Search Result

Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

PA-1 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	c-Myc (1) Calcium Channel (1) COX (1) Drug Derivative (1) FAK (2) NF-κB (1) NO Synthase (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) TNF Receptor (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1731

2′-Hydroxy-5′-methoxyacetophenone 2-Hydroxy-5-methoxyacetophenone	NF-κB COX TNF Receptor NO Synthase Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity against PA-1, Caov-3, and SK-OV-3 cell lines with IC₅₀s of 271, 326 and 405 µg/mL, respectively. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes .

HY-143407

FAK-IN-3	FAK	Cancer
FAK-IN-3 (Compound 36) is a potent inhibitor of focal adhesion kinase (FAK). FAK-IN-3 not only decreases migration and invasion of PA-1 cells, but also reduces expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis, and no obvious adverse effects. FAK-IN-3 has the potential for the research of ovarian cancer .

HY-176488

Y-99	Wnt β-catenin c-Myc	Cancer
Y-99 is a PORCN inhibitor with an IC₅₀ of 155.4 nM against the Wnt/β-catenin signaling pathway. Y-99 inhibits the expression of p-LRP6, β-catenin, and c-Myc .

HY-175459

PROTAC FAK degrader 3	PROTACs FAK	Inflammation/Immunology Cancer
PROTAC FAK degrader 3 is a selective FAK PROTAC degrader (DC₅₀ = 1.08 nM). PROTAC FAK degrader 3-induced FAK degradation is dependent on the ubiquitin-proteasome system and its binding to FAK and CRBN. PROTAC FAK degrader 3 upregulates MHC-I gene transcription and tumor cell surface expression by inhibiting the non-catalytic activity of FAK, leading to increased antigen presentation and activation of cytotoxic CD8 T cells. PROTAC FAK degrader 3 enhances in vivo anti-tumor activity by promoting MHC-I expression and enhancing T cell activation. PROTAC FAK degrader 3 can be used in cancer research targeting FAK degradation in ovarian cancer, hepatocellular carcinoma, and other cancers. (Pink: FAK-IN-3:HY-143407, Blue: Thalidomide-4-OH:HY-103596, Blue + Black: FAK ligand-3: HY-W939883, Black: Linker) .

HY-172566

1-Myristyl-2-hydroxy-sn-glycero-3-PA 1-Myristyl LPA	Drug Derivative Calcium Channel	Others
1-Myristyl-2-hydroxy-sn-glycero-3-PA (1-Myristyl LPA) is a lysophosphatidic acid derivative. 1-Myristyl-2-hydroxy-sn-glycero-3-PA can increase intracellular calcium concentration in HEL cells .

Cat. No.	Product Name	Type

HY-N1731

2′-Hydroxy-5′-methoxyacetophenone 2-Hydroxy-5-methoxyacetophenone	Biochemical Assay Reagents
2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity against PA-1, Caov-3, and SK-OV-3 cell lines with IC₅₀s of 271, 326 and 405 µg/mL, respectively. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes .

2′-Hydroxy-5′-methoxyacetophenone

2-Hydroxy-5-methoxyacetophenone

Biochemical Assay Reagents

2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity against PA-1, Caov-3, and SK-OV-3 cell lines with IC₅₀s of 271, 326 and 405 µg/mL, respectively. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.