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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

OVCAR-3 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Amyloid-β (2) Apoptosis (8) Bacterial (1) Caspase (1) CDK (2) COX (2) DNA/RNA Synthesis (1) Drug Derivative (1) Ephrin Receptor (1) Epigenetic Reader Domain (1) Fungal (1) Histone Acetyltransferase (1) Kinesin (7) Microtubule/Tubulin (5) mTOR (2) NO Synthase (2) p38 MAPK (2) Parasite (1) PARP (1) PI3K (3) PROTACs (1) Reactive Oxygen Species (2) Ser/Thr Protease (1) Toll-like Receptor (TLR) (2) Topoisomerase (1) Wee1 (2)
By Research Areas:	Cancer (27) Infection (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)

By Targets:

Akt (2)

Amyloid-β (2)

Apoptosis (8)

Bacterial (1)

Caspase (1)

CDK (2)

COX (2)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Ephrin Receptor (1)

Epigenetic Reader Domain (1)

Fungal (1)

Histone Acetyltransferase (1)

Kinesin (7)

Microtubule/Tubulin (5)

mTOR (2)

NO Synthase (2)

p38 MAPK (2)

Parasite (1)

PARP (1)

PI3K (3)

PROTACs (1)

Reactive Oxygen Species (2)

Ser/Thr Protease (1)

Toll-like Receptor (TLR) (2)

Topoisomerase (1)

Wee1 (2)

By Research Areas:

Cancer (27)

Infection (1)

Inflammation/Immunology (2)

Metabolic Disease (2)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3558

Ceanothic acid Emmolic acid	Others	Cancer
Ceanothic acid (Emmolic acid) is a ring-A homologue of betulinic acid. Ceanothic acid inhibits OVCAR-3, HeLa, and FS-5 cells with the cell survival of 68%, 65%, and 81%, respectively .

HY-N10544

δ-Cadinene (+)-δ-Cadinene	Bacterial Parasite Fungal Apoptosis	Infection Cancer
δ-Cadinene ((+)-δ-Cadinene) is a sesquiterpene in essential oils. δ-Cadinene shows antiproliferative and pro-apoptotic effects on human ovary cancer (OVCAR-3) cells. δ-Cadinene has trichomonacidal, antimicrobial, antifungal and anticancer properties .

HY-N0022

Isoacteoside 4 Publications Verification Isoverbascoside	Apoptosis Reactive Oxygen Species Akt mTOR PI3K NO Synthase COX p38 MAPK Toll-like Receptor (TLR) Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

HY-N7760

Neosalvianen	Others	Others
Neosalvianen is a N-containing compound that shows cytotoxic activities against the HeLa, HepG2, and OVCAR-3 cell lines, with IC₅₀ of 63.9 µM, 59.2 µM, and 74.6 µM, respectively .

HY-N10268

3-Hydroxyterphenyllin NSC 299113	Apoptosis	Cancer
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

HY-145389

SZ-015268	CDK	Cancer
SZ-015268 is a CDK7 inhibitor with an IC₅₀ of 23.56 nM. SZ-015268 has extremely significant anti-tumor advantages. SZ-015268 inhibits HCC70, OVCAR-3, HCT116 and HCC1806 cells proliferation with IC₅₀s of 33, 80.56, 12.53, and 61.55 nM, respectively .

HY-169476

Pyrrolidine linoleamide	Drug Derivative	Cancer
Pyrrolidine linoleamide is a derivative of linoleic acid amide with anticancer activity. Pyrrolidine linoleamide exhibits antiproliferative activity against a range of cancer cell lines, with IC₅₀ values of 12.0, 27.5, 7.7, 21.9, 36.6, 32.6, and 33.9 μg/mL against U251, MCF-7, NCI-ADR/RES, 786-0, NCI-H460, PC-3, and OVCAR-3 cell lines, respectively .

HY-167876

PQR514	PI3K	Cancer
PQR514 is a potent PI3K inhibitor with anticancer activity. PQR514 is able to inhibit cancer cell proliferation. PQR514 showed significant antitumor activity in the OVCAR-3 xenograft model, with the required concentration being approximately one-eighth that of PQR309. PQR514 has good pharmacokinetic properties and minimal brain penetration, making it an optimized candidate compound for inhibiting systemic tumors .

HY-158683

KIF18A-IN-11	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-11 (Compound 13) is a potent KIF18A inhibitor, with IC₅₀ values of less than 100 nM in OVCAR3 and MDA-MB-157 cells. KIF18A-IN-11 can be used for the research of cancer .

HY-N0022R

Isoacteoside (Standard) Isoverbascoside (Standard)	Toll-like Receptor (TLR) Amyloid-β Apoptosis Reactive Oxygen Species Akt mTOR PI3K NO Synthase COX p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Isoacteoside (Standard) is the analytical standard of Isoacteoside. This product is intended for research and analytical applications. Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside Standard regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside Standard exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

HY-168057

PROTAC CDK2 Degrader-1	PROTACs CDK	Cancer
PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader for cyclin-dependent kinase 2 (CDK2). PROTAC CDK2 Degrader-1 inhibits the phosphorylation of RB protein in CDK2 dependent cell line OVCAR3 with an IC₅₀ of 100-500 nM .

HY-N15345

Menominin A	Others	Cancer
Menominin A is a cyclic peptide identified from the freshwater sponge-associated cyanobacterium Nostoc sp., exhibiting cytotoxic properties. It displays antiproliferative activity against the ovarian cancer cell line OVCAR3, with an IC₅₀ value of 3.1 μM. Menominin A holds promise for research in the field of anticancer therapeutics .

HY-162532

KIF18A-IN-10	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-10 (Compound 24) is a potent KIF18A inhibitor, with an IC₅₀ value of 23.8 nM. KIF18A-IN-10 has anticancer activity, with IC₅₀ values of less than 100 nM in OVCAR3 and MDA-MB-157 cells .

HY-N15346

Menominin B	Others	Cancer
Menominin B is a cyclic peptide found in the freshwater sponge-associated cyanobacterium Nostoc sp. with cytotoxic properties. Menominin B exhibits antiproliferative activity against the ovarian cancer cell line OVCAR3 (with IC₅₀ of 2.4 μM). Menominin B holds promise for research in the field of anticancer therapy .

HY-162531

KIF18A-IN-9	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-9 (Compound 1) is a potent KIF18A inhibitor, with an IC₅₀ value of 3.8 nM. KIF18A-IN-9 has anticancer activity, with IC₅₀ values of less than 100 nM in OVCAR3 and MDA-MB-157 cells .

HY-143339

CBP/p300-IN-15	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC₅₀ values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC₅₀ values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research .

HY-153066

VLS-1272 KIF18A-IN-7	Kinesin Microtubule/Tubulin Apoptosis	Cancer
VLS-1272 (Compound 22) is an orally active KIF18A inhibitor that binds to the KIF18A-microtubule complex in an ATP-noncompetitive manner (IC₅₀ = 41 nM), blocking its ATPase activity and inhibiting microtubule translocation. This leads to abnormal accumulation of KIF18A at spindle poles, disrupting chromosome alignment and inducing mitotic arrest and apoptosis in CIN ^High tumor cells (e.g., ovarian cancer OVCAR-3, breast cancer JIMT-1). VLS-1272 is a promising candidate for anti-tumor research .

HY-168180

WEE1-IN-11	Wee1	Cancer
WEE1-IN-11 (Compound 13) is a potent CDK2 inhibitor with an IC₅₀ of 2.0 nM. WEE1-IN-11 inhibits NCI–H446, A427, OVCAR3, C33A,and WiDr cells with IC₅₀s of 93.9, 34.5, 86.7, 23.1, and 85 nM, respectively .

HY-164978

KIF18A-IN-14	Kinesin	Cancer
KIF18A-IN-14 (Compound Example 81) is a KIF18A inhibitor. KIF18A-IN-14 is available in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit OVCAR-3 cells viability with IC₅₀s of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be used in tumor (e.g. colon, breast, lung) studies .

HY-164979

KIF18A-IN-15	Kinesin	Cancer
KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC₅₀s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC₅₀s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies .

HY-170517

PKMYT1-IN-8	Wee1 Ephrin Receptor	Cancer
PKMYT1-IN-8 (Compound 137) is the inhibitor for PKMYT1 with an IC₅₀ of 9 nM. PKMYT1-IN-8 inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2with IC₅₀s of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. PKMYT1-IN-8 inhibits the proliferation of cancer cell OVCAR3 with GI₅₀ of 2.02 μM .

HY-N10922

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone	Others	Cancer
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

HY-173001

AuL1	Topoisomerase	Cancer
AuL1 is an inhibitor of topoisomerase IIα (Top II) with DNA-intercalating properties. AuL1 is cytotoxic to tumor cells and can be used in the research of anticancer agents .

HY-132840

Sovilnesib 1 Publications Verification AMG 650	Kinesin Microtubule/Tubulin	Cancer
Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC₅₀ value of 0.071 μM. Sovilnesib can be used for the research of cancer .

HY-104000

BAY-320	Ser/Thr Protease	Cancer
BAY-320 is a selective and ATP-competitive Bub1 inhibitor that inhibits the kinase activity of Bub1 with an IC₅₀ of 680 nM. BAY-320 inhibits endogenous Bub1-mediated Sgo1 localization. BAY-320 affects cellular mitotic chromosome arrangement and spindle assembly. BAY-320 inhibits cell proliferation. BAY-320 can be used in the study of cancer .

HY-N1639

1-Decarboxy-3-oxo-ceanothic acid DOCA	Apoptosis DNA/RNA Synthesis	Cancer
1-Decarboxy-3-oxo-ceanothic acid is an anticancer agent. 1-Decarboxy-3-oxo-ceanothic acid inhibits DNA synthesis. 1-Decarboxy-3-oxo-ceanothic acid induces Apoptosis .

HY-157137

PARP1-IN-17	PARP Caspase Apoptosis	Cancer
PARP1-IN-17 is a PARP-1 inhibitor (IC₅₀ = 19.24 nM for PARP-1 and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity .

HY-N3446

IVHD-valtrate	Apoptosis	Cancer
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

Ceanothic acid Emmolic acid	Other Terpenoids other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Ceanothic acid (Emmolic acid) is a ring-A homologue of betulinic acid. Ceanothic acid inhibits OVCAR-3, HeLa, and FS-5 cells with the cell survival of 68%, 65%, and 81%, respectively .

δ-Cadinene (+)-δ-Cadinene	Structural Classification Natural Products Labiatae Terpenoids Sesquiterpenes Plants Tithonia diversifolia A. Gray.	Bacterial Parasite Fungal Apoptosis
δ-Cadinene ((+)-δ-Cadinene) is a sesquiterpene in essential oils. δ-Cadinene shows antiproliferative and pro-apoptotic effects on human ovary cancer (OVCAR-3) cells. δ-Cadinene has trichomonacidal, antimicrobial, antifungal and anticancer properties .

Isoacteoside 4 Publications Verification Isoverbascoside	Structural Classification Classification of Application Fields Simple Phenylpropanols Cistanche deserticola Ma Source classification Phenols Polyphenols Orobanchaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields	Apoptosis Reactive Oxygen Species Akt mTOR PI3K NO Synthase COX p38 MAPK Toll-like Receptor (TLR) Amyloid-β
Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

Neosalvianen	Structural Classification Alkaloids Terpenoids Other Alkaloids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants	Others
Neosalvianen is a N-containing compound that shows cytotoxic activities against the HeLa, HepG2, and OVCAR-3 cell lines, with IC₅₀ of 63.9 µM, 59.2 µM, and 74.6 µM, respectively .

3-Hydroxyterphenyllin NSC 299113	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

Isoacteoside (Standard) Isoverbascoside (Standard)	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Source classification Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants	Toll-like Receptor (TLR) Amyloid-β Apoptosis Reactive Oxygen Species Akt mTOR PI3K NO Synthase COX p38 MAPK
Isoacteoside (Standard) is the analytical standard of Isoacteoside. This product is intended for research and analytical applications. Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside Standard regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside Standard exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

Menominin A	Structural Classification Microorganisms Cyclopeptides Source classification	Others
Menominin A is a cyclic peptide identified from the freshwater sponge-associated cyanobacterium Nostoc sp., exhibiting cytotoxic properties. It displays antiproliferative activity against the ovarian cancer cell line OVCAR3, with an IC₅₀ value of 3.1 μM. Menominin A holds promise for research in the field of anticancer therapeutics .

Menominin B	Structural Classification Natural Products Microorganisms Source classification	Others
Menominin B is a cyclic peptide found in the freshwater sponge-associated cyanobacterium Nostoc sp. with cytotoxic properties. Menominin B exhibits antiproliferative activity against the ovarian cancer cell line OVCAR3 (with IC₅₀ of 2.4 μM). Menominin B holds promise for research in the field of anticancer therapy .

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Celastrus Plants	Others
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

1-Decarboxy-3-oxo-ceanothic acid DOCA	Triterpenes Structural Classification Animals Terpenoids Source classification	Apoptosis DNA/RNA Synthesis
1-Decarboxy-3-oxo-ceanothic acid is an anticancer agent. 1-Decarboxy-3-oxo-ceanothic acid inhibits DNA synthesis. 1-Decarboxy-3-oxo-ceanothic acid induces Apoptosis .

IVHD-valtrate	Structural Classification Natural Products Classification of Application Fields Source classification Valeriana officinalis Linn. Plants Valerianaceae Disease Research Fields Cancer	Apoptosis
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

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