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P2Y14 agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (2) DNA/RNA Synthesis (1) Endogenous Metabolite (9) Isotope-Labeled Compounds (2) P2Y Receptor (18) p38 MAPK (2) Reference Standards (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (8) Infection (1) Inflammation/Immunology (11) Metabolic Disease (8) Neurological Disease (1)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010820

Uridine 5'-diphosphate sodium salt 2 Publications Verification	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent *P2Y₁₄* antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis .

HY-114364

UDP-Galactose disodium 1 Publications Verification	P2Y Receptor Endogenous Metabolite	Infection Neurological Disease Metabolic Disease
UDP-Galactose disodium is a natural agonist of the *P2Y₁₄* receptor with an EC₅₀ of 0.67 μM for the hP2Y₁₄ receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5). In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major .

HY-110322A

PPTN 3 Publications Verification	P2Y Receptor	Inflammation/Immunology
PPTN, a chemical probe, is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .

HY-110322

PPTN hydrochloride 3 Publications Verification	P2Y Receptor	Inflammation/Immunology
PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity .

HY-137607A

UDP trisodium	P2Y Receptor	Inflammation/Immunology
UDP trisodium (Compound 3), a nucleotide, is a P2Y₁₄ receptor agonist with an EC₅₀ of 160  nM for P2Y₁₄ receptor over the P2Y₆ receptor. UDP trisodium can be used for pain, diabetes, cystic fibrosis and other pulmonary diseases research .

HY-168139

MRS4865	P2Y Receptor	Cancer
MRS4865 (compund 7a) is a chimera of a *P2Y14* receptor antagonist and a UDP-glucose agonist that protects against neuropathic pain .

HY-122211

MRS2802	Endogenous Metabolite	Cardiovascular Disease
MRS2802 is a P2Y14 receptor agonist with an EC50 value of 63 nM. MRS2802 can effectively activate the P2Y14 receptor and may play a role in regulating platelet function. The selectivity and activity of MRS2802 are conducive to in-depth research on the biological functions and pharmacological properties of P2Y receptors. The development of MRS2802 provides a potential inhibitory strategy for the search for new antiplatelet compounds .

HY-131822

5'-UMPS Uridine-5'-O-monophosphorothioate	P2Y Receptor	Cancer
5'-UMPS (Uridine-5'-O-monophosphorothioate) is a P2Y14 receptor agonist. 5'-UMPS can induce HeLa cell growth slightly .

HY-150524

UDP-Galactose	Endogenous Metabolite P2Y Receptor	Metabolic Disease
UDP-Galactose is a monosaccharide involved in nucleotide sugar metabolism. UDP-Galactose and its derivatives act as a natural agonist for G_i protein-conjugated P2Y₁₄ receptors in the immune system (IC₅₀=0.67 μM, hP2Y₁₄) .

HY-103055

PPTN mesylate	P2Y Receptor	Inflammation/Immunology
PPTN mesylate is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN mesylate exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .

HY-N7032

Uridine 5′-diphosphoglucose disodium Maximum Cited Publications 6 Publications Verification UDP-D-Glucose disodium	Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

HY-113044

Uridine 5′-diphosphoglucose UDP-D-Glucose	Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

HY-113044R

Uridine 5′-diphosphoglucose (Standard) UDP-D-Glucose (Standard)	Reference Standards Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Uridine 5′-diphosphoglucose (Standard) (UDP-D-Glucose (Standard)) is the analytical standard of Uridine 5′-diphosphoglucose (HY-113044). This product is intended for research and analytical applications. Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

HY-116295

MRS2690	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 is a selective *P2Y14* receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease .

HY-116295A

MRS2690 disodium	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 disodium is a selective *P2Y14* receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease .

HY-N7032S

Uridine 5′-diphosphoglucose-13C disodium UDP-D-Glucose-¹³C disodium	Isotope-Labeled Compounds Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Uridine 5′-diphosphoglucose- ¹³C (UDP-D-Glucose- ¹³C) disodium is the ¹³C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

HY-N7032S1

Uridine 5′-diphosphoglucose-13C6 disodium UDP-D-Glucose-¹³C₆ disodium	Isotope-Labeled Compounds Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Uridine 5′-diphosphoglucose- ¹³C₆ (UDP-D-Glucose- ¹³C₆) disodium is the ¹³C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

HY-131821

5'-TMPS Thymidine-5'-O-monophosphorothioate	P2Y Receptor	Others
5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of P2Y₆R and an antagonist of *P2Y₁₄R*. Additionally, 5'-TMPS acts as a positive regulator of angiogenesis, exhibiting pro-angiogenic effects

HY-110369

MRS2905 trisodium a,β-Methylene-2-thio-UDP trisodium	P2Y Receptor	Inflammation/Immunology
MRS2905 (α,β-Methylene-2-thio-UDP) trisodium is a selective *P2Y14R* agonist with an EC₅₀ of 0.92 nM. MRS2905 trisodium is inactive at the UDP-activated P2Y6 receptor, and at other P2Y receptors .

Cat. No.	Product Name	Type

HY-114364

UDP-Galactose disodium 1 Publications Verification	Gene Sequencing and Synthesis
UDP-Galactose disodium is a natural agonist of the *P2Y₁₄* receptor with an EC₅₀ of 0.67 μM for the hP2Y₁₄ receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5). In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major .

UDP-Galactose disodium

1 Publications Verification

Gene Sequencing and Synthesis

UDP-Galactose disodium is a natural agonist of the P2Y₁₄ receptor with an EC₅₀ of 0.67 μM for the hP2Y₁₄ receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5). In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010820

Uridine 5'-diphosphate sodium salt 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent *P2Y₁₄* antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis .

HY-114364

UDP-Galactose disodium 1 Publications Verification	Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	P2Y Receptor Endogenous Metabolite
UDP-Galactose disodium is a natural agonist of the *P2Y₁₄* receptor with an EC₅₀ of 0.67 μM for the hP2Y₁₄ receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5). In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major .

HY-N7032

Uridine 5′-diphosphoglucose disodium Maximum Cited Publications 6 Publications Verification UDP-D-Glucose disodium	Natural Products Source classification Endogenous metabolite	Endogenous Metabolite P2Y Receptor
Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

HY-113044R

Uridine 5′-diphosphoglucose (Standard) UDP-D-Glucose (Standard)	Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite P2Y Receptor
Uridine 5′-diphosphoglucose (Standard) (UDP-D-Glucose (Standard)) is the analytical standard of Uridine 5′-diphosphoglucose (HY-113044). This product is intended for research and analytical applications. Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

HY-150524

UDP-Galactose	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite P2Y Receptor
UDP-Galactose is a monosaccharide involved in nucleotide sugar metabolism. UDP-Galactose and its derivatives act as a natural agonist for G_i protein-conjugated P2Y₁₄ receptors in the immune system (IC₅₀=0.67 μM, hP2Y₁₄) .

HY-113044

Uridine 5′-diphosphoglucose UDP-D-Glucose	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite P2Y Receptor
Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

Cat. No.	Product Name	Chemical Structure

HY-N7032S1

Uridine 5′-diphosphoglucose-13C6 disodium
Uridine 5′-diphosphoglucose- ¹³C₆ (UDP-D-Glucose- ¹³C₆) disodium is the ¹³C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

Uridine 5′-diphosphoglucose-13C6 disodium

Uridine 5′-diphosphoglucose- ¹³C₆ (UDP-D-Glucose- ¹³C₆) disodium is the ¹³C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

HY-N7032S

Uridine 5′-diphosphoglucose-13C disodium
Uridine 5′-diphosphoglucose- ¹³C (UDP-D-Glucose- ¹³C) disodium is the ¹³C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

Uridine 5′-diphosphoglucose-13C disodium

Uridine 5′-diphosphoglucose- ¹³C (UDP-D-Glucose- ¹³C) disodium is the ¹³C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

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P2Y14 agonist

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