siRNA Set A
  • HY-RS10154
    PCLAF Human Pre-designed siRNA Set A

    L5; PAF; OEATC; PAF15; OEATC1; p15PAF; NS5ATP9; OEATC-1; p15/PAF; KIAA0101; p15(PAF)

    		 Small Interfering RNA (siRNA) Others

    PCLAF Human Pre-designed siRNA Set A contains three designed siRNAs for PCLAF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PCLAF Human Pre-designed siRNA Set A
    PCLAF Human Pre-designed siRNA Set A
  • HY-174301
    USP7-IN-18

    		Deubiquitinase DNA Methyltransferase MDM-2/p53 Cancer
    USP7-IN-18 is a naphthalene derivative. USP7-IN-18 is a selective USP7 inhibitor (IC50 : 130.9 nM), with no or very weak inhibition of the other 8 DUBs including USP47. USP7-IN-18 specifically binds to the catalytic domain of USP7, blocking its deubiquitinase activity. USP7-IN-18 causes degradation of the oncogenic proteins MDM2 and DNMT1, and also degrades the novel target PCLAF. USP7-IN-18 activates the p53-p21 pathway. USP7-IN-18 exerts anti-tumor effects in colon cancer animal models and reshapes the tumor immune microenvironment. USP7-IN-18 achieves both direct cytotoxic and immune-synergistic anti-tumor actions[1].
    USP7-IN-18

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